RanBD1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0E4_LEIMA

TriTrypDb:

LmjF.36.6160 , LMJLV39_360074600 , LMJSD75_360074600

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

Q4Q0E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0E4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051236	establishment of RNA localization	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.702
CLV_C14_Caspase3-7	186	190	PF00656	0.577
CLV_NRD_NRD_1	158	160	PF00675	0.619
CLV_PCSK_SKI1_1	203	207	PF00082	0.511
CLV_PCSK_SKI1_1	267	271	PF00082	0.562
DEG_SPOP_SBC_1	21	25	PF00917	0.609
DOC_CYCLIN_RxL_1	264	273	PF00134	0.494
DOC_MAPK_gen_1	242	250	PF00069	0.639
DOC_PP4_FxxP_1	18	21	PF00568	0.753
DOC_PP4_FxxP_1	297	300	PF00568	0.482
DOC_PP4_FxxP_1	32	35	PF00568	0.554
DOC_USP7_MATH_1	151	155	PF00917	0.605
DOC_USP7_MATH_1	21	25	PF00917	0.637
DOC_USP7_MATH_1	81	85	PF00917	0.611
DOC_USP7_UBL2_3	274	278	PF12436	0.461
DOC_WW_Pin1_4	110	115	PF00397	0.782
DOC_WW_Pin1_4	220	225	PF00397	0.611
DOC_WW_Pin1_4	48	53	PF00397	0.645
DOC_WW_Pin1_4	57	62	PF00397	0.625
DOC_WW_Pin1_4	96	101	PF00397	0.622
LIG_BIR_III_4	187	191	PF00653	0.658
LIG_BRCT_BRCA1_1	144	148	PF00533	0.619
LIG_BRCT_BRCA1_1	28	32	PF00533	0.755
LIG_BRCT_BRCA1_1	83	87	PF00533	0.577
LIG_FHA_1	290	296	PF00498	0.418
LIG_FHA_1	58	64	PF00498	0.537
LIG_FHA_2	170	176	PF00498	0.574
LIG_LIR_Apic_2	17	21	PF02991	0.753
LIG_LIR_Apic_2	29	35	PF02991	0.611
LIG_LIR_Gen_1	211	220	PF02991	0.332
LIG_LIR_Nem_3	211	217	PF02991	0.314
LIG_LIR_Nem_3	66	70	PF02991	0.664
LIG_SH2_STAP1	259	263	PF00017	0.488
LIG_SH2_STAT5	214	217	PF00017	0.455
LIG_SH2_STAT5	293	296	PF00017	0.409
LIG_SH3_3	133	139	PF00018	0.656
LIG_SH3_3	58	64	PF00018	0.786
LIG_SUMO_SIM_par_1	280	288	PF11976	0.478
LIG_TRFH_1	32	36	PF08558	0.605
LIG_UBA3_1	269	274	PF00899	0.490
LIG_WRC_WIRS_1	152	157	PF05994	0.606
MOD_CDK_SPxK_1	220	226	PF00069	0.551
MOD_CK1_1	113	119	PF00069	0.735
MOD_CK1_1	23	29	PF00069	0.736
MOD_CK1_1	41	47	PF00069	0.683
MOD_CK1_1	48	54	PF00069	0.679
MOD_CK1_1	57	63	PF00069	0.630
MOD_CK1_1	76	82	PF00069	0.692
MOD_CK1_1	83	89	PF00069	0.564
MOD_CK1_1	9	15	PF00069	0.605
MOD_CK1_1	91	97	PF00069	0.643
MOD_CK2_1	151	157	PF00069	0.611
MOD_CK2_1	169	175	PF00069	0.572
MOD_CK2_1	270	276	PF00069	0.492
MOD_GlcNHglycan	107	110	PF01048	0.769
MOD_GlcNHglycan	149	152	PF01048	0.537
MOD_GlcNHglycan	199	203	PF01048	0.726
MOD_GlcNHglycan	40	43	PF01048	0.621
MOD_GlcNHglycan	75	78	PF01048	0.727
MOD_GlcNHglycan	90	93	PF01048	0.640
MOD_GSK3_1	147	154	PF00069	0.583
MOD_GSK3_1	188	195	PF00069	0.677
MOD_GSK3_1	21	28	PF00069	0.738
MOD_GSK3_1	268	275	PF00069	0.604
MOD_GSK3_1	303	310	PF00069	0.520
MOD_GSK3_1	34	41	PF00069	0.611
MOD_GSK3_1	48	55	PF00069	0.591
MOD_GSK3_1	69	76	PF00069	0.693
MOD_GSK3_1	79	86	PF00069	0.641
MOD_GSK3_1	91	98	PF00069	0.797
MOD_N-GLC_1	261	266	PF02516	0.462
MOD_N-GLC_1	304	309	PF02516	0.476
MOD_N-GLC_1	72	77	PF02516	0.562
MOD_NEK2_1	261	266	PF00069	0.483
MOD_NEK2_1	270	275	PF00069	0.520
MOD_NEK2_1	295	300	PF00069	0.517
MOD_NEK2_1	45	50	PF00069	0.695
MOD_PIKK_1	23	29	PF00454	0.571
MOD_Plk_1	261	267	PF00069	0.470
MOD_Plk_2-3	169	175	PF00069	0.572
MOD_Plk_4	151	157	PF00069	0.603
MOD_Plk_4	289	295	PF00069	0.413
MOD_ProDKin_1	110	116	PF00069	0.784
MOD_ProDKin_1	220	226	PF00069	0.610
MOD_ProDKin_1	48	54	PF00069	0.647
MOD_ProDKin_1	57	63	PF00069	0.623
MOD_ProDKin_1	96	102	PF00069	0.623
MOD_SUMO_for_1	217	220	PF00179	0.366
MOD_SUMO_rev_2	229	238	PF00179	0.503
MOD_SUMO_rev_2	240	244	PF00179	0.437
MOD_SUMO_rev_2	273	280	PF00179	0.456
TRG_DiLeu_BaEn_2	275	281	PF01217	0.315
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.479
TRG_ENDOCYTIC_2	214	217	PF00928	0.325
TRG_NLS_MonoExtC_3	158	164	PF00514	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFC6	Leptomonas seymouri	58%	77%
A0A0S4IHX6	Bodo saltans	30%	91%
A0A3Q8IWI8	Leishmania donovani	92%	100%
A4HQD5	Leishmania braziliensis	71%	99%
A4IE27	Leishmania infantum	92%	100%
E9AU51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%