Putative glycerophosphoryl diester phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerophosphoryl diester phosphodiesterase, putative

Species:

Leishmania major

UniProt:

Q4Q0G4_LEIMA

TriTrypDb:

LmjF.36.5960 , LMJLV39_360072400 , LMJSD75_360072400

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0G4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0G4

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	2
GO:0006576	biogenic amine metabolic process	5	2
GO:0006580	ethanolamine metabolic process	5	2
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	7
GO:0009308	amine metabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019637	organophosphate metabolic process	3	2
GO:0034308	primary alcohol metabolic process	4	2
GO:0042439	ethanolamine-containing compound metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	7
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0070291	N-acylethanolamine metabolic process	5	2
GO:0071704	organic substance metabolic process	2	7
GO:1901160	primary amino compound metabolic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901615	organic hydroxy compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008081	phosphoric diester hydrolase activity	5	7
GO:0008889	glycerophosphodiester phosphodiesterase activity	6	5
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	249	251	PF00675	0.312
CLV_PCSK_KEX2_1	196	198	PF00082	0.459
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.459
CLV_PCSK_SKI1_1	155	159	PF00082	0.417
CLV_PCSK_SKI1_1	205	209	PF00082	0.323
CLV_PCSK_SKI1_1	251	255	PF00082	0.364
CLV_PCSK_SKI1_1	44	48	PF00082	0.466
DEG_APCC_DBOX_1	39	47	PF00400	0.469
DEG_APCC_KENBOX_2	239	243	PF00400	0.291
DEG_COP1_1	138	145	PF00400	0.312
DOC_CYCLIN_RxL_1	40	51	PF00134	0.449
DOC_MAPK_gen_1	153	160	PF00069	0.351
DOC_MAPK_HePTP_8	202	214	PF00069	0.291
DOC_MAPK_MEF2A_6	205	214	PF00069	0.291
DOC_PP1_RVXF_1	203	209	PF00149	0.325
DOC_PP4_FxxP_1	140	143	PF00568	0.312
DOC_USP7_MATH_1	2	6	PF00917	0.541
DOC_USP7_MATH_1	253	257	PF00917	0.388
DOC_USP7_MATH_1	75	79	PF00917	0.350
DOC_WW_Pin1_4	35	40	PF00397	0.556
DOC_WW_Pin1_4	46	51	PF00397	0.399
LIG_14-3-3_CanoR_1	197	203	PF00244	0.450
LIG_14-3-3_CanoR_1	93	101	PF00244	0.465
LIG_Actin_WH2_2	118	133	PF00022	0.388
LIG_APCC_ABBA_1	100	105	PF00400	0.312
LIG_APCC_ABBAyCdc20_2	162	168	PF00400	0.349
LIG_FHA_1	112	118	PF00498	0.265
LIG_FHA_1	175	181	PF00498	0.373
LIG_FHA_2	119	125	PF00498	0.312
LIG_FHA_2	142	148	PF00498	0.312
LIG_Integrin_RGD_1	62	64	PF01839	0.312
LIG_Integrin_RGDW_4	62	65	PF00362	0.312
LIG_KLC1_Yacidic_2	164	168	PF13176	0.353
LIG_LIR_Apic_2	138	143	PF02991	0.312
LIG_LIR_Gen_1	188	198	PF02991	0.371
LIG_LIR_Nem_3	168	174	PF02991	0.360
LIG_LIR_Nem_3	188	194	PF02991	0.409
LIG_LIR_Nem_3	217	223	PF02991	0.359
LIG_LIR_Nem_3	283	289	PF02991	0.352
LIG_LIR_Nem_3	64	68	PF02991	0.312
LIG_LYPXL_S_1	170	174	PF13949	0.425
LIG_LYPXL_yS_3	171	174	PF13949	0.432
LIG_NRBOX	42	48	PF00104	0.466
LIG_NRP_CendR_1	313	316	PF00754	0.383
LIG_PCNA_yPIPBox_3	240	249	PF02747	0.310
LIG_SH2_STAP1	198	202	PF00017	0.453
LIG_SH2_STAP1	234	238	PF00017	0.321
LIG_SH2_STAT5	166	169	PF00017	0.359
LIG_SH2_STAT5	248	251	PF00017	0.312
LIG_SH2_STAT5	288	291	PF00017	0.312
LIG_SH2_STAT5	309	312	PF00017	0.380
LIG_SH2_STAT5	68	71	PF00017	0.350
LIG_SH3_4	26	33	PF00018	0.575
LIG_SUMO_SIM_anti_2	146	152	PF11976	0.343
LIG_SUMO_SIM_par_1	171	177	PF11976	0.440
LIG_SUMO_SIM_par_1	85	90	PF11976	0.321
LIG_TRAF2_1	144	147	PF00917	0.312
LIG_TYR_ITSM	216	223	PF00017	0.388
LIG_UBA3_1	157	162	PF00899	0.409
MOD_CDK_SPK_2	35	40	PF00069	0.485
MOD_CDK_SPxxK_3	46	53	PF00069	0.413
MOD_CK1_1	3	9	PF00069	0.643
MOD_CK1_1	49	55	PF00069	0.430
MOD_CK2_1	118	124	PF00069	0.328
MOD_CK2_1	141	147	PF00069	0.312
MOD_GlcNHglycan	198	201	PF01048	0.411
MOD_GlcNHglycan	2	5	PF01048	0.658
MOD_GlcNHglycan	255	258	PF01048	0.388
MOD_GSK3_1	103	110	PF00069	0.388
MOD_GSK3_1	180	187	PF00069	0.350
MOD_GSK3_1	212	219	PF00069	0.310
MOD_GSK3_1	261	268	PF00069	0.312
MOD_N-GLC_1	111	116	PF02516	0.364
MOD_N-GLC_1	135	140	PF02516	0.312
MOD_N-GLC_1	212	217	PF02516	0.291
MOD_NEK2_1	107	112	PF00069	0.490
MOD_NEK2_1	174	179	PF00069	0.363
MOD_PKA_1	196	202	PF00069	0.461
MOD_PKA_2	108	114	PF00069	0.219
MOD_PKA_2	196	202	PF00069	0.461
MOD_PKA_2	92	98	PF00069	0.444
MOD_Plk_1	103	109	PF00069	0.312
MOD_Plk_1	118	124	PF00069	0.183
MOD_Plk_1	138	144	PF00069	0.183
MOD_Plk_1	180	186	PF00069	0.352
MOD_Plk_1	215	221	PF00069	0.388
MOD_Plk_1	69	75	PF00069	0.312
MOD_Plk_4	180	186	PF00069	0.386
MOD_Plk_4	261	267	PF00069	0.312
MOD_ProDKin_1	35	41	PF00069	0.547
MOD_ProDKin_1	46	52	PF00069	0.394
MOD_SUMO_for_1	185	188	PF00179	0.434
MOD_SUMO_rev_2	49	55	PF00179	0.445
TRG_DiLeu_BaEn_1	146	151	PF01217	0.350
TRG_DiLeu_BaEn_4	146	152	PF01217	0.312
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.555
TRG_DiLeu_LyEn_5	169	174	PF01217	0.429
TRG_ENDOCYTIC_2	171	174	PF00928	0.356
TRG_ENDOCYTIC_2	220	223	PF00928	0.424
TRG_NES_CRM1_1	132	146	PF08389	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3U2	Leptomonas seymouri	71%	100%
A0A3Q8ILT6	Leishmania donovani	95%	100%
A4HQB5	Leishmania braziliensis	85%	100%
A4IE09	Leishmania infantum	95%	100%
E9AU31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%