TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0E5_LEIMA

TriTrypDb:

LmjF.36.6150 , LMJLV39_360074500 , LMJSD75_360074500

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q0E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0E5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.681
CLV_NRD_NRD_1	308	310	PF00675	0.472
CLV_NRD_NRD_1	335	337	PF00675	0.447
CLV_PCSK_KEX2_1	335	337	PF00082	0.374
CLV_PCSK_SKI1_1	279	283	PF00082	0.529
CLV_PCSK_SKI1_1	293	297	PF00082	0.314
CLV_PCSK_SKI1_1	313	317	PF00082	0.363
CLV_PCSK_SKI1_1	335	339	PF00082	0.369
CLV_PCSK_SKI1_1	345	349	PF00082	0.411
CLV_TASPASE1	58	64	PF01112	0.711
DEG_Nend_Nbox_1	1	3	PF02207	0.761
DEG_SPOP_SBC_1	245	249	PF00917	0.714
DEG_SPOP_SBC_1	281	285	PF00917	0.754
DOC_CDC14_PxL_1	349	357	PF14671	0.474
DOC_CYCLIN_RxL_1	50	60	PF00134	0.589
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.608
DOC_MAPK_gen_1	293	303	PF00069	0.598
DOC_MAPK_MEF2A_6	70	79	PF00069	0.574
DOC_MAPK_RevD_3	322	336	PF00069	0.579
DOC_PP4_FxxP_1	153	156	PF00568	0.754
DOC_PP4_FxxP_1	350	353	PF00568	0.513
DOC_USP7_MATH_1	110	114	PF00917	0.708
DOC_USP7_MATH_1	129	133	PF00917	0.628
DOC_USP7_MATH_1	187	191	PF00917	0.748
DOC_USP7_MATH_1	273	277	PF00917	0.804
DOC_WW_Pin1_4	152	157	PF00397	0.741
DOC_WW_Pin1_4	322	327	PF00397	0.598
LIG_14-3-3_CanoR_1	178	184	PF00244	0.752
LIG_CtBP_PxDLS_1	218	222	PF00389	0.728
LIG_deltaCOP1_diTrp_1	101	107	PF00928	0.709
LIG_deltaCOP1_diTrp_1	145	153	PF00928	0.757
LIG_EH1_1	315	323	PF00400	0.602
LIG_FHA_1	190	196	PF00498	0.771
LIG_FHA_1	247	253	PF00498	0.666
LIG_FHA_1	283	289	PF00498	0.587
LIG_FHA_1	40	46	PF00498	0.691
LIG_FHA_1	83	89	PF00498	0.550
LIG_FHA_2	230	236	PF00498	0.777
LIG_FHA_2	266	272	PF00498	0.708
LIG_FHA_2	69	75	PF00498	0.584
LIG_LIR_Apic_2	151	156	PF02991	0.760
LIG_LIR_Gen_1	146	157	PF02991	0.765
LIG_LIR_Gen_1	19	27	PF02991	0.633
LIG_LIR_Gen_1	289	299	PF02991	0.585
LIG_LIR_Gen_1	31	40	PF02991	0.538
LIG_LIR_Nem_3	101	106	PF02991	0.641
LIG_LIR_Nem_3	146	152	PF02991	0.829
LIG_LIR_Nem_3	19	24	PF02991	0.636
LIG_LIR_Nem_3	289	294	PF02991	0.641
LIG_LIR_Nem_3	31	37	PF02991	0.533
LIG_LYPXL_SIV_4	72	80	PF13949	0.578
LIG_NRBOX	333	339	PF00104	0.569
LIG_PDZ_Class_2	357	362	PF00595	0.411
LIG_Pex14_1	149	153	PF04695	0.771
LIG_SH2_CRK	305	309	PF00017	0.576
LIG_SH2_CRK	34	38	PF00017	0.567
LIG_SH2_GRB2like	298	301	PF00017	0.577
LIG_SH2_GRB2like	47	50	PF00017	0.621
LIG_SH2_SRC	47	50	PF00017	0.621
LIG_SH2_STAP1	291	295	PF00017	0.683
LIG_SH2_STAP1	73	77	PF00017	0.583
LIG_SH2_STAT3	343	346	PF00017	0.397
LIG_SH2_STAT5	305	308	PF00017	0.563
LIG_SH2_STAT5	317	320	PF00017	0.538
LIG_SH2_STAT5	343	346	PF00017	0.411
LIG_SH2_STAT5	47	50	PF00017	0.549
LIG_SH2_STAT5	97	100	PF00017	0.606
LIG_SH3_3	167	173	PF00018	0.723
LIG_SH3_3	204	210	PF00018	0.680
LIG_SH3_3	6	12	PF00018	0.613
LIG_SUMO_SIM_anti_2	247	254	PF11976	0.617
LIG_TYR_ITIM	303	308	PF00017	0.425
LIG_UBA3_1	94	100	PF00899	0.584
LIG_WRC_WIRS_1	263	268	PF05994	0.685
MOD_CDK_SPK_2	322	327	PF00069	0.492
MOD_CK1_1	113	119	PF00069	0.695
MOD_CK1_1	236	242	PF00069	0.677
MOD_CK1_1	262	268	PF00069	0.691
MOD_CK1_1	325	331	PF00069	0.470
MOD_CK1_1	83	89	PF00069	0.431
MOD_CK2_1	152	158	PF00069	0.704
MOD_CK2_1	16	22	PF00069	0.497
MOD_CK2_1	229	235	PF00069	0.622
MOD_CK2_1	286	292	PF00069	0.579
MOD_CK2_1	68	74	PF00069	0.508
MOD_CK2_1	83	89	PF00069	0.565
MOD_GlcNHglycan	115	118	PF01048	0.646
MOD_GlcNHglycan	174	177	PF01048	0.697
MOD_GlcNHglycan	189	192	PF01048	0.571
MOD_GlcNHglycan	198	201	PF01048	0.547
MOD_GlcNHglycan	227	230	PF01048	0.757
MOD_GlcNHglycan	235	238	PF01048	0.620
MOD_GlcNHglycan	4	7	PF01048	0.691
MOD_GSK3_1	106	113	PF00069	0.568
MOD_GSK3_1	172	179	PF00069	0.787
MOD_GSK3_1	209	216	PF00069	0.632
MOD_GSK3_1	225	232	PF00069	0.701
MOD_GSK3_1	235	242	PF00069	0.650
MOD_GSK3_1	244	251	PF00069	0.516
MOD_GSK3_1	265	272	PF00069	0.639
MOD_GSK3_1	282	289	PF00069	0.509
MOD_GSK3_1	35	42	PF00069	0.542
MOD_GSK3_1	64	71	PF00069	0.643
MOD_N-GLC_1	162	167	PF02516	0.704
MOD_NEK2_1	196	201	PF00069	0.697
MOD_NEK2_1	2	7	PF00069	0.704
MOD_NEK2_1	253	258	PF00069	0.709
MOD_NEK2_1	316	321	PF00069	0.480
MOD_NEK2_1	348	353	PF00069	0.416
MOD_NEK2_1	35	40	PF00069	0.552
MOD_OFUCOSY	161	166	PF10250	0.664
MOD_PIKK_1	129	135	PF00454	0.738
MOD_PIKK_1	189	195	PF00454	0.682
MOD_PIKK_1	253	259	PF00454	0.710
MOD_PKA_2	113	119	PF00069	0.680
MOD_PKA_2	177	183	PF00069	0.582
MOD_PKA_2	196	202	PF00069	0.809
MOD_PKB_1	223	231	PF00069	0.733
MOD_Plk_1	68	74	PF00069	0.597
MOD_Plk_1	83	89	PF00069	0.339
MOD_Plk_2-3	16	22	PF00069	0.497
MOD_Plk_4	16	22	PF00069	0.511
MOD_Plk_4	217	223	PF00069	0.650
MOD_Plk_4	248	254	PF00069	0.584
MOD_Plk_4	83	89	PF00069	0.579
MOD_ProDKin_1	152	158	PF00069	0.684
MOD_ProDKin_1	322	328	PF00069	0.478
TRG_DiLeu_BaEn_1	90	95	PF01217	0.560
TRG_DiLeu_BaEn_4	329	335	PF01217	0.565
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.413
TRG_DiLeu_BaLyEn_6	350	355	PF01217	0.513
TRG_ENDOCYTIC_2	291	294	PF00928	0.534
TRG_ENDOCYTIC_2	298	301	PF00928	0.395
TRG_ENDOCYTIC_2	305	308	PF00928	0.273
TRG_ENDOCYTIC_2	34	37	PF00928	0.489
TRG_ER_diArg_1	334	336	PF00400	0.551
TRG_NES_CRM1_1	46	60	PF08389	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I247	Leptomonas seymouri	40%	100%
A0A3S7XC14	Leishmania donovani	91%	100%
A4HQD4	Leishmania braziliensis	64%	99%
A4IE26	Leishmania infantum	92%	100%
E9AU50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%