Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0E1_LEIMA

TriTrypDb:

LmjF.36.6190 , LMJLV39_360074900 , LMJSD75_360075100

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0E1

PDB structure(s): 7aih_Bj , 7ane_Bj

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.711
CLV_NRD_NRD_1	178	180	PF00675	0.766
CLV_PCSK_KEX2_1	127	129	PF00082	0.589
CLV_PCSK_KEX2_1	178	180	PF00082	0.724
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.624
CLV_PCSK_SKI1_1	127	131	PF00082	0.579
CLV_PCSK_SKI1_1	157	161	PF00082	0.505
CLV_PCSK_SKI1_1	80	84	PF00082	0.547
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.441
DOC_MAPK_gen_1	74	84	PF00069	0.457
DOC_PP4_FxxP_1	97	100	PF00568	0.442
DOC_WW_Pin1_4	24	29	PF00397	0.638
LIG_14-3-3_CanoR_1	128	133	PF00244	0.581
LIG_14-3-3_CanoR_1	50	58	PF00244	0.467
LIG_14-3-3_CanoR_1	77	83	PF00244	0.437
LIG_Actin_WH2_2	19	35	PF00022	0.541
LIG_APCC_ABBA_1	103	108	PF00400	0.442
LIG_FHA_1	79	85	PF00498	0.414
LIG_HP1_1	101	105	PF01393	0.544
LIG_LIR_Apic_2	36	40	PF02991	0.439
LIG_LIR_Apic_2	94	100	PF02991	0.445
LIG_MYND_1	30	34	PF01753	0.498
LIG_SH2_CRK	153	157	PF00017	0.433
LIG_SH2_CRK	37	41	PF00017	0.448
LIG_SH2_STAT5	153	156	PF00017	0.430
LIG_SH2_STAT5	41	44	PF00017	0.442
LIG_SUMO_SIM_par_1	80	87	PF11976	0.445
LIG_WRC_WIRS_1	43	48	PF05994	0.483
MOD_CDK_SPxxK_3	24	31	PF00069	0.626
MOD_CK1_1	131	137	PF00069	0.468
MOD_CK1_1	170	176	PF00069	0.560
MOD_CK2_1	86	92	PF00069	0.442
MOD_GlcNHglycan	11	14	PF01048	0.506
MOD_GlcNHglycan	110	113	PF01048	0.415
MOD_GlcNHglycan	169	172	PF01048	0.528
MOD_GSK3_1	128	135	PF00069	0.447
MOD_NEK2_1	22	27	PF00069	0.638
MOD_NEK2_1	78	83	PF00069	0.430
MOD_NEK2_2	132	137	PF00069	0.561
MOD_PKA_2	108	114	PF00069	0.430
MOD_PKA_2	177	183	PF00069	0.697
MOD_PKA_2	49	55	PF00069	0.439
MOD_Plk_1	132	138	PF00069	0.456
MOD_Plk_1	70	76	PF00069	0.502
MOD_ProDKin_1	24	30	PF00069	0.638
TRG_ER_diArg_1	161	164	PF00400	0.486
TRG_ER_diArg_1	178	181	PF00400	0.614
TRG_ER_diArg_1	72	75	PF00400	0.467
TRG_NLS_MonoExtN_4	125	131	PF00514	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGK0	Leptomonas seymouri	85%	100%
A0A0S4JRU2	Bodo saltans	62%	100%
A0A1X0NLE2	Trypanosomatidae	72%	99%
A0A3Q8ILV7	Leishmania donovani	97%	100%
A0A3S5IQU3	Trypanosoma rangeli	77%	100%
A4HQD9	Leishmania braziliensis	92%	100%
A4IE30	Leishmania infantum	97%	100%
D0A3V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	88%
E9AU54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5B3P3	Trypanosoma cruzi	76%	100%