Defective in cullin neddylation protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cullin binding, putative

Species:

Leishmania major

UniProt:

Q4Q0J0_LEIMA

TriTrypDb:

LmjF.36.5710 , LMJLV39_360069500 , LMJSD75_360069500

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4Q0J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0J0

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0019538	protein metabolic process	3	2
GO:0031396	regulation of protein ubiquitination	8	2
GO:0031398	positive regulation of protein ubiquitination	9	2
GO:0031399	regulation of protein modification process	6	2
GO:0031401	positive regulation of protein modification process	7	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043085	positive regulation of catalytic activity	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044093	positive regulation of molecular function	3	2
GO:0044238	primary metabolic process	2	2
GO:0045116	protein neddylation	7	2
GO:0048518	positive regulation of biological process	3	2
GO:0050789	regulation of biological process	2	2
GO:0050790	regulation of catalytic activity	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051247	positive regulation of protein metabolic process	6	2
GO:0051338	regulation of transferase activity	4	2
GO:0051347	positive regulation of transferase activity	5	2
GO:0051438	regulation of ubiquitin-protein transferase activity	5	2
GO:0051443	positive regulation of ubiquitin-protein transferase activity	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1903320	regulation of protein modification by small protein conjugation or removal	7	2
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	8	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0031624	ubiquitin conjugating enzyme binding	5	2
GO:0032182	ubiquitin-like protein binding	3	2
GO:0044390	ubiquitin-like protein conjugating enzyme binding	4	2
GO:0097602	cullin family protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.455
CLV_NRD_NRD_1	182	184	PF00675	0.377
CLV_NRD_NRD_1	260	262	PF00675	0.523
CLV_PCSK_KEX2_1	136	138	PF00082	0.412
CLV_PCSK_KEX2_1	182	184	PF00082	0.438
CLV_PCSK_KEX2_1	78	80	PF00082	0.545
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.377
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.559
CLV_PCSK_SKI1_1	183	187	PF00082	0.408
DOC_MAPK_gen_1	182	191	PF00069	0.401
DOC_USP7_MATH_1	17	21	PF00917	0.316
DOC_USP7_MATH_1	208	212	PF00917	0.377
DOC_USP7_UBL2_3	78	82	PF12436	0.484
DOC_WW_Pin1_4	169	174	PF00397	0.422
LIG_14-3-3_CanoR_1	182	192	PF00244	0.455
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_BRCT_BRCA1_1	165	169	PF00533	0.422
LIG_CtBP_PxDLS_1	173	177	PF00389	0.221
LIG_deltaCOP1_diTrp_1	163	169	PF00928	0.310
LIG_deltaCOP1_diTrp_1	226	234	PF00928	0.310
LIG_deltaCOP1_diTrp_1	244	256	PF00928	0.310
LIG_FHA_1	184	190	PF00498	0.409
LIG_FHA_1	227	233	PF00498	0.415
LIG_FHA_2	175	181	PF00498	0.377
LIG_FHA_2	250	256	PF00498	0.377
LIG_LIR_Gen_1	138	149	PF02991	0.411
LIG_LIR_Gen_1	163	173	PF02991	0.330
LIG_LIR_Gen_1	186	194	PF02991	0.371
LIG_LIR_Gen_1	199	208	PF02991	0.296
LIG_LIR_Gen_1	226	235	PF02991	0.329
LIG_LIR_Gen_1	24	34	PF02991	0.419
LIG_LIR_Gen_1	42	50	PF02991	0.444
LIG_LIR_Nem_3	109	115	PF02991	0.411
LIG_LIR_Nem_3	138	144	PF02991	0.319
LIG_LIR_Nem_3	163	168	PF02991	0.310
LIG_LIR_Nem_3	186	191	PF02991	0.332
LIG_LIR_Nem_3	226	231	PF02991	0.314
LIG_LIR_Nem_3	238	243	PF02991	0.281
LIG_LIR_Nem_3	24	29	PF02991	0.367
LIG_LIR_Nem_3	254	259	PF02991	0.247
LIG_LIR_Nem_3	42	47	PF02991	0.434
LIG_MLH1_MIPbox_1	165	169	PF16413	0.422
LIG_PCNA_PIPBox_1	1	10	PF02747	0.446
LIG_Pex14_1	165	169	PF04695	0.310
LIG_Pex14_2	143	147	PF04695	0.310
LIG_SH2_CRK	112	116	PF00017	0.503
LIG_SH2_CRK	141	145	PF00017	0.310
LIG_SH2_NCK_1	30	34	PF00017	0.435
LIG_SH2_STAP1	30	34	PF00017	0.411
LIG_SH2_STAT5	188	191	PF00017	0.401
LIG_SH2_STAT5	259	262	PF00017	0.375
LIG_SH2_STAT5	28	31	PF00017	0.433
LIG_SH2_STAT5	67	70	PF00017	0.368
LIG_SH3_3	186	192	PF00018	0.412
LIG_SUMO_SIM_par_1	172	177	PF11976	0.221
LIG_TRAF2_1	132	135	PF00917	0.221
LIG_TRAF2_1	177	180	PF00917	0.422
LIG_UBA3_1	4	12	PF00899	0.447
MOD_CK1_1	11	17	PF00069	0.451
MOD_CK1_1	172	178	PF00069	0.408
MOD_CK1_1	221	227	PF00069	0.428
MOD_CK1_1	52	58	PF00069	0.455
MOD_CK2_1	129	135	PF00069	0.381
MOD_CK2_1	157	163	PF00069	0.413
MOD_CK2_1	174	180	PF00069	0.408
MOD_GlcNHglycan	159	162	PF01048	0.433
MOD_GlcNHglycan	169	172	PF01048	0.336
MOD_GlcNHglycan	212	215	PF01048	0.424
MOD_GlcNHglycan	219	223	PF01048	0.418
MOD_GlcNHglycan	74	78	PF01048	0.497
MOD_GSK3_1	163	170	PF00069	0.422
MOD_GSK3_1	206	213	PF00069	0.371
MOD_GSK3_1	245	252	PF00069	0.421
MOD_N-GLC_1	126	131	PF02516	0.455
MOD_N-GLC_2	146	148	PF02516	0.422
MOD_NEK2_1	126	131	PF00069	0.428
MOD_NEK2_1	263	268	PF00069	0.560
MOD_NEK2_1	8	13	PF00069	0.627
MOD_PIKK_1	226	232	PF00454	0.422
MOD_PKA_1	183	189	PF00069	0.377
MOD_Plk_1	126	132	PF00069	0.455
MOD_Plk_1	245	251	PF00069	0.386
MOD_Plk_1	62	68	PF00069	0.352
MOD_Plk_4	62	68	PF00069	0.361
MOD_ProDKin_1	169	175	PF00069	0.422
MOD_SUMO_rev_2	132	138	PF00179	0.221
MOD_SUMO_rev_2	206	213	PF00179	0.402
MOD_SUMO_rev_2	264	269	PF00179	0.392
TRG_ENDOCYTIC_2	112	115	PF00928	0.510
TRG_ENDOCYTIC_2	141	144	PF00928	0.310
TRG_ENDOCYTIC_2	188	191	PF00928	0.319
TRG_ENDOCYTIC_2	30	33	PF00928	0.471
TRG_NES_CRM1_1	62	75	PF08389	0.497
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC74	Leptomonas seymouri	63%	100%
A0A0S4IZZ0	Bodo saltans	26%	100%
A0A1X0P053	Trypanosomatidae	28%	100%
A0A3Q8ILQ1	Leishmania donovani	92%	100%
A0A422NSC3	Trypanosoma rangeli	24%	100%
A4HQ87	Leishmania braziliensis	83%	100%
A4IDY5	Leishmania infantum	92%	100%
D0A424	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AU05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P0CN06	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	25%	96%
P0CN07	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	25%	96%
V5DK31	Trypanosoma cruzi	27%	100%