Putative rab-like GTPase activating protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rab-like GTPase activating protein, putative

Species:

Leishmania major

UniProt:

Q4Q0F2_LEIMA

TriTrypDb:

LmjF.36.6080 , LMJLV39_360073600 , LMJSD75_360073600

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0000331	contractile vacuole	6	1
GO:0005773	vacuole	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

Q4Q0F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0F2

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	3
GO:0043087	regulation of GTPase activity	5	3
GO:0043547	positive regulation of GTPase activity	6	3
GO:0044093	positive regulation of molecular function	3	3
GO:0050790	regulation of catalytic activity	3	3
GO:0051336	regulation of hydrolase activity	4	3
GO:0051345	positive regulation of hydrolase activity	5	3
GO:0065007	biological regulation	1	3
GO:0065009	regulation of molecular function	2	3
GO:0090630	activation of GTPase activity	7	3

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	3
GO:0008047	enzyme activator activity	3	3
GO:0030234	enzyme regulator activity	2	3
GO:0030695	GTPase regulator activity	4	3
GO:0060589	nucleoside-triphosphatase regulator activity	3	3
GO:0098772	molecular function regulator activity	1	3
GO:0140677	molecular function activator activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.496
CLV_NRD_NRD_1	13	15	PF00675	0.574
CLV_NRD_NRD_1	148	150	PF00675	0.411
CLV_NRD_NRD_1	220	222	PF00675	0.231
CLV_NRD_NRD_1	361	363	PF00675	0.392
CLV_NRD_NRD_1	89	91	PF00675	0.605
CLV_PCSK_KEX2_1	115	117	PF00082	0.498
CLV_PCSK_KEX2_1	13	15	PF00082	0.574
CLV_PCSK_KEX2_1	144	146	PF00082	0.401
CLV_PCSK_KEX2_1	148	150	PF00082	0.401
CLV_PCSK_KEX2_1	155	157	PF00082	0.287
CLV_PCSK_KEX2_1	220	222	PF00082	0.231
CLV_PCSK_KEX2_1	361	363	PF00082	0.275
CLV_PCSK_KEX2_1	383	385	PF00082	0.429
CLV_PCSK_KEX2_1	89	91	PF00082	0.616
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.399
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.344
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.490
CLV_PCSK_SKI1_1	220	224	PF00082	0.288
CLV_PCSK_SKI1_1	272	276	PF00082	0.415
CLV_PCSK_SKI1_1	350	354	PF00082	0.370
CLV_PCSK_SKI1_1	361	365	PF00082	0.294
CLV_PCSK_SKI1_1	390	394	PF00082	0.365
CLV_PCSK_SKI1_1	82	86	PF00082	0.518
DEG_APCC_DBOX_1	349	357	PF00400	0.417
DEG_SPOP_SBC_1	33	37	PF00917	0.718
DEG_SPOP_SBC_1	65	69	PF00917	0.655
DOC_CKS1_1	85	90	PF01111	0.431
DOC_MAPK_MEF2A_6	170	178	PF00069	0.231
DOC_MAPK_MEF2A_6	346	355	PF00069	0.252
DOC_MAPK_MEF2A_6	390	397	PF00069	0.399
DOC_MAPK_RevD_3	1	14	PF00069	0.470
DOC_PP1_RVXF_1	392	398	PF00149	0.453
DOC_USP7_MATH_1	184	188	PF00917	0.289
DOC_USP7_MATH_1	59	63	PF00917	0.720
DOC_USP7_MATH_1	65	69	PF00917	0.695
DOC_USP7_UBL2_3	268	272	PF12436	0.250
DOC_USP7_UBL2_3	390	394	PF12436	0.422
DOC_WW_Pin1_4	14	19	PF00397	0.779
DOC_WW_Pin1_4	55	60	PF00397	0.664
DOC_WW_Pin1_4	61	66	PF00397	0.664
DOC_WW_Pin1_4	84	89	PF00397	0.682
LIG_14-3-3_CanoR_1	179	184	PF00244	0.289
LIG_14-3-3_CanoR_1	206	211	PF00244	0.250
LIG_14-3-3_CanoR_1	361	367	PF00244	0.491
LIG_14-3-3_CanoR_1	396	405	PF00244	0.420
LIG_14-3-3_CanoR_1	73	81	PF00244	0.706
LIG_AP2alpha_1	95	99	PF02296	0.395
LIG_APCC_ABBA_1	3	8	PF00400	0.695
LIG_Clathr_ClatBox_1	355	359	PF01394	0.376
LIG_DCNL_PONY_1	1	4	PF03556	0.447
LIG_deltaCOP1_diTrp_1	126	135	PF00928	0.385
LIG_deltaCOP1_diTrp_1	253	260	PF00928	0.420
LIG_eIF4E_1	287	293	PF01652	0.260
LIG_FHA_1	202	208	PF00498	0.346
LIG_FHA_1	23	29	PF00498	0.781
LIG_FHA_1	243	249	PF00498	0.335
LIG_FHA_1	368	374	PF00498	0.444
LIG_FHA_2	102	108	PF00498	0.484
LIG_FHA_2	33	39	PF00498	0.570
LIG_FHA_2	366	372	PF00498	0.505
LIG_GBD_Chelix_1	190	198	PF00786	0.357
LIG_LIR_Gen_1	126	136	PF02991	0.420
LIG_LIR_Gen_1	255	264	PF02991	0.324
LIG_LIR_Gen_1	334	341	PF02991	0.375
LIG_LIR_Gen_1	94	103	PF02991	0.540
LIG_LIR_Nem_3	133	138	PF02991	0.384
LIG_LIR_Nem_3	171	176	PF02991	0.287
LIG_LIR_Nem_3	254	260	PF02991	0.302
LIG_LIR_Nem_3	278	282	PF02991	0.382
LIG_LIR_Nem_3	313	317	PF02991	0.328
LIG_LIR_Nem_3	334	340	PF02991	0.339
LIG_LIR_Nem_3	343	348	PF02991	0.319
LIG_LIR_Nem_3	97	102	PF02991	0.386
LIG_NRBOX	218	224	PF00104	0.172
LIG_PAM2_1	310	322	PF00658	0.324
LIG_PCNA_PIPBox_1	297	306	PF02747	0.417
LIG_PCNA_yPIPBox_3	211	223	PF02747	0.358
LIG_Pex14_1	337	341	PF04695	0.339
LIG_Pex14_1	345	349	PF04695	0.304
LIG_Pex14_2	275	279	PF04695	0.378
LIG_Pex14_2	320	324	PF04695	0.304
LIG_Pex14_2	341	345	PF04695	0.389
LIG_Pex14_2	95	99	PF04695	0.376
LIG_PTB_Apo_2	263	270	PF02174	0.411
LIG_PTB_Phospho_1	263	269	PF10480	0.411
LIG_SH2_CRK	177	181	PF00017	0.273
LIG_SH2_GRB2like	226	229	PF00017	0.286
LIG_SH2_GRB2like	401	404	PF00017	0.308
LIG_SH2_NCK_1	120	124	PF00017	0.360
LIG_SH2_STAP1	120	124	PF00017	0.360
LIG_SH2_STAP1	315	319	PF00017	0.267
LIG_SH2_STAT3	401	404	PF00017	0.450
LIG_SH2_STAT5	124	127	PF00017	0.431
LIG_SH2_STAT5	146	149	PF00017	0.537
LIG_SH2_STAT5	235	238	PF00017	0.302
LIG_SH2_STAT5	287	290	PF00017	0.381
LIG_SH3_3	148	154	PF00018	0.504
LIG_SH3_3	271	277	PF00018	0.305
LIG_SH3_3	306	312	PF00018	0.192
LIG_SUMO_SIM_anti_2	368	377	PF11976	0.493
LIG_SUMO_SIM_par_1	362	371	PF11976	0.463
LIG_TRAF2_1	104	107	PF00917	0.457
LIG_TRAF2_1	36	39	PF00917	0.570
LIG_UBA3_1	372	377	PF00899	0.437
MOD_CDK_SPK_2	84	89	PF00069	0.420
MOD_CDK_SPxK_1	84	90	PF00069	0.670
MOD_CK1_1	17	23	PF00069	0.668
MOD_CK1_1	209	215	PF00069	0.461
MOD_CK1_1	365	371	PF00069	0.361
MOD_CK1_1	58	64	PF00069	0.726
MOD_CK2_1	101	107	PF00069	0.447
MOD_CK2_1	32	38	PF00069	0.570
MOD_CK2_1	365	371	PF00069	0.419
MOD_GlcNHglycan	211	214	PF01048	0.289
MOD_GlcNHglycan	398	401	PF01048	0.540
MOD_GlcNHglycan	61	64	PF01048	0.700
MOD_GlcNHglycan	77	80	PF01048	0.627
MOD_GSK3_1	13	20	PF00069	0.697
MOD_GSK3_1	55	62	PF00069	0.707
MOD_NEK2_1	163	168	PF00069	0.313
MOD_NEK2_1	198	203	PF00069	0.329
MOD_NEK2_1	242	247	PF00069	0.323
MOD_NEK2_1	388	393	PF00069	0.433
MOD_NEK2_1	74	79	PF00069	0.714
MOD_NEK2_2	319	324	PF00069	0.311
MOD_PIKK_1	179	185	PF00454	0.345
MOD_PIKK_1	42	48	PF00454	0.713
MOD_PK_1	206	212	PF00069	0.231
MOD_PKA_1	13	19	PF00069	0.572
MOD_PKA_2	13	19	PF00069	0.779
MOD_Plk_1	198	204	PF00069	0.250
MOD_Plk_2-3	34	40	PF00069	0.574
MOD_Plk_4	242	248	PF00069	0.305
MOD_Plk_4	310	316	PF00069	0.310
MOD_Plk_4	319	325	PF00069	0.311
MOD_ProDKin_1	14	20	PF00069	0.780
MOD_ProDKin_1	55	61	PF00069	0.665
MOD_ProDKin_1	84	90	PF00069	0.679
MOD_SUMO_for_1	356	359	PF00179	0.327
MOD_SUMO_rev_2	105	110	PF00179	0.553
MOD_SUMO_rev_2	182	190	PF00179	0.429
TRG_DiLeu_BaEn_1	359	364	PF01217	0.321
TRG_DiLeu_BaEn_4	359	365	PF01217	0.335
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.172
TRG_DiLeu_LyEn_5	359	364	PF01217	0.321
TRG_ENDOCYTIC_2	177	180	PF00928	0.307
TRG_ENDOCYTIC_2	301	304	PF00928	0.298
TRG_ER_diArg_1	12	14	PF00400	0.572
TRG_ER_diArg_1	219	221	PF00400	0.231
TRG_ER_diArg_1	361	363	PF00400	0.353
TRG_ER_diArg_1	88	90	PF00400	0.633
TRG_NES_CRM1_1	237	252	PF08389	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3T4	Leptomonas seymouri	58%	96%
A0A0N1PDX9	Leptomonas seymouri	36%	75%
A0A0S4II34	Bodo saltans	36%	97%
A0A0S4ITU5	Bodo saltans	26%	100%
A0A1X0NLM2	Trypanosomatidae	43%	100%
A0A1X0NLQ9	Trypanosomatidae	44%	97%
A0A1X0P1K5	Trypanosomatidae	27%	100%
A0A3S7X3S6	Leishmania donovani	25%	100%
A0A3S7XBZ8	Leishmania donovani	93%	100%
A0A3S7XC15	Leishmania donovani	35%	83%
A0A422NJ84	Trypanosoma rangeli	42%	99%
A0A422NJE8	Trypanosoma rangeli	40%	100%
A4HIL7	Leishmania braziliensis	23%	100%
A4HQC6	Leishmania braziliensis	38%	84%
A4HQC7	Leishmania braziliensis	71%	97%
A4I5W2	Leishmania infantum	24%	100%
A4IE19	Leishmania infantum	35%	83%
A4IE20	Leishmania infantum	93%	100%
D0A3X5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D0A3X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	99%
E9AU42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	74%
E9AU43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B157	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q09445	Caenorhabditis elegans	26%	100%
Q12317	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	84%
Q4Q0F3	Leishmania major	42%	83%
V5BDT8	Trypanosoma cruzi	27%	74%
V5BT66	Trypanosoma cruzi	43%	100%