HMG box domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0H7_LEIMA

TriTrypDb:

LmjF.36.5840 , LMJLV39_360070800 , LMJSD75_360070800

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0H7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	91	95	PF00656	0.487
CLV_NRD_NRD_1	12	14	PF00675	0.354
CLV_NRD_NRD_1	121	123	PF00675	0.447
CLV_NRD_NRD_1	150	152	PF00675	0.608
CLV_NRD_NRD_1	173	175	PF00675	0.688
CLV_NRD_NRD_1	177	179	PF00675	0.715
CLV_PCSK_KEX2_1	12	14	PF00082	0.340
CLV_PCSK_KEX2_1	173	175	PF00082	0.657
CLV_PCSK_KEX2_1	202	204	PF00082	0.616
CLV_PCSK_KEX2_1	206	208	PF00082	0.552
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.665
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.623
CLV_PCSK_PC7_1	8	14	PF00082	0.363
CLV_PCSK_SKI1_1	106	110	PF00082	0.439
CLV_PCSK_SKI1_1	12	16	PF00082	0.306
CLV_PCSK_SKI1_1	139	143	PF00082	0.683
CLV_PCSK_SKI1_1	203	207	PF00082	0.632
CLV_PCSK_SKI1_1	241	245	PF00082	0.501
CLV_PCSK_SKI1_1	32	36	PF00082	0.604
CLV_PCSK_SKI1_1	80	84	PF00082	0.414
DEG_Nend_Nbox_1	1	3	PF02207	0.499
DEG_SPOP_SBC_1	287	291	PF00917	0.802
DEG_SPOP_SBC_1	307	311	PF00917	0.629
DOC_ANK_TNKS_1	177	184	PF00023	0.513
DOC_ANK_TNKS_1	231	238	PF00023	0.518
DOC_MAPK_gen_1	104	113	PF00069	0.498
DOC_MAPK_MEF2A_6	139	147	PF00069	0.567
DOC_USP7_MATH_1	158	162	PF00917	0.662
DOC_USP7_MATH_1	169	173	PF00917	0.557
DOC_USP7_MATH_1	278	282	PF00917	0.606
DOC_USP7_MATH_1	287	291	PF00917	0.801
DOC_USP7_MATH_1	299	303	PF00917	0.662
DOC_USP7_MATH_1	308	312	PF00917	0.733
DOC_USP7_MATH_1	339	343	PF00917	0.734
DOC_USP7_UBL2_3	164	168	PF12436	0.641
DOC_USP7_UBL2_3	202	206	PF12436	0.580
DOC_WW_Pin1_4	139	144	PF00397	0.631
DOC_WW_Pin1_4	208	213	PF00397	0.493
DOC_WW_Pin1_4	274	279	PF00397	0.717
DOC_WW_Pin1_4	288	293	PF00397	0.697
DOC_WW_Pin1_4	316	321	PF00397	0.707
DOC_WW_Pin1_4	332	337	PF00397	0.659
DOC_WW_Pin1_4	99	104	PF00397	0.533
LIG_14-3-3_CanoR_1	178	186	PF00244	0.558
LIG_14-3-3_CanoR_1	239	244	PF00244	0.546
LIG_14-3-3_CanoR_1	282	292	PF00244	0.542
LIG_14-3-3_CanoR_1	3	11	PF00244	0.523
LIG_14-3-3_CanoR_1	337	347	PF00244	0.566
LIG_BRCT_BRCA1_1	43	47	PF00533	0.447
LIG_BRCT_BRCA1_2	43	49	PF00533	0.394
LIG_DCNL_PONY_1	1	4	PF03556	0.588
LIG_FHA_1	140	146	PF00498	0.728
LIG_FHA_1	310	316	PF00498	0.696
LIG_FHA_1	82	88	PF00498	0.378
LIG_FHA_2	242	248	PF00498	0.510
LIG_FHA_2	33	39	PF00498	0.639
LIG_FHA_2	81	87	PF00498	0.366
LIG_LIR_Gen_1	211	221	PF02991	0.498
LIG_LIR_Gen_1	83	89	PF02991	0.362
LIG_LIR_Nem_3	211	216	PF02991	0.463
LIG_LIR_Nem_3	238	243	PF02991	0.542
LIG_LIR_Nem_3	44	50	PF02991	0.429
LIG_LIR_Nem_3	83	88	PF02991	0.360
LIG_PDZ_Class_1	342	347	PF00595	0.517
LIG_PTAP_UEV_1	291	296	PF05743	0.511
LIG_Rb_LxCxE_1	18	35	PF01857	0.471
LIG_SH2_STAP1	213	217	PF00017	0.484
LIG_SH2_STAP1	85	89	PF00017	0.394
LIG_SH2_STAT5	78	81	PF00017	0.475
LIG_SH3_1	151	157	PF00018	0.620
LIG_SH3_2	146	151	PF14604	0.609
LIG_SH3_3	140	146	PF00018	0.531
LIG_SH3_3	151	157	PF00018	0.543
LIG_SH3_3	206	212	PF00018	0.563
LIG_SH3_3	289	295	PF00018	0.691
LIG_SH3_3	317	323	PF00018	0.610
LIG_SH3_3	333	339	PF00018	0.514
LIG_TRAF2_1	244	247	PF00917	0.574
LIG_UBA3_1	55	59	PF00899	0.443
MOD_CDK_SPK_2	332	337	PF00069	0.616
MOD_CDK_SPK_2	99	104	PF00069	0.542
MOD_CDK_SPxxK_3	99	106	PF00069	0.472
MOD_CK1_1	137	143	PF00069	0.508
MOD_CK1_1	159	165	PF00069	0.785
MOD_CK1_1	172	178	PF00069	0.555
MOD_CK1_1	194	200	PF00069	0.764
MOD_CK1_1	277	283	PF00069	0.698
MOD_CK1_1	290	296	PF00069	0.650
MOD_CK1_1	302	308	PF00069	0.813
MOD_CK1_1	309	315	PF00069	0.647
MOD_CK2_1	113	119	PF00069	0.350
MOD_CK2_1	241	247	PF00069	0.509
MOD_CK2_1	27	33	PF00069	0.499
MOD_CK2_1	80	86	PF00069	0.377
MOD_CK2_1	99	105	PF00069	0.439
MOD_GlcNHglycan	158	161	PF01048	0.796
MOD_GlcNHglycan	179	182	PF01048	0.653
MOD_GlcNHglycan	292	295	PF01048	0.601
MOD_GlcNHglycan	301	304	PF01048	0.660
MOD_GlcNHglycan	328	331	PF01048	0.686
MOD_GSK3_1	156	163	PF00069	0.685
MOD_GSK3_1	187	194	PF00069	0.719
MOD_GSK3_1	274	281	PF00069	0.721
MOD_GSK3_1	283	290	PF00069	0.648
MOD_GSK3_1	302	309	PF00069	0.737
MOD_GSK3_1	338	345	PF00069	0.717
MOD_N-GLC_1	27	32	PF02516	0.425
MOD_N-GLC_1	326	331	PF02516	0.776
MOD_NEK2_1	198	203	PF00069	0.483
MOD_NEK2_1	7	12	PF00069	0.490
MOD_PIKK_1	302	308	PF00454	0.664
MOD_PIKK_1	32	38	PF00454	0.418
MOD_PIKK_1	339	345	PF00454	0.596
MOD_PIKK_1	41	47	PF00454	0.374
MOD_PKA_1	167	173	PF00069	0.559
MOD_PKA_1	48	54	PF00069	0.423
MOD_PKA_2	172	178	PF00069	0.645
MOD_PKA_2	2	8	PF00069	0.513
MOD_PKB_1	239	247	PF00069	0.557
MOD_Plk_1	27	33	PF00069	0.433
MOD_ProDKin_1	139	145	PF00069	0.629
MOD_ProDKin_1	208	214	PF00069	0.491
MOD_ProDKin_1	274	280	PF00069	0.720
MOD_ProDKin_1	288	294	PF00069	0.695
MOD_ProDKin_1	316	322	PF00069	0.705
MOD_ProDKin_1	332	338	PF00069	0.648
MOD_ProDKin_1	99	105	PF00069	0.529
MOD_SUMO_rev_2	102	111	PF00179	0.502
MOD_SUMO_rev_2	271	278	PF00179	0.736
TRG_ENDOCYTIC_2	114	117	PF00928	0.526
TRG_ENDOCYTIC_2	213	216	PF00928	0.455
TRG_ENDOCYTIC_2	85	88	PF00928	0.404
TRG_ER_diArg_1	11	13	PF00400	0.357
TRG_ER_diArg_1	232	235	PF00400	0.522
TRG_NLS_Bipartite_1	151	170	PF00514	0.618
TRG_NLS_MonoCore_2	163	168	PF00514	0.557
TRG_NLS_MonoExtC_3	163	168	PF00514	0.667
TRG_NLS_MonoExtN_4	149	155	PF00514	0.617
TRG_NLS_MonoExtN_4	164	170	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	241	246	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P908	Leptomonas seymouri	47%	97%
A0A1X0NMA4	Trypanosomatidae	30%	100%
A0A3Q8IGP8	Leishmania donovani	88%	100%
A4HQA0	Leishmania braziliensis	70%	100%
A4IDZ6	Leishmania infantum	88%	100%
D0A409	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AU18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%