Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0I0_LEIMA

TriTrypDb:

LmjF.36.5810 , LMJLV39_360070500 , LMJSD75_360070500

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0I0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.515
CLV_C14_Caspase3-7	23	27	PF00656	0.585
CLV_C14_Caspase3-7	333	337	PF00656	0.471
CLV_C14_Caspase3-7	392	396	PF00656	0.577
CLV_C14_Caspase3-7	45	49	PF00656	0.513
CLV_NRD_NRD_1	169	171	PF00675	0.567
CLV_NRD_NRD_1	274	276	PF00675	0.472
CLV_NRD_NRD_1	31	33	PF00675	0.595
CLV_NRD_NRD_1	386	388	PF00675	0.637
CLV_PCSK_FUR_1	384	388	PF00082	0.607
CLV_PCSK_KEX2_1	274	276	PF00082	0.509
CLV_PCSK_KEX2_1	282	284	PF00082	0.634
CLV_PCSK_KEX2_1	386	388	PF00082	0.639
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.654
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.639
CLV_PCSK_PC7_1	384	390	PF00082	0.657
CLV_PCSK_SKI1_1	267	271	PF00082	0.506
CLV_PCSK_SKI1_1	305	309	PF00082	0.487
DEG_APCC_DBOX_1	177	185	PF00400	0.448
DEG_APCC_DBOX_1	266	274	PF00400	0.535
DEG_Nend_Nbox_1	1	3	PF02207	0.463
DOC_CKS1_1	200	205	PF01111	0.515
DOC_CYCLIN_RxL_1	264	271	PF00134	0.473
DOC_MAPK_gen_1	142	149	PF00069	0.530
DOC_MAPK_MEF2A_6	316	325	PF00069	0.456
DOC_MAPK_MEF2A_6	358	366	PF00069	0.468
DOC_PP2B_LxvP_1	122	125	PF13499	0.520
DOC_PP2B_LxvP_1	261	264	PF13499	0.536
DOC_PP2B_LxvP_1	345	348	PF13499	0.499
DOC_USP7_MATH_1	136	140	PF00917	0.556
DOC_USP7_MATH_1	51	55	PF00917	0.616
DOC_WW_Pin1_4	199	204	PF00397	0.669
DOC_WW_Pin1_4	33	38	PF00397	0.678
LIG_14-3-3_CanoR_1	146	155	PF00244	0.494
LIG_14-3-3_CanoR_1	216	226	PF00244	0.602
LIG_14-3-3_CanoR_1	258	264	PF00244	0.429
LIG_14-3-3_CanoR_1	296	304	PF00244	0.435
LIG_14-3-3_CanoR_1	316	322	PF00244	0.462
LIG_14-3-3_CanoR_1	67	75	PF00244	0.368
LIG_14-3-3_CanoR_1	92	96	PF00244	0.547
LIG_Actin_WH2_2	406	424	PF00022	0.448
LIG_BIR_III_2	48	52	PF00653	0.468
LIG_FHA_1	195	201	PF00498	0.586
LIG_FHA_1	70	76	PF00498	0.400
LIG_FHA_2	238	244	PF00498	0.679
LIG_FHA_2	403	409	PF00498	0.578
LIG_FHA_2	72	78	PF00498	0.549
LIG_LIR_Gen_1	299	308	PF02991	0.452
LIG_LIR_Gen_1	66	75	PF02991	0.536
LIG_LIR_Nem_3	188	193	PF02991	0.568
LIG_LIR_Nem_3	299	304	PF02991	0.442
LIG_LIR_Nem_3	66	71	PF02991	0.518
LIG_LYPXL_SIV_4	300	308	PF13949	0.465
LIG_NBox_RRM_1	331	341	PF00076	0.441
LIG_NRBOX	265	271	PF00104	0.535
LIG_NRBOX	340	346	PF00104	0.470
LIG_SH2_CRK	17	21	PF00017	0.608
LIG_SH2_STAP1	190	194	PF00017	0.544
LIG_SH2_STAT5	148	151	PF00017	0.518
LIG_SH2_STAT5	193	196	PF00017	0.582
LIG_SH2_STAT5	2	5	PF00017	0.517
LIG_SH3_3	197	203	PF00018	0.489
LIG_SH3_3	224	230	PF00018	0.665
LIG_SH3_3	31	37	PF00018	0.603
LIG_SH3_3	361	367	PF00018	0.660
LIG_SUMO_SIM_par_1	152	159	PF11976	0.456
LIG_SUMO_SIM_par_1	2	8	PF11976	0.508
LIG_TRAF2_1	156	159	PF00917	0.544
LIG_TYR_ITIM	15	20	PF00017	0.595
MOD_CK1_1	114	120	PF00069	0.796
MOD_CK1_1	201	207	PF00069	0.671
MOD_CK1_1	217	223	PF00069	0.646
MOD_CK1_1	350	356	PF00069	0.431
MOD_CK1_1	69	75	PF00069	0.368
MOD_CK2_1	153	159	PF00069	0.423
MOD_CK2_1	2	8	PF00069	0.508
MOD_CK2_1	237	243	PF00069	0.643
MOD_CK2_1	296	302	PF00069	0.460
MOD_CK2_1	402	408	PF00069	0.612
MOD_Cter_Amidation	384	387	PF01082	0.647
MOD_GlcNHglycan	100	103	PF01048	0.599
MOD_GlcNHglycan	113	116	PF01048	0.631
MOD_GlcNHglycan	138	141	PF01048	0.606
MOD_GlcNHglycan	23	26	PF01048	0.739
MOD_GlcNHglycan	253	256	PF01048	0.473
MOD_GlcNHglycan	261	264	PF01048	0.475
MOD_GlcNHglycan	298	301	PF01048	0.495
MOD_GlcNHglycan	349	352	PF01048	0.359
MOD_GlcNHglycan	367	370	PF01048	0.688
MOD_GlcNHglycan	431	434	PF01048	0.374
MOD_GlcNHglycan	44	47	PF01048	0.720
MOD_GSK3_1	114	121	PF00069	0.615
MOD_GSK3_1	149	156	PF00069	0.546
MOD_GSK3_1	194	201	PF00069	0.590
MOD_GSK3_1	217	224	PF00069	0.636
MOD_GSK3_1	232	239	PF00069	0.716
MOD_GSK3_1	402	409	PF00069	0.648
MOD_NEK2_1	147	152	PF00069	0.505
MOD_NEK2_1	257	262	PF00069	0.439
MOD_NEK2_1	352	357	PF00069	0.562
MOD_NEK2_1	428	433	PF00069	0.457
MOD_PIKK_1	268	274	PF00454	0.565
MOD_PIKK_1	400	406	PF00454	0.684
MOD_PKA_1	170	176	PF00069	0.568
MOD_PKA_2	257	263	PF00069	0.440
MOD_PKA_2	28	34	PF00069	0.788
MOD_PKA_2	429	435	PF00069	0.411
MOD_PKA_2	66	72	PF00069	0.435
MOD_PKA_2	91	97	PF00069	0.537
MOD_Plk_1	185	191	PF00069	0.440
MOD_Plk_1	326	332	PF00069	0.523
MOD_Plk_4	2	8	PF00069	0.430
MOD_Plk_4	352	358	PF00069	0.480
MOD_ProDKin_1	199	205	PF00069	0.669
MOD_ProDKin_1	33	39	PF00069	0.674
MOD_SUMO_rev_2	368	376	PF00179	0.692
TRG_DiLeu_BaEn_1	419	424	PF01217	0.481
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.491
TRG_DiLeu_LyEn_5	419	424	PF01217	0.336
TRG_ENDOCYTIC_2	17	20	PF00928	0.605
TRG_ENDOCYTIC_2	301	304	PF00928	0.438
TRG_ENDOCYTIC_2	68	71	PF00928	0.424
TRG_ER_diArg_1	143	146	PF00400	0.440
TRG_ER_diArg_1	273	275	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEF3	Leptomonas seymouri	44%	84%
A0A1X0NLI7	Trypanosomatidae	29%	100%
A0A3Q8IPS4	Leishmania donovani	89%	100%
A0A3R7NLX1	Trypanosoma rangeli	28%	100%
A4HQ97	Leishmania braziliensis	69%	100%
D0A414	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AHY4	Leishmania infantum	89%	100%
E9AU15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%