tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gcd10p family, putative

Species:

Leishmania major

UniProt:

Q4Q0I3_LEIMA

TriTrypDb:

LmjF.36.5780 , LMJLV39_360070200 , LMJSD75_360070200

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005643	nuclear pore	3	2
GO:0031515	tRNA (m1A) methyltransferase complex	6	11
GO:0032991	protein-containing complex	1	11
GO:0034708	methyltransferase complex	4	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0043527	tRNA methyltransferase complex	5	11
GO:0110165	cellular anatomical entity	1	11
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	11
GO:1990234	transferase complex	3	11

Expansion

Sequence features

Q4Q0I3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0I3

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006400	tRNA modification	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0030488	tRNA methylation	5	11
GO:0032259	methylation	2	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0043414	macromolecule methylation	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.247
CLV_C14_Caspase3-7	76	80	PF00656	0.277
CLV_C14_Caspase3-7	82	86	PF00656	0.225
CLV_NRD_NRD_1	107	109	PF00675	0.327
CLV_NRD_NRD_1	59	61	PF00675	0.366
CLV_PCSK_KEX2_1	107	109	PF00082	0.327
CLV_PCSK_KEX2_1	389	391	PF00082	0.527
CLV_PCSK_KEX2_1	437	439	PF00082	0.703
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.527
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.703
CLV_PCSK_SKI1_1	136	140	PF00082	0.362
CLV_PCSK_SKI1_1	201	205	PF00082	0.363
CLV_PCSK_SKI1_1	243	247	PF00082	0.477
CLV_PCSK_SKI1_1	261	265	PF00082	0.499
CLV_PCSK_SKI1_1	28	32	PF00082	0.323
CLV_PCSK_SKI1_1	314	318	PF00082	0.343
CLV_PCSK_SKI1_1	438	442	PF00082	0.512
CLV_PCSK_SKI1_1	451	455	PF00082	0.669
DEG_APCC_DBOX_1	260	268	PF00400	0.317
DOC_MAPK_gen_1	181	189	PF00069	0.248
DOC_MAPK_gen_1	27	34	PF00069	0.381
DOC_MAPK_MEF2A_6	183	191	PF00069	0.248
DOC_MAPK_MEF2A_6	27	34	PF00069	0.381
DOC_MAPK_MEF2A_6	368	376	PF00069	0.345
DOC_MAPK_MEF2A_6	389	397	PF00069	0.421
DOC_PP2B_LxvP_1	162	165	PF13499	0.313
DOC_PP2B_LxvP_1	245	248	PF13499	0.407
DOC_USP7_UBL2_3	136	140	PF12436	0.247
DOC_USP7_UBL2_3	251	255	PF12436	0.462
DOC_WW_Pin1_4	234	239	PF00397	0.317
DOC_WW_Pin1_4	351	356	PF00397	0.321
LIG_14-3-3_CanoR_1	153	157	PF00244	0.381
LIG_14-3-3_CanoR_1	219	227	PF00244	0.269
LIG_14-3-3_CanoR_1	418	426	PF00244	0.617
LIG_14-3-3_CanoR_1	438	447	PF00244	0.515
LIG_BIR_II_1	1	5	PF00653	0.521
LIG_Clathr_ClatBox_1	148	152	PF01394	0.381
LIG_FAT_LD_1	112	120	PF03623	0.313
LIG_FHA_1	184	190	PF00498	0.278
LIG_FHA_1	206	212	PF00498	0.397
LIG_FHA_1	237	243	PF00498	0.410
LIG_FHA_1	29	35	PF00498	0.363
LIG_FHA_1	303	309	PF00498	0.514
LIG_FHA_1	41	47	PF00498	0.288
LIG_FHA_1	418	424	PF00498	0.542
LIG_FHA_1	439	445	PF00498	0.723
LIG_FHA_2	171	177	PF00498	0.361
LIG_IRF3_LxIS_1	372	377	PF10401	0.345
LIG_LIR_Gen_1	361	372	PF02991	0.314
LIG_LIR_Gen_1	9	20	PF02991	0.233
LIG_LIR_Nem_3	252	257	PF02991	0.318
LIG_LIR_Nem_3	361	367	PF02991	0.308
LIG_LIR_Nem_3	66	72	PF02991	0.248
LIG_LIR_Nem_3	9	15	PF02991	0.297
LIG_LYPXL_yS_3	69	72	PF13949	0.248
LIG_NRBOX	111	117	PF00104	0.381
LIG_SH2_CRK	145	149	PF00017	0.267
LIG_SH2_CRK	50	54	PF00017	0.381
LIG_SH2_PTP2	12	15	PF00017	0.291
LIG_SH2_STAT5	12	15	PF00017	0.291
LIG_SH2_STAT5	137	140	PF00017	0.248
LIG_SH2_STAT5	403	406	PF00017	0.287
LIG_SH3_3	349	355	PF00018	0.312
LIG_SH3_3	411	417	PF00018	0.534
LIG_SH3_3	420	426	PF00018	0.568
LIG_SUMO_SIM_anti_2	185	191	PF11976	0.249
LIG_TRAF2_1	440	443	PF00917	0.740
LIG_TYR_ITIM	48	53	PF00017	0.182
LIG_UBA3_1	115	122	PF00899	0.327
LIG_UBA3_1	226	232	PF00899	0.247
LIG_UBA3_1	404	409	PF00899	0.303
MOD_CK1_1	125	131	PF00069	0.381
MOD_CK1_1	170	176	PF00069	0.247
MOD_CK1_1	215	221	PF00069	0.313
MOD_CK1_1	237	243	PF00069	0.284
MOD_CK1_1	321	327	PF00069	0.237
MOD_CK1_1	429	435	PF00069	0.705
MOD_CK1_1	449	455	PF00069	0.659
MOD_CK2_1	436	442	PF00069	0.619
MOD_CK2_1	96	102	PF00069	0.248
MOD_GlcNHglycan	121	125	PF01048	0.303
MOD_GlcNHglycan	15	18	PF01048	0.381
MOD_GlcNHglycan	273	276	PF01048	0.585
MOD_GlcNHglycan	319	323	PF01048	0.264
MOD_GlcNHglycan	36	39	PF01048	0.316
MOD_GlcNHglycan	428	431	PF01048	0.686
MOD_GlcNHglycan	438	441	PF01048	0.499
MOD_GlcNHglycan	451	454	PF01048	0.503
MOD_GSK3_1	163	170	PF00069	0.252
MOD_GSK3_1	271	278	PF00069	0.642
MOD_GSK3_1	317	324	PF00069	0.448
MOD_GSK3_1	391	398	PF00069	0.397
MOD_GSK3_1	417	424	PF00069	0.492
MOD_GSK3_1	451	458	PF00069	0.767
MOD_LATS_1	436	442	PF00433	0.514
MOD_N-GLC_1	171	176	PF02516	0.297
MOD_N-GLC_1	395	400	PF02516	0.434
MOD_NEK2_1	317	322	PF00069	0.360
MOD_NEK2_1	34	39	PF00069	0.296
MOD_NEK2_1	41	46	PF00069	0.296
MOD_NEK2_1	428	433	PF00069	0.561
MOD_PIKK_1	302	308	PF00454	0.393
MOD_PKA_2	152	158	PF00069	0.381
MOD_PKA_2	218	224	PF00069	0.269
MOD_PKA_2	275	281	PF00069	0.568
MOD_PKA_2	417	423	PF00069	0.562
MOD_PKB_1	181	189	PF00069	0.248
MOD_Plk_1	28	34	PF00069	0.269
MOD_Plk_2-3	152	158	PF00069	0.412
MOD_Plk_2-3	171	177	PF00069	0.291
MOD_Plk_4	144	150	PF00069	0.262
MOD_Plk_4	212	218	PF00069	0.313
MOD_Plk_4	321	327	PF00069	0.311
MOD_Plk_4	376	382	PF00069	0.373
MOD_Plk_4	41	47	PF00069	0.381
MOD_ProDKin_1	234	240	PF00069	0.311
MOD_ProDKin_1	351	357	PF00069	0.327
MOD_SUMO_for_1	149	152	PF00179	0.381
TRG_DiLeu_BaEn_1	312	317	PF01217	0.386
TRG_ENDOCYTIC_2	12	15	PF00928	0.291
TRG_ENDOCYTIC_2	145	148	PF00928	0.267
TRG_ENDOCYTIC_2	353	356	PF00928	0.368
TRG_ENDOCYTIC_2	50	53	PF00928	0.381
TRG_ENDOCYTIC_2	69	72	PF00928	0.248
TRG_ER_diArg_1	106	108	PF00400	0.349
TRG_ER_diArg_1	180	183	PF00400	0.260
TRG_ER_diArg_1	258	261	PF00400	0.524
TRG_NLS_MonoExtC_3	138	143	PF00514	0.248
TRG_NLS_MonoExtC_3	59	65	PF00514	0.247
TRG_NLS_MonoExtN_4	136	143	PF00514	0.248
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.348
TRG_Pf-PMV_PEXEL_1	314	319	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I267	Leptomonas seymouri	76%	98%
A0A1X0NLQ1	Trypanosomatidae	51%	99%
A0A3Q8IJV9	Leishmania donovani	93%	100%
A0A422NSE7	Trypanosoma rangeli	52%	99%
A4HQ94	Leishmania braziliensis	80%	85%
A4IDZ2	Leishmania infantum	94%	100%
D0A417	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	97%
E9AU12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
P0CS06	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	83%
P0CS07	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	83%
P41814	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	97%
Q2T9V5	Bos taurus	27%	93%
Q4WE58	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	22%	81%
Q54UB1	Dictyostelium discoideum	27%	89%
Q5A6Q4	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	100%
Q6BKK7	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	98%
Q6CF35	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	95%
Q6CLF6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	97%
Q6FNP9	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	23%	98%
Q75B32	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	100%
Q8CE96	Mus musculus	28%	93%
Q9HGL4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q9UJA5	Homo sapiens	27%	93%
V5B3L2	Trypanosoma cruzi	51%	99%