CCR4-NOT transcription complex subunit 10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CCR4-NOT transcription complex subunit 10, putative

Species:

Leishmania major

UniProt:

Q4Q0F0_LEIMA

TriTrypDb:

LmjF.36.6100 , LMJLV39_360073800 , LMJSD75_360073800

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0030014	CCR4-NOT complex	3	12
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	12
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	12

Expansion

Sequence features

Q4Q0F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0F0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006401	RNA catabolic process	5	2
GO:0006402	mRNA catabolic process	6	2
GO:0006417	regulation of translation	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009890	negative regulation of biosynthetic process	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010558	negative regulation of macromolecule biosynthetic process	6	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0010629	negative regulation of gene expression	6	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0017148	negative regulation of translation	7	2
GO:0019222	regulation of metabolic process	3	2
GO:0019439	aromatic compound catabolic process	4	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031327	negative regulation of cellular biosynthetic process	6	2
GO:0034248	regulation of amide metabolic process	5	2
GO:0034249	negative regulation of amide metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046700	heterocycle catabolic process	4	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051248	negative regulation of protein metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2
GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	7	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.531
CLV_NRD_NRD_1	139	141	PF00675	0.720
CLV_NRD_NRD_1	294	296	PF00675	0.593
CLV_NRD_NRD_1	298	300	PF00675	0.636
CLV_NRD_NRD_1	401	403	PF00675	0.499
CLV_NRD_NRD_1	453	455	PF00675	0.517
CLV_NRD_NRD_1	505	507	PF00675	0.595
CLV_PCSK_KEX2_1	111	113	PF00082	0.531
CLV_PCSK_KEX2_1	298	300	PF00082	0.605
CLV_PCSK_KEX2_1	401	403	PF00082	0.573
CLV_PCSK_KEX2_1	453	455	PF00082	0.517
CLV_PCSK_SKI1_1	111	115	PF00082	0.443
CLV_PCSK_SKI1_1	13	17	PF00082	0.534
CLV_PCSK_SKI1_1	348	352	PF00082	0.645
CLV_PCSK_SKI1_1	447	451	PF00082	0.458
DEG_APCC_DBOX_1	453	461	PF00400	0.524
DEG_SCF_FBW7_2	158	164	PF00400	0.388
DOC_ANK_TNKS_1	61	68	PF00023	0.677
DOC_CDC14_PxL_1	166	174	PF14671	0.622
DOC_CKS1_1	158	163	PF01111	0.382
DOC_MAPK_gen_1	474	482	PF00069	0.576
DOC_MAPK_MEF2A_6	476	484	PF00069	0.460
DOC_PP1_RVXF_1	550	556	PF00149	0.525
DOC_PP2B_LxvP_1	365	368	PF13499	0.454
DOC_USP7_MATH_1	181	185	PF00917	0.487
DOC_USP7_MATH_1	285	289	PF00917	0.476
DOC_USP7_MATH_1	338	342	PF00917	0.688
DOC_USP7_MATH_1	422	426	PF00917	0.553
DOC_USP7_MATH_1	472	476	PF00917	0.563
DOC_USP7_UBL2_3	137	141	PF12436	0.716
DOC_WW_Pin1_4	157	162	PF00397	0.564
LIG_14-3-3_CanoR_1	140	146	PF00244	0.713
LIG_14-3-3_CanoR_1	304	310	PF00244	0.694
LIG_14-3-3_CanoR_1	453	458	PF00244	0.531
LIG_Actin_WH2_2	151	169	PF00022	0.630
LIG_APCC_ABBA_1	532	537	PF00400	0.431
LIG_BRCT_BRCA1_1	220	224	PF00533	0.453
LIG_BRCT_BRCA1_1	274	278	PF00533	0.417
LIG_BRCT_BRCA1_2	220	226	PF00533	0.450
LIG_deltaCOP1_diTrp_1	548	555	PF00928	0.612
LIG_DLG_GKlike_1	453	460	PF00625	0.526
LIG_EH1_1	433	441	PF00400	0.434
LIG_eIF4E_1	434	440	PF01652	0.430
LIG_FHA_1	134	140	PF00498	0.595
LIG_FHA_1	354	360	PF00498	0.564
LIG_FHA_1	428	434	PF00498	0.506
LIG_FHA_2	66	72	PF00498	0.751
LIG_GBD_Chelix_1	44	52	PF00786	0.544
LIG_IRF3_LxIS_1	480	487	PF10401	0.582
LIG_LIR_Gen_1	264	272	PF02991	0.468
LIG_LIR_Gen_1	308	313	PF02991	0.613
LIG_LIR_Gen_1	320	330	PF02991	0.518
LIG_LIR_Gen_1	372	381	PF02991	0.576
LIG_LIR_Gen_1	478	489	PF02991	0.453
LIG_LIR_Gen_1	533	539	PF02991	0.551
LIG_LIR_Nem_3	264	268	PF02991	0.455
LIG_LIR_Nem_3	323	327	PF02991	0.578
LIG_LIR_Nem_3	372	376	PF02991	0.564
LIG_LIR_Nem_3	478	484	PF02991	0.453
LIG_LIR_Nem_3	533	538	PF02991	0.543
LIG_NRBOX	249	255	PF00104	0.467
LIG_PCNA_yPIPBox_3	242	254	PF02747	0.447
LIG_PCNA_yPIPBox_3	37	48	PF02747	0.586
LIG_PTB_Apo_2	318	325	PF02174	0.595
LIG_PTB_Apo_2	358	365	PF02174	0.518
LIG_SH2_CRK	389	393	PF00017	0.472
LIG_SH2_GRB2like	203	206	PF00017	0.423
LIG_SH2_GRB2like	319	322	PF00017	0.694
LIG_SH2_NCK_1	21	25	PF00017	0.585
LIG_SH2_NCK_1	509	513	PF00017	0.648
LIG_SH2_SRC	21	24	PF00017	0.616
LIG_SH2_STAP1	389	393	PF00017	0.465
LIG_SH2_STAT3	302	305	PF00017	0.662
LIG_SH2_STAT5	203	206	PF00017	0.423
LIG_SH2_STAT5	434	437	PF00017	0.497
LIG_SH2_STAT5	47	50	PF00017	0.598
LIG_SH2_STAT5	529	532	PF00017	0.496
LIG_SH3_3	155	161	PF00018	0.610
LIG_SH3_3	330	336	PF00018	0.700
LIG_SH3_4	234	241	PF00018	0.671
LIG_TRAF2_1	381	384	PF00917	0.583
LIG_TRAF2_1	410	413	PF00917	0.572
LIG_TRFH_1	324	328	PF08558	0.655
LIG_TRFH_1	364	368	PF08558	0.531
LIG_TYR_ITIM	387	392	PF00017	0.452
LIG_UBA3_1	131	137	PF00899	0.607
LIG_UBA3_1	363	369	PF00899	0.606
LIG_UBA3_1	500	507	PF00899	0.580
MOD_CK1_1	144	150	PF00069	0.740
MOD_CK1_1	157	163	PF00069	0.563
MOD_CK1_1	456	462	PF00069	0.540
MOD_CK2_1	208	214	PF00069	0.520
MOD_CK2_1	317	323	PF00069	0.683
MOD_CK2_1	338	344	PF00069	0.697
MOD_CK2_1	372	378	PF00069	0.483
MOD_CK2_1	472	478	PF00069	0.543
MOD_CK2_1	496	502	PF00069	0.463
MOD_Cter_Amidation	293	296	PF01082	0.396
MOD_GlcNHglycan	182	186	PF01048	0.549
MOD_GlcNHglycan	274	277	PF01048	0.507
MOD_GlcNHglycan	309	312	PF01048	0.620
MOD_GlcNHglycan	314	317	PF01048	0.591
MOD_GlcNHglycan	63	66	PF01048	0.672
MOD_GlcNHglycan	99	102	PF01048	0.470
MOD_GSK3_1	121	128	PF00069	0.477
MOD_GSK3_1	131	138	PF00069	0.431
MOD_GSK3_1	140	147	PF00069	0.470
MOD_GSK3_1	268	275	PF00069	0.506
MOD_GSK3_1	339	346	PF00069	0.675
MOD_GSK3_1	455	462	PF00069	0.507
MOD_GSK3_1	484	491	PF00069	0.507
MOD_GSK3_1	496	503	PF00069	0.382
MOD_GSK3_1	57	64	PF00069	0.639
MOD_N-GLC_1	482	487	PF02516	0.516
MOD_NEK2_1	125	130	PF00069	0.449
MOD_NEK2_1	131	136	PF00069	0.505
MOD_NEK2_1	154	159	PF00069	0.619
MOD_NEK2_1	175	180	PF00069	0.491
MOD_NEK2_1	272	277	PF00069	0.511
MOD_NEK2_1	312	317	PF00069	0.648
MOD_NEK2_1	397	402	PF00069	0.527
MOD_NEK2_1	427	432	PF00069	0.541
MOD_NEK2_1	484	489	PF00069	0.446
MOD_NEK2_1	490	495	PF00069	0.503
MOD_NEK2_1	551	556	PF00069	0.598
MOD_NEK2_2	57	62	PF00069	0.418
MOD_OFUCOSY	282	289	PF10250	0.550
MOD_PKA_1	140	146	PF00069	0.693
MOD_PKA_1	453	459	PF00069	0.532
MOD_PKA_2	139	145	PF00069	0.650
MOD_PKA_2	453	459	PF00069	0.534
MOD_PKA_2	522	528	PF00069	0.606
MOD_PKA_2	61	67	PF00069	0.669
MOD_Plk_1	482	488	PF00069	0.556
MOD_Plk_4	121	127	PF00069	0.527
MOD_Plk_4	154	160	PF00069	0.612
MOD_Plk_4	372	378	PF00069	0.567
MOD_Plk_4	427	433	PF00069	0.485
MOD_Plk_4	456	462	PF00069	0.545
MOD_Plk_4	496	502	PF00069	0.450
MOD_Plk_4	522	528	PF00069	0.606
MOD_ProDKin_1	157	163	PF00069	0.563
MOD_SUMO_for_1	225	228	PF00179	0.438
MOD_SUMO_rev_2	211	217	PF00179	0.562
MOD_SUMO_rev_2	34	38	PF00179	0.586
TRG_DiLeu_BaEn_1	105	110	PF01217	0.558
TRG_DiLeu_BaEn_1	171	176	PF01217	0.548
TRG_ENDOCYTIC_2	319	322	PF00928	0.610
TRG_ENDOCYTIC_2	389	392	PF00928	0.443
TRG_ENDOCYTIC_2	529	532	PF00928	0.441
TRG_ER_diArg_1	110	112	PF00400	0.532
TRG_ER_diArg_1	452	454	PF00400	0.507
TRG_ER_diArg_1	474	477	PF00400	0.598
TRG_NLS_MonoExtC_3	294	299	PF00514	0.632
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Z8	Leptomonas seymouri	78%	100%
A0A0S4ILH8	Bodo saltans	28%	100%
A0A1X0NLF6	Trypanosomatidae	48%	99%
A0A3Q8IJX9	Leishmania donovani	97%	100%
A0A422NJ69	Trypanosoma rangeli	48%	99%
A4HQC9	Leishmania braziliensis	89%	100%
A4IE22	Leishmania infantum	97%	100%
D0A3X0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AU45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BT61	Trypanosoma cruzi	48%	99%