C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

A distinct subfamily of CDD/CDA-like deaminases, putative

Species:

Leishmania major

UniProt:

Q4Q0G6_LEIMA

TriTrypDb:

LmjF.36.5940 , LMJLV39_360072100 , LMJSD75_360072100

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0G6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.680
CLV_C14_Caspase3-7	481	485	PF00656	0.408
CLV_C14_Caspase3-7	606	610	PF00656	0.538
CLV_NRD_NRD_1	444	446	PF00675	0.280
CLV_NRD_NRD_1	570	572	PF00675	0.274
CLV_NRD_NRD_1	594	596	PF00675	0.410
CLV_PCSK_KEX2_1	103	105	PF00082	0.679
CLV_PCSK_KEX2_1	150	152	PF00082	0.458
CLV_PCSK_KEX2_1	570	572	PF00082	0.387
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.679
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.458
CLV_PCSK_SKI1_1	232	236	PF00082	0.481
CLV_PCSK_SKI1_1	348	352	PF00082	0.374
CLV_PCSK_SKI1_1	544	548	PF00082	0.280
CLV_PCSK_SKI1_1	570	574	PF00082	0.319
CLV_PCSK_SKI1_1	596	600	PF00082	0.404
CLV_PCSK_SKI1_1	70	74	PF00082	0.630
DEG_APCC_DBOX_1	191	199	PF00400	0.503
DEG_SCF_FBW7_1	494	500	PF00400	0.319
DEG_SCF_FBW7_1	516	522	PF00400	0.280
DEG_SCF_FBW7_1	64	71	PF00400	0.683
DEG_SPOP_SBC_1	119	123	PF00917	0.631
DEG_SPOP_SBC_1	63	67	PF00917	0.578
DOC_CDC14_PxL_1	195	203	PF14671	0.505
DOC_CKS1_1	389	394	PF01111	0.297
DOC_CKS1_1	494	499	PF01111	0.462
DOC_CKS1_1	516	521	PF01111	0.291
DOC_MAPK_DCC_7	150	160	PF00069	0.499
DOC_MAPK_DCC_7	194	203	PF00069	0.506
DOC_MAPK_gen_1	595	602	PF00069	0.280
DOC_MAPK_MEF2A_6	151	160	PF00069	0.506
DOC_MAPK_MEF2A_6	194	203	PF00069	0.506
DOC_MAPK_MEF2A_6	595	602	PF00069	0.280
DOC_PP1_RVXF_1	181	187	PF00149	0.494
DOC_PP1_RVXF_1	593	600	PF00149	0.410
DOC_PP2B_LxvP_1	536	539	PF13499	0.490
DOC_PP2B_LxvP_1	600	603	PF13499	0.400
DOC_PP2B_LxvP_1	92	95	PF13499	0.554
DOC_PP4_FxxP_1	10	13	PF00568	0.369
DOC_SPAK_OSR1_1	159	163	PF12202	0.557
DOC_USP7_MATH_1	320	324	PF00917	0.471
DOC_USP7_MATH_1	440	444	PF00917	0.329
DOC_USP7_MATH_1	497	501	PF00917	0.339
DOC_USP7_MATH_1	50	54	PF00917	0.675
DOC_USP7_MATH_1	519	523	PF00917	0.291
DOC_USP7_MATH_1	68	72	PF00917	0.737
DOC_USP7_MATH_1	88	92	PF00917	0.649
DOC_WW_Pin1_4	113	118	PF00397	0.731
DOC_WW_Pin1_4	160	165	PF00397	0.528
DOC_WW_Pin1_4	264	269	PF00397	0.565
DOC_WW_Pin1_4	388	393	PF00397	0.348
DOC_WW_Pin1_4	493	498	PF00397	0.462
DOC_WW_Pin1_4	515	520	PF00397	0.291
DOC_WW_Pin1_4	590	595	PF00397	0.367
DOC_WW_Pin1_4	64	69	PF00397	0.645
DOC_WW_Pin1_4	70	75	PF00397	0.613
DOC_WW_Pin1_4	97	102	PF00397	0.736
LIG_14-3-3_CanoR_1	176	184	PF00244	0.468
LIG_14-3-3_CanoR_1	200	206	PF00244	0.498
LIG_14-3-3_CanoR_1	246	255	PF00244	0.496
LIG_14-3-3_CanoR_1	451	461	PF00244	0.294
LIG_14-3-3_CanoR_1	523	530	PF00244	0.280
LIG_14-3-3_CanoR_1	81	89	PF00244	0.614
LIG_Actin_WH2_2	557	572	PF00022	0.271
LIG_APCC_ABBA_1	258	263	PF00400	0.357
LIG_BIR_II_1	1	5	PF00653	0.515
LIG_BRCT_BRCA1_1	10	14	PF00533	0.411
LIG_BRCT_BRCA1_2	10	16	PF00533	0.444
LIG_EVH1_1	92	96	PF00568	0.553
LIG_EVH1_2	156	160	PF00568	0.536
LIG_FHA_1	134	140	PF00498	0.591
LIG_FHA_1	271	277	PF00498	0.574
LIG_FHA_1	336	342	PF00498	0.464
LIG_FHA_1	345	351	PF00498	0.448
LIG_FHA_1	389	395	PF00498	0.526
LIG_FHA_1	408	414	PF00498	0.636
LIG_FHA_1	427	433	PF00498	0.326
LIG_FHA_1	453	459	PF00498	0.298
LIG_FHA_1	486	492	PF00498	0.223
LIG_FHA_1	538	544	PF00498	0.306
LIG_FHA_1	571	577	PF00498	0.299
LIG_FHA_2	106	112	PF00498	0.782
LIG_FHA_2	307	313	PF00498	0.341
LIG_FHA_2	371	377	PF00498	0.487
LIG_FHA_2	410	416	PF00498	0.379
LIG_FHA_2	457	463	PF00498	0.305
LIG_FHA_2	476	482	PF00498	0.280
LIG_FHA_2	64	70	PF00498	0.616
LIG_LIR_Apic_2	8	13	PF02991	0.360
LIG_LIR_Gen_1	29	36	PF02991	0.368
LIG_LIR_Gen_1	334	342	PF02991	0.431
LIG_LIR_Gen_1	383	393	PF02991	0.454
LIG_LIR_Gen_1	408	416	PF02991	0.495
LIG_LIR_LC3C_4	450	454	PF02991	0.223
LIG_LIR_Nem_3	29	33	PF02991	0.364
LIG_LIR_Nem_3	334	339	PF02991	0.439
LIG_LIR_Nem_3	383	388	PF02991	0.428
LIG_LIR_Nem_3	408	414	PF02991	0.482
LIG_LIR_Nem_3	459	463	PF02991	0.426
LIG_LIR_Nem_3	6	12	PF02991	0.428
LIG_LRP6_Inhibitor_1	250	256	PF00058	0.306
LIG_NRP_CendR_1	622	624	PF00754	0.509
LIG_Pex14_1	332	336	PF04695	0.455
LIG_Pex14_2	10	14	PF04695	0.437
LIG_PTB_Apo_2	315	322	PF02174	0.442
LIG_PTB_Apo_2	554	561	PF02174	0.280
LIG_SH2_PTP2	161	164	PF00017	0.582
LIG_SH2_PTP2	30	33	PF00017	0.342
LIG_SH2_SRC	259	262	PF00017	0.431
LIG_SH2_STAT5	146	149	PF00017	0.416
LIG_SH2_STAT5	161	164	PF00017	0.430
LIG_SH2_STAT5	18	21	PF00017	0.396
LIG_SH2_STAT5	225	228	PF00017	0.400
LIG_SH2_STAT5	259	262	PF00017	0.454
LIG_SH2_STAT5	30	33	PF00017	0.349
LIG_SH3_3	150	156	PF00018	0.374
LIG_SH3_3	196	202	PF00018	0.517
LIG_SH3_3	362	368	PF00018	0.401
LIG_SH3_3	555	561	PF00018	0.280
LIG_SH3_3	595	601	PF00018	0.262
LIG_SH3_3	82	88	PF00018	0.635
LIG_SH3_3	90	96	PF00018	0.700
LIG_SUMO_SIM_anti_2	338	344	PF11976	0.419
LIG_SUMO_SIM_par_1	31	39	PF11976	0.403
LIG_SUMO_SIM_par_1	376	381	PF11976	0.421
LIG_UBA3_1	413	418	PF00899	0.367
LIG_WRC_WIRS_1	457	462	PF05994	0.410
LIG_WW_3	94	98	PF00397	0.515
MOD_CDC14_SPxK_1	100	103	PF00782	0.703
MOD_CDC14_SPxK_1	163	166	PF00782	0.589
MOD_CDK_SPK_2	160	165	PF00069	0.585
MOD_CDK_SPK_2	264	269	PF00069	0.535
MOD_CDK_SPK_2	590	595	PF00069	0.367
MOD_CDK_SPxK_1	160	166	PF00069	0.585
MOD_CDK_SPxK_1	590	596	PF00069	0.367
MOD_CDK_SPxK_1	64	70	PF00069	0.712
MOD_CDK_SPxK_1	97	103	PF00069	0.542
MOD_CDK_SPxxK_3	97	104	PF00069	0.594
MOD_CK1_1	105	111	PF00069	0.700
MOD_CK1_1	113	119	PF00069	0.586
MOD_CK1_1	123	129	PF00069	0.541
MOD_CK1_1	274	280	PF00069	0.522
MOD_CK1_1	288	294	PF00069	0.524
MOD_CK1_1	426	432	PF00069	0.276
MOD_CK1_1	456	462	PF00069	0.280
MOD_CK1_1	517	523	PF00069	0.306
MOD_CK1_1	53	59	PF00069	0.640
MOD_CK2_1	105	111	PF00069	0.774
MOD_CK2_1	169	175	PF00069	0.287
MOD_CK2_1	288	294	PF00069	0.509
MOD_CK2_1	475	481	PF00069	0.367
MOD_CK2_1	63	69	PF00069	0.720
MOD_DYRK1A_RPxSP_1	70	74	PF00069	0.748
MOD_GlcNHglycan	125	129	PF01048	0.701
MOD_GlcNHglycan	171	174	PF01048	0.325
MOD_GlcNHglycan	287	290	PF01048	0.431
MOD_GlcNHglycan	382	385	PF01048	0.557
MOD_GlcNHglycan	497	500	PF01048	0.481
MOD_GlcNHglycan	519	522	PF01048	0.311
MOD_GlcNHglycan	55	58	PF01048	0.754
MOD_GlcNHglycan	82	85	PF01048	0.666
MOD_GSK3_1	102	109	PF00069	0.636
MOD_GSK3_1	119	126	PF00069	0.553
MOD_GSK3_1	270	277	PF00069	0.536
MOD_GSK3_1	376	383	PF00069	0.337
MOD_GSK3_1	396	403	PF00069	0.210
MOD_GSK3_1	452	459	PF00069	0.287
MOD_GSK3_1	49	56	PF00069	0.630
MOD_GSK3_1	493	500	PF00069	0.330
MOD_GSK3_1	515	522	PF00069	0.384
MOD_GSK3_1	64	71	PF00069	0.542
MOD_GSK3_1	76	83	PF00069	0.591
MOD_N-GLC_1	426	431	PF02516	0.410
MOD_N-GLC_2	396	398	PF02516	0.352
MOD_N-GLC_2	434	436	PF02516	0.255
MOD_N-GLC_2	464	466	PF02516	0.410
MOD_NEK2_1	337	342	PF00069	0.369
MOD_NEK2_1	349	354	PF00069	0.388
MOD_NEK2_1	370	375	PF00069	0.449
MOD_NEK2_1	378	383	PF00069	0.432
MOD_NEK2_1	400	405	PF00069	0.482
MOD_NEK2_1	435	440	PF00069	0.400
MOD_NEK2_1	452	457	PF00069	0.364
MOD_NEK2_1	589	594	PF00069	0.302
MOD_NEK2_2	5	10	PF00069	0.563
MOD_NEK2_2	582	587	PF00069	0.410
MOD_OFUCOSY	174	179	PF10250	0.514
MOD_PIKK_1	3	9	PF00454	0.500
MOD_PKA_1	570	576	PF00069	0.295
MOD_PKA_2	105	111	PF00069	0.716
MOD_PKA_2	175	181	PF00069	0.352
MOD_PKA_2	522	528	PF00069	0.280
MOD_PKA_2	570	576	PF00069	0.410
MOD_PKA_2	80	86	PF00069	0.589
MOD_PKB_1	104	112	PF00069	0.604
MOD_PKB_1	192	200	PF00069	0.505
MOD_PKB_1	402	410	PF00069	0.543
MOD_Plk_1	262	268	PF00069	0.566
MOD_Plk_1	274	280	PF00069	0.378
MOD_Plk_1	407	413	PF00069	0.648
MOD_Plk_1	426	432	PF00069	0.321
MOD_Plk_1	582	588	PF00069	0.347
MOD_Plk_1	68	74	PF00069	0.552
MOD_Plk_2-3	409	415	PF00069	0.545
MOD_Plk_4	26	32	PF00069	0.497
MOD_Plk_4	337	343	PF00069	0.504
MOD_Plk_4	396	402	PF00069	0.425
MOD_Plk_4	420	426	PF00069	0.299
MOD_Plk_4	453	459	PF00069	0.280
MOD_Plk_4	5	11	PF00069	0.508
MOD_Plk_4	582	588	PF00069	0.387
MOD_ProDKin_1	113	119	PF00069	0.728
MOD_ProDKin_1	160	166	PF00069	0.527
MOD_ProDKin_1	264	270	PF00069	0.560
MOD_ProDKin_1	388	394	PF00069	0.341
MOD_ProDKin_1	493	499	PF00069	0.462
MOD_ProDKin_1	515	521	PF00069	0.291
MOD_ProDKin_1	590	596	PF00069	0.367
MOD_ProDKin_1	64	70	PF00069	0.649
MOD_ProDKin_1	97	103	PF00069	0.739
MOD_SUMO_for_1	416	419	PF00179	0.324
MOD_SUMO_rev_2	340	350	PF00179	0.483
TRG_AP2beta_CARGO_1	334	343	PF09066	0.455
TRG_ENDOCYTIC_2	18	21	PF00928	0.432
TRG_ENDOCYTIC_2	30	33	PF00928	0.294
TRG_ER_diArg_1	191	194	PF00400	0.538
TRG_ER_diArg_1	401	404	PF00400	0.351
TRG_ER_diArg_1	569	571	PF00400	0.387
TRG_ER_diArg_1	621	624	PF00400	0.508
TRG_NLS_MonoExtN_4	101	107	PF00514	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9C3	Leptomonas seymouri	65%	98%
A0A1X0NLM5	Trypanosomatidae	41%	100%
A0A3Q8IWI0	Leishmania donovani	91%	100%
A0A3R7NP46	Trypanosoma rangeli	40%	100%
A4HQB2	Leishmania braziliensis	76%	99%
D0A3Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AU29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B3J9	Trypanosoma cruzi	38%	100%