Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0I7_LEIMA

TriTrypDb:

LmjF.36.5740 , LMJLV39_360069800 , LMJSD75_360069800

Length:

777

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0I7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	634	638	PF00656	0.588
CLV_NRD_NRD_1	128	130	PF00675	0.791
CLV_NRD_NRD_1	148	150	PF00675	0.534
CLV_NRD_NRD_1	19	21	PF00675	0.509
CLV_NRD_NRD_1	323	325	PF00675	0.743
CLV_NRD_NRD_1	336	338	PF00675	0.590
CLV_NRD_NRD_1	375	377	PF00675	0.720
CLV_NRD_NRD_1	595	597	PF00675	0.581
CLV_PCSK_FUR_1	126	130	PF00082	0.715
CLV_PCSK_KEX2_1	126	128	PF00082	0.786
CLV_PCSK_KEX2_1	148	150	PF00082	0.709
CLV_PCSK_KEX2_1	19	21	PF00082	0.486
CLV_PCSK_KEX2_1	227	229	PF00082	0.705
CLV_PCSK_KEX2_1	323	325	PF00082	0.740
CLV_PCSK_KEX2_1	363	365	PF00082	0.702
CLV_PCSK_KEX2_1	375	377	PF00082	0.704
CLV_PCSK_KEX2_1	411	413	PF00082	0.781
CLV_PCSK_KEX2_1	595	597	PF00082	0.581
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.705
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.702
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.781
CLV_PCSK_PC7_1	319	325	PF00082	0.684
CLV_PCSK_SKI1_1	20	24	PF00082	0.459
CLV_PCSK_SKI1_1	98	102	PF00082	0.599
CLV_Separin_Metazoa	41	45	PF03568	0.501
DEG_SCF_FBW7_1	199	206	PF00400	0.610
DEG_SCF_FBW7_1	270	275	PF00400	0.687
DEG_SPOP_SBC_1	150	154	PF00917	0.691
DEG_SPOP_SBC_1	503	507	PF00917	0.851
DEG_SPOP_SBC_1	603	607	PF00917	0.709
DOC_CYCLIN_yClb5_NLxxxL_5	587	594	PF00134	0.687
DOC_PP1_RVXF_1	2	9	PF00149	0.447
DOC_PP2B_LxvP_1	769	772	PF13499	0.556
DOC_PP4_FxxP_1	614	617	PF00568	0.762
DOC_PP4_MxPP_1	703	706	PF00568	0.670
DOC_USP7_MATH_1	120	124	PF00917	0.629
DOC_USP7_MATH_1	144	148	PF00917	0.782
DOC_USP7_MATH_1	150	154	PF00917	0.714
DOC_USP7_MATH_1	161	165	PF00917	0.572
DOC_USP7_MATH_1	203	207	PF00917	0.643
DOC_USP7_MATH_1	297	301	PF00917	0.790
DOC_USP7_MATH_1	317	321	PF00917	0.506
DOC_USP7_MATH_1	348	352	PF00917	0.769
DOC_USP7_MATH_1	353	357	PF00917	0.710
DOC_USP7_MATH_1	407	411	PF00917	0.738
DOC_USP7_MATH_1	441	445	PF00917	0.650
DOC_USP7_MATH_1	473	477	PF00917	0.759
DOC_USP7_MATH_1	503	507	PF00917	0.760
DOC_USP7_MATH_1	598	602	PF00917	0.753
DOC_USP7_MATH_1	603	607	PF00917	0.673
DOC_USP7_MATH_1	660	664	PF00917	0.717
DOC_USP7_MATH_1	693	697	PF00917	0.712
DOC_USP7_MATH_1	715	719	PF00917	0.580
DOC_USP7_MATH_1	81	85	PF00917	0.701
DOC_WW_Pin1_4	155	160	PF00397	0.737
DOC_WW_Pin1_4	199	204	PF00397	0.685
DOC_WW_Pin1_4	213	218	PF00397	0.714
DOC_WW_Pin1_4	268	273	PF00397	0.707
DOC_WW_Pin1_4	293	298	PF00397	0.725
DOC_WW_Pin1_4	313	318	PF00397	0.506
DOC_WW_Pin1_4	332	337	PF00397	0.583
DOC_WW_Pin1_4	391	396	PF00397	0.635
DOC_WW_Pin1_4	445	450	PF00397	0.753
DOC_WW_Pin1_4	467	472	PF00397	0.786
DOC_WW_Pin1_4	494	499	PF00397	0.768
DOC_WW_Pin1_4	528	533	PF00397	0.740
DOC_WW_Pin1_4	689	694	PF00397	0.751
DOC_WW_Pin1_4	737	742	PF00397	0.706
DOC_WW_Pin1_4	746	751	PF00397	0.670
DOC_WW_Pin1_4	767	772	PF00397	0.560
DOC_WW_Pin1_4	83	88	PF00397	0.620
LIG_14-3-3_CanoR_1	149	159	PF00244	0.695
LIG_14-3-3_CanoR_1	167	176	PF00244	0.550
LIG_14-3-3_CanoR_1	246	255	PF00244	0.769
LIG_14-3-3_CanoR_1	323	327	PF00244	0.627
LIG_14-3-3_CanoR_1	412	416	PF00244	0.742
LIG_14-3-3_CanoR_1	51	59	PF00244	0.726
LIG_14-3-3_CanoR_1	542	548	PF00244	0.745
LIG_14-3-3_CanoR_1	651	658	PF00244	0.769
LIG_14-3-3_CanoR_1	697	706	PF00244	0.686
LIG_14-3-3_CanoR_1	763	768	PF00244	0.562
LIG_APCC_ABBA_1	24	29	PF00400	0.402
LIG_BIR_II_1	1	5	PF00653	0.450
LIG_BIR_III_2	690	694	PF00653	0.692
LIG_FHA_1	1	7	PF00498	0.446
LIG_FHA_1	214	220	PF00498	0.729
LIG_FHA_1	273	279	PF00498	0.644
LIG_FHA_1	415	421	PF00498	0.609
LIG_FHA_1	460	466	PF00498	0.695
LIG_FHA_1	714	720	PF00498	0.671
LIG_FHA_1	764	770	PF00498	0.563
LIG_FHA_2	246	252	PF00498	0.700
LIG_FHA_2	256	262	PF00498	0.764
LIG_FHA_2	507	513	PF00498	0.837
LIG_FHA_2	84	90	PF00498	0.511
LIG_LIR_Apic_2	444	449	PF02991	0.743
LIG_LIR_Apic_2	612	617	PF02991	0.690
LIG_LIR_Gen_1	25	35	PF02991	0.390
LIG_LIR_Nem_3	25	30	PF02991	0.394
LIG_LIR_Nem_3	629	635	PF02991	0.771
LIG_LIR_Nem_3	670	674	PF02991	0.616
LIG_LIR_Nem_3	95	100	PF02991	0.606
LIG_LYPXL_SIV_4	668	676	PF13949	0.678
LIG_NRBOX	102	108	PF00104	0.414
LIG_PCNA_yPIPBox_3	522	534	PF02747	0.666
LIG_Rb_LxCxE_1	645	667	PF01857	0.556
LIG_SH2_CRK	439	443	PF00017	0.734
LIG_SH2_CRK	446	450	PF00017	0.757
LIG_SH2_STAP1	635	639	PF00017	0.782
LIG_SH2_STAT3	661	664	PF00017	0.703
LIG_SH2_STAT3	674	677	PF00017	0.637
LIG_SH2_STAT5	326	329	PF00017	0.749
LIG_SH3_3	330	336	PF00018	0.769
LIG_SH3_3	654	660	PF00018	0.753
LIG_SH3_3	716	722	PF00018	0.560
LIG_SUMO_SIM_anti_2	99	105	PF11976	0.410
LIG_SUMO_SIM_par_1	543	549	PF11976	0.750
LIG_TRAF2_1	258	261	PF00917	0.810
LIG_TRAF2_1	369	372	PF00917	0.790
LIG_TRAF2_1	498	501	PF00917	0.716
LIG_TRAF2_1	509	512	PF00917	0.687
LIG_TYR_ITSM	23	30	PF00017	0.406
LIG_WW_3	770	774	PF00397	0.543
MOD_CDC14_SPxK_1	316	319	PF00782	0.644
MOD_CDC14_SPxK_1	335	338	PF00782	0.545
MOD_CDC14_SPxK_1	531	534	PF00782	0.674
MOD_CDC14_SPxK_1	770	773	PF00782	0.543
MOD_CDK_SPK_2	332	337	PF00069	0.708
MOD_CDK_SPK_2	83	88	PF00069	0.620
MOD_CDK_SPxK_1	293	299	PF00069	0.728
MOD_CDK_SPxK_1	313	319	PF00069	0.508
MOD_CDK_SPxK_1	332	338	PF00069	0.543
MOD_CDK_SPxK_1	528	534	PF00069	0.734
MOD_CDK_SPxK_1	767	773	PF00069	0.546
MOD_CDK_SPxxK_3	332	339	PF00069	0.712
MOD_CDK_SPxxK_3	737	744	PF00069	0.677
MOD_CK1_1	152	158	PF00069	0.740
MOD_CK1_1	163	169	PF00069	0.679
MOD_CK1_1	172	178	PF00069	0.573
MOD_CK1_1	190	196	PF00069	0.759
MOD_CK1_1	206	212	PF00069	0.788
MOD_CK1_1	213	219	PF00069	0.719
MOD_CK1_1	276	282	PF00069	0.645
MOD_CK1_1	304	310	PF00069	0.724
MOD_CK1_1	358	364	PF00069	0.750
MOD_CK1_1	391	397	PF00069	0.663
MOD_CK1_1	410	416	PF00069	0.738
MOD_CK1_1	424	430	PF00069	0.515
MOD_CK1_1	469	475	PF00069	0.759
MOD_CK1_1	494	500	PF00069	0.804
MOD_CK1_1	504	510	PF00069	0.790
MOD_CK1_1	546	552	PF00069	0.758
MOD_CK1_1	599	605	PF00069	0.664
MOD_CK1_1	606	612	PF00069	0.653
MOD_CK1_1	638	644	PF00069	0.767
MOD_CK1_1	670	676	PF00069	0.561
MOD_CK1_1	689	695	PF00069	0.777
MOD_CK1_1	713	719	PF00069	0.731
MOD_CK1_1	742	748	PF00069	0.813
MOD_CK1_1	765	771	PF00069	0.562
MOD_CK1_1	79	85	PF00069	0.694
MOD_CK2_1	255	261	PF00069	0.819
MOD_CK2_1	315	321	PF00069	0.743
MOD_CK2_1	366	372	PF00069	0.778
MOD_CK2_1	506	512	PF00069	0.784
MOD_CK2_1	606	612	PF00069	0.573
MOD_CK2_1	93	99	PF00069	0.555
MOD_Cter_Amidation	124	127	PF01082	0.647
MOD_GlcNHglycan	248	251	PF01048	0.742
MOD_GlcNHglycan	263	266	PF01048	0.588
MOD_GlcNHglycan	38	41	PF01048	0.597
MOD_GlcNHglycan	390	393	PF01048	0.657
MOD_GlcNHglycan	439	442	PF01048	0.650
MOD_GlcNHglycan	443	446	PF01048	0.682
MOD_GlcNHglycan	475	478	PF01048	0.731
MOD_GlcNHglycan	493	496	PF01048	0.779
MOD_GlcNHglycan	512	515	PF01048	0.588
MOD_GlcNHglycan	553	556	PF01048	0.659
MOD_GlcNHglycan	600	604	PF01048	0.606
MOD_GlcNHglycan	637	640	PF01048	0.721
MOD_GlcNHglycan	725	728	PF01048	0.697
MOD_GlcNHglycan	83	86	PF01048	0.719
MOD_GSK3_1	150	157	PF00069	0.763
MOD_GSK3_1	161	168	PF00069	0.620
MOD_GSK3_1	172	179	PF00069	0.623
MOD_GSK3_1	186	193	PF00069	0.687
MOD_GSK3_1	199	206	PF00069	0.644
MOD_GSK3_1	207	214	PF00069	0.738
MOD_GSK3_1	261	268	PF00069	0.772
MOD_GSK3_1	272	279	PF00069	0.592
MOD_GSK3_1	293	300	PF00069	0.742
MOD_GSK3_1	301	308	PF00069	0.717
MOD_GSK3_1	311	318	PF00069	0.651
MOD_GSK3_1	328	335	PF00069	0.561
MOD_GSK3_1	353	360	PF00069	0.778
MOD_GSK3_1	382	389	PF00069	0.693
MOD_GSK3_1	406	413	PF00069	0.732
MOD_GSK3_1	421	428	PF00069	0.573
MOD_GSK3_1	437	444	PF00069	0.543
MOD_GSK3_1	445	452	PF00069	0.770
MOD_GSK3_1	469	476	PF00069	0.771
MOD_GSK3_1	501	508	PF00069	0.786
MOD_GSK3_1	551	558	PF00069	0.751
MOD_GSK3_1	598	605	PF00069	0.732
MOD_GSK3_1	615	622	PF00069	0.768
MOD_GSK3_1	633	640	PF00069	0.777
MOD_GSK3_1	672	679	PF00069	0.736
MOD_GSK3_1	689	696	PF00069	0.749
MOD_GSK3_1	710	717	PF00069	0.792
MOD_GSK3_1	742	749	PF00069	0.757
MOD_GSK3_1	76	83	PF00069	0.777
MOD_GSK3_1	763	770	PF00069	0.562
MOD_LATS_1	626	632	PF00433	0.769
MOD_N-GLC_1	265	270	PF02516	0.709
MOD_N-GLC_1	328	333	PF02516	0.742
MOD_N-GLC_1	437	442	PF02516	0.736
MOD_N-GLC_1	693	698	PF02516	0.725
MOD_NEK2_1	176	181	PF00069	0.775
MOD_NEK2_1	207	212	PF00069	0.756
MOD_NEK2_1	22	27	PF00069	0.431
MOD_NEK2_1	305	310	PF00069	0.673
MOD_NEK2_1	328	333	PF00069	0.709
MOD_NEK2_1	491	496	PF00069	0.817
MOD_NEK2_1	676	681	PF00069	0.723
MOD_NEK2_1	699	704	PF00069	0.683
MOD_NEK2_1	708	713	PF00069	0.661
MOD_NEK2_1	714	719	PF00069	0.710
MOD_NEK2_1	8	13	PF00069	0.500
MOD_PIKK_1	165	171	PF00454	0.713
MOD_PIKK_1	305	311	PF00454	0.638
MOD_PIKK_1	479	485	PF00454	0.709
MOD_PIKK_1	50	56	PF00454	0.632
MOD_PIKK_1	507	513	PF00454	0.598
MOD_PIKK_1	638	644	PF00454	0.777
MOD_PIKK_1	660	666	PF00454	0.709
MOD_PIKK_1	739	745	PF00454	0.758
MOD_PKA_1	128	134	PF00069	0.658
MOD_PKA_1	411	417	PF00069	0.776
MOD_PKA_2	128	134	PF00069	0.716
MOD_PKA_2	169	175	PF00069	0.702
MOD_PKA_2	245	251	PF00069	0.792
MOD_PKA_2	322	328	PF00069	0.684
MOD_PKA_2	353	359	PF00069	0.646
MOD_PKA_2	411	417	PF00069	0.728
MOD_PKA_2	50	56	PF00069	0.695
MOD_PKA_2	615	621	PF00069	0.680
MOD_PKA_2	627	633	PF00069	0.640
MOD_PKA_2	650	656	PF00069	0.777
MOD_PKA_2	762	768	PF00069	0.563
MOD_PKB_1	126	134	PF00069	0.682
MOD_Plk_1	172	178	PF00069	0.698
MOD_Plk_1	237	243	PF00069	0.603
MOD_Plk_1	328	334	PF00069	0.779
MOD_Plk_1	437	443	PF00069	0.735
MOD_Plk_1	628	634	PF00069	0.770
MOD_Plk_4	237	243	PF00069	0.730
MOD_Plk_4	273	279	PF00069	0.647
MOD_Plk_4	301	307	PF00069	0.591
MOD_Plk_4	425	431	PF00069	0.738
MOD_Plk_4	99	105	PF00069	0.422
MOD_ProDKin_1	155	161	PF00069	0.739
MOD_ProDKin_1	199	205	PF00069	0.682
MOD_ProDKin_1	213	219	PF00069	0.715
MOD_ProDKin_1	268	274	PF00069	0.704
MOD_ProDKin_1	293	299	PF00069	0.728
MOD_ProDKin_1	313	319	PF00069	0.508
MOD_ProDKin_1	332	338	PF00069	0.585
MOD_ProDKin_1	391	397	PF00069	0.633
MOD_ProDKin_1	445	451	PF00069	0.757
MOD_ProDKin_1	467	473	PF00069	0.784
MOD_ProDKin_1	494	500	PF00069	0.769
MOD_ProDKin_1	528	534	PF00069	0.743
MOD_ProDKin_1	689	695	PF00069	0.751
MOD_ProDKin_1	737	743	PF00069	0.707
MOD_ProDKin_1	746	752	PF00069	0.669
MOD_ProDKin_1	767	773	PF00069	0.562
MOD_ProDKin_1	83	89	PF00069	0.615
TRG_DiLeu_BaEn_1	99	104	PF01217	0.408
TRG_ENDOCYTIC_2	27	30	PF00928	0.578
TRG_ENDOCYTIC_2	439	442	PF00928	0.752
TRG_ENDOCYTIC_2	97	100	PF00928	0.634
TRG_ER_diArg_1	126	129	PF00400	0.707
TRG_ER_diArg_1	19	21	PF00400	0.486
TRG_ER_diArg_1	322	324	PF00400	0.751
TRG_ER_diArg_1	43	46	PF00400	0.588
TRG_ER_diArg_1	594	596	PF00400	0.577
TRG_NES_CRM1_1	99	112	PF08389	0.547
TRG_NLS_Bipartite_1	323	341	PF00514	0.683
TRG_NLS_MonoExtN_4	336	341	PF00514	0.720

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XBV2	Leishmania donovani	85%	100%
A4HQ90	Leishmania braziliensis	53%	100%
A4IDY8	Leishmania infantum	85%	100%
E9AU08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%