Putative choline/ethanolamine phosphotransferase (CEPT)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

choline/ethanolamine phosphotransferase, putative

Species:

Leishmania major

UniProt:

Q4Q0H0_LEIMA

TriTrypDb:

LmjF.36.5900 , LMJLV39_360071500 , LMJSD75_360071500

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	12
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q0H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0H0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	10
GO:0006644	phospholipid metabolic process	4	10
GO:0006646	phosphatidylethanolamine biosynthetic process	6	2
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0008610	lipid biosynthetic process	4	10
GO:0008654	phospholipid biosynthetic process	5	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0019637	organophosphate metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	10
GO:0045017	glycerolipid biosynthetic process	4	2
GO:0046337	phosphatidylethanolamine metabolic process	6	2
GO:0046474	glycerophospholipid biosynthetic process	5	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0071704	organic substance metabolic process	2	10
GO:0090407	organophosphate biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004142	diacylglycerol cholinephosphotransferase activity	6	4
GO:0004307	ethanolaminephosphotransferase activity	6	8
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	12
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.447
CLV_NRD_NRD_1	119	121	PF00675	0.247
CLV_NRD_NRD_1	28	30	PF00675	0.351
CLV_PCSK_KEX2_1	119	121	PF00082	0.247
CLV_PCSK_SKI1_1	245	249	PF00082	0.372
CLV_PCSK_SKI1_1	43	47	PF00082	0.361
DEG_APCC_DBOX_1	157	165	PF00400	0.368
DEG_APCC_DBOX_1	244	252	PF00400	0.407
DEG_APCC_DBOX_1	325	333	PF00400	0.469
DEG_ODPH_VHL_1	284	297	PF01847	0.329
DEG_ODPH_VHL_1	61	73	PF01847	0.498
DOC_CKS1_1	138	143	PF01111	0.299
DOC_MAPK_MEF2A_6	245	252	PF00069	0.372
DOC_MAPK_MEF2A_6	277	284	PF00069	0.496
DOC_PP1_RVXF_1	243	250	PF00149	0.299
DOC_PP1_RVXF_1	336	343	PF00149	0.522
DOC_PP4_FxxP_1	138	141	PF00568	0.315
DOC_USP7_MATH_1	233	237	PF00917	0.407
DOC_USP7_MATH_1	352	356	PF00917	0.443
DOC_USP7_MATH_1	363	367	PF00917	0.379
DOC_USP7_MATH_1	413	417	PF00917	0.695
DOC_WW_Pin1_4	122	127	PF00397	0.487
DOC_WW_Pin1_4	137	142	PF00397	0.209
DOC_WW_Pin1_4	226	231	PF00397	0.254
DOC_WW_Pin1_4	276	281	PF00397	0.528
LIG_14-3-3_CanoR_1	158	167	PF00244	0.446
LIG_14-3-3_CanoR_1	326	330	PF00244	0.474
LIG_14-3-3_CanoR_1	331	337	PF00244	0.492
LIG_Actin_WH2_2	254	272	PF00022	0.430
LIG_BRCT_BRCA1_1	228	232	PF00533	0.373
LIG_BRCT_BRCA1_1	245	249	PF00533	0.235
LIG_BRCT_BRCA1_1	254	258	PF00533	0.334
LIG_eIF4E_1	99	105	PF01652	0.299
LIG_FHA_1	138	144	PF00498	0.290
LIG_FHA_1	179	185	PF00498	0.485
LIG_FHA_1	236	242	PF00498	0.361
LIG_FHA_1	257	263	PF00498	0.328
LIG_FHA_1	277	283	PF00498	0.441
LIG_FHA_1	289	295	PF00498	0.288
LIG_FHA_1	67	73	PF00498	0.331
LIG_FHA_1	76	82	PF00498	0.300
LIG_FHA_2	152	158	PF00498	0.407
LIG_HP1_1	141	145	PF01393	0.212
LIG_IRF3_LxIS_1	400	407	PF10401	0.558
LIG_LIR_Apic_2	136	141	PF02991	0.455
LIG_LIR_Apic_2	16	22	PF02991	0.597
LIG_LIR_Gen_1	168	177	PF02991	0.380
LIG_LIR_Gen_1	246	257	PF02991	0.344
LIG_LIR_Gen_1	339	350	PF02991	0.491
LIG_LIR_Gen_1	382	392	PF02991	0.382
LIG_LIR_Gen_1	395	404	PF02991	0.473
LIG_LIR_LC3C_4	291	295	PF02991	0.212
LIG_LIR_Nem_3	168	173	PF02991	0.391
LIG_LIR_Nem_3	221	227	PF02991	0.387
LIG_LIR_Nem_3	246	252	PF02991	0.307
LIG_LIR_Nem_3	255	261	PF02991	0.315
LIG_LIR_Nem_3	313	319	PF02991	0.331
LIG_LIR_Nem_3	339	345	PF02991	0.491
LIG_LIR_Nem_3	395	400	PF02991	0.464
LIG_LIR_Nem_3	67	71	PF02991	0.419
LIG_LIR_Nem_3	94	98	PF02991	0.387
LIG_LYPXL_yS_3	224	227	PF13949	0.335
LIG_MLH1_MIPbox_1	228	232	PF16413	0.418
LIG_MYND_1	226	230	PF01753	0.255
LIG_PCNA_PIPBox_1	153	162	PF02747	0.352
LIG_PCNA_yPIPBox_3	146	158	PF02747	0.446
LIG_Pex14_1	95	99	PF04695	0.299
LIG_Pex14_2	170	174	PF04695	0.315
LIG_Rb_pABgroove_1	125	133	PF01858	0.447
LIG_SH2_CRK	316	320	PF00017	0.384
LIG_SH2_CRK	337	341	PF00017	0.570
LIG_SH2_GRB2like	186	189	PF00017	0.539
LIG_SH2_GRB2like	49	52	PF00017	0.497
LIG_SH2_NCK_1	220	224	PF00017	0.396
LIG_SH2_PTP2	19	22	PF00017	0.576
LIG_SH2_SRC	186	189	PF00017	0.539
LIG_SH2_SRC	19	22	PF00017	0.576
LIG_SH2_STAP1	220	224	PF00017	0.421
LIG_SH2_STAP1	99	103	PF00017	0.315
LIG_SH2_STAT3	44	47	PF00017	0.502
LIG_SH2_STAT5	186	189	PF00017	0.509
LIG_SH2_STAT5	19	22	PF00017	0.527
LIG_SH2_STAT5	24	27	PF00017	0.497
LIG_SH2_STAT5	403	406	PF00017	0.527
LIG_SH2_STAT5	44	47	PF00017	0.360
LIG_SH2_STAT5	85	88	PF00017	0.271
LIG_SH3_3	184	190	PF00018	0.588
LIG_SH3_3	219	225	PF00018	0.345
LIG_SH3_3	227	233	PF00018	0.405
LIG_SH3_3	265	271	PF00018	0.521
LIG_SH3_3	296	302	PF00018	0.362
LIG_SH3_3	303	309	PF00018	0.347
LIG_SUMO_SIM_anti_2	140	146	PF11976	0.212
LIG_SUMO_SIM_anti_2	34	42	PF11976	0.539
LIG_SUMO_SIM_anti_2	405	410	PF11976	0.548
LIG_TRAF2_1	7	10	PF00917	0.550
LIG_TYR_ITIM	222	227	PF00017	0.337
LIG_TYR_ITIM	314	319	PF00017	0.407
LIG_UBA3_1	408	415	PF00899	0.573
LIG_WW_1	21	24	PF00397	0.547
MOD_CK1_1	148	154	PF00069	0.408
MOD_CK1_1	162	168	PF00069	0.253
MOD_CK1_1	178	184	PF00069	0.403
MOD_CK1_1	243	249	PF00069	0.288
MOD_CK1_1	276	282	PF00069	0.501
MOD_CK1_1	330	336	PF00069	0.417
MOD_CK1_1	39	45	PF00069	0.508
MOD_CK1_1	395	401	PF00069	0.476
MOD_CK1_1	407	413	PF00069	0.530
MOD_CK2_1	151	157	PF00069	0.407
MOD_GlcNHglycan	203	206	PF01048	0.418
MOD_GlcNHglycan	213	217	PF01048	0.579
MOD_GlcNHglycan	235	238	PF01048	0.628
MOD_GlcNHglycan	332	335	PF01048	0.363
MOD_GlcNHglycan	354	357	PF01048	0.396
MOD_GlcNHglycan	394	397	PF01048	0.368
MOD_GSK3_1	118	125	PF00069	0.474
MOD_GSK3_1	148	155	PF00069	0.323
MOD_GSK3_1	159	166	PF00069	0.375
MOD_GSK3_1	252	259	PF00069	0.371
MOD_GSK3_1	269	276	PF00069	0.583
MOD_GSK3_1	318	325	PF00069	0.299
MOD_GSK3_1	32	39	PF00069	0.532
MOD_N-GLC_1	145	150	PF02516	0.384
MOD_N-GLC_1	302	307	PF02516	0.517
MOD_NEK2_1	145	150	PF00069	0.448
MOD_NEK2_1	159	164	PF00069	0.229
MOD_NEK2_1	201	206	PF00069	0.297
MOD_NEK2_1	252	257	PF00069	0.313
MOD_NEK2_1	312	317	PF00069	0.340
MOD_NEK2_1	318	323	PF00069	0.300
MOD_NEK2_1	327	332	PF00069	0.464
MOD_NEK2_1	374	379	PF00069	0.394
MOD_NEK2_1	392	397	PF00069	0.279
MOD_NEK2_1	404	409	PF00069	0.493
MOD_NEK2_1	75	80	PF00069	0.297
MOD_NEK2_2	235	240	PF00069	0.361
MOD_NEK2_2	302	307	PF00069	0.339
MOD_PIKK_1	395	401	PF00454	0.472
MOD_PK_1	402	408	PF00069	0.542
MOD_PK_1	8	14	PF00069	0.614
MOD_PKA_2	118	124	PF00069	0.447
MOD_PKA_2	269	275	PF00069	0.567
MOD_PKA_2	325	331	PF00069	0.323
MOD_Plk_1	145	151	PF00069	0.419
MOD_Plk_1	212	218	PF00069	0.351
MOD_Plk_1	302	308	PF00069	0.324
MOD_Plk_1	312	318	PF00069	0.273
MOD_Plk_1	36	42	PF00069	0.497
MOD_Plk_1	361	367	PF00069	0.382
MOD_Plk_4	148	154	PF00069	0.395
MOD_Plk_4	165	171	PF00069	0.165
MOD_Plk_4	207	213	PF00069	0.336
MOD_Plk_4	264	270	PF00069	0.520
MOD_Plk_4	36	42	PF00069	0.488
MOD_Plk_4	369	375	PF00069	0.323
MOD_Plk_4	379	385	PF00069	0.348
MOD_ProDKin_1	122	128	PF00069	0.487
MOD_ProDKin_1	137	143	PF00069	0.209
MOD_ProDKin_1	226	232	PF00069	0.250
MOD_ProDKin_1	276	282	PF00069	0.478
MOD_SUMO_rev_2	111	118	PF00179	0.447
TRG_ENDOCYTIC_2	107	110	PF00928	0.299
TRG_ENDOCYTIC_2	224	227	PF00928	0.354
TRG_ENDOCYTIC_2	316	319	PF00928	0.377
TRG_ENDOCYTIC_2	337	340	PF00928	0.489
TRG_ENDOCYTIC_2	389	392	PF00928	0.294
TRG_ENDOCYTIC_2	403	406	PF00928	0.463
TRG_ENDOCYTIC_2	49	52	PF00928	0.494
TRG_ENDOCYTIC_2	83	86	PF00928	0.293
TRG_ENDOCYTIC_2	99	102	PF00928	0.334
TRG_NLS_MonoExtN_4	26	33	PF00514	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I260	Leptomonas seymouri	63%	100%
A0A0S4JA45	Bodo saltans	38%	95%
A0A1X0NLI0	Trypanosomatidae	49%	92%
A0A3Q8IRT0	Leishmania donovani	94%	100%
A0A3R7NAX1	Trypanosoma rangeli	48%	97%
A4HQA8	Leishmania braziliensis	81%	100%
A4IE03	Leishmania infantum	94%	100%
D0A400	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
E9AU25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O82567	Arabidopsis thaliana	31%	100%
O82568	Arabidopsis thaliana	32%	100%
P17898	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q54XM0	Dictyostelium discoideum	30%	100%
Q550W1	Dictyostelium discoideum	29%	100%
Q55AQ3	Dictyostelium discoideum	31%	100%
V5B3K4	Trypanosoma cruzi	48%	96%