Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0J2_LEIMA

TriTrypDb:

LmjF.36.5690 , LMJLV39_360069300 , LMJSD75_360069300

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0J2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0J2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.456
CLV_C14_Caspase3-7	96	100	PF00656	0.623
CLV_NRD_NRD_1	228	230	PF00675	0.350
CLV_NRD_NRD_1	291	293	PF00675	0.511
CLV_NRD_NRD_1	300	302	PF00675	0.559
CLV_NRD_NRD_1	39	41	PF00675	0.658
CLV_PCSK_KEX2_1	215	217	PF00082	0.370
CLV_PCSK_KEX2_1	228	230	PF00082	0.419
CLV_PCSK_KEX2_1	281	283	PF00082	0.597
CLV_PCSK_KEX2_1	300	302	PF00082	0.614
CLV_PCSK_KEX2_1	39	41	PF00082	0.658
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.370
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.542
CLV_PCSK_PC7_1	211	217	PF00082	0.401
CLV_PCSK_SKI1_1	143	147	PF00082	0.341
CLV_PCSK_SKI1_1	292	296	PF00082	0.563
CLV_PCSK_SKI1_1	306	310	PF00082	0.560
CLV_PCSK_SKI1_1	85	89	PF00082	0.501
DEG_APCC_DBOX_1	38	46	PF00400	0.606
DEG_Nend_UBRbox_3	1	3	PF02207	0.671
DOC_CYCLIN_RxL_1	137	150	PF00134	0.355
DOC_CYCLIN_yCln2_LP_2	246	249	PF00134	0.435
DOC_MAPK_MEF2A_6	118	125	PF00069	0.519
DOC_PP2B_LxvP_1	246	249	PF13499	0.556
DOC_PP2B_LxvP_1	309	312	PF13499	0.591
DOC_PP4_FxxP_1	286	289	PF00568	0.558
DOC_PP4_FxxP_1	295	298	PF00568	0.591
DOC_USP7_MATH_1	18	22	PF00917	0.670
DOC_USP7_MATH_1	233	237	PF00917	0.619
DOC_USP7_UBL2_3	143	147	PF12436	0.473
DOC_USP7_UBL2_3	293	297	PF12436	0.572
DOC_USP7_UBL2_3	54	58	PF12436	0.492
DOC_WW_Pin1_4	1	6	PF00397	0.466
DOC_WW_Pin1_4	23	28	PF00397	0.612
DOC_WW_Pin1_4	30	35	PF00397	0.682
LIG_14-3-3_CanoR_1	232	240	PF00244	0.640
LIG_14-3-3_CanoR_1	52	57	PF00244	0.493
LIG_APCC_ABBA_1	161	166	PF00400	0.523
LIG_FHA_1	105	111	PF00498	0.483
LIG_LIR_Apic_2	284	289	PF02991	0.558
LIG_LIR_Gen_1	150	157	PF02991	0.337
LIG_LIR_Gen_1	88	97	PF02991	0.659
LIG_LIR_Nem_3	173	178	PF02991	0.398
LIG_LIR_Nem_3	88	94	PF02991	0.553
LIG_Pex14_2	63	67	PF04695	0.539
LIG_SH2_CRK	53	57	PF00017	0.620
LIG_SH2_SRC	178	181	PF00017	0.341
LIG_SH2_STAT5	103	106	PF00017	0.544
LIG_SH2_STAT5	178	181	PF00017	0.338
LIG_SH2_STAT5	285	288	PF00017	0.514
LIG_SH3_3	273	279	PF00018	0.455
LIG_SH3_3	309	315	PF00018	0.538
LIG_SUMO_SIM_par_1	121	128	PF11976	0.474
MOD_CK1_1	21	27	PF00069	0.637
MOD_CK1_1	33	39	PF00069	0.589
MOD_CK2_1	247	253	PF00069	0.494
MOD_GlcNHglycan	157	160	PF01048	0.419
MOD_GlcNHglycan	235	238	PF01048	0.637
MOD_GlcNHglycan	255	258	PF01048	0.469
MOD_GSK3_1	18	25	PF00069	0.602
MOD_GSK3_1	249	256	PF00069	0.589
MOD_LATS_1	50	56	PF00433	0.580
MOD_LATS_1	83	89	PF00433	0.504
MOD_NEK2_1	155	160	PF00069	0.394
MOD_NEK2_1	22	27	PF00069	0.630
MOD_NEK2_2	18	23	PF00069	0.515
MOD_PKA_2	155	161	PF00069	0.426
MOD_PKA_2	61	67	PF00069	0.558
MOD_Plk_1	217	223	PF00069	0.451
MOD_Plk_4	171	177	PF00069	0.389
MOD_Plk_4	52	58	PF00069	0.523
MOD_ProDKin_1	1	7	PF00069	0.466
MOD_ProDKin_1	23	29	PF00069	0.613
MOD_ProDKin_1	30	36	PF00069	0.680
MOD_SUMO_rev_2	236	244	PF00179	0.701
TRG_ENDOCYTIC_2	53	56	PF00928	0.622
TRG_ENDOCYTIC_2	75	78	PF00928	0.529
TRG_ER_diArg_1	228	230	PF00400	0.350
TRG_ER_diArg_1	289	292	PF00400	0.550
TRG_ER_diArg_1	299	301	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGJ4	Leptomonas seymouri	76%	99%
A0A0S4IS55	Bodo saltans	45%	100%
A0A1X0P0I2	Trypanosomatidae	59%	100%
A0A3R7M3K5	Trypanosoma rangeli	55%	100%
A0A3S7XBV5	Leishmania donovani	95%	100%
A4HQ85	Leishmania braziliensis	85%	100%
A4IDY3	Leishmania infantum	95%	100%
D0A426	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AU03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%