Cilia- and flagella-associated protein 157

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0G7_LEIMA

TriTrypDb:

LmjF.36.5930 , LMJLV39_360072000 , LMJSD75_360072000

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0G7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0G7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	5
GO:0005488	binding	1	5
GO:0005515	protein binding	2	5
GO:0019905	syntaxin binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.574
CLV_NRD_NRD_1	163	165	PF00675	0.418
CLV_NRD_NRD_1	235	237	PF00675	0.512
CLV_NRD_NRD_1	39	41	PF00675	0.565
CLV_NRD_NRD_1	81	83	PF00675	0.492
CLV_PCSK_KEX2_1	141	143	PF00082	0.493
CLV_PCSK_KEX2_1	206	208	PF00082	0.477
CLV_PCSK_KEX2_1	234	236	PF00082	0.506
CLV_PCSK_KEX2_1	91	93	PF00082	0.584
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.493
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.543
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.584
CLV_PCSK_SKI1_1	114	118	PF00082	0.488
CLV_PCSK_SKI1_1	221	225	PF00082	0.522
CLV_PCSK_SKI1_1	236	240	PF00082	0.414
CLV_PCSK_SKI1_1	273	277	PF00082	0.470
CLV_PCSK_SKI1_1	49	53	PF00082	0.503
CLV_PCSK_SKI1_1	72	76	PF00082	0.609
CLV_Separin_Metazoa	231	235	PF03568	0.527
DOC_CDC14_PxL_1	157	165	PF14671	0.459
DOC_CYCLIN_RxL_1	14	24	PF00134	0.504
DOC_MAPK_gen_1	14	22	PF00069	0.541
DOC_SPAK_OSR1_1	194	198	PF12202	0.478
DOC_USP7_MATH_1	225	229	PF00917	0.497
DOC_USP7_MATH_1	237	241	PF00917	0.446
DOC_USP7_MATH_1	260	264	PF00917	0.577
DOC_USP7_MATH_1	287	291	PF00917	0.548
DOC_USP7_UBL2_3	246	250	PF12436	0.426
LIG_14-3-3_CanoR_1	142	149	PF00244	0.466
LIG_14-3-3_CanoR_1	194	198	PF00244	0.493
LIG_14-3-3_CanoR_1	262	271	PF00244	0.448
LIG_BIR_II_1	1	5	PF00653	0.522
LIG_FHA_1	169	175	PF00498	0.445
LIG_FHA_1	218	224	PF00498	0.598
LIG_FHA_1	256	262	PF00498	0.448
LIG_FHA_2	167	173	PF00498	0.570
LIG_FHA_2	212	218	PF00498	0.516
LIG_FHA_2	264	270	PF00498	0.407
LIG_LIR_Gen_1	133	143	PF02991	0.476
LIG_LIR_Gen_1	266	275	PF02991	0.540
LIG_LIR_Nem_3	133	138	PF02991	0.509
LIG_LIR_Nem_3	266	271	PF02991	0.529
LIG_LIR_Nem_3	68	74	PF02991	0.558
LIG_PCNA_PIPBox_1	185	194	PF02747	0.420
LIG_PCNA_yPIPBox_3	178	192	PF02747	0.454
LIG_Pex14_2	191	195	PF04695	0.596
LIG_SH2_CRK	71	75	PF00017	0.554
LIG_SH2_NCK_1	209	213	PF00017	0.557
LIG_TRAF2_1	55	58	PF00917	0.529
LIG_WRC_WIRS_1	265	270	PF05994	0.449
MOD_CK1_1	2	8	PF00069	0.581
MOD_CK1_1	211	217	PF00069	0.509
MOD_CK1_1	263	269	PF00069	0.355
MOD_CK1_1	285	291	PF00069	0.539
MOD_CK2_1	109	115	PF00069	0.483
MOD_CK2_1	127	133	PF00069	0.583
MOD_CK2_1	141	147	PF00069	0.485
MOD_CK2_1	166	172	PF00069	0.569
MOD_CK2_1	225	231	PF00069	0.494
MOD_CK2_1	237	243	PF00069	0.429
MOD_CK2_1	263	269	PF00069	0.405
MOD_CK2_1	52	58	PF00069	0.519
MOD_GlcNHglycan	1	4	PF01048	0.522
MOD_GlcNHglycan	129	132	PF01048	0.626
MOD_GlcNHglycan	210	213	PF01048	0.449
MOD_GlcNHglycan	284	287	PF01048	0.742
MOD_GSK3_1	168	175	PF00069	0.511
MOD_GSK3_1	193	200	PF00069	0.488
MOD_GSK3_1	260	267	PF00069	0.504
MOD_GSK3_1	52	59	PF00069	0.490
MOD_PIKK_1	197	203	PF00454	0.546
MOD_PIKK_1	260	266	PF00454	0.503
MOD_PIKK_1	275	281	PF00454	0.469
MOD_PK_1	52	58	PF00069	0.490
MOD_PKA_1	141	147	PF00069	0.585
MOD_PKA_2	141	147	PF00069	0.512
MOD_PKA_2	193	199	PF00069	0.464
MOD_PKA_2	217	223	PF00069	0.571
MOD_PKB_1	234	242	PF00069	0.550
MOD_SUMO_for_1	33	36	PF00179	0.537
MOD_SUMO_rev_2	200	208	PF00179	0.446
MOD_SUMO_rev_2	28	33	PF00179	0.527
TRG_AP2beta_CARGO_1	133	142	PF09066	0.589
TRG_ENDOCYTIC_2	71	74	PF00928	0.556
TRG_ER_diArg_1	13	16	PF00400	0.463
TRG_ER_diArg_1	233	236	PF00400	0.517
TRG_NLS_MonoExtC_3	89	95	PF00514	0.500
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	18	23	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEB0	Leptomonas seymouri	63%	100%
A0A1X0NMA0	Trypanosomatidae	33%	100%
A0A3Q8IK37	Leishmania donovani	93%	100%
A0A3R7KFM9	Trypanosoma rangeli	36%	100%
A4HQB1	Leishmania braziliensis	75%	100%
A4IE06	Leishmania infantum	93%	100%
D0A3Z4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AU28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BNM8	Trypanosoma cruzi	35%	100%