RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0I8_LEIMA

TriTrypDb:

LmjF.36.5730 , LMJLV39_360069700 , LMJSD75_360069700

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0I8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	656	660	PF00656	0.442
CLV_NRD_NRD_1	158	160	PF00675	0.423
CLV_NRD_NRD_1	23	25	PF00675	0.489
CLV_NRD_NRD_1	240	242	PF00675	0.504
CLV_NRD_NRD_1	360	362	PF00675	0.745
CLV_NRD_NRD_1	392	394	PF00675	0.605
CLV_NRD_NRD_1	437	439	PF00675	0.459
CLV_NRD_NRD_1	635	637	PF00675	0.466
CLV_PCSK_FUR_1	390	394	PF00082	0.596
CLV_PCSK_KEX2_1	158	160	PF00082	0.508
CLV_PCSK_KEX2_1	23	25	PF00082	0.464
CLV_PCSK_KEX2_1	360	362	PF00082	0.677
CLV_PCSK_KEX2_1	382	384	PF00082	0.688
CLV_PCSK_KEX2_1	392	394	PF00082	0.578
CLV_PCSK_KEX2_1	437	439	PF00082	0.459
CLV_PCSK_KEX2_1	635	637	PF00082	0.468
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.579
CLV_PCSK_PC7_1	378	384	PF00082	0.592
CLV_PCSK_SKI1_1	234	238	PF00082	0.387
CLV_PCSK_SKI1_1	392	396	PF00082	0.626
CLV_PCSK_SKI1_1	429	433	PF00082	0.463
CLV_PCSK_SKI1_1	606	610	PF00082	0.587
CLV_PCSK_SKI1_1	626	630	PF00082	0.447
DEG_APCC_DBOX_1	233	241	PF00400	0.371
DEG_APCC_DBOX_1	38	46	PF00400	0.511
DEG_APCC_DBOX_1	625	633	PF00400	0.445
DEG_SPOP_SBC_1	366	370	PF00917	0.703
DOC_CDC14_PxL_1	512	520	PF14671	0.669
DOC_CYCLIN_RxL_1	123	131	PF00134	0.436
DOC_CYCLIN_RxL_1	536	545	PF00134	0.499
DOC_MAPK_DCC_7	39	47	PF00069	0.541
DOC_MAPK_FxFP_2	202	205	PF00069	0.568
DOC_MAPK_gen_1	179	187	PF00069	0.512
DOC_MAPK_gen_1	23	30	PF00069	0.526
DOC_MAPK_JIP1_4	181	187	PF00069	0.532
DOC_MAPK_MEF2A_6	322	330	PF00069	0.398
DOC_MAPK_MEF2A_6	39	47	PF00069	0.544
DOC_PP1_RVXF_1	660	667	PF00149	0.552
DOC_PP2B_LxvP_1	350	353	PF13499	0.590
DOC_PP4_FxxP_1	202	205	PF00568	0.568
DOC_USP7_MATH_1	134	138	PF00917	0.711
DOC_USP7_MATH_1	144	148	PF00917	0.659
DOC_USP7_MATH_1	153	157	PF00917	0.638
DOC_USP7_MATH_1	366	370	PF00917	0.755
DOC_WW_Pin1_4	359	364	PF00397	0.660
DOC_WW_Pin1_4	385	390	PF00397	0.663
DOC_WW_Pin1_4	70	75	PF00397	0.516
LIG_14-3-3_CanoR_1	143	153	PF00244	0.677
LIG_14-3-3_CanoR_1	181	186	PF00244	0.423
LIG_14-3-3_CanoR_1	234	243	PF00244	0.519
LIG_14-3-3_CanoR_1	383	388	PF00244	0.511
LIG_14-3-3_CanoR_1	437	441	PF00244	0.536
LIG_14-3-3_CanoR_1	442	451	PF00244	0.517
LIG_14-3-3_CanoR_1	468	472	PF00244	0.507
LIG_14-3-3_CanoR_1	530	536	PF00244	0.519
LIG_14-3-3_CanoR_1	553	557	PF00244	0.679
LIG_14-3-3_CanoR_1	64	70	PF00244	0.341
LIG_Actin_WH2_2	540	555	PF00022	0.599
LIG_Actin_WH2_2	56	73	PF00022	0.489
LIG_CtBP_PxDLS_1	464	468	PF00389	0.565
LIG_DLG_GKlike_1	159	167	PF00625	0.404
LIG_EH1_1	495	503	PF00400	0.453
LIG_eIF4E_1	496	502	PF01652	0.522
LIG_FHA_1	152	158	PF00498	0.687
LIG_FHA_1	182	188	PF00498	0.403
LIG_FHA_1	192	198	PF00498	0.356
LIG_FHA_1	476	482	PF00498	0.407
LIG_FHA_1	542	548	PF00498	0.455
LIG_FHA_2	442	448	PF00498	0.542
LIG_FHA_2	571	577	PF00498	0.631
LIG_FHA_2	598	604	PF00498	0.468
LIG_FHA_2	71	77	PF00498	0.553
LIG_LIR_Apic_2	401	407	PF02991	0.617
LIG_LIR_Gen_1	531	540	PF02991	0.616
LIG_LIR_Nem_3	531	535	PF02991	0.629
LIG_NRBOX	109	115	PF00104	0.484
LIG_NRBOX	607	613	PF00104	0.574
LIG_Pex14_1	633	637	PF04695	0.502
LIG_PTB_Apo_2	340	347	PF02174	0.528
LIG_RPA_C_Fungi	10	22	PF08784	0.509
LIG_SH2_CRK	404	408	PF00017	0.510
LIG_SH2_CRK	503	507	PF00017	0.535
LIG_SH2_NCK_1	404	408	PF00017	0.510
LIG_SH2_PTP2	411	414	PF00017	0.467
LIG_SH2_SRC	411	414	PF00017	0.472
LIG_SH2_SRC	95	98	PF00017	0.445
LIG_SH2_STAP1	263	267	PF00017	0.382
LIG_SH2_STAP1	637	641	PF00017	0.502
LIG_SH2_STAT5	293	296	PF00017	0.413
LIG_SH2_STAT5	404	407	PF00017	0.529
LIG_SH2_STAT5	411	414	PF00017	0.357
LIG_SH2_STAT5	496	499	PF00017	0.587
LIG_SH2_STAT5	503	506	PF00017	0.379
LIG_SH3_1	360	366	PF00018	0.572
LIG_SH3_3	360	366	PF00018	0.623
LIG_SH3_3	507	513	PF00018	0.466
LIG_SH3_3	554	560	PF00018	0.576
LIG_SUMO_SIM_anti_2	183	189	PF11976	0.396
LIG_SUMO_SIM_anti_2	478	484	PF11976	0.371
LIG_SUMO_SIM_par_1	126	131	PF11976	0.515
LIG_SUMO_SIM_par_1	183	189	PF11976	0.496
LIG_SUMO_SIM_par_1	538	545	PF11976	0.585
LIG_TRAF2_1	578	581	PF00917	0.636
LIG_TRFH_1	404	408	PF08558	0.566
LIG_TYR_ITIM	501	506	PF00017	0.524
LIG_UBA3_1	236	242	PF00899	0.444
LIG_UBA3_1	604	609	PF00899	0.543
LIG_WRC_WIRS_1	160	165	PF05994	0.453
MOD_CDK_SPK_2	359	364	PF00069	0.600
MOD_CDK_SPK_2	385	390	PF00069	0.618
MOD_CDK_SPxxK_3	385	392	PF00069	0.577
MOD_CK1_1	142	148	PF00069	0.719
MOD_CK1_1	186	192	PF00069	0.418
MOD_CK1_1	362	368	PF00069	0.762
MOD_CK1_1	370	376	PF00069	0.814
MOD_CK1_1	402	408	PF00069	0.564
MOD_CK1_1	65	71	PF00069	0.335
MOD_CK2_1	186	192	PF00069	0.495
MOD_CK2_1	306	312	PF00069	0.465
MOD_CK2_1	441	447	PF00069	0.504
MOD_CK2_1	570	576	PF00069	0.628
MOD_CK2_1	70	76	PF00069	0.447
MOD_Cter_Amidation	380	383	PF01082	0.592
MOD_Cter_Amidation	633	636	PF01082	0.398
MOD_GlcNHglycan	117	120	PF01048	0.412
MOD_GlcNHglycan	372	375	PF01048	0.755
MOD_GlcNHglycan	560	563	PF01048	0.594
MOD_GSK3_1	109	116	PF00069	0.386
MOD_GSK3_1	128	135	PF00069	0.537
MOD_GSK3_1	142	149	PF00069	0.697
MOD_GSK3_1	159	166	PF00069	0.515
MOD_GSK3_1	186	193	PF00069	0.388
MOD_GSK3_1	253	260	PF00069	0.479
MOD_GSK3_1	362	369	PF00069	0.767
MOD_GSK3_1	429	436	PF00069	0.462
MOD_GSK3_1	46	53	PF00069	0.578
MOD_GSK3_1	575	582	PF00069	0.550
MOD_GSK3_1	593	600	PF00069	0.486
MOD_LATS_1	303	309	PF00433	0.406
MOD_N-GLC_1	245	250	PF02516	0.515
MOD_N-GLC_1	268	273	PF02516	0.480
MOD_N-GLC_1	399	404	PF02516	0.715
MOD_NEK2_1	113	118	PF00069	0.464
MOD_NEK2_1	128	133	PF00069	0.570
MOD_NEK2_1	163	168	PF00069	0.397
MOD_NEK2_1	190	195	PF00069	0.483
MOD_NEK2_1	236	241	PF00069	0.476
MOD_NEK2_1	257	262	PF00069	0.464
MOD_NEK2_1	306	311	PF00069	0.407
MOD_NEK2_1	467	472	PF00069	0.472
MOD_NEK2_1	528	533	PF00069	0.533
MOD_NEK2_1	552	557	PF00069	0.605
MOD_NEK2_1	604	609	PF00069	0.559
MOD_NEK2_1	614	619	PF00069	0.498
MOD_NEK2_1	62	67	PF00069	0.362
MOD_NEK2_2	153	158	PF00069	0.581
MOD_PIKK_1	132	138	PF00454	0.624
MOD_PIKK_1	274	280	PF00454	0.464
MOD_PIKK_1	281	287	PF00454	0.376
MOD_PIKK_1	50	56	PF00454	0.611
MOD_PK_1	477	483	PF00069	0.462
MOD_PKA_2	114	120	PF00069	0.414
MOD_PKA_2	142	148	PF00069	0.761
MOD_PKA_2	180	186	PF00069	0.474
MOD_PKA_2	370	376	PF00069	0.632
MOD_PKA_2	433	439	PF00069	0.497
MOD_PKA_2	441	447	PF00069	0.499
MOD_PKA_2	467	473	PF00069	0.507
MOD_PKA_2	552	558	PF00069	0.616
MOD_PKB_1	179	187	PF00069	0.512
MOD_Plk_1	11	17	PF00069	0.409
MOD_Plk_1	402	408	PF00069	0.572
MOD_Plk_1	475	481	PF00069	0.452
MOD_Plk_2-3	593	599	PF00069	0.487
MOD_Plk_4	109	115	PF00069	0.395
MOD_Plk_4	159	165	PF00069	0.501
MOD_Plk_4	183	189	PF00069	0.397
MOD_Plk_4	306	312	PF00069	0.407
MOD_Plk_4	65	71	PF00069	0.356
MOD_ProDKin_1	359	365	PF00069	0.660
MOD_ProDKin_1	385	391	PF00069	0.657
MOD_ProDKin_1	70	76	PF00069	0.521
MOD_SUMO_for_1	473	476	PF00179	0.537
TRG_DiLeu_BaEn_1	109	114	PF01217	0.450
TRG_DiLeu_BaEn_1	33	38	PF01217	0.437
TRG_DiLeu_BaEn_1	447	452	PF01217	0.454
TRG_DiLeu_BaEn_4	580	586	PF01217	0.593
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.506
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.549
TRG_ENDOCYTIC_2	411	414	PF00928	0.421
TRG_ENDOCYTIC_2	428	431	PF00928	0.339
TRG_ENDOCYTIC_2	503	506	PF00928	0.526
TRG_ER_diArg_1	157	159	PF00400	0.466
TRG_ER_diArg_1	389	392	PF00400	0.594
TRG_ER_diArg_1	635	637	PF00400	0.439
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS6	Leptomonas seymouri	65%	98%
A0A0S4IXA8	Bodo saltans	28%	94%
A0A1X0NNB6	Trypanosomatidae	42%	100%
A0A3Q8IHX9	Leishmania donovani	94%	100%
A4HQ89	Leishmania braziliensis	82%	100%
A4IDY7	Leishmania infantum	94%	100%
D0A422	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AU07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5B3L6	Trypanosoma cruzi	42%	100%