Sucraseferredoxin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sucrase/ferredoxin-like, putative

Species:

Leishmania major

UniProt:

Q4Q0E2_LEIMA

TriTrypDb:

LmjF.36.6180 , LMJLV39_360074800 , LMJSD75_360075000

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q0E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0E2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	84	86	PF00082	0.391
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.391
CLV_PCSK_PC7_1	80	86	PF00082	0.468
CLV_PCSK_SKI1_1	100	104	PF00082	0.398
CLV_PCSK_SKI1_1	189	193	PF00082	0.448
DEG_Nend_UBRbox_4	1	3	PF02207	0.602
DEG_SPOP_SBC_1	6	10	PF00917	0.468
DOC_USP7_MATH_1	104	108	PF00917	0.377
DOC_USP7_MATH_1	6	10	PF00917	0.673
LIG_14-3-3_CanoR_1	203	207	PF00244	0.433
LIG_14-3-3_CanoR_1	27	35	PF00244	0.567
LIG_CtBP_PxDLS_1	255	259	PF00389	0.382
LIG_eIF4E_1	179	185	PF01652	0.336
LIG_FHA_1	152	158	PF00498	0.472
LIG_FHA_1	199	205	PF00498	0.323
LIG_FHA_1	57	63	PF00498	0.537
LIG_FHA_1	8	14	PF00498	0.594
LIG_FHA_1	84	90	PF00498	0.352
LIG_FHA_2	32	38	PF00498	0.473
LIG_LIR_Apic_2	142	148	PF02991	0.450
LIG_LIR_Gen_1	136	145	PF02991	0.290
LIG_LIR_Gen_1	162	171	PF02991	0.419
LIG_LIR_Gen_1	22	30	PF02991	0.562
LIG_LIR_Nem_3	136	141	PF02991	0.358
LIG_LIR_Nem_3	160	166	PF02991	0.343
LIG_LIR_Nem_3	22	26	PF02991	0.551
LIG_SH2_CRK	138	142	PF00017	0.357
LIG_SH2_NCK_1	138	142	PF00017	0.290
LIG_SH2_STAT5	163	166	PF00017	0.406
LIG_SH2_STAT5	179	182	PF00017	0.202
LIG_SH3_3	138	144	PF00018	0.439
LIG_SUMO_SIM_par_1	153	158	PF11976	0.472
LIG_TYR_ITSM	134	141	PF00017	0.370
MOD_CK1_1	139	145	PF00069	0.358
MOD_CK1_1	169	175	PF00069	0.401
MOD_CK1_1	9	15	PF00069	0.670
MOD_CK2_1	137	143	PF00069	0.268
MOD_CK2_1	63	69	PF00069	0.538
MOD_GlcNHglycan	158	162	PF01048	0.368
MOD_GlcNHglycan	16	19	PF01048	0.640
MOD_GSK3_1	104	111	PF00069	0.443
MOD_GSK3_1	133	140	PF00069	0.306
MOD_GSK3_1	198	205	PF00069	0.371
MOD_GSK3_1	5	12	PF00069	0.706
MOD_NEK2_1	108	113	PF00069	0.393
MOD_NEK2_1	166	171	PF00069	0.370
MOD_NEK2_1	7	12	PF00069	0.698
MOD_NEK2_1	72	77	PF00069	0.391
MOD_NEK2_2	63	68	PF00069	0.568
MOD_PIKK_1	133	139	PF00454	0.346
MOD_PIKK_1	7	13	PF00454	0.702
MOD_PIKK_1	93	99	PF00454	0.459
MOD_PKA_2	202	208	PF00069	0.413
MOD_Plk_1	104	110	PF00069	0.472
MOD_Plk_1	117	123	PF00069	0.351
MOD_Plk_2-3	114	120	PF00069	0.394
MOD_Plk_2-3	19	25	PF00069	0.558
MOD_Plk_4	117	123	PF00069	0.355
MOD_Plk_4	179	185	PF00069	0.415
MOD_SUMO_for_1	235	238	PF00179	0.450
MOD_SUMO_rev_2	127	133	PF00179	0.394
MOD_SUMO_rev_2	146	154	PF00179	0.321
MOD_SUMO_rev_2	245	253	PF00179	0.394
TRG_DiLeu_BaEn_2	161	167	PF01217	0.352
TRG_ENDOCYTIC_2	138	141	PF00928	0.357
TRG_ENDOCYTIC_2	163	166	PF00928	0.450
TRG_ENDOCYTIC_2	232	235	PF00928	0.450
TRG_ER_diArg_1	258	261	PF00400	0.495
TRG_NES_CRM1_1	146	158	PF08389	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U1	Leptomonas seymouri	41%	100%
A0A0N1I8X6	Leptomonas seymouri	74%	100%
A0A0S4JXX0	Bodo saltans	44%	100%
A0A1X0NM84	Trypanosomatidae	47%	100%
A0A3Q8IGR7	Leishmania donovani	93%	100%
A0A422NAD6	Trypanosoma rangeli	47%	100%
A4HQD8	Leishmania braziliensis	81%	100%
A4IE29	Leishmania infantum	93%	100%
D0A3V9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	94%
E9AU53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DJZ4	Trypanosoma cruzi	49%	82%