TYR_PHOSPHATASE_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0E6_LEIMA

TriTrypDb:

LmjF.36.6140 , LMJLV39_360074300 , LMJSD75_360074300

Length:

766

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0E6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.697
CLV_NRD_NRD_1	200	202	PF00675	0.666
CLV_NRD_NRD_1	252	254	PF00675	0.700
CLV_NRD_NRD_1	275	277	PF00675	0.664
CLV_NRD_NRD_1	284	286	PF00675	0.578
CLV_NRD_NRD_1	389	391	PF00675	0.620
CLV_NRD_NRD_1	469	471	PF00675	0.718
CLV_NRD_NRD_1	663	665	PF00675	0.610
CLV_NRD_NRD_1	75	77	PF00675	0.612
CLV_PCSK_KEX2_1	200	202	PF00082	0.551
CLV_PCSK_KEX2_1	252	254	PF00082	0.700
CLV_PCSK_KEX2_1	284	286	PF00082	0.643
CLV_PCSK_KEX2_1	299	301	PF00082	0.614
CLV_PCSK_KEX2_1	469	471	PF00082	0.670
CLV_PCSK_KEX2_1	662	664	PF00082	0.610
CLV_PCSK_KEX2_1	670	672	PF00082	0.609
CLV_PCSK_KEX2_1	75	77	PF00082	0.612
CLV_PCSK_KEX2_1	759	761	PF00082	0.670
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.641
CLV_PCSK_PC1ET2_1	670	672	PF00082	0.628
CLV_PCSK_PC1ET2_1	759	761	PF00082	0.670
CLV_PCSK_PC7_1	659	665	PF00082	0.662
CLV_PCSK_SKI1_1	629	633	PF00082	0.657
DEG_MDM2_SWIB_1	209	217	PF02201	0.476
DEG_SCF_FBW7_1	183	189	PF00400	0.616
DEG_SPOP_SBC_1	122	126	PF00917	0.517
DEG_SPOP_SBC_1	422	426	PF00917	0.660
DEG_SPOP_SBC_1	583	587	PF00917	0.649
DOC_CKS1_1	183	188	PF01111	0.618
DOC_PP2B_LxvP_1	445	448	PF13499	0.565
DOC_PP2B_LxvP_1	635	638	PF13499	0.629
DOC_PP4_FxxP_1	180	183	PF00568	0.615
DOC_PP4_FxxP_1	650	653	PF00568	0.648
DOC_PP4_FxxP_1	683	686	PF00568	0.536
DOC_USP7_MATH_1	108	112	PF00917	0.571
DOC_USP7_MATH_1	11	15	PF00917	0.603
DOC_USP7_MATH_1	122	126	PF00917	0.608
DOC_USP7_MATH_1	132	136	PF00917	0.628
DOC_USP7_MATH_1	158	162	PF00917	0.660
DOC_USP7_MATH_1	186	190	PF00917	0.624
DOC_USP7_MATH_1	239	243	PF00917	0.575
DOC_USP7_MATH_1	27	31	PF00917	0.515
DOC_USP7_MATH_1	384	388	PF00917	0.653
DOC_USP7_MATH_1	416	420	PF00917	0.693
DOC_USP7_MATH_1	422	426	PF00917	0.766
DOC_USP7_MATH_1	452	456	PF00917	0.671
DOC_USP7_MATH_1	548	552	PF00917	0.690
DOC_USP7_MATH_1	560	564	PF00917	0.572
DOC_USP7_MATH_1	583	587	PF00917	0.734
DOC_USP7_MATH_1	61	65	PF00917	0.518
DOC_USP7_MATH_1	642	646	PF00917	0.616
DOC_USP7_MATH_1	657	661	PF00917	0.614
DOC_USP7_MATH_1	702	706	PF00917	0.713
DOC_USP7_MATH_1	71	75	PF00917	0.567
DOC_USP7_MATH_1	744	748	PF00917	0.668
DOC_USP7_UBL2_3	480	484	PF12436	0.573
DOC_WW_Pin1_4	128	133	PF00397	0.573
DOC_WW_Pin1_4	142	147	PF00397	0.633
DOC_WW_Pin1_4	179	184	PF00397	0.645
DOC_WW_Pin1_4	191	196	PF00397	0.506
DOC_WW_Pin1_4	285	290	PF00397	0.618
DOC_WW_Pin1_4	292	297	PF00397	0.649
DOC_WW_Pin1_4	352	357	PF00397	0.683
DOC_WW_Pin1_4	361	366	PF00397	0.644
DOC_WW_Pin1_4	373	378	PF00397	0.594
DOC_WW_Pin1_4	489	494	PF00397	0.727
DOC_WW_Pin1_4	514	519	PF00397	0.574
DOC_WW_Pin1_4	527	532	PF00397	0.594
DOC_WW_Pin1_4	555	560	PF00397	0.614
DOC_WW_Pin1_4	579	584	PF00397	0.665
DOC_WW_Pin1_4	605	610	PF00397	0.625
DOC_WW_Pin1_4	613	618	PF00397	0.643
DOC_WW_Pin1_4	633	638	PF00397	0.768
DOC_WW_Pin1_4	649	654	PF00397	0.530
DOC_WW_Pin1_4	724	729	PF00397	0.660
LIG_14-3-3_CanoR_1	138	144	PF00244	0.675
LIG_14-3-3_CanoR_1	276	281	PF00244	0.657
LIG_14-3-3_CanoR_1	284	289	PF00244	0.621
LIG_14-3-3_CanoR_1	309	314	PF00244	0.608
LIG_14-3-3_CanoR_1	34	38	PF00244	0.576
LIG_14-3-3_CanoR_1	393	402	PF00244	0.710
LIG_14-3-3_CanoR_1	430	439	PF00244	0.680
LIG_14-3-3_CanoR_1	547	553	PF00244	0.598
LIG_14-3-3_CanoR_1	566	571	PF00244	0.549
LIG_14-3-3_CanoR_1	578	582	PF00244	0.717
LIG_14-3-3_CanoR_1	603	607	PF00244	0.597
LIG_14-3-3_CanoR_1	738	744	PF00244	0.609
LIG_14-3-3_CanoR_1	75	80	PF00244	0.616
LIG_Actin_WH2_2	99	117	PF00022	0.514
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_BRCT_BRCA1_1	35	39	PF00533	0.498
LIG_deltaCOP1_diTrp_1	32	39	PF00928	0.507
LIG_FHA_1	107	113	PF00498	0.723
LIG_FHA_1	402	408	PF00498	0.614
LIG_FHA_1	410	416	PF00498	0.660
LIG_FHA_1	565	571	PF00498	0.720
LIG_FHA_2	33	39	PF00498	0.565
LIG_FHA_2	60	66	PF00498	0.614
LIG_FHA_2	634	640	PF00498	0.663
LIG_FHA_2	68	74	PF00498	0.511
LIG_IBAR_NPY_1	80	82	PF08397	0.562
LIG_LIR_Apic_2	140	146	PF02991	0.627
LIG_LIR_Gen_1	102	108	PF02991	0.539
LIG_LIR_Nem_3	194	199	PF02991	0.662
LIG_LIR_Nem_3	78	82	PF02991	0.555
LIG_Pex14_2	209	213	PF04695	0.479
LIG_PTAP_UEV_1	712	717	PF05743	0.670
LIG_SH2_CRK	82	86	PF00017	0.548
LIG_SH2_STAT5	113	116	PF00017	0.565
LIG_SH3_1	710	716	PF00018	0.670
LIG_SH3_2	248	253	PF14604	0.566
LIG_SH3_2	81	86	PF14604	0.567
LIG_SH3_3	143	149	PF00018	0.662
LIG_SH3_3	180	186	PF00018	0.600
LIG_SH3_3	213	219	PF00018	0.476
LIG_SH3_3	245	251	PF00018	0.556
LIG_SH3_3	313	319	PF00018	0.599
LIG_SH3_3	353	359	PF00018	0.555
LIG_SH3_3	603	609	PF00018	0.648
LIG_SH3_3	635	641	PF00018	0.783
LIG_SH3_3	692	698	PF00018	0.639
LIG_SH3_3	710	716	PF00018	0.580
LIG_SH3_3	755	761	PF00018	0.643
LIG_SH3_3	78	84	PF00018	0.559
LIG_SUMO_SIM_anti_2	166	173	PF11976	0.672
LIG_SUMO_SIM_anti_2	334	342	PF11976	0.639
LIG_SUMO_SIM_anti_2	344	350	PF11976	0.551
LIG_SUMO_SIM_anti_2	517	523	PF11976	0.628
LIG_SUMO_SIM_par_1	596	602	PF11976	0.565
LIG_SxIP_EBH_1	611	623	PF03271	0.644
LIG_TRAF2_1	165	168	PF00917	0.651
LIG_TRAF2_2	296	301	PF00917	0.666
LIG_WW_3	317	321	PF00397	0.535
LIG_WW_3	492	496	PF00397	0.643
LIG_WW_3	696	700	PF00397	0.595
MOD_CDC14_SPxK_1	492	495	PF00782	0.711
MOD_CDC14_SPxK_1	530	533	PF00782	0.566
MOD_CDK_SPK_2	128	133	PF00069	0.561
MOD_CDK_SPxK_1	489	495	PF00069	0.716
MOD_CDK_SPxK_1	527	533	PF00069	0.563
MOD_CDK_SPxxK_3	292	299	PF00069	0.671
MOD_CDK_SPxxK_3	361	368	PF00069	0.694
MOD_CDK_SPxxK_3	555	562	PF00069	0.713
MOD_CDK_SPxxK_3	613	620	PF00069	0.633
MOD_CDK_SPxxK_3	724	731	PF00069	0.588
MOD_CK1_1	126	132	PF00069	0.559
MOD_CK1_1	137	143	PF00069	0.637
MOD_CK1_1	145	151	PF00069	0.763
MOD_CK1_1	182	188	PF00069	0.740
MOD_CK1_1	242	248	PF00069	0.812
MOD_CK1_1	25	31	PF00069	0.537
MOD_CK1_1	287	293	PF00069	0.681
MOD_CK1_1	339	345	PF00069	0.606
MOD_CK1_1	355	361	PF00069	0.627
MOD_CK1_1	370	376	PF00069	0.557
MOD_CK1_1	423	429	PF00069	0.662
MOD_CK1_1	433	439	PF00069	0.535
MOD_CK1_1	486	492	PF00069	0.652
MOD_CK1_1	517	523	PF00069	0.549
MOD_CK1_1	538	544	PF00069	0.726
MOD_CK1_1	582	588	PF00069	0.680
MOD_CK1_1	602	608	PF00069	0.498
MOD_CK1_1	705	711	PF00069	0.605
MOD_CK2_1	465	471	PF00069	0.594
MOD_CK2_1	59	65	PF00069	0.611
MOD_CK2_1	633	639	PF00069	0.647
MOD_CK2_1	67	73	PF00069	0.504
MOD_DYRK1A_RPxSP_1	285	289	PF00069	0.661
MOD_DYRK1A_RPxSP_1	514	518	PF00069	0.628
MOD_GlcNHglycan	10	14	PF01048	0.573
MOD_GlcNHglycan	125	128	PF01048	0.584
MOD_GlcNHglycan	175	178	PF01048	0.611
MOD_GlcNHglycan	229	232	PF01048	0.620
MOD_GlcNHglycan	242	245	PF01048	0.738
MOD_GlcNHglycan	260	264	PF01048	0.540
MOD_GlcNHglycan	290	293	PF01048	0.644
MOD_GlcNHglycan	322	325	PF01048	0.605
MOD_GlcNHglycan	371	375	PF01048	0.707
MOD_GlcNHglycan	385	389	PF01048	0.555
MOD_GlcNHglycan	395	398	PF01048	0.618
MOD_GlcNHglycan	432	435	PF01048	0.593
MOD_GlcNHglycan	445	448	PF01048	0.636
MOD_GlcNHglycan	449	452	PF01048	0.665
MOD_GlcNHglycan	454	457	PF01048	0.666
MOD_GlcNHglycan	462	465	PF01048	0.499
MOD_GlcNHglycan	537	540	PF01048	0.681
MOD_GlcNHglycan	55	58	PF01048	0.541
MOD_GlcNHglycan	550	553	PF01048	0.580
MOD_GlcNHglycan	562	565	PF01048	0.593
MOD_GlcNHglycan	589	592	PF01048	0.602
MOD_GlcNHglycan	629	632	PF01048	0.717
MOD_GlcNHglycan	704	707	PF01048	0.759
MOD_GlcNHglycan	754	757	PF01048	0.649
MOD_GSK3_1	122	129	PF00069	0.619
MOD_GSK3_1	145	152	PF00069	0.689
MOD_GSK3_1	181	188	PF00069	0.646
MOD_GSK3_1	259	266	PF00069	0.615
MOD_GSK3_1	28	35	PF00069	0.535
MOD_GSK3_1	283	290	PF00069	0.676
MOD_GSK3_1	308	315	PF00069	0.754
MOD_GSK3_1	320	327	PF00069	0.582
MOD_GSK3_1	351	358	PF00069	0.700
MOD_GSK3_1	416	423	PF00069	0.827
MOD_GSK3_1	443	450	PF00069	0.714
MOD_GSK3_1	460	467	PF00069	0.499
MOD_GSK3_1	483	490	PF00069	0.669
MOD_GSK3_1	560	567	PF00069	0.625
MOD_GSK3_1	577	584	PF00069	0.715
MOD_GSK3_1	67	74	PF00069	0.632
MOD_GSK3_1	711	718	PF00069	0.733
MOD_GSK3_1	9	16	PF00069	0.576
MOD_N-GLC_1	292	297	PF02516	0.646
MOD_N-GLC_1	587	592	PF02516	0.605
MOD_N-GLC_1	722	727	PF02516	0.695
MOD_N-GLC_1	731	736	PF02516	0.642
MOD_NEK2_1	474	479	PF00069	0.626
MOD_NEK2_1	690	695	PF00069	0.607
MOD_NEK2_2	108	113	PF00069	0.540
MOD_PIKK_1	237	243	PF00454	0.625
MOD_PIKK_1	424	430	PF00454	0.698
MOD_PIKK_1	642	648	PF00454	0.563
MOD_PIKK_1	690	696	PF00454	0.662
MOD_PK_1	731	737	PF00069	0.641
MOD_PKA_1	276	282	PF00069	0.625
MOD_PKA_1	284	290	PF00069	0.578
MOD_PKA_1	75	81	PF00069	0.569
MOD_PKA_1	759	765	PF00069	0.670
MOD_PKA_2	132	138	PF00069	0.656
MOD_PKA_2	283	289	PF00069	0.681
MOD_PKA_2	308	314	PF00069	0.608
MOD_PKA_2	33	39	PF00069	0.506
MOD_PKA_2	392	398	PF00069	0.620
MOD_PKA_2	546	552	PF00069	0.714
MOD_PKA_2	577	583	PF00069	0.662
MOD_PKA_2	602	608	PF00069	0.612
MOD_PKA_2	622	628	PF00069	0.563
MOD_PKA_2	711	717	PF00069	0.648
MOD_PKA_2	730	736	PF00069	0.517
MOD_PKA_2	737	743	PF00069	0.641
MOD_PKA_2	745	751	PF00069	0.710
MOD_PKA_2	75	81	PF00069	0.670
MOD_PKA_2	759	765	PF00069	0.630
MOD_Plk_1	339	345	PF00069	0.606
MOD_Plk_1	576	582	PF00069	0.714
MOD_Plk_1	731	737	PF00069	0.713
MOD_Plk_2-3	336	342	PF00069	0.601
MOD_Plk_4	108	114	PF00069	0.520
MOD_Plk_4	139	145	PF00069	0.741
MOD_Plk_4	242	248	PF00069	0.694
MOD_Plk_4	517	523	PF00069	0.557
MOD_Plk_4	685	691	PF00069	0.619
MOD_ProDKin_1	128	134	PF00069	0.573
MOD_ProDKin_1	142	148	PF00069	0.644
MOD_ProDKin_1	179	185	PF00069	0.642
MOD_ProDKin_1	191	197	PF00069	0.501
MOD_ProDKin_1	285	291	PF00069	0.621
MOD_ProDKin_1	292	298	PF00069	0.651
MOD_ProDKin_1	352	358	PF00069	0.683
MOD_ProDKin_1	361	367	PF00069	0.643
MOD_ProDKin_1	373	379	PF00069	0.587
MOD_ProDKin_1	489	495	PF00069	0.731
MOD_ProDKin_1	514	520	PF00069	0.576
MOD_ProDKin_1	527	533	PF00069	0.599
MOD_ProDKin_1	555	561	PF00069	0.613
MOD_ProDKin_1	579	585	PF00069	0.663
MOD_ProDKin_1	605	611	PF00069	0.627
MOD_ProDKin_1	613	619	PF00069	0.642
MOD_ProDKin_1	633	639	PF00069	0.770
MOD_ProDKin_1	649	655	PF00069	0.532
MOD_ProDKin_1	724	730	PF00069	0.660
MOD_SUMO_for_1	45	48	PF00179	0.480
MOD_SUMO_for_1	631	634	PF00179	0.685
MOD_SUMO_for_1	91	94	PF00179	0.597
MOD_SUMO_rev_2	344	354	PF00179	0.673
MOD_SUMO_rev_2	38	47	PF00179	0.503
TRG_DiLeu_BaEn_1	166	171	PF01217	0.600
TRG_ENDOCYTIC_2	221	224	PF00928	0.583
TRG_ENDOCYTIC_2	82	85	PF00928	0.545
TRG_ER_diArg_1	199	201	PF00400	0.567
TRG_ER_diArg_1	251	253	PF00400	0.739
TRG_ER_diArg_1	662	664	PF00400	0.611
TRG_ER_diArg_1	710	713	PF00400	0.722
TRG_NLS_MonoExtC_3	389	394	PF00514	0.663
TRG_Pf-PMV_PEXEL_1	670	674	PF00026	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMJ9	Leptomonas seymouri	33%	87%
A0A3S7XC30	Leishmania donovani	90%	100%
A4HQD3	Leishmania braziliensis	59%	98%
A4IE25	Leishmania infantum	88%	100%
E9AU49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%