2-haloalkanoic acid dehalogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

enolase-phosphatase e1-like

Species:

Leishmania major

UniProt:

Q4Q0G9_LEIMA

TriTrypDb:

LmjF.36.5910 , LMJLV39_360071700 , LMJSD75_360071700

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0G9

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	5
GO:0000097	sulfur amino acid biosynthetic process	5	5
GO:0006082	organic acid metabolic process	3	5
GO:0006520	amino acid metabolic process	3	5
GO:0006555	methionine metabolic process	5	5
GO:0006790	sulfur compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0008652	amino acid biosynthetic process	4	5
GO:0009058	biosynthetic process	2	5
GO:0009066	aspartate family amino acid metabolic process	5	5
GO:0009067	aspartate family amino acid biosynthetic process	6	5
GO:0009086	methionine biosynthetic process	6	5
GO:0009987	cellular process	1	5
GO:0016053	organic acid biosynthetic process	4	5
GO:0019509	L-methionine salvage from methylthioadenosine	6	5
GO:0019752	carboxylic acid metabolic process	5	5
GO:0043094	cellular metabolic compound salvage	3	5
GO:0043102	amino acid salvage	4	5
GO:0043436	oxoacid metabolic process	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044249	cellular biosynthetic process	3	5
GO:0044272	sulfur compound biosynthetic process	4	5
GO:0044281	small molecule metabolic process	2	5
GO:0044283	small molecule biosynthetic process	3	5
GO:0046394	carboxylic acid biosynthetic process	5	5
GO:0071265	L-methionine biosynthetic process	7	5
GO:0071267	L-methionine salvage	5	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5
GO:1901566	organonitrogen compound biosynthetic process	4	5
GO:1901576	organic substance biosynthetic process	3	5
GO:1901605	alpha-amino acid metabolic process	4	5
GO:1901607	alpha-amino acid biosynthetic process	5	5

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	5
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0016791	phosphatase activity	5	5
GO:0042578	phosphoric ester hydrolase activity	4	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0043874	acireductone synthase activity	6	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	180	182	PF00082	0.607
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.607
CLV_PCSK_SKI1_1	144	148	PF00082	0.515
CLV_PCSK_SKI1_1	230	234	PF00082	0.522
CLV_PCSK_SKI1_1	280	284	PF00082	0.559
CLV_PCSK_SKI1_1	3	7	PF00082	0.470
DEG_Nend_Nbox_1	1	3	PF02207	0.524
DOC_CYCLIN_RxL_1	274	285	PF00134	0.565
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.322
DOC_PP2B_LxvP_1	287	290	PF13499	0.510
DOC_USP7_MATH_1	309	313	PF00917	0.435
DOC_USP7_MATH_1	314	318	PF00917	0.422
DOC_USP7_MATH_1	69	73	PF00917	0.675
DOC_USP7_UBL2_3	270	274	PF12436	0.506
DOC_USP7_UBL2_3	365	369	PF12436	0.544
DOC_WW_Pin1_4	130	135	PF00397	0.701
DOC_WW_Pin1_4	204	209	PF00397	0.339
DOC_WW_Pin1_4	86	91	PF00397	0.408
LIG_14-3-3_CanoR_1	17	23	PF00244	0.469
LIG_14-3-3_CanoR_1	3	13	PF00244	0.468
LIG_BRCT_BRCA1_1	142	146	PF00533	0.517
LIG_BRCT_BRCA1_1	206	210	PF00533	0.551
LIG_Clathr_ClatBox_1	81	85	PF01394	0.540
LIG_deltaCOP1_diTrp_1	327	331	PF00928	0.502
LIG_EH_1	254	258	PF12763	0.478
LIG_eIF4E_1	261	267	PF01652	0.555
LIG_FHA_1	145	151	PF00498	0.504
LIG_FHA_1	17	23	PF00498	0.466
LIG_FHA_1	279	285	PF00498	0.331
LIG_FHA_1	44	50	PF00498	0.582
LIG_FHA_1	76	82	PF00498	0.476
LIG_FHA_1	86	92	PF00498	0.337
LIG_FHA_2	165	171	PF00498	0.453
LIG_LIR_Apic_2	259	264	PF02991	0.414
LIG_LIR_Gen_1	117	128	PF02991	0.488
LIG_LIR_Gen_1	169	179	PF02991	0.489
LIG_LIR_Gen_1	27	35	PF02991	0.575
LIG_LIR_Gen_1	275	284	PF02991	0.484
LIG_LIR_Gen_1	327	335	PF02991	0.574
LIG_LIR_Gen_1	344	349	PF02991	0.417
LIG_LIR_Nem_3	117	123	PF02991	0.490
LIG_LIR_Nem_3	169	174	PF02991	0.480
LIG_LIR_Nem_3	207	213	PF02991	0.523
LIG_LIR_Nem_3	215	220	PF02991	0.492
LIG_LIR_Nem_3	249	254	PF02991	0.563
LIG_LIR_Nem_3	259	265	PF02991	0.478
LIG_LIR_Nem_3	27	31	PF02991	0.495
LIG_LIR_Nem_3	275	279	PF02991	0.345
LIG_LIR_Nem_3	327	331	PF02991	0.574
LIG_LIR_Nem_3	344	348	PF02991	0.417
LIG_Pex14_1	196	200	PF04695	0.429
LIG_Pex14_2	171	175	PF04695	0.549
LIG_REV1ctd_RIR_1	214	222	PF16727	0.489
LIG_SH2_CRK	276	280	PF00017	0.431
LIG_SH2_NCK_1	142	146	PF00017	0.517
LIG_SH2_NCK_1	68	72	PF00017	0.663
LIG_SH2_STAP1	142	146	PF00017	0.517
LIG_SH2_STAP1	28	32	PF00017	0.594
LIG_SH2_STAT5	261	264	PF00017	0.446
LIG_SH2_STAT5	341	344	PF00017	0.531
LIG_SH3_3	128	134	PF00018	0.539
LIG_SH3_3	205	211	PF00018	0.322
LIG_SH3_3	217	223	PF00018	0.279
LIG_SH3_3	60	66	PF00018	0.635
LIG_SH3_3	94	100	PF00018	0.450
LIG_SUMO_SIM_par_1	263	269	PF11976	0.568
LIG_SUMO_SIM_par_1	280	285	PF11976	0.290
LIG_TYR_ITIM	26	31	PF00017	0.523
LIG_WRC_WIRS_1	213	218	PF05994	0.479
LIG_WRC_WIRS_1	342	347	PF05994	0.410
MOD_CDK_SPxxK_3	130	137	PF00069	0.699
MOD_CK1_1	235	241	PF00069	0.443
MOD_CK1_1	304	310	PF00069	0.513
MOD_CK2_1	101	107	PF00069	0.494
MOD_CK2_1	304	310	PF00069	0.530
MOD_DYRK1A_RPxSP_1	130	134	PF00069	0.475
MOD_GlcNHglycan	152	155	PF01048	0.592
MOD_GlcNHglycan	235	238	PF01048	0.478
MOD_GlcNHglycan	305	309	PF01048	0.491
MOD_GlcNHglycan	310	314	PF01048	0.472
MOD_GlcNHglycan	316	319	PF01048	0.417
MOD_GlcNHglycan	73	76	PF01048	0.531
MOD_GSK3_1	140	147	PF00069	0.523
MOD_GSK3_1	297	304	PF00069	0.500
MOD_GSK3_1	71	78	PF00069	0.499
MOD_N-GLC_1	301	306	PF02516	0.580
MOD_NEK2_1	101	106	PF00069	0.485
MOD_NEK2_1	150	155	PF00069	0.498
MOD_NEK2_1	18	23	PF00069	0.513
MOD_NEK2_1	233	238	PF00069	0.549
MOD_NEK2_1	246	251	PF00069	0.410
MOD_NEK2_1	266	271	PF00069	0.494
MOD_NEK2_1	343	348	PF00069	0.422
MOD_PIKK_1	343	349	PF00454	0.452
MOD_PKA_2	129	135	PF00069	0.502
MOD_PKA_2	16	22	PF00069	0.587
MOD_Plk_1	226	232	PF00069	0.422
MOD_Plk_2-3	327	333	PF00069	0.579
MOD_Plk_4	212	218	PF00069	0.567
MOD_Plk_4	272	278	PF00069	0.503
MOD_Plk_4	330	336	PF00069	0.484
MOD_Plk_4	75	81	PF00069	0.439
MOD_ProDKin_1	130	136	PF00069	0.696
MOD_ProDKin_1	204	210	PF00069	0.333
MOD_ProDKin_1	86	92	PF00069	0.412
MOD_SUMO_rev_2	198	205	PF00179	0.591
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.481
TRG_ENDOCYTIC_2	251	254	PF00928	0.496
TRG_ENDOCYTIC_2	276	279	PF00928	0.430
TRG_ENDOCYTIC_2	28	31	PF00928	0.530
TRG_ER_diArg_1	228	231	PF00400	0.480
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEN0	Leptomonas seymouri	45%	96%
A0A0S4JWP4	Bodo saltans	36%	100%
A0A1X0NM36	Trypanosomatidae	29%	100%
A0A3Q8IJW9	Leishmania donovani	91%	100%
A0A3R7M5E0	Trypanosoma rangeli	29%	100%
A4HQB3	Leishmania braziliensis	74%	100%
A4IE04	Leishmania infantum	91%	100%
A6SRT0	Botryotinia fuckeliana (strain B05.10)	27%	100%
A7E3Z4	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	29%	100%
A9RBS1	Physcomitrium patens	30%	74%
A9V2Y9	Monosiga brevicollis	30%	100%
B4G0F3	Zea mays	31%	72%
B4GFE6	Drosophila persimilis	31%	100%
B4QW91	Drosophila simulans	34%	100%
B5X2D1	Salmo salar	32%	100%
B9N1F9	Populus trichocarpa	30%	72%
B9SQI7	Ricinus communis	30%	71%
B9WAM8	Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)	24%	100%
C3XR70	Branchiostoma floridae	27%	100%
C4YJE1	Candida albicans (strain WO-1)	23%	100%
C9SUS0	Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)	31%	100%
D2UYP1	Naegleria gruberi	29%	100%
E0CTF3	Vitis vinifera	30%	70%
E9AU26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q0VD27	Bos taurus	33%	100%
Q28C69	Xenopus tropicalis	30%	100%
Q296B0	Drosophila pseudoobscura pseudoobscura	31%	100%
Q55FM6	Dictyostelium discoideum	28%	100%
Q5PPH0	Rattus norvegicus	32%	100%
Q6FLR5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	25%	100%
Q6GMI7	Danio rerio	31%	100%
Q7Q9C0	Anopheles gambiae	28%	100%
Q8BGB7	Mus musculus	32%	100%
Q9FN41	Arabidopsis thaliana	32%	74%
Q9UHY7	Homo sapiens	32%	100%
V5BJ24	Trypanosoma cruzi	27%	100%