Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hook complex protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0G1_LEIMA

TriTrypDb:

LmjF.36.5990 , LMJLV39_360072700 , LMJSD75_360072700

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0G1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0G1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.526
CLV_C14_Caspase3-7	603	607	PF00656	0.662
CLV_MEL_PAP_1	444	450	PF00089	0.533
CLV_NRD_NRD_1	184	186	PF00675	0.523
CLV_NRD_NRD_1	237	239	PF00675	0.636
CLV_NRD_NRD_1	242	244	PF00675	0.594
CLV_NRD_NRD_1	249	251	PF00675	0.441
CLV_NRD_NRD_1	390	392	PF00675	0.696
CLV_NRD_NRD_1	446	448	PF00675	0.573
CLV_NRD_NRD_1	539	541	PF00675	0.518
CLV_NRD_NRD_1	554	556	PF00675	0.603
CLV_NRD_NRD_1	614	616	PF00675	0.706
CLV_NRD_NRD_1	647	649	PF00675	0.680
CLV_PCSK_KEX2_1	184	186	PF00082	0.523
CLV_PCSK_KEX2_1	237	239	PF00082	0.636
CLV_PCSK_KEX2_1	242	244	PF00082	0.594
CLV_PCSK_KEX2_1	249	251	PF00082	0.441
CLV_PCSK_KEX2_1	334	336	PF00082	0.600
CLV_PCSK_KEX2_1	390	392	PF00082	0.696
CLV_PCSK_KEX2_1	446	448	PF00082	0.573
CLV_PCSK_KEX2_1	539	541	PF00082	0.517
CLV_PCSK_KEX2_1	554	556	PF00082	0.602
CLV_PCSK_KEX2_1	614	616	PF00082	0.706
CLV_PCSK_KEX2_1	647	649	PF00082	0.682
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.493
CLV_PCSK_PC7_1	233	239	PF00082	0.609
CLV_PCSK_SKI1_1	116	120	PF00082	0.454
CLV_PCSK_SKI1_1	127	131	PF00082	0.342
CLV_PCSK_SKI1_1	146	150	PF00082	0.334
CLV_PCSK_SKI1_1	369	373	PF00082	0.459
CLV_PCSK_SKI1_1	614	618	PF00082	0.656
CLV_PCSK_SKI1_1	628	632	PF00082	0.574
CLV_Separin_Metazoa	551	555	PF03568	0.495
DEG_SCF_FBW7_1	198	205	PF00400	0.623
DEG_SCF_FBW7_1	617	622	PF00400	0.629
DEG_SCF_FBW7_1	633	639	PF00400	0.637
DEG_SCF_TRCP1_1	382	388	PF00400	0.561
DEG_SPOP_SBC_1	47	51	PF00917	0.542
DEG_SPOP_SBC_1	593	597	PF00917	0.662
DOC_CKS1_1	199	204	PF01111	0.625
DOC_CKS1_1	630	635	PF01111	0.622
DOC_CYCLIN_RxL_1	143	150	PF00134	0.307
DOC_CYCLIN_yCln2_LP_2	270	276	PF00134	0.459
DOC_MAPK_gen_1	127	136	PF00069	0.303
DOC_MAPK_gen_1	246	256	PF00069	0.501
DOC_MAPK_MEF2A_6	249	258	PF00069	0.453
DOC_MAPK_MEF2A_6	369	376	PF00069	0.475
DOC_PP1_RVXF_1	144	150	PF00149	0.303
DOC_PP1_RVXF_1	302	309	PF00149	0.437
DOC_PP4_FxxP_1	125	128	PF00568	0.485
DOC_PP4_FxxP_1	448	451	PF00568	0.622
DOC_PP4_FxxP_1	630	633	PF00568	0.577
DOC_USP7_MATH_1	177	181	PF00917	0.603
DOC_USP7_MATH_1	231	235	PF00917	0.618
DOC_USP7_MATH_1	47	51	PF00917	0.665
DOC_USP7_MATH_1	527	531	PF00917	0.664
DOC_USP7_MATH_1	593	597	PF00917	0.747
DOC_USP7_MATH_1	621	625	PF00917	0.620
DOC_USP7_MATH_1	626	630	PF00917	0.596
DOC_USP7_MATH_1	636	640	PF00917	0.432
DOC_WW_Pin1_4	173	178	PF00397	0.656
DOC_WW_Pin1_4	198	203	PF00397	0.611
DOC_WW_Pin1_4	383	388	PF00397	0.633
DOC_WW_Pin1_4	389	394	PF00397	0.711
DOC_WW_Pin1_4	446	451	PF00397	0.653
DOC_WW_Pin1_4	499	504	PF00397	0.611
DOC_WW_Pin1_4	516	521	PF00397	0.661
DOC_WW_Pin1_4	615	620	PF00397	0.651
DOC_WW_Pin1_4	629	634	PF00397	0.560
DOC_WW_Pin1_4	646	651	PF00397	0.678
LIG_14-3-3_CanoR_1	165	170	PF00244	0.816
LIG_14-3-3_CanoR_1	260	264	PF00244	0.530
LIG_14-3-3_CanoR_1	314	318	PF00244	0.508
LIG_14-3-3_CanoR_1	327	331	PF00244	0.385
LIG_14-3-3_CanoR_1	499	503	PF00244	0.808
LIG_14-3-3_CanoR_1	564	570	PF00244	0.613
LIG_14-3-3_CanoR_1	594	599	PF00244	0.613
LIG_14-3-3_CanoR_1	642	650	PF00244	0.698
LIG_BIR_III_4	138	142	PF00653	0.383
LIG_BIR_III_4	25	29	PF00653	0.426
LIG_DCNL_PONY_1	1	4	PF03556	0.404
LIG_deltaCOP1_diTrp_1	353	361	PF00928	0.464
LIG_deltaCOP1_diTrp_1	571	576	PF00928	0.511
LIG_eIF4E_1	455	461	PF01652	0.593
LIG_FHA_1	142	148	PF00498	0.324
LIG_FHA_1	173	179	PF00498	0.727
LIG_FHA_1	263	269	PF00498	0.555
LIG_FHA_1	294	300	PF00498	0.397
LIG_FHA_1	52	58	PF00498	0.530
LIG_FHA_1	527	533	PF00498	0.641
LIG_FHA_1	565	571	PF00498	0.577
LIG_FHA_1	607	613	PF00498	0.695
LIG_FHA_1	82	88	PF00498	0.425
LIG_FHA_1	95	101	PF00498	0.408
LIG_LIR_Apic_2	356	360	PF02991	0.377
LIG_LIR_Apic_2	627	633	PF02991	0.581
LIG_LIR_Nem_3	17	21	PF02991	0.360
LIG_LIR_Nem_3	353	357	PF02991	0.473
LIG_LIR_Nem_3	5	9	PF02991	0.346
LIG_Pex14_2	18	22	PF04695	0.373
LIG_Pex14_2	37	41	PF04695	0.355
LIG_Pex14_2	630	634	PF04695	0.576
LIG_SH2_CRK	357	361	PF00017	0.373
LIG_SH2_CRK	455	459	PF00017	0.759
LIG_SH2_CRK	9	13	PF00017	0.280
LIG_SH2_NCK_1	105	109	PF00017	0.502
LIG_SH2_NCK_1	357	361	PF00017	0.373
LIG_SH2_NCK_1	455	459	PF00017	0.621
LIG_SH2_SRC	357	360	PF00017	0.433
LIG_SH2_STAP1	132	136	PF00017	0.303
LIG_SH2_STAP1	282	286	PF00017	0.387
LIG_SH2_STAT5	124	127	PF00017	0.429
LIG_SH2_STAT5	291	294	PF00017	0.509
LIG_SH2_STAT5	548	551	PF00017	0.505
LIG_SH3_1	390	396	PF00018	0.615
LIG_SH3_3	390	396	PF00018	0.758
LIG_SH3_3	448	454	PF00018	0.593
LIG_SH3_3	488	494	PF00018	0.600
LIG_SH3_3	560	566	PF00018	0.594
LIG_SH3_3	630	636	PF00018	0.541
LIG_SH3_3	649	655	PF00018	0.664
LIG_SUMO_SIM_anti_2	456	462	PF11976	0.516
LIG_SUMO_SIM_anti_2	464	470	PF11976	0.499
LIG_SUMO_SIM_par_1	464	470	PF11976	0.524
LIG_TRFH_1	340	344	PF08558	0.384
LIG_TYR_ITIM	7	12	PF00017	0.331
LIG_WRC_WIRS_1	15	20	PF05994	0.359
LIG_WRC_WIRS_1	95	100	PF05994	0.403
LIG_WW_3	201	205	PF00397	0.616
MOD_CDC14_SPxK_1	176	179	PF00782	0.677
MOD_CDC14_SPxK_1	181	184	PF00782	0.630
MOD_CDK_SPK_2	615	620	PF00069	0.639
MOD_CDK_SPxK_1	173	179	PF00069	0.681
MOD_CDK_SPxK_1	198	204	PF00069	0.739
MOD_CDK_SPxK_1	499	505	PF00069	0.612
MOD_CDK_SPxxK_3	178	185	PF00069	0.590
MOD_CDK_SPxxK_3	383	390	PF00069	0.608
MOD_CDK_SPxxK_3	446	453	PF00069	0.641
MOD_CK1_1	103	109	PF00069	0.495
MOD_CK1_1	171	177	PF00069	0.680
MOD_CK1_1	241	247	PF00069	0.644
MOD_CK1_1	383	389	PF00069	0.683
MOD_CK1_1	394	400	PF00069	0.746
MOD_CK1_1	51	57	PF00069	0.674
MOD_CK1_1	587	593	PF00069	0.699
MOD_CK1_1	597	603	PF00069	0.522
MOD_CK1_1	607	613	PF00069	0.633
MOD_CK1_1	629	635	PF00069	0.594
MOD_CK1_1	646	652	PF00069	0.685
MOD_CK2_1	326	332	PF00069	0.384
MOD_CK2_1	565	571	PF00069	0.606
MOD_CMANNOS	573	576	PF00535	0.502
MOD_DYRK1A_RPxSP_1	615	619	PF00069	0.646
MOD_DYRK1A_RPxSP_1	648	652	PF00069	0.640
MOD_GlcNHglycan	105	108	PF01048	0.502
MOD_GlcNHglycan	382	385	PF01048	0.562
MOD_GlcNHglycan	396	399	PF01048	0.657
MOD_GlcNHglycan	403	406	PF01048	0.537
MOD_GlcNHglycan	488	491	PF01048	0.744
MOD_GlcNHglycan	51	54	PF01048	0.735
MOD_GlcNHglycan	599	602	PF01048	0.684
MOD_GlcNHglycan	637	641	PF01048	0.630
MOD_GSK3_1	165	172	PF00069	0.747
MOD_GSK3_1	173	180	PF00069	0.581
MOD_GSK3_1	198	205	PF00069	0.625
MOD_GSK3_1	219	226	PF00069	0.609
MOD_GSK3_1	241	248	PF00069	0.577
MOD_GSK3_1	289	296	PF00069	0.440
MOD_GSK3_1	33	40	PF00069	0.476
MOD_GSK3_1	385	392	PF00069	0.791
MOD_GSK3_1	467	474	PF00069	0.730
MOD_GSK3_1	47	54	PF00069	0.583
MOD_GSK3_1	580	587	PF00069	0.545
MOD_GSK3_1	593	600	PF00069	0.643
MOD_GSK3_1	606	613	PF00069	0.628
MOD_GSK3_1	615	622	PF00069	0.592
MOD_GSK3_1	632	639	PF00069	0.692
MOD_GSK3_1	642	649	PF00069	0.616
MOD_LATS_1	469	475	PF00433	0.609
MOD_N-GLC_1	497	502	PF02516	0.759
MOD_NEK2_1	147	152	PF00069	0.398
MOD_NEK2_1	223	228	PF00069	0.629
MOD_NEK2_1	326	331	PF00069	0.387
MOD_NEK2_1	37	42	PF00069	0.387
MOD_NEK2_1	467	472	PF00069	0.635
MOD_NEK2_1	643	648	PF00069	0.544
MOD_NEK2_2	280	285	PF00069	0.401
MOD_PIKK_1	100	106	PF00454	0.445
MOD_PIKK_1	231	237	PF00454	0.610
MOD_PIKK_1	293	299	PF00454	0.432
MOD_PK_1	264	270	PF00069	0.531
MOD_PK_1	584	590	PF00069	0.703
MOD_PK_1	594	600	PF00069	0.622
MOD_PK_1	604	610	PF00069	0.635
MOD_PKA_2	100	106	PF00069	0.445
MOD_PKA_2	190	196	PF00069	0.659
MOD_PKA_2	241	247	PF00069	0.657
MOD_PKA_2	259	265	PF00069	0.352
MOD_PKA_2	293	299	PF00069	0.500
MOD_PKA_2	313	319	PF00069	0.297
MOD_PKA_2	326	332	PF00069	0.377
MOD_PKA_2	470	476	PF00069	0.612
MOD_PKA_2	498	504	PF00069	0.682
MOD_PKA_2	593	599	PF00069	0.615
MOD_PKA_2	619	625	PF00069	0.703
MOD_PKA_2	643	649	PF00069	0.679
MOD_PKB_1	582	590	PF00069	0.616
MOD_Plk_1	219	225	PF00069	0.556
MOD_Plk_1	280	286	PF00069	0.412
MOD_Plk_1	626	632	PF00069	0.600
MOD_Plk_4	219	225	PF00069	0.681
MOD_Plk_4	456	462	PF00069	0.516
MOD_Plk_4	481	487	PF00069	0.637
MOD_Plk_4	565	571	PF00069	0.546
MOD_Plk_4	587	593	PF00069	0.633
MOD_Plk_4	607	613	PF00069	0.794
MOD_Plk_4	626	632	PF00069	0.408
MOD_ProDKin_1	173	179	PF00069	0.655
MOD_ProDKin_1	198	204	PF00069	0.613
MOD_ProDKin_1	383	389	PF00069	0.636
MOD_ProDKin_1	446	452	PF00069	0.650
MOD_ProDKin_1	499	505	PF00069	0.612
MOD_ProDKin_1	516	522	PF00069	0.658
MOD_ProDKin_1	615	621	PF00069	0.650
MOD_ProDKin_1	629	635	PF00069	0.566
MOD_ProDKin_1	646	652	PF00069	0.675
MOD_SUMO_rev_2	155	161	PF00179	0.432
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.426
TRG_DiLeu_BaLyEn_6	652	657	PF01217	0.628
TRG_ENDOCYTIC_2	455	458	PF00928	0.772
TRG_ENDOCYTIC_2	9	12	PF00928	0.282
TRG_ER_diArg_1	183	185	PF00400	0.524
TRG_ER_diArg_1	236	238	PF00400	0.633
TRG_ER_diArg_1	249	252	PF00400	0.422
TRG_ER_diArg_1	445	447	PF00400	0.527
TRG_ER_diArg_1	539	541	PF00400	0.521
TRG_ER_diArg_1	553	555	PF00400	0.594
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	554	559	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS1	Leptomonas seymouri	47%	94%
A0A3R7KCV9	Trypanosoma rangeli	39%	83%
A0A3S7XBZ6	Leishmania donovani	92%	100%
A4HQB8	Leishmania braziliensis	63%	97%
A4IE12	Leishmania infantum	92%	100%
E9AU34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%