WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q0G2_LEIMA

TriTrypDb:

LmjF.36.5980 , LMJLV39_360072600 , LMJSD75_360072600

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0G2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.542
CLV_C14_Caspase3-7	399	403	PF00656	0.553
CLV_NRD_NRD_1	159	161	PF00675	0.480
CLV_NRD_NRD_1	474	476	PF00675	0.469
CLV_PCSK_KEX2_1	159	161	PF00082	0.480
CLV_PCSK_KEX2_1	474	476	PF00082	0.469
CLV_PCSK_SKI1_1	112	116	PF00082	0.474
CLV_PCSK_SKI1_1	22	26	PF00082	0.522
CLV_PCSK_SKI1_1	87	91	PF00082	0.489
DEG_Nend_UBRbox_2	1	3	PF02207	0.496
DEG_SPOP_SBC_1	414	418	PF00917	0.660
DOC_CYCLIN_RxL_1	109	117	PF00134	0.473
DOC_CYCLIN_yCln2_LP_2	291	294	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	330	336	PF00134	0.432
DOC_MAPK_DCC_7	289	297	PF00069	0.454
DOC_MAPK_gen_1	159	168	PF00069	0.504
DOC_MAPK_gen_1	322	331	PF00069	0.405
DOC_MAPK_MEF2A_6	289	297	PF00069	0.438
DOC_MAPK_MEF2A_6	78	85	PF00069	0.532
DOC_MAPK_NFAT4_5	78	86	PF00069	0.544
DOC_PP2B_LxvP_1	290	293	PF13499	0.365
DOC_PP2B_LxvP_1	330	333	PF13499	0.474
DOC_PP4_FxxP_1	31	34	PF00568	0.590
DOC_USP7_MATH_1	164	168	PF00917	0.558
DOC_USP7_MATH_1	172	176	PF00917	0.559
DOC_USP7_MATH_1	315	319	PF00917	0.517
DOC_USP7_MATH_1	413	417	PF00917	0.657
DOC_USP7_MATH_1	420	424	PF00917	0.570
DOC_USP7_MATH_1	429	433	PF00917	0.691
DOC_USP7_MATH_1	435	439	PF00917	0.625
DOC_WW_Pin1_4	114	119	PF00397	0.539
DOC_WW_Pin1_4	304	309	PF00397	0.630
DOC_WW_Pin1_4	311	316	PF00397	0.583
DOC_WW_Pin1_4	33	38	PF00397	0.622
DOC_WW_Pin1_4	409	414	PF00397	0.695
LIG_14-3-3_CanoR_1	105	114	PF00244	0.481
LIG_14-3-3_CanoR_1	176	180	PF00244	0.562
LIG_14-3-3_CanoR_1	355	360	PF00244	0.435
LIG_14-3-3_CanoR_1	474	478	PF00244	0.498
LIG_Actin_WH2_2	68	84	PF00022	0.572
LIG_BIR_III_4	54	58	PF00653	0.567
LIG_deltaCOP1_diTrp_1	133	141	PF00928	0.460
LIG_EVH1_1	31	35	PF00568	0.629
LIG_EVH1_1	461	465	PF00568	0.426
LIG_FHA_1	105	111	PF00498	0.462
LIG_FHA_1	12	18	PF00498	0.630
LIG_FHA_1	230	236	PF00498	0.391
LIG_FHA_1	240	246	PF00498	0.424
LIG_FHA_1	307	313	PF00498	0.601
LIG_FHA_1	326	332	PF00498	0.377
LIG_FHA_1	404	410	PF00498	0.606
LIG_FHA_2	180	186	PF00498	0.556
LIG_FHA_2	202	208	PF00498	0.516
LIG_FHA_2	252	258	PF00498	0.488
LIG_FHA_2	397	403	PF00498	0.599
LIG_LIR_Apic_2	29	34	PF02991	0.559
LIG_LIR_Apic_2	488	494	PF02991	0.441
LIG_LIR_Apic_2	54	59	PF02991	0.609
LIG_LIR_Gen_1	133	144	PF02991	0.401
LIG_LIR_Gen_1	161	171	PF02991	0.490
LIG_LIR_Gen_1	340	347	PF02991	0.443
LIG_LIR_Nem_3	133	139	PF02991	0.414
LIG_LIR_Nem_3	161	166	PF02991	0.536
LIG_LIR_Nem_3	252	256	PF02991	0.454
LIG_LIR_Nem_3	286	291	PF02991	0.420
LIG_LIR_Nem_3	458	464	PF02991	0.520
LIG_LIR_Nem_3	476	482	PF02991	0.398
LIG_MYND_2	293	297	PF01753	0.446
LIG_NRP_CendR_1	501	504	PF00754	0.578
LIG_Pex14_1	136	140	PF04695	0.442
LIG_Pex14_1	349	353	PF04695	0.412
LIG_Pex14_2	343	347	PF04695	0.433
LIG_SH2_CRK	367	371	PF00017	0.414
LIG_SH2_CRK	44	48	PF00017	0.658
LIG_SH2_STAT3	480	483	PF00017	0.427
LIG_SH2_STAT5	244	247	PF00017	0.444
LIG_SH2_STAT5	480	483	PF00017	0.402
LIG_SH3_3	122	128	PF00018	0.494
LIG_SH3_3	29	35	PF00018	0.667
LIG_SH3_3	330	336	PF00018	0.475
LIG_SH3_3	456	462	PF00018	0.527
LIG_SH3_3	57	63	PF00018	0.627
LIG_SUMO_SIM_anti_2	326	333	PF11976	0.469
LIG_SUMO_SIM_par_1	293	298	PF11976	0.403
LIG_TRAF2_1	128	131	PF00917	0.500
LIG_TRAF2_1	182	185	PF00917	0.532
LIG_TYR_ITIM	365	370	PF00017	0.406
LIG_ULM_U2AF65_1	159	164	PF00076	0.506
LIG_WW_2	462	465	PF00397	0.430
LIG_WW_2	60	63	PF00397	0.647
MOD_CK1_1	11	17	PF00069	0.644
MOD_CK1_1	175	181	PF00069	0.672
MOD_CK1_1	23	29	PF00069	0.614
MOD_CK1_1	239	245	PF00069	0.305
MOD_CK1_1	446	452	PF00069	0.629
MOD_CK1_1	473	479	PF00069	0.422
MOD_CK2_1	105	111	PF00069	0.430
MOD_CK2_1	139	145	PF00069	0.449
MOD_CK2_1	179	185	PF00069	0.527
MOD_CK2_1	295	301	PF00069	0.517
MOD_CK2_1	311	317	PF00069	0.537
MOD_CK2_1	413	419	PF00069	0.709
MOD_Cter_Amidation	157	160	PF01082	0.487
MOD_Cter_Amidation	484	487	PF01082	0.549
MOD_GlcNHglycan	142	145	PF01048	0.403
MOD_GlcNHglycan	222	225	PF01048	0.467
MOD_GlcNHglycan	238	241	PF01048	0.454
MOD_GlcNHglycan	25	28	PF01048	0.695
MOD_GlcNHglycan	317	320	PF01048	0.495
MOD_GlcNHglycan	376	379	PF01048	0.383
MOD_GlcNHglycan	422	425	PF01048	0.671
MOD_GlcNHglycan	437	440	PF01048	0.696
MOD_GlcNHglycan	445	448	PF01048	0.546
MOD_GlcNHglycan	483	486	PF01048	0.504
MOD_GlcNHglycan	65	68	PF01048	0.765
MOD_GSK3_1	100	107	PF00069	0.474
MOD_GSK3_1	11	18	PF00069	0.665
MOD_GSK3_1	135	142	PF00069	0.462
MOD_GSK3_1	175	182	PF00069	0.629
MOD_GSK3_1	235	242	PF00069	0.278
MOD_GSK3_1	295	302	PF00069	0.487
MOD_GSK3_1	306	313	PF00069	0.536
MOD_GSK3_1	405	412	PF00069	0.684
MOD_GSK3_1	414	421	PF00069	0.711
MOD_GSK3_1	431	438	PF00069	0.817
MOD_GSK3_1	443	450	PF00069	0.716
MOD_GSK3_1	481	488	PF00069	0.456
MOD_GSK3_1	61	68	PF00069	0.602
MOD_N-GLC_1	403	408	PF02516	0.635
MOD_N-GLC_1	429	434	PF02516	0.682
MOD_NEK2_1	220	225	PF00069	0.396
MOD_NEK2_1	396	401	PF00069	0.550
MOD_NEK2_1	481	486	PF00069	0.498
MOD_NEK2_1	65	70	PF00069	0.667
MOD_NEK2_1	8	13	PF00069	0.657
MOD_NEK2_2	135	140	PF00069	0.423
MOD_PIKK_1	306	312	PF00454	0.494
MOD_PIKK_1	493	499	PF00454	0.518
MOD_PKA_1	299	305	PF00069	0.557
MOD_PKA_1	486	492	PF00069	0.522
MOD_PKA_2	104	110	PF00069	0.418
MOD_PKA_2	158	164	PF00069	0.446
MOD_PKA_2	175	181	PF00069	0.607
MOD_PKA_2	201	207	PF00069	0.598
MOD_PKA_2	473	479	PF00069	0.422
MOD_PKA_2	8	14	PF00069	0.695
MOD_Plk_1	325	331	PF00069	0.417
MOD_Plk_4	135	141	PF00069	0.442
MOD_Plk_4	215	221	PF00069	0.363
MOD_Plk_4	239	245	PF00069	0.338
MOD_Plk_4	26	32	PF00069	0.636
MOD_Plk_4	325	331	PF00069	0.469
MOD_ProDKin_1	114	120	PF00069	0.544
MOD_ProDKin_1	304	310	PF00069	0.631
MOD_ProDKin_1	311	317	PF00069	0.571
MOD_ProDKin_1	33	39	PF00069	0.625
MOD_ProDKin_1	409	415	PF00069	0.696
TRG_DiLeu_BaEn_1	286	291	PF01217	0.420
TRG_DiLeu_BaEn_1	326	331	PF01217	0.319
TRG_DiLeu_LyEn_5	286	291	PF01217	0.436
TRG_ENDOCYTIC_2	367	370	PF00928	0.414
TRG_ENDOCYTIC_2	44	47	PF00928	0.660
TRG_ENDOCYTIC_2	479	482	PF00928	0.389
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC61	Leptomonas seymouri	53%	78%
A0A0S4IPB1	Bodo saltans	32%	95%
A0A3S7XBY9	Leishmania donovani	93%	82%
A4HQB7	Leishmania braziliensis	76%	86%
A4IE11	Leishmania infantum	94%	100%
E9AU33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	82%