CUE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0J1_LEIMA

TriTrypDb:

LmjF.36.5700 , LMJLV39_360069400 , LMJSD75_360069400

Length:

789

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0J1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0J1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0032182	ubiquitin-like protein binding	3	2
GO:0043130	ubiquitin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.543
CLV_C14_Caspase3-7	584	588	PF00656	0.670
CLV_C14_Caspase3-7	658	662	PF00656	0.715
CLV_C14_Caspase3-7	664	668	PF00656	0.708
CLV_NRD_NRD_1	105	107	PF00675	0.573
CLV_NRD_NRD_1	254	256	PF00675	0.489
CLV_NRD_NRD_1	289	291	PF00675	0.633
CLV_NRD_NRD_1	682	684	PF00675	0.690
CLV_NRD_NRD_1	77	79	PF00675	0.502
CLV_PCSK_FUR_1	679	683	PF00082	0.694
CLV_PCSK_KEX2_1	105	107	PF00082	0.535
CLV_PCSK_KEX2_1	254	256	PF00082	0.490
CLV_PCSK_KEX2_1	288	290	PF00082	0.620
CLV_PCSK_KEX2_1	681	683	PF00082	0.697
CLV_PCSK_KEX2_1	730	732	PF00082	0.595
CLV_PCSK_KEX2_1	735	737	PF00082	0.589
CLV_PCSK_KEX2_1	781	783	PF00082	0.688
CLV_PCSK_PC1ET2_1	730	732	PF00082	0.603
CLV_PCSK_PC1ET2_1	735	737	PF00082	0.594
CLV_PCSK_PC1ET2_1	781	783	PF00082	0.632
CLV_PCSK_PC7_1	677	683	PF00082	0.733
CLV_PCSK_PC7_1	731	737	PF00082	0.689
CLV_PCSK_SKI1_1	124	128	PF00082	0.480
CLV_PCSK_SKI1_1	255	259	PF00082	0.512
CLV_PCSK_SKI1_1	480	484	PF00082	0.503
CLV_PCSK_SKI1_1	778	782	PF00082	0.606
CLV_Separin_Metazoa	390	394	PF03568	0.568
DOC_CKS1_1	450	455	PF01111	0.776
DOC_CYCLIN_RxL_1	121	130	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.469
DOC_CYCLIN_yCln2_LP_2	506	512	PF00134	0.598
DOC_MAPK_gen_1	225	234	PF00069	0.486
DOC_MAPK_gen_1	380	389	PF00069	0.434
DOC_MAPK_MEF2A_6	124	133	PF00069	0.519
DOC_MAPK_MEF2A_6	225	234	PF00069	0.375
DOC_MAPK_MEF2A_6	353	362	PF00069	0.568
DOC_MAPK_MEF2A_6	382	391	PF00069	0.405
DOC_MAPK_MEF2A_6	54	62	PF00069	0.494
DOC_MAPK_MEF2A_6	88	96	PF00069	0.502
DOC_MAPK_RevD_3	92	106	PF00069	0.497
DOC_PP1_RVXF_1	122	128	PF00149	0.516
DOC_PP2B_LxvP_1	340	343	PF13499	0.405
DOC_PP4_FxxP_1	296	299	PF00568	0.445
DOC_PP4_FxxP_1	339	342	PF00568	0.468
DOC_SPAK_OSR1_1	172	176	PF12202	0.435
DOC_USP7_MATH_1	139	143	PF00917	0.432
DOC_USP7_MATH_1	15	19	PF00917	0.477
DOC_USP7_MATH_1	421	425	PF00917	0.536
DOC_USP7_MATH_1	445	449	PF00917	0.654
DOC_USP7_MATH_1	537	541	PF00917	0.722
DOC_USP7_MATH_1	551	555	PF00917	0.658
DOC_USP7_MATH_1	69	73	PF00917	0.448
DOC_USP7_MATH_1	710	714	PF00917	0.712
DOC_USP7_MATH_1	769	773	PF00917	0.751
DOC_USP7_UBL2_3	762	766	PF12436	0.673
DOC_WW_Pin1_4	235	240	PF00397	0.383
DOC_WW_Pin1_4	249	254	PF00397	0.445
DOC_WW_Pin1_4	446	451	PF00397	0.708
DOC_WW_Pin1_4	543	548	PF00397	0.727
LIG_14-3-3_CanoR_1	116	120	PF00244	0.461
LIG_14-3-3_CanoR_1	260	265	PF00244	0.540
LIG_14-3-3_CanoR_1	304	313	PF00244	0.502
LIG_14-3-3_CanoR_1	95	102	PF00244	0.391
LIG_AP2alpha_1	562	566	PF02296	0.707
LIG_APCC_ABBAyCdc20_2	393	399	PF00400	0.546
LIG_BIR_II_1	1	5	PF00653	0.496
LIG_BIR_III_4	11	15	PF00653	0.549
LIG_BRCT_BRCA1_1	17	21	PF00533	0.472
LIG_BRCT_BRCA1_1	368	372	PF00533	0.534
LIG_BRCT_BRCA1_1	619	623	PF00533	0.709
LIG_Clathr_ClatBox_1	386	390	PF01394	0.441
LIG_EH1_1	126	134	PF00400	0.501
LIG_eIF4E_1	328	334	PF01652	0.489
LIG_EVH1_2	342	346	PF00568	0.547
LIG_FHA_1	144	150	PF00498	0.398
LIG_FHA_1	202	208	PF00498	0.461
LIG_FHA_1	361	367	PF00498	0.561
LIG_FHA_1	42	48	PF00498	0.475
LIG_FHA_1	421	427	PF00498	0.485
LIG_FHA_1	742	748	PF00498	0.692
LIG_FHA_2	163	169	PF00498	0.460
LIG_FHA_2	406	412	PF00498	0.437
LIG_FHA_2	452	458	PF00498	0.737
LIG_FHA_2	582	588	PF00498	0.653
LIG_FHA_2	609	615	PF00498	0.781
LIG_FHA_2	62	68	PF00498	0.387
LIG_FXI_DFP_1	559	563	PF00024	0.713
LIG_GBD_Chelix_1	113	121	PF00786	0.491
LIG_HP1_1	462	466	PF01393	0.563
LIG_LIR_Apic_2	294	299	PF02991	0.553
LIG_LIR_Gen_1	165	175	PF02991	0.474
LIG_LIR_Gen_1	18	26	PF02991	0.484
LIG_LIR_Gen_1	195	203	PF02991	0.469
LIG_LIR_Gen_1	218	227	PF02991	0.481
LIG_LIR_Gen_1	305	313	PF02991	0.434
LIG_LIR_Gen_1	44	50	PF02991	0.442
LIG_LIR_Gen_1	578	587	PF02991	0.587
LIG_LIR_Gen_1	698	709	PF02991	0.792
LIG_LIR_Nem_3	165	170	PF02991	0.512
LIG_LIR_Nem_3	18	24	PF02991	0.480
LIG_LIR_Nem_3	195	200	PF02991	0.403
LIG_LIR_Nem_3	218	223	PF02991	0.433
LIG_LIR_Nem_3	28	34	PF02991	0.363
LIG_LIR_Nem_3	305	309	PF02991	0.429
LIG_LIR_Nem_3	42	48	PF02991	0.347
LIG_LIR_Nem_3	469	474	PF02991	0.568
LIG_LIR_Nem_3	578	583	PF02991	0.612
LIG_LIR_Nem_3	698	704	PF02991	0.684
LIG_MLH1_MIPbox_1	17	21	PF16413	0.485
LIG_Pex14_1	123	127	PF04695	0.514
LIG_Pex14_2	162	166	PF04695	0.526
LIG_Pex14_2	562	566	PF04695	0.707
LIG_PTB_Apo_2	149	156	PF02174	0.369
LIG_PTB_Apo_2	300	307	PF02174	0.535
LIG_PTB_Phospho_1	149	155	PF10480	0.371
LIG_PTB_Phospho_1	300	306	PF10480	0.533
LIG_SH2_CRK	220	224	PF00017	0.446
LIG_SH2_GRB2like	486	489	PF00017	0.444
LIG_SH2_GRB2like	758	761	PF00017	0.737
LIG_SH2_SRC	592	595	PF00017	0.693
LIG_SH2_STAP1	486	490	PF00017	0.550
LIG_SH2_STAP1	641	645	PF00017	0.606
LIG_SH2_STAT3	282	285	PF00017	0.544
LIG_SH2_STAT3	312	315	PF00017	0.507
LIG_SH2_STAT5	155	158	PF00017	0.390
LIG_SH2_STAT5	312	315	PF00017	0.515
LIG_SH3_3	116	122	PF00018	0.491
LIG_SH3_3	233	239	PF00018	0.488
LIG_SH3_3	250	256	PF00018	0.553
LIG_SH3_3	437	443	PF00018	0.674
LIG_SH3_3	444	450	PF00018	0.669
LIG_SH3_3	456	462	PF00018	0.658
LIG_SH3_3	690	696	PF00018	0.802
LIG_SUMO_SIM_anti_2	115	121	PF11976	0.457
LIG_SUMO_SIM_anti_2	130	135	PF11976	0.317
LIG_SUMO_SIM_anti_2	146	152	PF11976	0.378
LIG_SUMO_SIM_anti_2	385	390	PF11976	0.426
LIG_SUMO_SIM_par_1	232	238	PF11976	0.368
LIG_SUMO_SIM_par_1	358	363	PF11976	0.541
LIG_SUMO_SIM_par_1	385	390	PF11976	0.426
LIG_TRAF2_1	408	411	PF00917	0.553
LIG_TRAF2_1	525	528	PF00917	0.636
LIG_UBA3_1	359	364	PF00899	0.586
LIG_WRC_WIRS_1	159	164	PF05994	0.501
LIG_WRC_WIRS_1	194	199	PF05994	0.510
MOD_CDK_SPK_2	249	254	PF00069	0.589
MOD_CDK_SPxK_1	249	255	PF00069	0.586
MOD_CDK_SPxxK_3	543	550	PF00069	0.768
MOD_CK1_1	112	118	PF00069	0.441
MOD_CK1_1	449	455	PF00069	0.673
MOD_CK1_1	617	623	PF00069	0.667
MOD_CK1_1	71	77	PF00069	0.565
MOD_CK1_1	713	719	PF00069	0.708
MOD_CK1_1	772	778	PF00069	0.672
MOD_CK2_1	192	198	PF00069	0.528
MOD_CK2_1	405	411	PF00069	0.452
MOD_CK2_1	513	519	PF00069	0.603
MOD_GlcNHglycan	136	139	PF01048	0.452
MOD_GlcNHglycan	273	276	PF01048	0.459
MOD_GlcNHglycan	423	426	PF01048	0.558
MOD_GlcNHglycan	474	477	PF01048	0.562
MOD_GlcNHglycan	552	556	PF01048	0.677
MOD_GlcNHglycan	712	715	PF01048	0.732
MOD_GlcNHglycan	748	751	PF01048	0.671
MOD_GSK3_1	139	146	PF00069	0.392
MOD_GSK3_1	15	22	PF00069	0.427
MOD_GSK3_1	158	165	PF00069	0.395
MOD_GSK3_1	215	222	PF00069	0.438
MOD_GSK3_1	256	263	PF00069	0.443
MOD_GSK3_1	360	367	PF00069	0.488
MOD_GSK3_1	406	413	PF00069	0.589
MOD_GSK3_1	445	452	PF00069	0.683
MOD_GSK3_1	710	717	PF00069	0.647
MOD_N-GLC_1	270	275	PF02516	0.512
MOD_N-GLC_1	302	307	PF02516	0.486
MOD_N-GLC_1	329	334	PF02516	0.566
MOD_NEK2_1	1	6	PF00069	0.494
MOD_NEK2_1	134	139	PF00069	0.474
MOD_NEK2_1	278	283	PF00069	0.389
MOD_NEK2_1	741	746	PF00069	0.656
MOD_NEK2_2	537	542	PF00069	0.695
MOD_PIKK_1	281	287	PF00454	0.544
MOD_PK_1	260	266	PF00069	0.496
MOD_PKA_1	761	767	PF00069	0.651
MOD_PKA_2	115	121	PF00069	0.484
MOD_PKA_2	134	140	PF00069	0.340
MOD_PKA_2	201	207	PF00069	0.479
MOD_PKA_2	376	382	PF00069	0.548
MOD_PKA_2	94	100	PF00069	0.452
MOD_Plk_1	302	308	PF00069	0.488
MOD_Plk_1	321	327	PF00069	0.505
MOD_Plk_1	41	47	PF00069	0.456
MOD_Plk_1	495	501	PF00069	0.489
MOD_Plk_1	603	609	PF00069	0.795
MOD_Plk_2-3	581	587	PF00069	0.635
MOD_Plk_2-3	661	667	PF00069	0.745
MOD_Plk_4	115	121	PF00069	0.470
MOD_Plk_4	127	133	PF00069	0.299
MOD_Plk_4	144	150	PF00069	0.278
MOD_Plk_4	158	164	PF00069	0.283
MOD_Plk_4	16	22	PF00069	0.420
MOD_Plk_4	260	266	PF00069	0.457
MOD_Plk_4	329	335	PF00069	0.469
MOD_Plk_4	41	47	PF00069	0.372
MOD_Plk_4	614	620	PF00069	0.695
MOD_ProDKin_1	235	241	PF00069	0.380
MOD_ProDKin_1	249	255	PF00069	0.441
MOD_ProDKin_1	446	452	PF00069	0.709
MOD_ProDKin_1	543	549	PF00069	0.725
MOD_SUMO_rev_2	624	631	PF00179	0.657
TRG_DiLeu_BaEn_4	410	416	PF01217	0.569
TRG_ENDOCYTIC_2	220	223	PF00928	0.469
TRG_ENDOCYTIC_2	306	309	PF00928	0.407
TRG_ENDOCYTIC_2	572	575	PF00928	0.581
TRG_ENDOCYTIC_2	580	583	PF00928	0.519
TRG_ER_diArg_1	104	106	PF00400	0.593
TRG_ER_diArg_1	183	186	PF00400	0.566
TRG_ER_diArg_1	253	255	PF00400	0.592
TRG_ER_diArg_1	287	290	PF00400	0.510
TRG_ER_diArg_1	380	383	PF00400	0.445
TRG_ER_diArg_1	631	634	PF00400	0.453
TRG_ER_diArg_1	681	683	PF00400	0.745
TRG_NES_CRM1_1	235	250	PF08389	0.472
TRG_NLS_MonoExtN_4	778	785	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	577	581	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	634	638	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3W0	Leptomonas seymouri	63%	99%
A0A1X0P037	Trypanosomatidae	38%	100%
A0A3S7XBW7	Leishmania donovani	92%	100%
A0A422NSD1	Trypanosoma rangeli	39%	100%
A4HQ86	Leishmania braziliensis	79%	100%
A4IDY4	Leishmania infantum	92%	100%
D0A425	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AU04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
V5BTA0	Trypanosoma cruzi	38%	100%