Leucine-rich_repeat_protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein (LRRP), putative

Species:

Leishmania major

UniProt:

Q4Q0I2_LEIMA

TriTrypDb:

LmjF.36.5790 , LMJLV39_360070300 , LMJSD75_360070300

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

Q4Q0I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0I2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.489
CLV_NRD_NRD_1	115	117	PF00675	0.548
CLV_NRD_NRD_1	120	122	PF00675	0.384
CLV_NRD_NRD_1	146	148	PF00675	0.490
CLV_NRD_NRD_1	32	34	PF00675	0.500
CLV_NRD_NRD_1	8	10	PF00675	0.563
CLV_PCSK_FUR_1	6	10	PF00082	0.526
CLV_PCSK_KEX2_1	146	148	PF00082	0.490
CLV_PCSK_KEX2_1	32	34	PF00082	0.526
CLV_PCSK_KEX2_1	8	10	PF00082	0.540
CLV_PCSK_SKI1_1	105	109	PF00082	0.466
CLV_PCSK_SKI1_1	12	16	PF00082	0.568
CLV_PCSK_SKI1_1	121	125	PF00082	0.366
CLV_PCSK_SKI1_1	211	215	PF00082	0.442
CLV_PCSK_SKI1_1	261	265	PF00082	0.580
DEG_APCC_KENBOX_2	313	317	PF00400	0.448
DEG_SPOP_SBC_1	303	307	PF00917	0.564
DOC_CDC14_PxL_1	228	236	PF14671	0.463
DOC_MAPK_gen_1	356	364	PF00069	0.613
DOC_MAPK_MEF2A_6	327	336	PF00069	0.470
DOC_PP4_FxxP_1	141	144	PF00568	0.433
DOC_USP7_MATH_1	193	197	PF00917	0.335
DOC_USP7_MATH_1	21	25	PF00917	0.658
DOC_USP7_MATH_1	227	231	PF00917	0.521
DOC_USP7_MATH_1	249	253	PF00917	0.553
DOC_USP7_MATH_1	255	259	PF00917	0.506
DOC_USP7_MATH_1	26	30	PF00917	0.646
DOC_USP7_MATH_1	282	286	PF00917	0.551
DOC_USP7_MATH_1	325	329	PF00917	0.508
DOC_USP7_MATH_1	338	342	PF00917	0.580
DOC_USP7_MATH_1	96	100	PF00917	0.525
DOC_WW_Pin1_4	251	256	PF00397	0.614
LIG_14-3-3_CanoR_1	109	113	PF00244	0.478
LIG_14-3-3_CanoR_1	121	129	PF00244	0.455
LIG_14-3-3_CanoR_1	173	178	PF00244	0.424
LIG_14-3-3_CanoR_1	27	31	PF00244	0.568
LIG_14-3-3_CanoR_1	298	303	PF00244	0.486
LIG_14-3-3_CanoR_1	32	41	PF00244	0.523
LIG_14-3-3_CanoR_1	50	56	PF00244	0.586
LIG_Actin_WH2_2	283	300	PF00022	0.373
LIG_Actin_WH2_2	94	111	PF00022	0.536
LIG_Clathr_ClatBox_1	262	266	PF01394	0.529
LIG_DLG_GKlike_1	298	306	PF00625	0.535
LIG_EH1_1	197	205	PF00400	0.437
LIG_FHA_1	26	32	PF00498	0.592
LIG_FHA_1	316	322	PF00498	0.527
LIG_FHA_1	335	341	PF00498	0.360
LIG_FHA_1	359	365	PF00498	0.628
LIG_FHA_1	50	56	PF00498	0.601
LIG_FHA_1	79	85	PF00498	0.512
LIG_FHA_1	8	14	PF00498	0.584
LIG_FHA_1	96	102	PF00498	0.582
LIG_FHA_2	122	128	PF00498	0.605
LIG_FHA_2	304	310	PF00498	0.575
LIG_FHA_2	337	343	PF00498	0.541
LIG_FHA_2	35	41	PF00498	0.533
LIG_FHA_2	58	64	PF00498	0.507
LIG_HP1_1	227	231	PF01393	0.424
LIG_LIR_Apic_2	87	93	PF02991	0.504
LIG_LIR_Gen_1	328	336	PF02991	0.522
LIG_LIR_Gen_1	56	66	PF02991	0.507
LIG_LIR_Nem_3	328	332	PF02991	0.507
LIG_LIR_Nem_3	56	61	PF02991	0.514
LIG_RPA_C_Fungi	111	123	PF08784	0.433
LIG_SH2_CRK	58	62	PF00017	0.486
LIG_SH2_CRK	90	94	PF00017	0.505
LIG_SH2_PTP2	142	145	PF00017	0.313
LIG_SH2_STAP1	58	62	PF00017	0.512
LIG_SH2_STAT3	135	138	PF00017	0.462
LIG_SH2_STAT5	142	145	PF00017	0.313
LIG_SH2_STAT5	296	299	PF00017	0.517
LIG_SH3_1	90	96	PF00018	0.499
LIG_SH3_3	226	232	PF00018	0.533
LIG_SH3_3	90	96	PF00018	0.499
LIG_SUMO_SIM_anti_2	258	266	PF11976	0.601
LIG_SUMO_SIM_par_1	165	170	PF11976	0.433
LIG_SUMO_SIM_par_1	258	266	PF11976	0.649
LIG_SUMO_SIM_par_1	51	56	PF11976	0.523
LIG_TRAF2_2	255	260	PF00917	0.601
LIG_TYR_ITIM	140	145	PF00017	0.317
LIG_WRC_WIRS_1	326	331	PF05994	0.508
MOD_CK1_1	175	181	PF00069	0.440
MOD_CK1_1	221	227	PF00069	0.477
MOD_CK1_1	305	311	PF00069	0.563
MOD_CK1_1	328	334	PF00069	0.559
MOD_CK1_1	341	347	PF00069	0.509
MOD_CK1_1	360	366	PF00069	0.599
MOD_CK1_1	99	105	PF00069	0.532
MOD_CK2_1	175	181	PF00069	0.477
MOD_CK2_1	298	304	PF00069	0.553
MOD_CK2_1	336	342	PF00069	0.644
MOD_CK2_1	57	63	PF00069	0.512
MOD_GlcNHglycan	154	158	PF01048	0.369
MOD_GlcNHglycan	168	172	PF01048	0.383
MOD_GlcNHglycan	177	180	PF01048	0.373
MOD_GlcNHglycan	251	254	PF01048	0.513
MOD_GlcNHglycan	98	101	PF01048	0.519
MOD_GSK3_1	108	115	PF00069	0.532
MOD_GSK3_1	15	22	PF00069	0.632
MOD_GSK3_1	175	182	PF00069	0.478
MOD_GSK3_1	251	258	PF00069	0.650
MOD_GSK3_1	298	305	PF00069	0.530
MOD_GSK3_1	334	341	PF00069	0.600
MOD_GSK3_1	49	56	PF00069	0.527
MOD_GSK3_1	95	102	PF00069	0.500
MOD_N-GLC_1	315	320	PF02516	0.537
MOD_NEK2_1	108	113	PF00069	0.497
MOD_NEK2_1	129	134	PF00069	0.487
MOD_NEK2_1	297	302	PF00069	0.551
MOD_NEK2_1	336	341	PF00069	0.528
MOD_NEK2_1	53	58	PF00069	0.523
MOD_NEK2_1	62	67	PF00069	0.471
MOD_NEK2_1	7	12	PF00069	0.571
MOD_NEK2_1	84	89	PF00069	0.524
MOD_NEK2_2	193	198	PF00069	0.343
MOD_PIKK_1	129	135	PF00454	0.540
MOD_PIKK_1	7	13	PF00454	0.530
MOD_PK_1	218	224	PF00069	0.473
MOD_PKA_1	121	127	PF00069	0.373
MOD_PKA_2	108	114	PF00069	0.476
MOD_PKA_2	172	178	PF00069	0.404
MOD_PKA_2	26	32	PF00069	0.562
MOD_PKA_2	297	303	PF00069	0.469
MOD_PKA_2	34	40	PF00069	0.514
MOD_PKA_2	49	55	PF00069	0.572
MOD_PKA_2	7	13	PF00069	0.530
MOD_Plk_1	153	159	PF00069	0.331
MOD_Plk_1	193	199	PF00069	0.434
MOD_Plk_1	341	347	PF00069	0.530
MOD_Plk_4	185	191	PF00069	0.452
MOD_Plk_4	26	32	PF00069	0.611
MOD_Plk_4	292	298	PF00069	0.412
MOD_Plk_4	57	63	PF00069	0.512
MOD_ProDKin_1	251	257	PF00069	0.612
MOD_SUMO_rev_2	115	124	PF00179	0.435
TRG_ENDOCYTIC_2	142	145	PF00928	0.390
TRG_ENDOCYTIC_2	150	153	PF00928	0.414
TRG_ENDOCYTIC_2	58	61	PF00928	0.513
TRG_ER_diArg_1	145	147	PF00400	0.465
TRG_ER_diArg_1	31	33	PF00400	0.552
TRG_ER_diArg_1	6	9	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XBW4	Leishmania donovani	88%	100%
A4HQ95	Leishmania braziliensis	70%	100%
A4IDZ3	Leishmania infantum	88%	100%
E9AU13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%