Paraflagellar_rod_protein_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania major

UniProt:

Q4Q0H3_LEIMA

TriTrypDb:

LmjF.36.5870 , LMJLV39_360071200 , LMJSD75_360071200

Length:

795

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q0H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0H3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	475	479	PF00656	0.654
CLV_MEL_PAP_1	267	273	PF00089	0.433
CLV_MEL_PAP_1	485	491	PF00089	0.517
CLV_NRD_NRD_1	325	327	PF00675	0.600
CLV_NRD_NRD_1	438	440	PF00675	0.511
CLV_NRD_NRD_1	503	505	PF00675	0.483
CLV_NRD_NRD_1	579	581	PF00675	0.434
CLV_NRD_NRD_1	724	726	PF00675	0.722
CLV_PCSK_FUR_1	436	440	PF00082	0.495
CLV_PCSK_FUR_1	501	505	PF00082	0.536
CLV_PCSK_KEX2_1	327	329	PF00082	0.499
CLV_PCSK_KEX2_1	438	440	PF00082	0.511
CLV_PCSK_KEX2_1	503	505	PF00082	0.486
CLV_PCSK_KEX2_1	723	725	PF00082	0.534
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.477
CLV_PCSK_SKI1_1	161	165	PF00082	0.410
CLV_PCSK_SKI1_1	183	187	PF00082	0.411
CLV_PCSK_SKI1_1	388	392	PF00082	0.337
CLV_PCSK_SKI1_1	439	443	PF00082	0.369
CLV_PCSK_SKI1_1	503	507	PF00082	0.469
CLV_PCSK_SKI1_1	560	564	PF00082	0.574
CLV_PCSK_SKI1_1	589	593	PF00082	0.616
CLV_PCSK_SKI1_1	68	72	PF00082	0.613
CLV_PCSK_SKI1_1	748	752	PF00082	0.512
DEG_APCC_DBOX_1	182	190	PF00400	0.458
DEG_APCC_DBOX_1	438	446	PF00400	0.367
DEG_APCC_DBOX_1	502	510	PF00400	0.468
DEG_APCC_DBOX_1	53	61	PF00400	0.552
DEG_APCC_DBOX_1	588	596	PF00400	0.708
DEG_APCC_DBOX_1	724	732	PF00400	0.513
DEG_APCC_DBOX_1	747	755	PF00400	0.483
DEG_Nend_UBRbox_2	1	3	PF02207	0.570
DEG_SPOP_SBC_1	189	193	PF00917	0.525
DEG_SPOP_SBC_1	227	231	PF00917	0.750
DOC_CKS1_1	333	338	PF01111	0.389
DOC_MAPK_DCC_7	748	756	PF00069	0.489
DOC_MAPK_gen_1	324	331	PF00069	0.463
DOC_MAPK_gen_1	501	508	PF00069	0.481
DOC_MAPK_gen_1	580	586	PF00069	0.458
DOC_MAPK_gen_1	721	730	PF00069	0.526
DOC_MAPK_gen_1	745	753	PF00069	0.481
DOC_MAPK_MEF2A_6	371	379	PF00069	0.584
DOC_MAPK_MEF2A_6	452	460	PF00069	0.387
DOC_MAPK_MEF2A_6	748	756	PF00069	0.559
DOC_MAPK_MEF2A_6	758	767	PF00069	0.660
DOC_PP1_RVXF_1	159	165	PF00149	0.449
DOC_PP1_RVXF_1	762	768	PF00149	0.462
DOC_PP2B_LxvP_1	390	393	PF13499	0.481
DOC_PP2B_LxvP_1	465	468	PF13499	0.389
DOC_PP4_FxxP_1	49	52	PF00568	0.550
DOC_PP4_FxxP_1	53	56	PF00568	0.575
DOC_PP4_FxxP_1	749	752	PF00568	0.566
DOC_USP7_MATH_1	118	122	PF00917	0.641
DOC_USP7_MATH_1	297	301	PF00917	0.535
DOC_USP7_MATH_1	369	373	PF00917	0.643
DOC_USP7_MATH_1	556	560	PF00917	0.692
DOC_USP7_MATH_1	585	589	PF00917	0.504
DOC_USP7_MATH_1	658	662	PF00917	0.657
DOC_USP7_MATH_1	733	737	PF00917	0.547
DOC_WW_Pin1_4	21	26	PF00397	0.618
DOC_WW_Pin1_4	230	235	PF00397	0.685
DOC_WW_Pin1_4	252	257	PF00397	0.555
DOC_WW_Pin1_4	269	274	PF00397	0.659
DOC_WW_Pin1_4	332	337	PF00397	0.417
DOC_WW_Pin1_4	69	74	PF00397	0.561
DOC_WW_Pin1_4	716	721	PF00397	0.527
DOC_WW_Pin1_4	757	762	PF00397	0.601
DOC_WW_Pin1_4	9	14	PF00397	0.543
DOC_WW_Pin1_4	94	99	PF00397	0.467
LIG_14-3-3_CanoR_1	452	457	PF00244	0.273
LIG_14-3-3_CanoR_1	545	555	PF00244	0.467
LIG_14-3-3_CanoR_1	59	65	PF00244	0.465
LIG_14-3-3_CanoR_1	660	664	PF00244	0.665
LIG_14-3-3_CanoR_1	764	770	PF00244	0.654
LIG_Actin_WH2_2	53	70	PF00022	0.574
LIG_AP2alpha_2	312	314	PF02296	0.583
LIG_BRCT_BRCA1_1	398	402	PF00533	0.472
LIG_eIF4E_1	61	67	PF01652	0.505
LIG_FHA_1	133	139	PF00498	0.537
LIG_FHA_1	284	290	PF00498	0.541
LIG_FHA_1	303	309	PF00498	0.689
LIG_FHA_1	333	339	PF00498	0.507
LIG_FHA_1	371	377	PF00498	0.600
LIG_FHA_1	406	412	PF00498	0.422
LIG_FHA_1	453	459	PF00498	0.392
LIG_FHA_1	514	520	PF00498	0.544
LIG_FHA_1	529	535	PF00498	0.371
LIG_FHA_1	61	67	PF00498	0.437
LIG_FHA_1	660	666	PF00498	0.687
LIG_FHA_1	699	705	PF00498	0.468
LIG_FHA_1	758	764	PF00498	0.635
LIG_LIR_Apic_2	47	52	PF02991	0.517
LIG_LIR_Gen_1	110	119	PF02991	0.489
LIG_LIR_Gen_1	12	22	PF02991	0.599
LIG_LIR_Gen_1	133	142	PF02991	0.402
LIG_LIR_Gen_1	24	35	PF02991	0.559
LIG_LIR_Gen_1	39	50	PF02991	0.447
LIG_LIR_Gen_1	455	465	PF02991	0.339
LIG_LIR_Gen_1	779	790	PF02991	0.412
LIG_LIR_Nem_3	110	114	PF02991	0.487
LIG_LIR_Nem_3	12	17	PF02991	0.602
LIG_LIR_Nem_3	133	139	PF02991	0.390
LIG_LIR_Nem_3	157	163	PF02991	0.437
LIG_LIR_Nem_3	24	30	PF02991	0.577
LIG_LIR_Nem_3	39	45	PF02991	0.458
LIG_LIR_Nem_3	455	460	PF02991	0.323
LIG_LIR_Nem_3	683	689	PF02991	0.384
LIG_LIR_Nem_3	779	785	PF02991	0.430
LIG_LYPXL_S_1	685	689	PF13949	0.378
LIG_PCNA_yPIPBox_3	404	413	PF02747	0.367
LIG_Pex14_1	314	318	PF04695	0.656
LIG_Pex14_2	160	164	PF04695	0.400
LIG_Pex14_2	49	53	PF04695	0.605
LIG_Pex14_2	749	753	PF04695	0.399
LIG_PTB_Apo_2	562	569	PF02174	0.458
LIG_SH2_CRK	111	115	PF00017	0.480
LIG_SH2_CRK	134	138	PF00017	0.389
LIG_SH2_CRK	139	143	PF00017	0.430
LIG_SH2_CRK	184	188	PF00017	0.565
LIG_SH2_CRK	27	31	PF00017	0.543
LIG_SH2_CRK	81	85	PF00017	0.435
LIG_SH2_GRB2like	27	30	PF00017	0.547
LIG_SH2_GRB2like	429	432	PF00017	0.554
LIG_SH2_PTP2	429	432	PF00017	0.456
LIG_SH2_SRC	27	30	PF00017	0.547
LIG_SH2_SRC	429	432	PF00017	0.557
LIG_SH2_STAP1	134	138	PF00017	0.512
LIG_SH2_STAP1	27	31	PF00017	0.543
LIG_SH2_STAT5	134	137	PF00017	0.385
LIG_SH2_STAT5	318	321	PF00017	0.534
LIG_SH2_STAT5	429	432	PF00017	0.456
LIG_SH2_STAT5	668	671	PF00017	0.488
LIG_SH3_1	270	276	PF00018	0.409
LIG_SH3_3	126	132	PF00018	0.456
LIG_SH3_3	176	182	PF00018	0.420
LIG_SH3_3	270	276	PF00018	0.530
LIG_SH3_3	637	643	PF00018	0.707
LIG_SH3_3	661	667	PF00018	0.638
LIG_SH3_3	7	13	PF00018	0.551
LIG_SUMO_SIM_anti_2	461	467	PF11976	0.434
LIG_SUMO_SIM_anti_2	574	580	PF11976	0.509
LIG_SUMO_SIM_anti_2	86	95	PF11976	0.444
LIG_SUMO_SIM_par_1	185	193	PF11976	0.382
LIG_SUMO_SIM_par_1	228	239	PF11976	0.481
LIG_SUMO_SIM_par_1	375	381	PF11976	0.563
LIG_SUMO_SIM_par_1	530	536	PF11976	0.392
LIG_TRAF2_1	169	172	PF00917	0.529
LIG_TRAF2_1	18	21	PF00917	0.664
LIG_TRAF2_1	272	275	PF00917	0.566
LIG_TYR_ITIM	79	84	PF00017	0.501
LIG_UBA3_1	376	382	PF00899	0.505
LIG_UBA3_1	575	581	PF00899	0.516
LIG_UBA3_1	789	794	PF00899	0.550
LIG_WRC_WIRS_1	407	412	PF05994	0.507
MOD_CDK_SPK_2	69	74	PF00069	0.561
MOD_CDK_SPK_2	716	721	PF00069	0.507
MOD_CDK_SPxxK_3	716	723	PF00069	0.511
MOD_CDK_SPxxK_3	757	764	PF00069	0.494
MOD_CK1_1	12	18	PF00069	0.629
MOD_CK1_1	225	231	PF00069	0.679
MOD_CK1_1	255	261	PF00069	0.542
MOD_CK1_1	378	384	PF00069	0.659
MOD_CK1_1	69	75	PF00069	0.402
MOD_CK1_1	719	725	PF00069	0.592
MOD_CK2_1	120	126	PF00069	0.487
MOD_CK2_1	166	172	PF00069	0.507
MOD_CK2_1	269	275	PF00069	0.626
MOD_CK2_1	474	480	PF00069	0.574
MOD_GlcNHglycan	102	105	PF01048	0.532
MOD_GlcNHglycan	192	195	PF01048	0.629
MOD_GlcNHglycan	363	366	PF01048	0.678
MOD_GlcNHglycan	482	485	PF01048	0.568
MOD_GlcNHglycan	523	526	PF01048	0.426
MOD_GlcNHglycan	589	592	PF01048	0.530
MOD_GlcNHglycan	602	605	PF01048	0.739
MOD_GlcNHglycan	654	657	PF01048	0.703
MOD_GlcNHglycan	68	71	PF01048	0.623
MOD_GlcNHglycan	704	707	PF01048	0.483
MOD_GSK3_1	120	127	PF00069	0.479
MOD_GSK3_1	222	229	PF00069	0.686
MOD_GSK3_1	255	262	PF00069	0.468
MOD_GSK3_1	546	553	PF00069	0.594
MOD_GSK3_1	587	594	PF00069	0.527
MOD_GSK3_1	698	705	PF00069	0.485
MOD_N-GLC_1	480	485	PF02516	0.516
MOD_N-GLC_1	550	555	PF02516	0.512
MOD_N-GLC_2	493	495	PF02516	0.409
MOD_NEK2_1	119	124	PF00069	0.529
MOD_NEK2_1	190	195	PF00069	0.571
MOD_NEK2_1	214	219	PF00069	0.531
MOD_NEK2_1	260	265	PF00069	0.519
MOD_NEK2_1	659	664	PF00069	0.515
MOD_NEK2_1	66	71	PF00069	0.600
MOD_OFUCOSY	732	737	PF10250	0.546
MOD_PIKK_1	166	172	PF00454	0.518
MOD_PIKK_1	236	242	PF00454	0.684
MOD_PIKK_1	255	261	PF00454	0.561
MOD_PIKK_1	495	501	PF00454	0.472
MOD_PIKK_1	566	572	PF00454	0.355
MOD_PKA_2	302	308	PF00069	0.546
MOD_PKA_2	521	527	PF00069	0.560
MOD_PKA_2	659	665	PF00069	0.660
MOD_Plk_1	119	125	PF00069	0.390
MOD_Plk_1	132	138	PF00069	0.510
MOD_Plk_1	396	402	PF00069	0.487
MOD_Plk_1	405	411	PF00069	0.348
MOD_Plk_1	550	556	PF00069	0.640
MOD_Plk_1	741	747	PF00069	0.468
MOD_Plk_2-3	120	126	PF00069	0.414
MOD_Plk_4	120	126	PF00069	0.414
MOD_Plk_4	132	138	PF00069	0.543
MOD_Plk_4	397	403	PF00069	0.577
MOD_Plk_4	406	412	PF00069	0.467
MOD_Plk_4	452	458	PF00069	0.461
MOD_ProDKin_1	21	27	PF00069	0.669
MOD_ProDKin_1	230	236	PF00069	0.684
MOD_ProDKin_1	252	258	PF00069	0.547
MOD_ProDKin_1	269	275	PF00069	0.670
MOD_ProDKin_1	332	338	PF00069	0.412
MOD_ProDKin_1	69	75	PF00069	0.560
MOD_ProDKin_1	716	722	PF00069	0.528
MOD_ProDKin_1	757	763	PF00069	0.606
MOD_ProDKin_1	9	15	PF00069	0.542
MOD_ProDKin_1	94	100	PF00069	0.462
MOD_SUMO_for_1	412	415	PF00179	0.532
MOD_SUMO_rev_2	415	425	PF00179	0.583
TRG_DiLeu_BaEn_2	405	411	PF01217	0.379
TRG_DiLeu_BaEn_3	88	94	PF01217	0.490
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.702
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.402
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.509
TRG_DiLeu_BaLyEn_6	726	731	PF01217	0.668
TRG_DiLeu_LyEn_5	126	131	PF01217	0.488
TRG_ENDOCYTIC_2	111	114	PF00928	0.467
TRG_ENDOCYTIC_2	134	137	PF00928	0.385
TRG_ENDOCYTIC_2	184	187	PF00928	0.519
TRG_ENDOCYTIC_2	197	200	PF00928	0.430
TRG_ENDOCYTIC_2	27	30	PF00928	0.547
TRG_ENDOCYTIC_2	686	689	PF00928	0.367
TRG_ENDOCYTIC_2	782	785	PF00928	0.386
TRG_ENDOCYTIC_2	81	84	PF00928	0.452
TRG_ER_diArg_1	323	326	PF00400	0.533
TRG_ER_diArg_1	436	439	PF00400	0.383
TRG_ER_diArg_1	502	504	PF00400	0.500
TRG_ER_diArg_1	723	725	PF00400	0.643
TRG_ER_diArg_1	743	746	PF00400	0.487
TRG_NES_CRM1_1	34	48	PF08389	0.461
TRG_NES_CRM1_1	480	492	PF08389	0.540
TRG_NES_CRM1_1	75	89	PF08389	0.552
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.480
TRG_PTS1	792	795	PF00515	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS3	Leptomonas seymouri	44%	97%
A0A0S4JAE8	Bodo saltans	27%	100%
A0A1X0NLN9	Trypanosomatidae	28%	100%
A0A3Q8IJ99	Leishmania donovani	89%	100%
A0A3R7K3C1	Trypanosoma rangeli	28%	100%
A4HQA5	Leishmania braziliensis	67%	100%
A4IE00	Leishmania infantum	88%	100%
D0A406	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AU22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BJ29	Trypanosoma cruzi	28%	100%