Conserved oligomeric Golgi complex subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COG (conserved oligomeric Golgi) complex component, COG2/Domain of unknown function (DUF3510), putative

Species:

Leishmania major

UniProt:

Q4Q0F6_LEIMA

TriTrypDb:

LmjF.36.6040 , LMJLV39_360073200 , LMJSD75_360073200

Length:

979

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0017119	Golgi transport complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0099023	vesicle tethering complex	2	2
GO:0110165	cellular anatomical entity	1	11
GO:0005794	Golgi apparatus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9

Expansion

Sequence features

Q4Q0F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0F6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006891	intra-Golgi vesicle-mediated transport	6	2
GO:0006996	organelle organization	4	11
GO:0007030	Golgi organization	5	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016043	cellular component organization	3	11
GO:0016192	vesicle-mediated transport	4	2
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.270
CLV_C14_Caspase3-7	197	201	PF00656	0.204
CLV_C14_Caspase3-7	59	63	PF00656	0.619
CLV_NRD_NRD_1	127	129	PF00675	0.333
CLV_NRD_NRD_1	676	678	PF00675	0.546
CLV_NRD_NRD_1	803	805	PF00675	0.289
CLV_NRD_NRD_1	877	879	PF00675	0.271
CLV_NRD_NRD_1	961	963	PF00675	0.397
CLV_PCSK_KEX2_1	126	128	PF00082	0.333
CLV_PCSK_KEX2_1	676	678	PF00082	0.588
CLV_PCSK_KEX2_1	876	878	PF00082	0.271
CLV_PCSK_KEX2_1	961	963	PF00082	0.397
CLV_PCSK_SKI1_1	425	429	PF00082	0.351
CLV_PCSK_SKI1_1	464	468	PF00082	0.432
CLV_PCSK_SKI1_1	481	485	PF00082	0.357
CLV_PCSK_SKI1_1	651	655	PF00082	0.435
CLV_PCSK_SKI1_1	931	935	PF00082	0.417
DEG_APCC_DBOX_1	192	200	PF00400	0.404
DEG_APCC_DBOX_1	424	432	PF00400	0.389
DEG_APCC_DBOX_1	453	461	PF00400	0.366
DEG_APCC_DBOX_1	930	938	PF00400	0.416
DEG_SCF_FBW7_1	890	895	PF00400	0.270
DEG_SPOP_SBC_1	397	401	PF00917	0.699
DOC_ANK_TNKS_1	469	476	PF00023	0.483
DOC_CDC14_PxL_1	492	500	PF14671	0.431
DOC_CKS1_1	636	641	PF01111	0.351
DOC_CYCLIN_yCln2_LP_2	453	459	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	636	642	PF00134	0.392
DOC_MAPK_gen_1	143	152	PF00069	0.335
DOC_MAPK_gen_1	919	926	PF00069	0.271
DOC_MAPK_MEF2A_6	565	572	PF00069	0.464
DOC_MAPK_MEF2A_6	919	928	PF00069	0.271
DOC_MAPK_NFAT4_5	921	929	PF00069	0.295
DOC_PP2B_LxvP_1	453	456	PF13499	0.360
DOC_PP2B_LxvP_1	942	945	PF13499	0.509
DOC_PP4_FxxP_1	388	391	PF00568	0.431
DOC_USP7_MATH_1	151	155	PF00917	0.349
DOC_USP7_MATH_1	181	185	PF00917	0.204
DOC_USP7_MATH_1	296	300	PF00917	0.644
DOC_USP7_MATH_1	368	372	PF00917	0.553
DOC_USP7_MATH_1	398	402	PF00917	0.653
DOC_USP7_MATH_1	459	463	PF00917	0.400
DOC_USP7_MATH_1	469	473	PF00917	0.381
DOC_USP7_MATH_1	593	597	PF00917	0.446
DOC_USP7_MATH_1	607	611	PF00917	0.470
DOC_USP7_MATH_1	665	669	PF00917	0.698
DOC_USP7_MATH_1	724	728	PF00917	0.626
DOC_USP7_MATH_1	762	766	PF00917	0.432
DOC_USP7_MATH_1	829	833	PF00917	0.421
DOC_USP7_MATH_1	892	896	PF00917	0.397
DOC_USP7_MATH_1	96	100	PF00917	0.426
DOC_USP7_UBL2_3	223	227	PF12436	0.335
DOC_USP7_UBL2_3	72	76	PF12436	0.493
DOC_WW_Pin1_4	198	203	PF00397	0.248
DOC_WW_Pin1_4	26	31	PF00397	0.510
DOC_WW_Pin1_4	399	404	PF00397	0.799
DOC_WW_Pin1_4	418	423	PF00397	0.389
DOC_WW_Pin1_4	49	54	PF00397	0.727
DOC_WW_Pin1_4	564	569	PF00397	0.324
DOC_WW_Pin1_4	596	601	PF00397	0.430
DOC_WW_Pin1_4	635	640	PF00397	0.342
DOC_WW_Pin1_4	661	666	PF00397	0.611
DOC_WW_Pin1_4	7	12	PF00397	0.822
DOC_WW_Pin1_4	741	746	PF00397	0.657
DOC_WW_Pin1_4	888	893	PF00397	0.388
LIG_14-3-3_CanoR_1	322	330	PF00244	0.489
LIG_14-3-3_CanoR_1	470	477	PF00244	0.392
LIG_14-3-3_CanoR_1	586	594	PF00244	0.450
LIG_14-3-3_CanoR_1	643	647	PF00244	0.390
LIG_14-3-3_CanoR_1	749	755	PF00244	0.528
LIG_14-3-3_CanoR_1	773	779	PF00244	0.430
LIG_14-3-3_CanoR_1	797	807	PF00244	0.322
LIG_14-3-3_CanoR_1	848	857	PF00244	0.270
LIG_Actin_WH2_2	328	344	PF00022	0.450
LIG_Actin_WH2_2	628	645	PF00022	0.375
LIG_APCC_ABBA_1	335	340	PF00400	0.472
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_BIR_III_2	50	54	PF00653	0.564
LIG_BRCT_BRCA1_1	111	115	PF00533	0.313
LIG_BRCT_BRCA1_1	629	633	PF00533	0.399
LIG_FHA_1	178	184	PF00498	0.393
LIG_FHA_1	279	285	PF00498	0.477
LIG_FHA_1	381	387	PF00498	0.561
LIG_FHA_1	40	46	PF00498	0.613
LIG_FHA_1	474	480	PF00498	0.362
LIG_FHA_1	487	493	PF00498	0.384
LIG_FHA_1	507	513	PF00498	0.277
LIG_FHA_1	694	700	PF00498	0.474
LIG_FHA_1	710	716	PF00498	0.488
LIG_FHA_1	749	755	PF00498	0.506
LIG_FHA_1	885	891	PF00498	0.474
LIG_FHA_1	921	927	PF00498	0.271
LIG_FHA_2	203	209	PF00498	0.204
LIG_FHA_2	913	919	PF00498	0.271
LIG_FHA_2	946	952	PF00498	0.508
LIG_LIR_Apic_2	13	17	PF02991	0.607
LIG_LIR_Apic_2	812	817	PF02991	0.256
LIG_LIR_Gen_1	112	122	PF02991	0.334
LIG_LIR_Gen_1	180	190	PF02991	0.404
LIG_LIR_Gen_1	237	248	PF02991	0.332
LIG_LIR_Gen_1	630	641	PF02991	0.389
LIG_LIR_Gen_1	852	862	PF02991	0.470
LIG_LIR_Nem_3	112	118	PF02991	0.439
LIG_LIR_Nem_3	180	185	PF02991	0.491
LIG_LIR_Nem_3	511	517	PF02991	0.414
LIG_LIR_Nem_3	630	636	PF02991	0.435
LIG_LIR_Nem_3	84	90	PF02991	0.349
LIG_LIR_Nem_3	852	857	PF02991	0.378
LIG_LIR_Nem_3	869	875	PF02991	0.261
LIG_LIR_Nem_3	954	960	PF02991	0.409
LIG_MYND_1	817	821	PF01753	0.371
LIG_NRBOX	260	266	PF00104	0.499
LIG_PCNA_yPIPBox_3	840	848	PF02747	0.335
LIG_PDZ_Class_2	974	979	PF00595	0.631
LIG_Pex14_2	444	448	PF04695	0.477
LIG_Pex14_2	953	957	PF04695	0.493
LIG_PTAP_UEV_1	52	57	PF05743	0.580
LIG_SH2_CRK	136	140	PF00017	0.404
LIG_SH2_CRK	14	18	PF00017	0.609
LIG_SH2_CRK	582	586	PF00017	0.357
LIG_SH2_CRK	650	654	PF00017	0.463
LIG_SH2_GRB2like	58	61	PF00017	0.514
LIG_SH2_NCK_1	251	255	PF00017	0.404
LIG_SH2_NCK_1	3	7	PF00017	0.610
LIG_SH2_NCK_1	435	439	PF00017	0.361
LIG_SH2_NCK_1	58	62	PF00017	0.512
LIG_SH2_PTP2	814	817	PF00017	0.371
LIG_SH2_SRC	58	61	PF00017	0.514
LIG_SH2_SRC	814	817	PF00017	0.248
LIG_SH2_STAP1	251	255	PF00017	0.404
LIG_SH2_STAP1	3	7	PF00017	0.610
LIG_SH2_STAP1	545	549	PF00017	0.443
LIG_SH2_STAT5	162	165	PF00017	0.348
LIG_SH2_STAT5	244	247	PF00017	0.404
LIG_SH2_STAT5	364	367	PF00017	0.450
LIG_SH2_STAT5	618	621	PF00017	0.441
LIG_SH2_STAT5	814	817	PF00017	0.271
LIG_SH3_3	288	294	PF00018	0.586
LIG_SH3_3	384	390	PF00018	0.453
LIG_SH3_3	449	455	PF00018	0.507
LIG_SH3_3	490	496	PF00018	0.475
LIG_SH3_3	50	56	PF00018	0.601
LIG_SH3_3	528	534	PF00018	0.422
LIG_SH3_3	594	600	PF00018	0.491
LIG_SH3_3	934	940	PF00018	0.523
LIG_SH3_3	969	975	PF00018	0.497
LIG_SUMO_SIM_anti_2	377	384	PF11976	0.454
LIG_SUMO_SIM_anti_2	476	481	PF11976	0.381
LIG_SUMO_SIM_anti_2	546	554	PF11976	0.402
LIG_SUMO_SIM_anti_2	730	736	PF11976	0.440
LIG_SUMO_SIM_par_1	377	384	PF11976	0.362
LIG_SUMO_SIM_par_1	546	554	PF11976	0.457
LIG_SUMO_SIM_par_1	695	703	PF11976	0.470
LIG_SUMO_SIM_par_1	940	946	PF11976	0.465
LIG_TYR_ITIM	249	254	PF00017	0.291
LIG_UBA3_1	337	342	PF00899	0.467
MOD_CDK_SPxxK_3	418	425	PF00069	0.479
MOD_CDK_SPxxK_3	596	603	PF00069	0.457
MOD_CK1_1	101	107	PF00069	0.406
MOD_CK1_1	109	115	PF00069	0.408
MOD_CK1_1	2	8	PF00069	0.610
MOD_CK1_1	201	207	PF00069	0.469
MOD_CK1_1	212	218	PF00069	0.388
MOD_CK1_1	278	284	PF00069	0.602
MOD_CK1_1	286	292	PF00069	0.582
MOD_CK1_1	303	309	PF00069	0.508
MOD_CK1_1	316	322	PF00069	0.455
MOD_CK1_1	350	356	PF00069	0.630
MOD_CK1_1	392	398	PF00069	0.596
MOD_CK1_1	399	405	PF00069	0.745
MOD_CK1_1	411	417	PF00069	0.601
MOD_CK1_1	49	55	PF00069	0.709
MOD_CK1_1	596	602	PF00069	0.520
MOD_CK1_1	669	675	PF00069	0.645
MOD_CK1_1	747	753	PF00069	0.524
MOD_CK1_1	795	801	PF00069	0.298
MOD_CK1_1	809	815	PF00069	0.271
MOD_CK1_1	832	838	PF00069	0.294
MOD_CK1_1	943	949	PF00069	0.568
MOD_CK2_1	202	208	PF00069	0.329
MOD_CK2_1	524	530	PF00069	0.461
MOD_CK2_1	724	730	PF00069	0.510
MOD_CK2_1	945	951	PF00069	0.515
MOD_GlcNHglycan	185	188	PF01048	0.271
MOD_GlcNHglycan	270	273	PF01048	0.557
MOD_GlcNHglycan	277	280	PF01048	0.721
MOD_GlcNHglycan	285	288	PF01048	0.594
MOD_GlcNHglycan	304	308	PF01048	0.460
MOD_GlcNHglycan	32	35	PF01048	0.711
MOD_GlcNHglycan	393	397	PF01048	0.617
MOD_GlcNHglycan	4	7	PF01048	0.608
MOD_GlcNHglycan	403	406	PF01048	0.557
MOD_GlcNHglycan	410	413	PF01048	0.507
MOD_GlcNHglycan	471	474	PF01048	0.450
MOD_GlcNHglycan	668	671	PF01048	0.732
MOD_GlcNHglycan	688	691	PF01048	0.677
MOD_GlcNHglycan	726	729	PF01048	0.530
MOD_GlcNHglycan	762	765	PF01048	0.474
MOD_GlcNHglycan	797	800	PF01048	0.289
MOD_GlcNHglycan	808	811	PF01048	0.310
MOD_GlcNHglycan	831	834	PF01048	0.403
MOD_GlcNHglycan	896	901	PF01048	0.321
MOD_GSK3_1	102	109	PF00069	0.314
MOD_GSK3_1	110	117	PF00069	0.236
MOD_GSK3_1	173	180	PF00069	0.404
MOD_GSK3_1	194	201	PF00069	0.248
MOD_GSK3_1	208	215	PF00069	0.294
MOD_GSK3_1	22	29	PF00069	0.813
MOD_GSK3_1	268	275	PF00069	0.582
MOD_GSK3_1	278	285	PF00069	0.655
MOD_GSK3_1	296	303	PF00069	0.421
MOD_GSK3_1	311	318	PF00069	0.447
MOD_GSK3_1	392	399	PF00069	0.725
MOD_GSK3_1	411	418	PF00069	0.678
MOD_GSK3_1	469	476	PF00069	0.365
MOD_GSK3_1	627	634	PF00069	0.351
MOD_GSK3_1	661	668	PF00069	0.607
MOD_GSK3_1	680	687	PF00069	0.770
MOD_GSK3_1	705	712	PF00069	0.502
MOD_GSK3_1	733	740	PF00069	0.609
MOD_GSK3_1	744	751	PF00069	0.670
MOD_GSK3_1	861	868	PF00069	0.273
MOD_GSK3_1	880	887	PF00069	0.407
MOD_GSK3_1	888	895	PF00069	0.338
MOD_GSK3_1	94	101	PF00069	0.350
MOD_LATS_1	345	351	PF00433	0.406
MOD_N-GLC_1	408	413	PF02516	0.620
MOD_N-GLC_1	684	689	PF02516	0.773
MOD_NEK2_1	1	6	PF00069	0.703
MOD_NEK2_1	217	222	PF00069	0.284
MOD_NEK2_1	250	255	PF00069	0.406
MOD_NEK2_1	265	270	PF00069	0.388
MOD_NEK2_1	313	318	PF00069	0.578
MOD_NEK2_1	380	385	PF00069	0.420
MOD_NEK2_1	487	492	PF00069	0.403
MOD_NEK2_1	517	522	PF00069	0.440
MOD_NEK2_1	627	632	PF00069	0.389
MOD_NEK2_1	642	647	PF00069	0.395
MOD_NEK2_1	839	844	PF00069	0.469
MOD_NEK2_1	846	851	PF00069	0.360
MOD_PIKK_1	212	218	PF00454	0.330
MOD_PIKK_1	381	387	PF00454	0.568
MOD_PIKK_1	39	45	PF00454	0.613
MOD_PIKK_1	464	470	PF00454	0.376
MOD_PIKK_1	607	613	PF00454	0.412
MOD_PK_1	209	215	PF00069	0.270
MOD_PKA_2	321	327	PF00069	0.508
MOD_PKA_2	469	475	PF00069	0.395
MOD_PKA_2	585	591	PF00069	0.484
MOD_PKA_2	642	648	PF00069	0.358
MOD_PKA_2	675	681	PF00069	0.654
MOD_PKA_2	748	754	PF00069	0.580
MOD_PKA_2	774	780	PF00069	0.454
MOD_PKA_2	803	809	PF00069	0.404
MOD_PKA_2	858	864	PF00069	0.404
MOD_PKA_2	909	915	PF00069	0.299
MOD_Plk_1	106	112	PF00069	0.335
MOD_Plk_1	194	200	PF00069	0.404
MOD_Plk_1	368	374	PF00069	0.402
MOD_Plk_1	408	414	PF00069	0.732
MOD_Plk_1	868	874	PF00069	0.271
MOD_Plk_2-3	194	200	PF00069	0.384
MOD_Plk_2-3	914	920	PF00069	0.271
MOD_Plk_4	137	143	PF00069	0.322
MOD_Plk_4	194	200	PF00069	0.360
MOD_Plk_4	209	215	PF00069	0.314
MOD_Plk_4	360	366	PF00069	0.600
MOD_Plk_4	368	374	PF00069	0.484
MOD_Plk_4	508	514	PF00069	0.367
MOD_Plk_4	517	523	PF00069	0.381
MOD_Plk_4	524	530	PF00069	0.378
MOD_Plk_4	628	634	PF00069	0.407
MOD_Plk_4	642	648	PF00069	0.445
MOD_Plk_4	693	699	PF00069	0.429
MOD_Plk_4	774	780	PF00069	0.477
MOD_Plk_4	809	815	PF00069	0.271
MOD_Plk_4	858	864	PF00069	0.300
MOD_Plk_4	880	886	PF00069	0.446
MOD_ProDKin_1	198	204	PF00069	0.248
MOD_ProDKin_1	26	32	PF00069	0.512
MOD_ProDKin_1	399	405	PF00069	0.797
MOD_ProDKin_1	418	424	PF00069	0.374
MOD_ProDKin_1	49	55	PF00069	0.728
MOD_ProDKin_1	564	570	PF00069	0.318
MOD_ProDKin_1	596	602	PF00069	0.431
MOD_ProDKin_1	635	641	PF00069	0.334
MOD_ProDKin_1	661	667	PF00069	0.624
MOD_ProDKin_1	7	13	PF00069	0.821
MOD_ProDKin_1	741	747	PF00069	0.654
MOD_ProDKin_1	888	894	PF00069	0.388
MOD_SUMO_rev_2	164	171	PF00179	0.384
MOD_SUMO_rev_2	33	40	PF00179	0.532
TRG_DiLeu_BaEn_1	332	337	PF01217	0.468
TRG_DiLeu_BaEn_4	559	565	PF01217	0.404
TRG_DiLeu_BaLyEn_6	490	495	PF01217	0.423
TRG_ENDOCYTIC_2	136	139	PF00928	0.404
TRG_ENDOCYTIC_2	251	254	PF00928	0.314
TRG_ENDOCYTIC_2	545	548	PF00928	0.450
TRG_ENDOCYTIC_2	582	585	PF00928	0.319
TRG_ENDOCYTIC_2	650	653	PF00928	0.445
TRG_ER_diArg_1	126	128	PF00400	0.333
TRG_ER_diArg_1	875	878	PF00400	0.271
TRG_ER_diArg_1	960	962	PF00400	0.382
TRG_NES_CRM1_1	208	222	PF08389	0.270
TRG_NES_CRM1_1	845	860	PF08389	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9C0	Leptomonas seymouri	61%	100%
A0A1X0P3C4	Trypanosomatidae	32%	100%
A0A3Q8II01	Leishmania donovani	90%	100%
A0A3R7L6I8	Trypanosoma rangeli	34%	100%
A4HQC3	Leishmania braziliensis	75%	100%
A4IE16	Leishmania infantum	90%	100%
D0A8R7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AU39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5DND8	Trypanosoma cruzi	33%	100%