A44l protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

a44l protein-like protein

Species:

Leishmania major

UniProt:

Q4Q0H4_LEIMA

TriTrypDb:

LmjF.36.5860 , LMJLV39_360071100 , LMJSD75_360071100

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q0H4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0H4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0005488	binding	1	16
GO:0005524	ATP binding	5	16
GO:0016462	pyrophosphatase activity	5	16
GO:0016787	hydrolase activity	2	16
GO:0016817	hydrolase activity, acting on acid anhydrides	3	16
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	16
GO:0016887	ATP hydrolysis activity	7	16
GO:0017076	purine nucleotide binding	4	16
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.622
CLV_C14_Caspase3-7	460	464	PF00656	0.773
CLV_C14_Caspase3-7	628	632	PF00656	0.627
CLV_NRD_NRD_1	115	117	PF00675	0.319
CLV_NRD_NRD_1	204	206	PF00675	0.393
CLV_NRD_NRD_1	211	213	PF00675	0.376
CLV_NRD_NRD_1	228	230	PF00675	0.346
CLV_NRD_NRD_1	346	348	PF00675	0.321
CLV_NRD_NRD_1	372	374	PF00675	0.335
CLV_NRD_NRD_1	402	404	PF00675	0.525
CLV_NRD_NRD_1	596	598	PF00675	0.424
CLV_NRD_NRD_1	643	645	PF00675	0.433
CLV_PCSK_FUR_1	400	404	PF00082	0.448
CLV_PCSK_KEX2_1	204	206	PF00082	0.393
CLV_PCSK_KEX2_1	228	230	PF00082	0.344
CLV_PCSK_KEX2_1	322	324	PF00082	0.303
CLV_PCSK_KEX2_1	346	348	PF00082	0.279
CLV_PCSK_KEX2_1	402	404	PF00082	0.543
CLV_PCSK_KEX2_1	596	598	PF00082	0.424
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.324
CLV_PCSK_PC7_1	318	324	PF00082	0.324
CLV_PCSK_SKI1_1	122	126	PF00082	0.413
CLV_PCSK_SKI1_1	164	168	PF00082	0.411
CLV_PCSK_SKI1_1	205	209	PF00082	0.354
CLV_PCSK_SKI1_1	288	292	PF00082	0.380
CLV_PCSK_SKI1_1	375	379	PF00082	0.331
CLV_PCSK_SKI1_1	405	409	PF00082	0.465
CLV_PCSK_SKI1_1	446	450	PF00082	0.490
CLV_PCSK_SKI1_1	520	524	PF00082	0.323
CLV_PCSK_SKI1_1	564	568	PF00082	0.439
CLV_PCSK_SKI1_1	606	610	PF00082	0.469
DEG_APCC_DBOX_1	479	487	PF00400	0.562
DEG_Nend_Nbox_1	1	3	PF02207	0.450
DEG_SPOP_SBC_1	360	364	PF00917	0.574
DEG_SPOP_SBC_1	457	461	PF00917	0.758
DOC_CKS1_1	191	196	PF01111	0.543
DOC_CKS1_1	677	682	PF01111	0.651
DOC_CYCLIN_yClb1_LxF_4	307	312	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.603
DOC_MAPK_gen_1	130	138	PF00069	0.574
DOC_MAPK_gen_1	162	171	PF00069	0.611
DOC_MAPK_gen_1	204	211	PF00069	0.623
DOC_MAPK_gen_1	373	379	PF00069	0.600
DOC_MAPK_gen_1	517	527	PF00069	0.588
DOC_MAPK_MEF2A_6	162	171	PF00069	0.617
DOC_MAPK_MEF2A_6	204	211	PF00069	0.601
DOC_MAPK_MEF2A_6	335	342	PF00069	0.519
DOC_MAPK_NFAT4_5	162	170	PF00069	0.518
DOC_PP1_RVXF_1	307	313	PF00149	0.553
DOC_PP1_RVXF_1	372	379	PF00149	0.595
DOC_PP1_RVXF_1	615	621	PF00149	0.631
DOC_PP2B_LxvP_1	165	168	PF13499	0.618
DOC_PP2B_LxvP_1	2	5	PF13499	0.565
DOC_PP2B_LxvP_1	99	102	PF13499	0.558
DOC_PP4_FxxP_1	75	78	PF00568	0.576
DOC_USP7_MATH_1	13	17	PF00917	0.398
DOC_USP7_MATH_1	203	207	PF00917	0.553
DOC_USP7_MATH_1	341	345	PF00917	0.465
DOC_USP7_MATH_1	392	396	PF00917	0.687
DOC_USP7_MATH_1	416	420	PF00917	0.643
DOC_USP7_MATH_1	464	468	PF00917	0.762
DOC_USP7_UBL2_3	633	637	PF12436	0.597
DOC_WW_Pin1_4	190	195	PF00397	0.546
DOC_WW_Pin1_4	213	218	PF00397	0.615
DOC_WW_Pin1_4	256	261	PF00397	0.580
DOC_WW_Pin1_4	45	50	PF00397	0.471
DOC_WW_Pin1_4	577	582	PF00397	0.624
DOC_WW_Pin1_4	662	667	PF00397	0.577
DOC_WW_Pin1_4	669	674	PF00397	0.705
DOC_WW_Pin1_4	676	681	PF00397	0.595
LIG_14-3-3_CanoR_1	130	135	PF00244	0.627
LIG_14-3-3_CanoR_1	15	19	PF00244	0.402
LIG_14-3-3_CanoR_1	204	208	PF00244	0.658
LIG_14-3-3_CanoR_1	391	401	PF00244	0.650
LIG_14-3-3_CanoR_1	405	411	PF00244	0.751
LIG_14-3-3_CanoR_1	480	490	PF00244	0.505
LIG_14-3-3_CanoR_1	520	529	PF00244	0.573
LIG_Actin_WH2_2	2	17	PF00022	0.495
LIG_BIR_III_4	463	467	PF00653	0.678
LIG_FHA_1	106	112	PF00498	0.460
LIG_FHA_1	124	130	PF00498	0.611
LIG_FHA_1	191	197	PF00498	0.558
LIG_FHA_1	442	448	PF00498	0.736
LIG_FHA_1	457	463	PF00498	0.714
LIG_FHA_1	53	59	PF00498	0.391
LIG_FHA_1	96	102	PF00498	0.644
LIG_FHA_2	123	129	PF00498	0.617
LIG_FHA_2	178	184	PF00498	0.528
LIG_FHA_2	383	389	PF00498	0.648
LIG_FHA_2	609	615	PF00498	0.653
LIG_Integrin_RGD_1	347	349	PF01839	0.265
LIG_LIR_Apic_2	140	145	PF02991	0.677
LIG_LIR_Gen_1	206	214	PF02991	0.549
LIG_LIR_Gen_1	365	376	PF02991	0.633
LIG_LIR_Gen_1	528	536	PF02991	0.568
LIG_LIR_Gen_1	672	680	PF02991	0.598
LIG_LIR_Nem_3	149	154	PF02991	0.652
LIG_LIR_Nem_3	206	211	PF02991	0.534
LIG_LIR_Nem_3	349	355	PF02991	0.460
LIG_LIR_Nem_3	365	371	PF02991	0.576
LIG_LIR_Nem_3	46	50	PF02991	0.524
LIG_LIR_Nem_3	528	532	PF02991	0.517
LIG_LIR_Nem_3	672	677	PF02991	0.605
LIG_LIR_Nem_3	93	99	PF02991	0.634
LIG_NRBOX	309	315	PF00104	0.492
LIG_NRBOX	482	488	PF00104	0.589
LIG_PTB_Apo_2	128	135	PF02174	0.620
LIG_RPA_C_Fungi	17	29	PF08784	0.476
LIG_RPA_C_Fungi	368	380	PF08784	0.336
LIG_SH2_CRK	142	146	PF00017	0.605
LIG_SH2_CRK	674	678	PF00017	0.544
LIG_SH2_NCK_1	142	146	PF00017	0.543
LIG_SH2_PTP2	529	532	PF00017	0.370
LIG_SH2_SRC	100	103	PF00017	0.585
LIG_SH2_STAP1	249	253	PF00017	0.375
LIG_SH2_STAP1	97	101	PF00017	0.471
LIG_SH2_STAT3	301	304	PF00017	0.335
LIG_SH2_STAT5	113	116	PF00017	0.384
LIG_SH2_STAT5	238	241	PF00017	0.415
LIG_SH2_STAT5	254	257	PF00017	0.415
LIG_SH2_STAT5	356	359	PF00017	0.610
LIG_SH2_STAT5	529	532	PF00017	0.370
LIG_SH2_STAT5	703	706	PF00017	0.429
LIG_SH2_STAT5	73	76	PF00017	0.518
LIG_SH2_STAT5	83	86	PF00017	0.478
LIG_SH2_STAT5	97	100	PF00017	0.566
LIG_SH3_3	151	157	PF00018	0.559
LIG_SH3_3	166	172	PF00018	0.430
LIG_SH3_3	265	271	PF00018	0.525
LIG_SH3_3	276	282	PF00018	0.446
LIG_SH3_3	335	341	PF00018	0.502
LIG_SH3_3	398	404	PF00018	0.726
LIG_SH3_3	452	458	PF00018	0.580
LIG_SH3_4	429	436	PF00018	0.584
LIG_SUMO_SIM_anti_2	495	504	PF11976	0.411
LIG_SUMO_SIM_anti_2	53	58	PF11976	0.342
LIG_SUMO_SIM_par_1	137	143	PF11976	0.477
LIG_SUMO_SIM_par_1	500	506	PF11976	0.457
LIG_SUMO_SIM_par_1	55	62	PF11976	0.318
LIG_SUMO_SIM_par_1	587	594	PF11976	0.571
LIG_TRAF2_1	364	367	PF00917	0.663
LIG_TRAF2_1	440	443	PF00917	0.558
LIG_UBA3_1	110	117	PF00899	0.435
LIG_UBA3_1	135	144	PF00899	0.451
LIG_WRC_WIRS_1	158	163	PF05994	0.429
LIG_WRC_WIRS_1	342	347	PF05994	0.381
MOD_CDK_SPK_2	190	195	PF00069	0.399
MOD_CDK_SPK_2	256	261	PF00069	0.349
MOD_CDK_SPxxK_3	190	197	PF00069	0.408
MOD_CDK_SPxxK_3	577	584	PF00069	0.523
MOD_CDK_SPxxK_3	662	669	PF00069	0.461
MOD_CK1_1	140	146	PF00069	0.539
MOD_CK1_1	437	443	PF00069	0.638
MOD_CK1_1	467	473	PF00069	0.712
MOD_CK1_1	482	488	PF00069	0.420
MOD_CK1_1	577	583	PF00069	0.698
MOD_CK1_1	662	668	PF00069	0.536
MOD_CK2_1	122	128	PF00069	0.507
MOD_CK2_1	13	19	PF00069	0.616
MOD_CK2_1	143	149	PF00069	0.485
MOD_CK2_1	360	366	PF00069	0.596
MOD_CK2_1	437	443	PF00069	0.740
MOD_Cter_Amidation	320	323	PF01082	0.381
MOD_GlcNHglycan	10	13	PF01048	0.573
MOD_GlcNHglycan	200	203	PF01048	0.636
MOD_GlcNHglycan	418	422	PF01048	0.620
MOD_GlcNHglycan	466	469	PF01048	0.632
MOD_GlcNHglycan	575	579	PF01048	0.710
MOD_GlcNHglycan	625	628	PF01048	0.689
MOD_GlcNHglycan	700	703	PF01048	0.386
MOD_GlcNHglycan	709	712	PF01048	0.489
MOD_GlcNHglycan	93	96	PF01048	0.664
MOD_GSK3_1	14	21	PF00069	0.505
MOD_GSK3_1	317	324	PF00069	0.295
MOD_GSK3_1	405	412	PF00069	0.594
MOD_GSK3_1	437	444	PF00069	0.658
MOD_GSK3_1	550	557	PF00069	0.734
MOD_GSK3_1	91	98	PF00069	0.595
MOD_N-GLC_1	130	135	PF02516	0.584
MOD_N-GLC_1	705	710	PF02516	0.528
MOD_N-GLC_2	593	595	PF02516	0.523
MOD_NEK2_1	176	181	PF00069	0.553
MOD_NEK2_1	18	23	PF00069	0.553
MOD_NEK2_1	264	269	PF00069	0.429
MOD_NEK2_1	481	486	PF00069	0.559
MOD_NEK2_1	52	57	PF00069	0.344
MOD_NEK2_1	574	579	PF00069	0.603
MOD_NEK2_1	625	630	PF00069	0.533
MOD_NEK2_2	157	162	PF00069	0.427
MOD_NEK2_2	203	208	PF00069	0.418
MOD_NEK2_2	341	346	PF00069	0.225
MOD_NEK2_2	95	100	PF00069	0.436
MOD_PIKK_1	409	415	PF00454	0.737
MOD_PIKK_1	429	435	PF00454	0.583
MOD_PIKK_1	660	666	PF00454	0.489
MOD_PKA_2	14	20	PF00069	0.493
MOD_PKA_2	203	209	PF00069	0.556
MOD_PKA_2	317	323	PF00069	0.381
MOD_PKA_2	392	398	PF00069	0.687
MOD_PKA_2	479	485	PF00069	0.370
MOD_PKB_1	403	411	PF00069	0.597
MOD_Plk_1	130	136	PF00069	0.576
MOD_Plk_1	52	58	PF00069	0.367
MOD_Plk_4	130	136	PF00069	0.486
MOD_Plk_4	137	143	PF00069	0.495
MOD_Plk_4	275	281	PF00069	0.447
MOD_Plk_4	286	292	PF00069	0.393
MOD_Plk_4	467	473	PF00069	0.618
MOD_Plk_4	482	488	PF00069	0.482
MOD_Plk_4	52	58	PF00069	0.355
MOD_Plk_4	95	101	PF00069	0.531
MOD_ProDKin_1	190	196	PF00069	0.416
MOD_ProDKin_1	213	219	PF00069	0.497
MOD_ProDKin_1	256	262	PF00069	0.464
MOD_ProDKin_1	45	51	PF00069	0.584
MOD_ProDKin_1	577	583	PF00069	0.522
MOD_ProDKin_1	662	668	PF00069	0.455
MOD_ProDKin_1	669	675	PF00069	0.628
MOD_ProDKin_1	676	682	PF00069	0.479
MOD_SUMO_rev_2	626	634	PF00179	0.478
TRG_DiLeu_BaEn_1	19	24	PF01217	0.470
TRG_DiLeu_BaEn_1	366	371	PF01217	0.467
TRG_DiLeu_BaEn_1	531	536	PF01217	0.523
TRG_DiLeu_BaEn_4	366	372	PF01217	0.468
TRG_DiLeu_LyEn_5	19	24	PF01217	0.470
TRG_ENDOCYTIC_2	151	154	PF00928	0.552
TRG_ENDOCYTIC_2	47	50	PF00928	0.657
TRG_ENDOCYTIC_2	529	532	PF00928	0.453
TRG_ENDOCYTIC_2	571	574	PF00928	0.605
TRG_ENDOCYTIC_2	674	677	PF00928	0.507
TRG_ENDOCYTIC_2	85	88	PF00928	0.502
TRG_ENDOCYTIC_2	96	99	PF00928	0.679
TRG_ER_diArg_1	209	212	PF00400	0.502
TRG_ER_diArg_1	227	229	PF00400	0.409
TRG_ER_diArg_1	345	347	PF00400	0.336
TRG_ER_diArg_1	390	393	PF00400	0.511
TRG_ER_diArg_1	399	402	PF00400	0.636
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	606	610	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P906	Leptomonas seymouri	46%	98%
A0A3Q8IC80	Leishmania donovani	29%	100%
A0A3Q8IC95	Leishmania donovani	28%	100%
A0A3Q8IHZ0	Leishmania donovani	90%	100%
A0A422NUH1	Trypanosoma rangeli	31%	100%
A4HCE5	Leishmania braziliensis	27%	100%
A4HZW7	Leishmania infantum	29%	100%
A4IDZ9	Leishmania infantum	90%	100%
E9AU21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9AVS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	99%
Q4QBQ3	Leishmania major	28%	98%
Q4QBQ4	Leishmania major	28%	100%
V5DMJ8	Trypanosoma cruzi	28%	100%