Nitroreductase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nitroreductase family, putative

Species:

Leishmania major

UniProt:

Q4Q0H8_LEIMA

TriTrypDb:

LmjF.36.5830 , LMJLV39_360070700 , LMJSD75_360070700

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0H8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0H8

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	8
GO:0006979	response to oxidative stress	3	8
GO:0009987	cellular process	1	8
GO:0033554	cellular response to stress	3	8
GO:0034599	cellular response to oxidative stress	4	8
GO:0042221	response to chemical	2	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0062197	cellular response to chemical stress	4	8
GO:0070887	cellular response to chemical stimulus	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016491	oxidoreductase activity	2	8
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	8
GO:0016657	oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	42	44	PF00675	0.346
CLV_PCSK_KEX2_1	41	43	PF00082	0.383
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.506
CLV_PCSK_SKI1_1	190	194	PF00082	0.431
CLV_PCSK_SKI1_1	97	101	PF00082	0.434
DEG_Nend_UBRbox_1	1	4	PF02207	0.694
DOC_CKS1_1	210	215	PF01111	0.494
DOC_MAPK_MEF2A_6	77	85	PF00069	0.428
DOC_PP4_FxxP_1	193	196	PF00568	0.434
DOC_USP7_MATH_1	148	152	PF00917	0.366
DOC_USP7_MATH_1	206	210	PF00917	0.434
DOC_USP7_MATH_1	28	32	PF00917	0.582
DOC_USP7_UBL2_3	137	141	PF12436	0.428
DOC_USP7_UBL2_3	97	101	PF12436	0.351
DOC_WW_Pin1_4	209	214	PF00397	0.511
LIG_14-3-3_CanoR_1	2	11	PF00244	0.628
LIG_14-3-3_CanoR_1	219	227	PF00244	0.566
LIG_14-3-3_CanoR_1	43	49	PF00244	0.390
LIG_Actin_WH2_2	88	103	PF00022	0.381
LIG_BRCT_BRCA1_1	31	35	PF00533	0.536
LIG_FHA_1	78	84	PF00498	0.428
LIG_FHA_2	102	108	PF00498	0.434
LIG_FHA_2	210	216	PF00498	0.505
LIG_FHA_2	64	70	PF00498	0.437
LIG_LIR_Gen_1	197	207	PF02991	0.506
LIG_LIR_Nem_3	197	202	PF02991	0.434
LIG_SH2_SRC	130	133	PF00017	0.506
LIG_SH2_STAP1	146	150	PF00017	0.434
LIG_SUMO_SIM_anti_2	57	64	PF11976	0.364
LIG_SUMO_SIM_anti_2	78	85	PF11976	0.363
LIG_SUMO_SIM_par_1	57	64	PF11976	0.364
LIG_TRAF2_1	104	107	PF00917	0.434
LIG_WRC_WIRS_1	150	155	PF05994	0.506
MOD_CDK_SPxxK_3	209	216	PF00069	0.492
MOD_CK1_1	151	157	PF00069	0.394
MOD_CK1_1	209	215	PF00069	0.484
MOD_CK1_1	5	11	PF00069	0.687
MOD_CK2_1	101	107	PF00069	0.390
MOD_CK2_1	52	58	PF00069	0.421
MOD_CK2_1	63	69	PF00069	0.402
MOD_GlcNHglycan	157	160	PF01048	0.383
MOD_GlcNHglycan	166	169	PF01048	0.385
MOD_GlcNHglycan	19	22	PF01048	0.681
MOD_GlcNHglycan	31	34	PF01048	0.593
MOD_GSK3_1	151	158	PF00069	0.381
MOD_GSK3_1	17	24	PF00069	0.702
MOD_GSK3_1	2	9	PF00069	0.675
MOD_GSK3_1	37	44	PF00069	0.407
MOD_GSK3_1	50	57	PF00069	0.327
MOD_N-GLC_1	116	121	PF02516	0.390
MOD_N-GLC_1	148	153	PF02516	0.273
MOD_N-GLC_1	17	22	PF02516	0.659
MOD_NEK2_1	52	57	PF00069	0.476
MOD_PIKK_1	151	157	PF00454	0.506
MOD_PIKK_1	50	56	PF00454	0.390
MOD_PKA_1	101	107	PF00069	0.392
MOD_PKA_1	41	47	PF00069	0.434
MOD_PKA_2	218	224	PF00069	0.571
MOD_PKA_2	41	47	PF00069	0.381
MOD_Plk_1	116	122	PF00069	0.484
MOD_Plk_1	148	154	PF00069	0.273
MOD_Plk_4	123	129	PF00069	0.381
MOD_Plk_4	77	83	PF00069	0.428
MOD_ProDKin_1	209	215	PF00069	0.519
MOD_SUMO_rev_2	107	116	PF00179	0.434
MOD_SUMO_rev_2	209	218	PF00179	0.574
TRG_DiLeu_BaEn_1	197	202	PF01217	0.434
TRG_ENDOCYTIC_2	181	184	PF00928	0.346
TRG_NES_CRM1_1	183	198	PF08389	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAF5	Leptomonas seymouri	61%	100%
A0A3Q8IWH0	Leishmania donovani	95%	100%
A4HQ99	Leishmania braziliensis	74%	100%
C9ZSG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AHY5	Leishmania infantum	94%	100%
E9AU17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
P37261	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q96VH4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%