Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0D6_LEIMA

TriTrypDb:

LmjF.36.6240 , LMJLV39_360075400 , LMJSD75_360075600

Length:

759

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0D6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	388	392	PF00656	0.669
CLV_C14_Caspase3-7	598	602	PF00656	0.735
CLV_C14_Caspase3-7	691	695	PF00656	0.784
CLV_C14_Caspase3-7	747	751	PF00656	0.736
CLV_NRD_NRD_1	247	249	PF00675	0.490
CLV_NRD_NRD_1	504	506	PF00675	0.585
CLV_NRD_NRD_1	688	690	PF00675	0.832
CLV_NRD_NRD_1	723	725	PF00675	0.687
CLV_NRD_NRD_1	726	728	PF00675	0.676
CLV_PCSK_FUR_1	245	249	PF00082	0.495
CLV_PCSK_KEX2_1	247	249	PF00082	0.490
CLV_PCSK_KEX2_1	503	505	PF00082	0.759
CLV_PCSK_KEX2_1	688	690	PF00082	0.757
CLV_PCSK_KEX2_1	70	72	PF00082	0.664
CLV_PCSK_KEX2_1	723	725	PF00082	0.731
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.759
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.662
CLV_PCSK_PC7_1	66	72	PF00082	0.653
CLV_PCSK_SKI1_1	247	251	PF00082	0.565
CLV_PCSK_SKI1_1	256	260	PF00082	0.528
CLV_PCSK_SKI1_1	270	274	PF00082	0.478
CLV_PCSK_SKI1_1	466	470	PF00082	0.673
CLV_PCSK_SKI1_1	666	670	PF00082	0.621
CLV_PCSK_SKI1_1	688	692	PF00082	0.714
CLV_PCSK_SKI1_1	78	82	PF00082	0.449
DEG_SCF_FBW7_1	362	368	PF00400	0.600
DEG_SPOP_SBC_1	482	486	PF00917	0.827
DOC_ANK_TNKS_1	709	716	PF00023	0.578
DOC_CKS1_1	362	367	PF01111	0.717
DOC_CKS1_1	609	614	PF01111	0.810
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	554	560	PF00134	0.735
DOC_MAPK_gen_1	70	81	PF00069	0.519
DOC_MAPK_gen_1	707	714	PF00069	0.579
DOC_MAPK_MEF2A_6	74	81	PF00069	0.502
DOC_PP2B_LxvP_1	122	125	PF13499	0.678
DOC_PP2B_LxvP_1	207	210	PF13499	0.495
DOC_PP2B_LxvP_1	545	548	PF13499	0.823
DOC_USP7_MATH_1	377	381	PF00917	0.755
DOC_USP7_MATH_1	385	389	PF00917	0.727
DOC_USP7_MATH_1	393	397	PF00917	0.593
DOC_USP7_MATH_1	413	417	PF00917	0.775
DOC_USP7_MATH_1	482	486	PF00917	0.784
DOC_USP7_MATH_1	493	497	PF00917	0.628
DOC_USP7_MATH_1	508	512	PF00917	0.691
DOC_USP7_MATH_1	540	544	PF00917	0.749
DOC_USP7_MATH_1	656	660	PF00917	0.627
DOC_WW_Pin1_4	103	108	PF00397	0.565
DOC_WW_Pin1_4	327	332	PF00397	0.707
DOC_WW_Pin1_4	361	366	PF00397	0.753
DOC_WW_Pin1_4	408	413	PF00397	0.784
DOC_WW_Pin1_4	478	483	PF00397	0.828
DOC_WW_Pin1_4	521	526	PF00397	0.724
DOC_WW_Pin1_4	553	558	PF00397	0.700
DOC_WW_Pin1_4	608	613	PF00397	0.742
DOC_WW_Pin1_4	7	12	PF00397	0.500
LIG_14-3-3_CanoR_1	194	200	PF00244	0.499
LIG_14-3-3_CanoR_1	247	254	PF00244	0.583
LIG_14-3-3_CanoR_1	299	305	PF00244	0.553
LIG_14-3-3_CanoR_1	426	434	PF00244	0.727
LIG_14-3-3_CanoR_1	457	465	PF00244	0.654
LIG_14-3-3_CanoR_1	483	490	PF00244	0.660
LIG_14-3-3_CanoR_1	497	507	PF00244	0.616
LIG_14-3-3_CanoR_1	625	631	PF00244	0.755
LIG_BIR_II_1	1	5	PF00653	0.510
LIG_BIR_III_4	475	479	PF00653	0.702
LIG_BIR_III_4	732	736	PF00653	0.595
LIG_BRCT_BRCA1_1	1	5	PF00533	0.510
LIG_BRCT_BRCA1_2	1	7	PF00533	0.511
LIG_eIF4E_1	181	187	PF01652	0.560
LIG_FHA_1	107	113	PF00498	0.531
LIG_FHA_1	160	166	PF00498	0.641
LIG_FHA_1	204	210	PF00498	0.497
LIG_FHA_1	248	254	PF00498	0.591
LIG_FHA_1	271	277	PF00498	0.489
LIG_FHA_1	333	339	PF00498	0.689
LIG_FHA_1	409	415	PF00498	0.748
LIG_FHA_1	436	442	PF00498	0.763
LIG_FHA_1	513	519	PF00498	0.802
LIG_FHA_1	611	617	PF00498	0.628
LIG_FHA_1	630	636	PF00498	0.761
LIG_FHA_1	668	674	PF00498	0.751
LIG_FHA_2	127	133	PF00498	0.478
LIG_FHA_2	299	305	PF00498	0.601
LIG_FHA_2	689	695	PF00498	0.826
LIG_LIR_Gen_1	132	139	PF02991	0.506
LIG_LIR_Gen_1	383	393	PF02991	0.582
LIG_LIR_Gen_1	753	759	PF02991	0.702
LIG_LIR_Nem_3	132	137	PF02991	0.488
LIG_LIR_Nem_3	753	757	PF02991	0.709
LIG_MAD2	256	264	PF02301	0.649
LIG_MAD2	634	642	PF02301	0.739
LIG_MLH1_MIPbox_1	1	5	PF16413	0.510
LIG_NRBOX	27	33	PF00104	0.484
LIG_NRBOX	309	315	PF00104	0.629
LIG_PDZ_Class_2	754	759	PF00595	0.794
LIG_PTB_Apo_2	748	755	PF02174	0.799
LIG_REV1ctd_RIR_1	2	10	PF16727	0.503
LIG_RPA_C_Fungi	492	504	PF08784	0.738
LIG_SH2_GRB2like	440	443	PF00017	0.613
LIG_SH2_SRC	440	443	PF00017	0.613
LIG_SH2_STAP1	217	221	PF00017	0.437
LIG_SH2_STAT3	201	204	PF00017	0.507
LIG_SH2_STAT5	105	108	PF00017	0.553
LIG_SH2_STAT5	27	30	PF00017	0.573
LIG_SH2_STAT5	386	389	PF00017	0.586
LIG_SH2_STAT5	440	443	PF00017	0.613
LIG_SH2_STAT5	711	714	PF00017	0.580
LIG_SH3_1	359	365	PF00018	0.726
LIG_SH3_3	346	352	PF00018	0.673
LIG_SH3_3	359	365	PF00018	0.677
LIG_SH3_3	504	510	PF00018	0.711
LIG_SH3_3	560	566	PF00018	0.752
LIG_SH3_3	603	609	PF00018	0.718
LIG_SUMO_SIM_anti_2	657	662	PF11976	0.646
LIG_TRAF2_1	202	205	PF00917	0.445
LIG_TRAF2_1	301	304	PF00917	0.598
LIG_TRAF2_1	696	699	PF00917	0.778
LIG_TYR_ITIM	709	714	PF00017	0.579
LIG_UBA3_1	661	666	PF00899	0.606
MOD_CDK_SPK_2	478	483	PF00069	0.751
MOD_CK1_1	144	150	PF00069	0.696
MOD_CK1_1	277	283	PF00069	0.499
MOD_CK1_1	327	333	PF00069	0.800
MOD_CK1_1	35	41	PF00069	0.628
MOD_CK1_1	376	382	PF00069	0.779
MOD_CK1_1	435	441	PF00069	0.750
MOD_CK1_1	47	53	PF00069	0.703
MOD_CK1_1	477	483	PF00069	0.746
MOD_CK1_1	484	490	PF00069	0.761
MOD_CK1_1	543	549	PF00069	0.824
MOD_CK2_1	194	200	PF00069	0.536
MOD_CK2_1	298	304	PF00069	0.597
MOD_CK2_1	457	463	PF00069	0.671
MOD_CK2_1	508	514	PF00069	0.690
MOD_CK2_1	546	552	PF00069	0.706
MOD_GlcNHglycan	148	151	PF01048	0.772
MOD_GlcNHglycan	230	233	PF01048	0.554
MOD_GlcNHglycan	276	279	PF01048	0.474
MOD_GlcNHglycan	375	378	PF01048	0.766
MOD_GlcNHglycan	417	420	PF01048	0.785
MOD_GlcNHglycan	427	430	PF01048	0.831
MOD_GlcNHglycan	46	49	PF01048	0.763
MOD_GlcNHglycan	475	479	PF01048	0.737
MOD_GlcNHglycan	490	493	PF01048	0.571
MOD_GlcNHglycan	531	535	PF01048	0.838
MOD_GlcNHglycan	542	545	PF01048	0.705
MOD_GlcNHglycan	55	58	PF01048	0.649
MOD_GlcNHglycan	61	64	PF01048	0.328
MOD_GlcNHglycan	643	646	PF01048	0.830
MOD_GlcNHglycan	679	682	PF01048	0.746
MOD_GlcNHglycan	694	697	PF01048	0.775
MOD_GlcNHglycan	704	707	PF01048	0.734
MOD_GlcNHglycan	96	99	PF01048	0.568
MOD_GSK3_1	141	148	PF00069	0.680
MOD_GSK3_1	23	30	PF00069	0.688
MOD_GSK3_1	270	277	PF00069	0.536
MOD_GSK3_1	32	39	PF00069	0.598
MOD_GSK3_1	361	368	PF00069	0.807
MOD_GSK3_1	369	376	PF00069	0.762
MOD_GSK3_1	380	387	PF00069	0.641
MOD_GSK3_1	393	400	PF00069	0.707
MOD_GSK3_1	425	432	PF00069	0.818
MOD_GSK3_1	44	51	PF00069	0.794
MOD_GSK3_1	453	460	PF00069	0.737
MOD_GSK3_1	474	481	PF00069	0.814
MOD_GSK3_1	482	489	PF00069	0.753
MOD_GSK3_1	508	515	PF00069	0.726
MOD_GSK3_1	517	524	PF00069	0.747
MOD_GSK3_1	688	695	PF00069	0.751
MOD_GSK3_1	84	91	PF00069	0.444
MOD_LATS_1	726	732	PF00433	0.600
MOD_N-GLC_1	219	224	PF02516	0.573
MOD_N-GLC_1	332	337	PF02516	0.584
MOD_N-GLC_1	373	378	PF02516	0.825
MOD_N-GLC_1	435	440	PF02516	0.826
MOD_N-GLC_1	445	450	PF02516	0.684
MOD_N-GLC_1	521	526	PF02516	0.785
MOD_N-GLC_1	750	755	PF02516	0.746
MOD_NEK2_1	325	330	PF00069	0.716
MOD_NEK2_1	373	378	PF00069	0.821
MOD_NEK2_1	702	707	PF00069	0.738
MOD_NEK2_1	81	86	PF00069	0.492
MOD_NEK2_2	265	270	PF00069	0.629
MOD_NEK2_2	377	382	PF00069	0.734
MOD_NEK2_2	623	628	PF00069	0.628
MOD_PIKK_1	48	54	PF00454	0.705
MOD_PIKK_1	558	564	PF00454	0.585
MOD_PIKK_1	629	635	PF00454	0.713
MOD_PIKK_1	697	703	PF00454	0.697
MOD_PKA_1	247	253	PF00069	0.487
MOD_PKA_1	688	694	PF00069	0.711
MOD_PKA_1	70	76	PF00069	0.547
MOD_PKA_1	728	734	PF00069	0.592
MOD_PKA_2	195	201	PF00069	0.498
MOD_PKA_2	247	253	PF00069	0.437
MOD_PKA_2	298	304	PF00069	0.549
MOD_PKA_2	425	431	PF00069	0.728
MOD_PKA_2	482	488	PF00069	0.706
MOD_PKA_2	688	694	PF00069	0.725
MOD_PKA_2	70	76	PF00069	0.643
MOD_PKA_2	81	87	PF00069	0.454
MOD_PKA_2	94	100	PF00069	0.284
MOD_PKB_1	245	253	PF00069	0.490
MOD_Plk_1	265	271	PF00069	0.520
MOD_Plk_1	39	45	PF00069	0.742
MOD_Plk_1	581	587	PF00069	0.794
MOD_Plk_1	656	662	PF00069	0.622
MOD_Plk_2-3	750	756	PF00069	0.698
MOD_Plk_4	27	33	PF00069	0.578
MOD_Plk_4	293	299	PF00069	0.482
MOD_Plk_4	436	442	PF00069	0.639
MOD_Plk_4	656	662	PF00069	0.626
MOD_Plk_4	88	94	PF00069	0.445
MOD_ProDKin_1	103	109	PF00069	0.569
MOD_ProDKin_1	327	333	PF00069	0.710
MOD_ProDKin_1	361	367	PF00069	0.754
MOD_ProDKin_1	408	414	PF00069	0.787
MOD_ProDKin_1	478	484	PF00069	0.828
MOD_ProDKin_1	521	527	PF00069	0.723
MOD_ProDKin_1	553	559	PF00069	0.699
MOD_ProDKin_1	608	614	PF00069	0.744
MOD_ProDKin_1	7	13	PF00069	0.501
MOD_SUMO_for_1	202	205	PF00179	0.503
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.565
TRG_ENDOCYTIC_2	386	389	PF00928	0.586
TRG_ENDOCYTIC_2	711	714	PF00928	0.580
TRG_ER_diArg_1	193	196	PF00400	0.496
TRG_ER_diArg_1	245	248	PF00400	0.506
TRG_ER_diArg_1	504	506	PF00400	0.585
TRG_ER_diArg_1	687	689	PF00400	0.758
TRG_NLS_MonoExtC_3	726	732	PF00514	0.834
TRG_NLS_MonoExtN_4	724	731	PF00514	0.715
TRG_Pf-PMV_PEXEL_1	565	569	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	628	633	PF00026	0.816

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAD4	Leptomonas seymouri	42%	100%
A0A3Q8IJC2	Leishmania donovani	91%	100%
A4HQE4	Leishmania braziliensis	67%	100%
A4IE35	Leishmania infantum	91%	100%
E9AU59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%