LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q0E7_LEIMA
TriTrypDb:
LmjF.36.6130 * , LMJLV39_360074200 * , LMJSD75_360074200 *
Length:
319

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0E7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0E7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 162 164 PF00675 0.492
CLV_NRD_NRD_1 232 234 PF00675 0.629
CLV_NRD_NRD_1 4 6 PF00675 0.625
CLV_PCSK_KEX2_1 162 164 PF00082 0.492
CLV_PCSK_KEX2_1 27 29 PF00082 0.640
CLV_PCSK_KEX2_1 4 6 PF00082 0.657
CLV_PCSK_PC1ET2_1 27 29 PF00082 0.640
CLV_PCSK_SKI1_1 127 131 PF00082 0.486
DEG_COP1_1 53 63 PF00400 0.635
DEG_SCF_FBW7_1 29 34 PF00400 0.625
DOC_CKS1_1 220 225 PF01111 0.491
DOC_CKS1_1 51 56 PF01111 0.574
DOC_MAPK_gen_1 305 311 PF00069 0.585
DOC_MAPK_RevD_3 218 234 PF00069 0.623
DOC_PP2B_LxvP_1 58 61 PF13499 0.513
DOC_PP4_FxxP_1 215 218 PF00568 0.512
DOC_USP7_MATH_1 12 16 PF00917 0.674
DOC_USP7_MATH_1 203 207 PF00917 0.640
DOC_USP7_MATH_1 221 225 PF00917 0.579
DOC_USP7_MATH_1 23 27 PF00917 0.607
DOC_USP7_MATH_1 241 245 PF00917 0.582
DOC_USP7_MATH_1 249 253 PF00917 0.607
DOC_USP7_MATH_1 271 275 PF00917 0.649
DOC_USP7_MATH_1 83 87 PF00917 0.602
DOC_WW_Pin1_4 219 224 PF00397 0.535
DOC_WW_Pin1_4 264 269 PF00397 0.572
DOC_WW_Pin1_4 27 32 PF00397 0.643
DOC_WW_Pin1_4 50 55 PF00397 0.576
DOC_WW_Pin1_4 6 11 PF00397 0.623
LIG_14-3-3_CanoR_1 127 132 PF00244 0.487
LIG_14-3-3_CanoR_1 142 150 PF00244 0.366
LIG_14-3-3_CanoR_1 240 246 PF00244 0.602
LIG_BIR_II_1 1 5 PF00653 0.663
LIG_CaM_IQ_9 101 116 PF13499 0.478
LIG_CaM_IQ_9 284 300 PF13499 0.484
LIG_FHA_1 28 34 PF00498 0.628
LIG_FHA_1 306 312 PF00498 0.596
LIG_GBD_Chelix_1 178 186 PF00786 0.437
LIG_LIR_Apic_2 214 218 PF02991 0.507
LIG_LIR_Gen_1 206 216 PF02991 0.678
LIG_LIR_Nem_3 206 212 PF02991 0.585
LIG_NRBOX 114 120 PF00104 0.480
LIG_PCNA_PIPBox_1 169 178 PF02747 0.462
LIG_PCNA_yPIPBox_3 106 119 PF02747 0.479
LIG_PCNA_yPIPBox_3 162 176 PF02747 0.468
LIG_PTAP_UEV_1 254 259 PF05743 0.606
LIG_SH2_NCK_1 209 213 PF00017 0.595
LIG_SH2_STAP1 209 213 PF00017 0.595
LIG_SH2_STAP1 283 287 PF00017 0.625
LIG_SH2_STAP1 73 77 PF00017 0.493
LIG_SH2_STAT3 73 76 PF00017 0.494
LIG_SH2_STAT5 283 286 PF00017 0.624
LIG_SH2_STAT5 73 76 PF00017 0.494
LIG_SH3_3 217 223 PF00018 0.613
LIG_SH3_3 252 258 PF00018 0.711
LIG_TRAF2_1 167 170 PF00917 0.468
LIG_WRC_WIRS_1 212 217 PF05994 0.604
LIG_WRC_WIRS_1 33 38 PF05994 0.653
MOD_CK1_1 15 21 PF00069 0.652
MOD_CK1_1 22 28 PF00069 0.596
MOD_CK1_1 256 262 PF00069 0.690
MOD_CK1_1 43 49 PF00069 0.602
MOD_CK1_1 86 92 PF00069 0.602
MOD_GlcNHglycan 115 118 PF01048 0.574
MOD_GlcNHglycan 14 17 PF01048 0.691
MOD_GlcNHglycan 204 208 PF01048 0.576
MOD_GlcNHglycan 21 24 PF01048 0.627
MOD_GlcNHglycan 245 248 PF01048 0.598
MOD_GlcNHglycan 255 258 PF01048 0.544
MOD_GlcNHglycan 259 262 PF01048 0.531
MOD_GlcNHglycan 273 276 PF01048 0.736
MOD_GlcNHglycan 313 316 PF01048 0.534
MOD_GlcNHglycan 88 91 PF01048 0.565
MOD_GSK3_1 11 18 PF00069 0.673
MOD_GSK3_1 19 26 PF00069 0.582
MOD_GSK3_1 203 210 PF00069 0.576
MOD_GSK3_1 222 229 PF00069 0.560
MOD_GSK3_1 249 256 PF00069 0.622
MOD_GSK3_1 27 34 PF00069 0.523
MOD_GSK3_1 40 47 PF00069 0.562
MOD_GSK3_1 82 89 PF00069 0.552
MOD_GSK3_1 92 99 PF00069 0.454
MOD_N-GLC_1 249 254 PF02516 0.553
MOD_NEK2_1 168 173 PF00069 0.462
MOD_NEK2_1 197 202 PF00069 0.572
MOD_NEK2_1 40 45 PF00069 0.615
MOD_NEK2_1 65 70 PF00069 0.505
MOD_NEK2_1 97 102 PF00069 0.485
MOD_PIKK_1 142 148 PF00454 0.482
MOD_PIKK_1 197 203 PF00454 0.442
MOD_PIKK_1 71 77 PF00454 0.623
MOD_PIKK_1 92 98 PF00454 0.504
MOD_PIKK_1 99 105 PF00454 0.424
MOD_PKA_1 305 311 PF00069 0.589
MOD_PKA_2 253 259 PF00069 0.671
MOD_PKA_2 291 297 PF00069 0.666
MOD_PKA_2 311 317 PF00069 0.458
MOD_PKA_2 40 46 PF00069 0.646
MOD_Plk_1 203 209 PF00069 0.576
MOD_Plk_4 211 217 PF00069 0.698
MOD_Plk_4 226 232 PF00069 0.509
MOD_Plk_4 305 311 PF00069 0.594
MOD_ProDKin_1 219 225 PF00069 0.538
MOD_ProDKin_1 264 270 PF00069 0.572
MOD_ProDKin_1 27 33 PF00069 0.644
MOD_ProDKin_1 50 56 PF00069 0.576
MOD_ProDKin_1 6 12 PF00069 0.622
TRG_ENDOCYTIC_2 136 139 PF00928 0.481
TRG_ENDOCYTIC_2 209 212 PF00928 0.593
TRG_ER_diArg_1 161 163 PF00400 0.495
TRG_ER_diArg_1 38 41 PF00400 0.625

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IK47 Leishmania donovani 86% 99%
A4IE24 Leishmania infantum 86% 99%
E9AU48 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS