Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellum targeting protein kharon1, putative

Species:

Leishmania major

UniProt:

Q4Q0H5_LEIMA

TriTrypDb:

LmjF.36.5850 , LMJLV39_360071000 , LMJSD75_360071000

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0H5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.497
CLV_C14_Caspase3-7	415	419	PF00656	0.546
CLV_NRD_NRD_1	103	105	PF00675	0.694
CLV_NRD_NRD_1	140	142	PF00675	0.654
CLV_NRD_NRD_1	177	179	PF00675	0.643
CLV_NRD_NRD_1	18	20	PF00675	0.474
CLV_NRD_NRD_1	345	347	PF00675	0.673
CLV_NRD_NRD_1	355	357	PF00675	0.639
CLV_NRD_NRD_1	439	441	PF00675	0.743
CLV_NRD_NRD_1	78	80	PF00675	0.646
CLV_PCSK_KEX2_1	103	105	PF00082	0.694
CLV_PCSK_KEX2_1	140	142	PF00082	0.654
CLV_PCSK_KEX2_1	177	179	PF00082	0.685
CLV_PCSK_KEX2_1	276	278	PF00082	0.717
CLV_PCSK_KEX2_1	439	441	PF00082	0.743
CLV_PCSK_KEX2_1	455	457	PF00082	0.707
CLV_PCSK_KEX2_1	498	500	PF00082	0.699
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.717
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.809
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.690
CLV_PCSK_SKI1_1	123	127	PF00082	0.620
CLV_PCSK_SKI1_1	134	138	PF00082	0.682
CLV_PCSK_SKI1_1	20	24	PF00082	0.473
CLV_PCSK_SKI1_1	284	288	PF00082	0.678
CLV_PCSK_SKI1_1	469	473	PF00082	0.759
DEG_APCC_DBOX_1	177	185	PF00400	0.564
DEG_Nend_UBRbox_1	1	4	PF02207	0.493
DEG_SCF_FBW7_1	489	496	PF00400	0.514
DOC_CDC14_PxL_1	289	297	PF14671	0.562
DOC_CDC14_PxL_1	33	41	PF14671	0.467
DOC_CKS1_1	364	369	PF01111	0.735
DOC_MAPK_gen_1	528	536	PF00069	0.766
DOC_MAPK_MEF2A_6	147	154	PF00069	0.464
DOC_MAPK_MEF2A_6	89	96	PF00069	0.643
DOC_MAPK_NFAT4_5	89	97	PF00069	0.647
DOC_PP1_RVXF_1	18	25	PF00149	0.474
DOC_PP2B_LxvP_1	513	516	PF13499	0.559
DOC_PP4_FxxP_1	119	122	PF00568	0.647
DOC_PP4_FxxP_1	126	129	PF00568	0.573
DOC_PP4_MxPP_1	410	413	PF00568	0.532
DOC_USP7_MATH_1	194	198	PF00917	0.605
DOC_USP7_MATH_1	28	32	PF00917	0.455
DOC_USP7_MATH_1	425	429	PF00917	0.728
DOC_USP7_MATH_1	50	54	PF00917	0.505
DOC_USP7_MATH_1	97	101	PF00917	0.641
DOC_USP7_MATH_2	122	128	PF00917	0.549
DOC_USP7_UBL2_3	311	315	PF12436	0.723
DOC_USP7_UBL2_3	469	473	PF12436	0.633
DOC_WW_Pin1_4	118	123	PF00397	0.732
DOC_WW_Pin1_4	24	29	PF00397	0.467
DOC_WW_Pin1_4	363	368	PF00397	0.734
DOC_WW_Pin1_4	41	46	PF00397	0.422
DOC_WW_Pin1_4	449	454	PF00397	0.703
DOC_WW_Pin1_4	475	480	PF00397	0.531
DOC_WW_Pin1_4	489	494	PF00397	0.450
DOC_WW_Pin1_4	59	64	PF00397	0.753
LIG_14-3-3_CanoR_1	116	122	PF00244	0.703
LIG_14-3-3_CanoR_1	177	182	PF00244	0.682
LIG_14-3-3_CanoR_1	346	355	PF00244	0.640
LIG_14-3-3_CanoR_1	448	453	PF00244	0.781
LIG_14-3-3_CanoR_1	6	12	PF00244	0.469
LIG_BIR_III_2	269	273	PF00653	0.681
LIG_BIR_III_4	190	194	PF00653	0.562
LIG_DLG_GKlike_1	177	184	PF00625	0.565
LIG_EVH1_2	132	136	PF00568	0.686
LIG_EVH1_2	45	49	PF00568	0.472
LIG_FHA_1	167	173	PF00498	0.566
LIG_FHA_1	400	406	PF00498	0.648
LIG_FHA_2	159	165	PF00498	0.645
LIG_FHA_2	233	239	PF00498	0.618
LIG_FHA_2	327	333	PF00498	0.665
LIG_LIR_Apic_2	124	129	PF02991	0.601
LIG_LIR_Apic_2	377	383	PF02991	0.684
LIG_LIR_Nem_3	190	195	PF02991	0.597
LIG_LIR_Nem_3	339	343	PF02991	0.502
LIG_PTB_Apo_2	180	187	PF02174	0.559
LIG_PTB_Phospho_1	180	186	PF10480	0.562
LIG_SH2_CRK	192	196	PF00017	0.648
LIG_SH2_STAT5	158	161	PF00017	0.587
LIG_SH2_STAT5	258	261	PF00017	0.706
LIG_SH2_STAT5	328	331	PF00017	0.662
LIG_SH3_2	129	134	PF14604	0.619
LIG_SH3_2	237	242	PF14604	0.748
LIG_SH3_3	126	132	PF00018	0.621
LIG_SH3_3	231	237	PF00018	0.759
LIG_SH3_3	261	267	PF00018	0.761
LIG_SH3_3	276	282	PF00018	0.575
LIG_SH3_3	31	37	PF00018	0.488
LIG_SH3_3	352	358	PF00018	0.642
LIG_SH3_3	447	453	PF00018	0.586
LIG_SH3_3	494	500	PF00018	0.703
LIG_SUMO_SIM_anti_2	14	19	PF11976	0.471
LIG_SUMO_SIM_anti_2	318	324	PF11976	0.592
LIG_TRAF2_1	349	352	PF00917	0.750
LIG_TRAF2_1	368	371	PF00917	0.613
LIG_UBA3_1	35	42	PF00899	0.470
LIG_WW_3	113	117	PF00397	0.784
LIG_WW_3	131	135	PF00397	0.515
LIG_WW_3	265	269	PF00397	0.795
LIG_WW_3	353	357	PF00397	0.611
MOD_CDC14_SPxK_1	452	455	PF00782	0.736
MOD_CDC14_SPxK_1	496	499	PF00782	0.559
MOD_CDC14_SPxK_1	62	65	PF00782	0.715
MOD_CDK_SPK_2	118	123	PF00069	0.732
MOD_CDK_SPK_2	449	454	PF00069	0.586
MOD_CDK_SPK_2	493	498	PF00069	0.544
MOD_CDK_SPxK_1	363	369	PF00069	0.736
MOD_CDK_SPxK_1	449	455	PF00069	0.586
MOD_CDK_SPxK_1	493	499	PF00069	0.548
MOD_CDK_SPxK_1	59	65	PF00069	0.713
MOD_CDK_SPxxK_3	449	456	PF00069	0.701
MOD_CK1_1	166	172	PF00069	0.794
MOD_CK1_1	27	33	PF00069	0.459
MOD_CK1_1	313	319	PF00069	0.514
MOD_CK1_1	434	440	PF00069	0.664
MOD_CK1_1	449	455	PF00069	0.691
MOD_CK1_1	52	58	PF00069	0.662
MOD_CK1_1	530	536	PF00069	0.662
MOD_CK2_1	118	124	PF00069	0.625
MOD_CK2_1	232	238	PF00069	0.625
MOD_CK2_1	326	332	PF00069	0.570
MOD_CK2_1	346	352	PF00069	0.651
MOD_CK2_1	501	507	PF00069	0.809
MOD_Cter_Amidation	274	277	PF01082	0.710
MOD_GlcNHglycan	126	129	PF01048	0.564
MOD_GlcNHglycan	187	190	PF01048	0.772
MOD_GlcNHglycan	348	351	PF01048	0.649
MOD_GlcNHglycan	418	421	PF01048	0.801
MOD_GlcNHglycan	433	436	PF01048	0.676
MOD_GlcNHglycan	52	55	PF01048	0.513
MOD_GlcNHglycan	82	85	PF01048	0.566
MOD_GlcNHglycan	99	102	PF01048	0.670
MOD_GSK3_1	1	8	PF00069	0.483
MOD_GSK3_1	142	149	PF00069	0.561
MOD_GSK3_1	207	214	PF00069	0.720
MOD_GSK3_1	24	31	PF00069	0.463
MOD_GSK3_1	485	492	PF00069	0.541
MOD_GSK3_1	501	508	PF00069	0.710
MOD_GSK3_1	55	62	PF00069	0.590
MOD_N-GLC_1	117	122	PF02516	0.610
MOD_N-GLC_1	313	318	PF02516	0.615
MOD_N-GLC_1	80	85	PF02516	0.704
MOD_N-GLC_2	230	232	PF02516	0.774
MOD_NEK2_1	302	307	PF00069	0.700
MOD_NEK2_1	40	45	PF00069	0.459
MOD_NEK2_1	49	54	PF00069	0.483
MOD_PIKK_1	55	61	PF00454	0.529
MOD_PK_1	211	217	PF00069	0.750
MOD_PKA_1	177	183	PF00069	0.721
MOD_PKA_1	346	352	PF00069	0.651
MOD_PKA_2	1	7	PF00069	0.487
MOD_PKA_2	146	152	PF00069	0.595
MOD_PKA_2	177	183	PF00069	0.721
MOD_PKA_2	431	437	PF00069	0.629
MOD_PKA_2	530	536	PF00069	0.765
MOD_PKB_1	209	217	PF00069	0.746
MOD_Plk_1	163	169	PF00069	0.690
MOD_Plk_1	316	322	PF00069	0.571
MOD_Plk_4	13	19	PF00069	0.549
MOD_Plk_4	28	34	PF00069	0.426
MOD_ProDKin_1	118	124	PF00069	0.727
MOD_ProDKin_1	24	30	PF00069	0.464
MOD_ProDKin_1	363	369	PF00069	0.736
MOD_ProDKin_1	41	47	PF00069	0.425
MOD_ProDKin_1	449	455	PF00069	0.703
MOD_ProDKin_1	475	481	PF00069	0.530
MOD_ProDKin_1	489	495	PF00069	0.456
MOD_ProDKin_1	59	65	PF00069	0.757
MOD_SUMO_for_1	368	371	PF00179	0.618
MOD_SUMO_rev_2	504	510	PF00179	0.815
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.465
TRG_ENDOCYTIC_2	192	195	PF00928	0.648
TRG_ENDOCYTIC_2	407	410	PF00928	0.585
TRG_ER_diArg_1	103	105	PF00400	0.747
TRG_ER_diArg_1	139	141	PF00400	0.654
TRG_ER_diArg_1	208	211	PF00400	0.702
TRG_ER_diArg_1	222	225	PF00400	0.679
TRG_NLS_MonoCore_2	205	210	PF00514	0.595
TRG_NLS_MonoExtN_4	204	210	PF00514	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9C6	Leptomonas seymouri	51%	100%
A0A3Q8IL75	Leishmania donovani	77%	100%
A4HQA3	Leishmania braziliensis	60%	100%
A4IDZ8	Leishmania infantum	77%	100%
E9AU20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%