Mechanosensitive ion channel

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mechanosensitive ion channel MscS, putative

Species:

Leishmania major

UniProt:

Q4Q0I4_LEIMA

TriTrypDb:

LmjF.36.5770 , LMJLV39_360070100 , LMJSD75_360070100

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q0I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0I4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0005216	monoatomic ion channel activity	4	12
GO:0008381	mechanosensitive monoatomic ion channel activity	5	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015267	channel activity	4	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0022803	passive transmembrane transporter activity	3	12
GO:0022836	gated channel activity	5	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	2	4	PF00082	0.501
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.481
CLV_PCSK_SKI1_1	2	6	PF00082	0.464
DEG_Nend_UBRbox_1	1	4	PF02207	0.482
DOC_MAPK_gen_1	83	93	PF00069	0.348
DOC_MAPK_MEF2A_6	86	95	PF00069	0.377
DOC_USP7_MATH_1	161	165	PF00917	0.610
DOC_USP7_UBL2_3	167	171	PF12436	0.589
DOC_WW_Pin1_4	46	51	PF00397	0.262
LIG_14-3-3_CanoR_1	26	30	PF00244	0.402
LIG_14-3-3_CanoR_1	3	9	PF00244	0.500
LIG_Actin_WH2_2	70	88	PF00022	0.299
LIG_FHA_1	10	16	PF00498	0.452
LIG_FHA_1	107	113	PF00498	0.306
LIG_FHA_1	41	47	PF00498	0.294
LIG_FHA_2	101	107	PF00498	0.433
LIG_LIR_Gen_1	108	118	PF02991	0.283
LIG_LIR_Nem_3	108	114	PF02991	0.283
LIG_PCNA_yPIPBox_3	127	137	PF02747	0.295
LIG_Pex14_1	107	111	PF04695	0.283
LIG_Pex14_2	69	73	PF04695	0.299
LIG_SH2_PTP2	111	114	PF00017	0.374
LIG_SH2_STAT5	111	114	PF00017	0.285
LIG_SH3_3	119	125	PF00018	0.407
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.264
LIG_SUMO_SIM_par_1	28	33	PF11976	0.337
MOD_CK1_1	22	28	PF00069	0.443
MOD_CK2_1	4	10	PF00069	0.511
MOD_GlcNHglycan	100	103	PF01048	0.413
MOD_GlcNHglycan	163	166	PF01048	0.564
MOD_GlcNHglycan	79	82	PF01048	0.318
MOD_GSK3_1	153	160	PF00069	0.570
MOD_GSK3_1	36	43	PF00069	0.348
MOD_GSK3_1	73	80	PF00069	0.305
MOD_N-GLC_1	153	158	PF02516	0.701
MOD_NEK2_1	4	9	PF00069	0.504
MOD_NEK2_1	73	78	PF00069	0.299
MOD_PKA_2	25	31	PF00069	0.410
MOD_Plk_4	100	106	PF00069	0.441
MOD_Plk_4	129	135	PF00069	0.296
MOD_Plk_4	25	31	PF00069	0.283
MOD_Plk_4	4	10	PF00069	0.551
MOD_ProDKin_1	46	52	PF00069	0.262
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.343
TRG_ENDOCYTIC_2	111	114	PF00928	0.283

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9C9	Leptomonas seymouri	71%	100%
A0A0S4JFG0	Bodo saltans	55%	78%
A0A1X0NLP4	Trypanosomatidae	68%	100%
A0A3S7XBY0	Leishmania donovani	95%	100%
A0A422NSI6	Trypanosoma rangeli	59%	100%
A4HQ93	Leishmania braziliensis	82%	100%
A4IDZ1	Leishmania infantum	95%	100%
D0A418	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AU11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B3P8	Trypanosoma cruzi	64%	100%