Putative kinetoplast DNA-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast DNA-associated protein, putative

Species:

Leishmania major

UniProt:

Q4Q0G8_LEIMA

TriTrypDb:

LmjF.36.5920 , LMJLV39_360071800 , LMJSD75_360071800

Length:

161

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q0G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0G8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	51	53	PF00675	0.439
CLV_NRD_NRD_1	64	66	PF00675	0.472
CLV_NRD_NRD_1	73	75	PF00675	0.451
CLV_NRD_NRD_1	94	96	PF00675	0.440
CLV_PCSK_KEX2_1	145	147	PF00082	0.762
CLV_PCSK_KEX2_1	34	36	PF00082	0.381
CLV_PCSK_KEX2_1	51	53	PF00082	0.435
CLV_PCSK_KEX2_1	56	58	PF00082	0.426
CLV_PCSK_KEX2_1	68	70	PF00082	0.478
CLV_PCSK_KEX2_1	96	98	PF00082	0.419
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.762
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.412
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.455
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.506
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.419
CLV_PCSK_PC7_1	52	58	PF00082	0.413
CLV_PCSK_SKI1_1	117	121	PF00082	0.587
CLV_PCSK_SKI1_1	125	129	PF00082	0.457
CLV_PCSK_SKI1_1	136	140	PF00082	0.582
CLV_PCSK_SKI1_1	142	146	PF00082	0.635
DEG_Nend_Nbox_1	1	3	PF02207	0.522
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.555
DOC_USP7_MATH_1	138	142	PF00917	0.465
DOC_USP7_MATH_1	154	158	PF00917	0.678
DOC_USP7_UBL2_3	131	135	PF12436	0.608
DOC_USP7_UBL2_3	136	140	PF12436	0.578
DOC_USP7_UBL2_3	151	155	PF12436	0.712
DOC_USP7_UBL2_3	156	160	PF12436	0.694
DOC_USP7_UBL2_3	37	41	PF12436	0.422
DOC_WW_Pin1_4	150	155	PF00397	0.689
DOC_WW_Pin1_4	9	14	PF00397	0.427
LIG_14-3-3_CanoR_1	74	82	PF00244	0.500
LIG_14-3-3_CanoR_1	95	105	PF00244	0.441
LIG_FHA_1	114	120	PF00498	0.557
LIG_LIR_Gen_1	12	19	PF02991	0.366
LIG_LIR_Gen_1	76	86	PF02991	0.406
LIG_LIR_Nem_3	12	17	PF02991	0.365
LIG_LIR_Nem_3	40	46	PF02991	0.432
LIG_LIR_Nem_3	76	81	PF02991	0.413
LIG_SH2_CRK	86	90	PF00017	0.330
LIG_UBA3_1	38	44	PF00899	0.435
LIG_WW_3	71	75	PF00397	0.472
MOD_CDK_SPK_2	150	155	PF00069	0.689
MOD_CDK_SPxK_1	150	156	PF00069	0.473
MOD_CK1_1	12	18	PF00069	0.367
MOD_CK1_1	129	135	PF00069	0.469
MOD_CK1_1	99	105	PF00069	0.461
MOD_Cter_Amidation	158	161	PF01082	0.659
MOD_GlcNHglycan	128	131	PF01048	0.641
MOD_GlcNHglycan	98	101	PF01048	0.454
MOD_GSK3_1	125	132	PF00069	0.617
MOD_GSK3_1	136	143	PF00069	0.675
MOD_GSK3_1	150	157	PF00069	0.651
MOD_GSK3_1	60	67	PF00069	0.424
MOD_NEK2_1	64	69	PF00069	0.393
MOD_PIKK_1	44	50	PF00454	0.441
MOD_PIKK_1	99	105	PF00454	0.383
MOD_PKA_1	125	131	PF00069	0.496
MOD_PKA_1	155	161	PF00069	0.647
MOD_PKA_1	96	102	PF00069	0.473
MOD_PKA_2	64	70	PF00069	0.504
MOD_PKA_2	73	79	PF00069	0.581
MOD_PKA_2	96	102	PF00069	0.427
MOD_ProDKin_1	150	156	PF00069	0.690
MOD_ProDKin_1	9	15	PF00069	0.426
TRG_DiLeu_BaEn_2	76	82	PF01217	0.442
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.472
TRG_ENDOCYTIC_2	43	46	PF00928	0.410
TRG_ENDOCYTIC_2	86	89	PF00928	0.371
TRG_ER_diArg_1	69	72	PF00400	0.592
TRG_ER_diArg_1	94	97	PF00400	0.444
TRG_NLS_Bipartite_1	135	149	PF00514	0.505
TRG_NLS_Bipartite_1	51	72	PF00514	0.498
TRG_NLS_MonoExtC_3	64	69	PF00514	0.577
TRG_NLS_MonoExtN_4	142	149	PF00514	0.751
TRG_NLS_MonoExtN_4	62	69	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8Y9	Leptomonas seymouri	70%	95%
A0A0N1IC67	Leptomonas seymouri	34%	100%
A0A0S4IRH7	Bodo saltans	34%	100%
A0A0S4J9G1	Bodo saltans	33%	100%
A0A0S4JC95	Bodo saltans	32%	100%
A0A0S4JL06	Bodo saltans	30%	100%
A0A1X0NLS3	Trypanosomatidae	39%	100%
A0A1X0NNA1	Trypanosomatidae	62%	90%
A0A1X0NNA5	Trypanosomatidae	39%	100%
A0A1X0NND5	Trypanosomatidae	36%	100%
A0A3Q8ILR8	Leishmania donovani	37%	100%
A0A3Q8IPT9	Leishmania donovani	93%	100%
A0A3R7MMA3	Trypanosoma rangeli	36%	100%
A0A3R7NF04	Trypanosoma rangeli	55%	86%
A0A422NSG2	Trypanosoma rangeli	35%	100%
A0A422NSJ6	Trypanosoma rangeli	36%	100%
A4HQA1	Leishmania braziliensis	35%	100%
A4HQA9	Leishmania braziliensis	88%	97%
A4IDZ7	Leishmania infantum	37%	100%
A4IE05	Leishmania infantum	93%	100%
D0A3Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	77%
D0A408	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	87%
D0A410	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AU19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AU27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q07053	Crithidia fasciculata	33%	100%
Q4Q0H6	Leishmania major	37%	100%
V5BT80	Trypanosoma cruzi	57%	87%
V5DK57	Trypanosoma cruzi	34%	100%