Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0F5_LEIMA

TriTrypDb:

LmjF.36.6050 , LMJLV39_360073300 , LMJSD75_360073300

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0F5

PDB structure(s): 7aih_An , 7am2_An , 7ane_An

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.378
CLV_C14_Caspase3-7	249	253	PF00656	0.514
CLV_NRD_NRD_1	145	147	PF00675	0.420
CLV_NRD_NRD_1	160	162	PF00675	0.395
CLV_NRD_NRD_1	17	19	PF00675	0.524
CLV_NRD_NRD_1	215	217	PF00675	0.527
CLV_NRD_NRD_1	311	313	PF00675	0.451
CLV_PCSK_KEX2_1	145	147	PF00082	0.420
CLV_PCSK_KEX2_1	160	162	PF00082	0.457
CLV_PCSK_KEX2_1	310	312	PF00082	0.485
CLV_PCSK_SKI1_1	14	18	PF00082	0.596
CLV_PCSK_SKI1_1	152	156	PF00082	0.507
CLV_PCSK_SKI1_1	297	301	PF00082	0.476
DEG_APCC_DBOX_1	194	202	PF00400	0.368
DEG_APCC_DBOX_1	281	289	PF00400	0.411
DEG_Kelch_Keap1_1	303	308	PF01344	0.442
DEG_Nend_Nbox_1	1	3	PF02207	0.538
DEG_SPOP_SBC_1	189	193	PF00917	0.423
DOC_ANK_TNKS_1	56	63	PF00023	0.458
DOC_PP1_RVXF_1	143	150	PF00149	0.414
DOC_USP7_UBL2_3	10	14	PF12436	0.652
DOC_WW_Pin1_4	93	98	PF00397	0.519
LIG_14-3-3_CanoR_1	282	288	PF00244	0.452
LIG_14-3-3_CanoR_1	67	76	PF00244	0.413
LIG_AP_GAE_1	106	112	PF02883	0.469
LIG_CSL_BTD_1	82	85	PF09270	0.453
LIG_deltaCOP1_diTrp_1	265	268	PF00928	0.378
LIG_FHA_1	128	134	PF00498	0.332
LIG_FHA_1	191	197	PF00498	0.470
LIG_FHA_1	3	9	PF00498	0.653
LIG_FHA_2	135	141	PF00498	0.369
LIG_FHA_2	170	176	PF00498	0.363
LIG_FHA_2	189	195	PF00498	0.283
LIG_FHA_2	39	45	PF00498	0.540
LIG_GBD_Chelix_1	201	209	PF00786	0.399
LIG_LIR_Apic_2	91	95	PF02991	0.505
LIG_LIR_Gen_1	106	116	PF02991	0.381
LIG_LIR_Gen_1	257	264	PF02991	0.397
LIG_LIR_Nem_3	106	112	PF02991	0.390
LIG_LIR_Nem_3	183	189	PF02991	0.427
LIG_LIR_Nem_3	79	84	PF02991	0.488
LIG_LYPXL_yS_3	81	84	PF13949	0.482
LIG_Pex14_1	105	109	PF04695	0.373
LIG_Pex14_1	77	81	PF04695	0.433
LIG_PTB_Apo_2	162	169	PF02174	0.516
LIG_SH2_PTP2	92	95	PF00017	0.564
LIG_SH2_SRC	92	95	PF00017	0.487
LIG_SH2_STAP1	72	76	PF00017	0.454
LIG_SH2_STAT5	124	127	PF00017	0.356
LIG_SH2_STAT5	54	57	PF00017	0.485
LIG_SH2_STAT5	92	95	PF00017	0.592
LIG_SH3_1	232	238	PF00018	0.487
LIG_SH3_3	232	238	PF00018	0.470
LIG_SH3_3	269	275	PF00018	0.421
LIG_SH3_3	79	85	PF00018	0.421
LIG_SH3_3	91	97	PF00018	0.432
LIG_TRAF2_1	117	120	PF00917	0.538
LIG_TRFH_1	186	190	PF08558	0.339
MOD_CDK_SPK_2	93	98	PF00069	0.565
MOD_CK2_1	114	120	PF00069	0.417
MOD_CK2_1	169	175	PF00069	0.386
MOD_CK2_1	38	44	PF00069	0.470
MOD_CMANNOS	74	77	PF00535	0.381
MOD_GlcNHglycan	276	279	PF01048	0.379
MOD_GlcNHglycan	305	308	PF01048	0.434
MOD_GlcNHglycan	69	72	PF01048	0.410
MOD_GSK3_1	226	233	PF00069	0.545
MOD_GSK3_1	323	330	PF00069	0.651
MOD_GSK3_1	63	70	PF00069	0.398
MOD_N-GLC_1	283	288	PF02516	0.429
MOD_NEK2_1	134	139	PF00069	0.352
MOD_NEK2_1	2	7	PF00069	0.518
MOD_NEK2_1	207	212	PF00069	0.443
MOD_PIKK_1	134	140	PF00454	0.359
MOD_PIKK_1	76	82	PF00454	0.393
MOD_PIKK_1	8	14	PF00454	0.568
MOD_PKA_2	66	72	PF00069	0.402
MOD_Plk_1	169	175	PF00069	0.360
MOD_Plk_1	283	289	PF00069	0.441
MOD_Plk_2-3	169	175	PF00069	0.360
MOD_Plk_4	120	126	PF00069	0.523
MOD_Plk_4	283	289	PF00069	0.421
MOD_ProDKin_1	93	99	PF00069	0.516
MOD_SUMO_rev_2	148	154	PF00179	0.478
MOD_SUMO_rev_2	192	201	PF00179	0.396
TRG_ENDOCYTIC_2	27	30	PF00928	0.465
TRG_ENDOCYTIC_2	81	84	PF00928	0.500
TRG_ER_diArg_1	144	146	PF00400	0.395
TRG_ER_diArg_1	160	162	PF00400	0.395
TRG_ER_diArg_1	310	312	PF00400	0.535
TRG_NLS_MonoExtC_3	17	22	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	145	150	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P900	Leptomonas seymouri	84%	100%
A0A0S4KF76	Bodo saltans	62%	100%
A0A1X0P370	Trypanosomatidae	63%	94%
A0A3R7NW18	Trypanosoma rangeli	67%	98%
A0A3S7XC20	Leishmania donovani	97%	100%
A4HQC4	Leishmania braziliensis	89%	100%
A4IE17	Leishmania infantum	97%	100%
D0A8R6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	99%
E9AU40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BRZ1	Trypanosoma cruzi	68%	98%