Galactose oxidase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Galactose oxidase

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0E3_LEIMA

TriTrypDb:

LmjF.36.6170 , LMJLV39_360074700 , LMJSD75_360074700 , LMJSD75_360074800 , LMJSD75_360074900

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0E3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.714
CLV_NRD_NRD_1	479	481	PF00675	0.723
CLV_PCSK_KEX2_1	123	125	PF00082	0.714
CLV_PCSK_KEX2_1	22	24	PF00082	0.806
CLV_PCSK_KEX2_1	478	480	PF00082	0.826
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.806
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.826
CLV_PCSK_SKI1_1	442	446	PF00082	0.555
DEG_SCF_FBW7_1	332	339	PF00400	0.330
DOC_CKS1_1	263	268	PF01111	0.509
DOC_CYCLIN_RxL_1	439	449	PF00134	0.658
DOC_MAPK_DCC_7	134	142	PF00069	0.770
DOC_MAPK_MEF2A_6	134	142	PF00069	0.770
DOC_MAPK_MEF2A_6	461	469	PF00069	0.729
DOC_PP1_RVXF_1	440	447	PF00149	0.650
DOC_USP7_MATH_1	16	20	PF00917	0.566
DOC_USP7_MATH_1	199	203	PF00917	0.756
DOC_USP7_MATH_1	376	380	PF00917	0.724
DOC_USP7_MATH_1	4	8	PF00917	0.714
DOC_USP7_MATH_1	410	414	PF00917	0.723
DOC_USP7_MATH_1	415	419	PF00917	0.745
DOC_USP7_MATH_1	481	485	PF00917	0.756
DOC_USP7_MATH_1	89	93	PF00917	0.601
DOC_USP7_MATH_1	98	102	PF00917	0.488
DOC_USP7_UBL2_3	18	22	PF12436	0.787
DOC_WW_Pin1_4	133	138	PF00397	0.750
DOC_WW_Pin1_4	148	153	PF00397	0.593
DOC_WW_Pin1_4	206	211	PF00397	0.797
DOC_WW_Pin1_4	233	238	PF00397	0.698
DOC_WW_Pin1_4	262	267	PF00397	0.505
DOC_WW_Pin1_4	278	283	PF00397	0.563
DOC_WW_Pin1_4	332	337	PF00397	0.560
LIG_14-3-3_CanoR_1	147	152	PF00244	0.745
LIG_14-3-3_CanoR_1	178	184	PF00244	0.545
LIG_14-3-3_CanoR_1	23	27	PF00244	0.799
LIG_14-3-3_CanoR_1	349	359	PF00244	0.484
LIG_14-3-3_CanoR_1	392	401	PF00244	0.583
LIG_14-3-3_CanoR_1	420	424	PF00244	0.715
LIG_14-3-3_CanoR_1	433	443	PF00244	0.379
LIG_Actin_WH2_2	265	281	PF00022	0.594
LIG_BIR_II_1	1	5	PF00653	0.680
LIG_BIR_III_1	1	5	PF00653	0.714
LIG_BIR_III_3	1	5	PF00653	0.714
LIG_CSL_BTD_1	333	336	PF09270	0.569
LIG_CtBP_PxDLS_1	137	141	PF00389	0.825
LIG_deltaCOP1_diTrp_1	258	263	PF00928	0.557
LIG_FHA_1	251	257	PF00498	0.513
LIG_FHA_1	263	269	PF00498	0.541
LIG_FHA_1	279	285	PF00498	0.639
LIG_FHA_1	310	316	PF00498	0.581
LIG_FHA_1	34	40	PF00498	0.670
LIG_FHA_1	59	65	PF00498	0.503
LIG_FHA_2	152	158	PF00498	0.632
LIG_FHA_2	236	242	PF00498	0.674
LIG_Integrin_isoDGR_2	385	387	PF01839	0.663
LIG_LIR_Gen_1	367	376	PF02991	0.599
LIG_LIR_Gen_1	75	86	PF02991	0.341
LIG_LIR_Nem_3	241	247	PF02991	0.337
LIG_LIR_Nem_3	333	337	PF02991	0.565
LIG_LIR_Nem_3	367	372	PF02991	0.474
LIG_LIR_Nem_3	430	435	PF02991	0.681
LIG_LIR_Nem_3	75	81	PF02991	0.341
LIG_LYPXL_SIV_4	12	20	PF13949	0.724
LIG_NRP_CendR_1	483	485	PF00754	0.838
LIG_Pex14_1	334	338	PF04695	0.572
LIG_SH2_NCK_1	13	17	PF00017	0.776
LIG_SH2_SRC	13	16	PF00017	0.778
LIG_SH2_STAP1	13	17	PF00017	0.776
LIG_SH2_STAP1	67	71	PF00017	0.503
LIG_SH2_STAT5	245	248	PF00017	0.465
LIG_SH2_STAT5	369	372	PF00017	0.476
LIG_SH3_2	82	87	PF14604	0.612
LIG_SH3_3	132	138	PF00018	0.770
LIG_SH3_3	192	198	PF00018	0.599
LIG_SH3_3	204	210	PF00018	0.666
LIG_SH3_3	79	85	PF00018	0.406
LIG_TYR_ITIM	65	70	PF00017	0.503
LIG_WRC_WIRS_1	429	434	PF05994	0.478
MOD_CK1_1	136	142	PF00069	0.823
MOD_CK1_1	309	315	PF00069	0.577
MOD_CK1_1	327	333	PF00069	0.432
MOD_CK1_1	413	419	PF00069	0.781
MOD_CK1_1	471	477	PF00069	0.576
MOD_CK2_1	151	157	PF00069	0.728
MOD_CK2_1	235	241	PF00069	0.695
MOD_CK2_1	35	41	PF00069	0.497
MOD_CK2_1	4	10	PF00069	0.771
MOD_CMANNOS	260	263	PF00535	0.556
MOD_GlcNHglycan	179	182	PF01048	0.518
MOD_GlcNHglycan	195	198	PF01048	0.430
MOD_GlcNHglycan	231	234	PF01048	0.684
MOD_GlcNHglycan	309	312	PF01048	0.555
MOD_GlcNHglycan	329	332	PF01048	0.373
MOD_GlcNHglycan	449	452	PF01048	0.577
MOD_GlcNHglycan	91	94	PF01048	0.597
MOD_GSK3_1	136	143	PF00069	0.798
MOD_GSK3_1	146	153	PF00069	0.836
MOD_GSK3_1	201	208	PF00069	0.806
MOD_GSK3_1	215	222	PF00069	0.808
MOD_GSK3_1	229	236	PF00069	0.567
MOD_GSK3_1	332	339	PF00069	0.330
MOD_GSK3_1	35	42	PF00069	0.635
MOD_GSK3_1	409	416	PF00069	0.689
MOD_GSK3_1	453	460	PF00069	0.787
MOD_GSK3_1	72	79	PF00069	0.348
MOD_N-GLC_1	249	254	PF02516	0.583
MOD_N-GLC_1	350	355	PF02516	0.681
MOD_NEK2_1	140	145	PF00069	0.783
MOD_NEK2_1	193	198	PF00069	0.539
MOD_NEK2_1	393	398	PF00069	0.485
MOD_NEK2_1	40	45	PF00069	0.427
MOD_NEK2_1	401	406	PF00069	0.573
MOD_NEK2_1	419	424	PF00069	0.539
MOD_NEK2_1	447	452	PF00069	0.677
MOD_NEK2_2	226	231	PF00069	0.763
MOD_NEK2_2	415	420	PF00069	0.788
MOD_PIKK_1	199	205	PF00454	0.746
MOD_PIKK_1	410	416	PF00454	0.555
MOD_PIKK_1	455	461	PF00454	0.787
MOD_PIKK_1	58	64	PF00454	0.428
MOD_PKA_1	22	28	PF00069	0.744
MOD_PKA_2	146	152	PF00069	0.748
MOD_PKA_2	157	163	PF00069	0.738
MOD_PKA_2	177	183	PF00069	0.345
MOD_PKA_2	22	28	PF00069	0.744
MOD_PKA_2	419	425	PF00069	0.714
MOD_Plk_1	40	46	PF00069	0.503
MOD_Plk_2-3	468	474	PF00069	0.538
MOD_Plk_4	226	232	PF00069	0.779
MOD_Plk_4	319	325	PF00069	0.526
MOD_Plk_4	35	41	PF00069	0.497
MOD_Plk_4	364	370	PF00069	0.574
MOD_Plk_4	98	104	PF00069	0.613
MOD_ProDKin_1	133	139	PF00069	0.751
MOD_ProDKin_1	148	154	PF00069	0.593
MOD_ProDKin_1	206	212	PF00069	0.798
MOD_ProDKin_1	233	239	PF00069	0.685
MOD_ProDKin_1	262	268	PF00069	0.508
MOD_ProDKin_1	278	284	PF00069	0.563
MOD_ProDKin_1	332	338	PF00069	0.569
MOD_SUMO_rev_2	42	52	PF00179	0.392
MOD_SUMO_rev_2	468	477	PF00179	0.716
TRG_DiLeu_BaEn_2	47	53	PF01217	0.503
TRG_ENDOCYTIC_2	369	372	PF00928	0.476
TRG_ENDOCYTIC_2	67	70	PF00928	0.503
TRG_ER_diArg_1	122	124	PF00400	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XC07	Leishmania donovani	89%	100%
A4IE28	Leishmania infantum	90%	100%
D0A3W0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AU52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%