Putative small G-protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small G-protein, putative

Species:

Leishmania major

UniProt:

Q4Q0D5_LEIMA

TriTrypDb:

LmjF.36.6250 , LMJLV39_360075500 , LMJSD75_360075700

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005773	vacuole	5	2
GO:0005776	autophagosome	6	2
GO:0010008	endosome membrane	5	2
GO:0012506	vesicle membrane	4	2
GO:0016020	membrane	2	2
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0035869	ciliary transition zone	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097014	ciliary plasm	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0D5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0D5

Function

Biological processes
Term	Name	Level	Count
GO:0000045	autophagosome assembly	6	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006996	organelle organization	4	2
GO:0007033	vacuole organization	5	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0070925	organelle assembly	5	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:1905037	autophagosome organization	6	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0003924	GTPase activity	7	10
GO:0005488	binding	1	10
GO:0005525	GTP binding	5	10
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0019001	guanyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032561	guanyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	26	28	PF00675	0.304
CLV_NRD_NRD_1	37	39	PF00675	0.338
CLV_PCSK_KEX2_1	26	28	PF00082	0.293
CLV_PCSK_KEX2_1	290	292	PF00082	0.744
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.683
CLV_PCSK_SKI1_1	160	164	PF00082	0.224
CLV_PCSK_SKI1_1	253	257	PF00082	0.628
CLV_PCSK_SKI1_1	290	294	PF00082	0.730
CLV_PCSK_SKI1_1	48	52	PF00082	0.318
CLV_PCSK_SKI1_1	60	64	PF00082	0.313
DEG_APCC_DBOX_1	94	102	PF00400	0.224
DEG_Nend_Nbox_1	1	3	PF02207	0.517
DEG_SPOP_SBC_1	228	232	PF00917	0.691
DOC_MAPK_gen_1	53	63	PF00069	0.224
DOC_MAPK_MEF2A_6	56	63	PF00069	0.224
DOC_PP2B_LxvP_1	144	147	PF13499	0.316
DOC_USP7_MATH_1	198	202	PF00917	0.785
DOC_USP7_MATH_1	203	207	PF00917	0.719
DOC_USP7_MATH_1	228	232	PF00917	0.751
DOC_USP7_MATH_1	237	241	PF00917	0.749
DOC_USP7_UBL2_3	289	293	PF12436	0.673
DOC_USP7_UBL2_3	56	60	PF12436	0.224
DOC_WW_Pin1_4	230	235	PF00397	0.774
LIG_14-3-3_CanoR_1	150	157	PF00244	0.316
LIG_14-3-3_CanoR_1	291	297	PF00244	0.719
LIG_14-3-3_CanoR_1	53	59	PF00244	0.352
LIG_FHA_1	114	120	PF00498	0.388
LIG_FHA_1	20	26	PF00498	0.316
LIG_FHA_2	120	126	PF00498	0.316
LIG_FHA_2	131	137	PF00498	0.316
LIG_FHA_2	207	213	PF00498	0.716
LIG_FHA_2	275	281	PF00498	0.715
LIG_Integrin_RGD_1	30	32	PF01839	0.380
LIG_LIR_Gen_1	70	80	PF02991	0.303
LIG_LIR_Gen_1	89	98	PF02991	0.342
LIG_LIR_Nem_3	70	75	PF02991	0.303
LIG_LIR_Nem_3	89	93	PF02991	0.342
LIG_PDZ_Class_1	292	297	PF00595	0.634
LIG_SUMO_SIM_par_1	10	16	PF11976	0.341
LIG_TRAF2_1	67	70	PF00917	0.316
LIG_UBA3_1	98	105	PF00899	0.443
LIG_WRC_WIRS_1	87	92	PF05994	0.341
MOD_CAAXbox	294	297	PF01239	0.610
MOD_CK1_1	206	212	PF00069	0.679
MOD_CK1_1	218	224	PF00069	0.496
MOD_CK1_1	240	246	PF00069	0.683
MOD_CK1_1	254	260	PF00069	0.732
MOD_CK1_1	54	60	PF00069	0.319
MOD_CK1_1	97	103	PF00069	0.302
MOD_CK2_1	130	136	PF00069	0.316
MOD_CK2_1	139	145	PF00069	0.316
MOD_CK2_1	206	212	PF00069	0.719
MOD_CK2_1	274	280	PF00069	0.736
MOD_Cter_Amidation	192	195	PF01082	0.536
MOD_GlcNHglycan	151	154	PF01048	0.384
MOD_GlcNHglycan	172	176	PF01048	0.525
MOD_GlcNHglycan	200	203	PF01048	0.730
MOD_GSK3_1	194	201	PF00069	0.670
MOD_GSK3_1	203	210	PF00069	0.660
MOD_GSK3_1	237	244	PF00069	0.720
MOD_GSK3_1	262	269	PF00069	0.726
MOD_N-GLC_1	238	243	PF02516	0.700
MOD_N-GLC_1	262	267	PF02516	0.767
MOD_N-GLC_1	274	279	PF02516	0.663
MOD_NEK2_1	119	124	PF00069	0.316
MOD_NEK2_1	149	154	PF00069	0.307
MOD_NEK2_1	163	168	PF00069	0.326
MOD_NEK2_1	292	297	PF00069	0.666
MOD_NEK2_1	51	56	PF00069	0.334
MOD_NEK2_1	63	68	PF00069	0.283
MOD_NEK2_1	88	93	PF00069	0.341
MOD_PIKK_1	139	145	PF00454	0.330
MOD_PIKK_1	73	79	PF00454	0.316
MOD_PK_1	107	113	PF00069	0.416
MOD_PKA_1	194	200	PF00069	0.534
MOD_PKA_2	149	155	PF00069	0.316
MOD_PKA_2	37	43	PF00069	0.373
MOD_PKA_2	52	58	PF00069	0.127
MOD_PKA_2	94	100	PF00069	0.416
MOD_Plk_1	238	244	PF00069	0.689
MOD_Plk_1	274	280	PF00069	0.598
MOD_Plk_4	54	60	PF00069	0.224
MOD_Plk_4	94	100	PF00069	0.307
MOD_ProDKin_1	230	236	PF00069	0.774
TRG_DiLeu_BaEn_2	46	52	PF01217	0.341
TRG_ER_diArg_1	25	27	PF00400	0.293
TRG_NLS_MonoCore_2	287	292	PF00514	0.586
TRG_NLS_MonoExtC_3	288	293	PF00514	0.534
TRG_NLS_MonoExtN_4	288	294	PF00514	0.534
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.224

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I1	Leptomonas seymouri	31%	100%
A0A0N1HYV5	Leptomonas seymouri	31%	100%
A0A0N1IC49	Leptomonas seymouri	60%	95%
A0A0N1IJ36	Leptomonas seymouri	29%	100%
A0A0S4IJB7	Bodo saltans	32%	100%
A0A0S4IM06	Bodo saltans	29%	100%
A0A0S4J1G8	Bodo saltans	31%	100%
A0A0S4J9T5	Bodo saltans	25%	100%
A0A0S4KLN8	Bodo saltans	27%	100%
A0A1X0NKS6	Trypanosomatidae	27%	100%
A0A1X0NLK7	Trypanosomatidae	61%	100%
A0A1X0NQB8	Trypanosomatidae	30%	100%
A0A1X0NVM5	Trypanosomatidae	30%	100%
A0A3Q8I8T8	Leishmania donovani	32%	100%
A0A3Q8ICX9	Leishmania donovani	33%	100%
A0A3Q8ID64	Leishmania donovani	33%	100%
A0A3Q8IE68	Leishmania donovani	33%	100%
A0A3Q8IK84	Leishmania donovani	34%	100%
A0A3Q8IRV7	Leishmania donovani	85%	100%
A0A3R7KA22	Trypanosoma rangeli	62%	100%
A0A3R7KBN3	Trypanosoma rangeli	30%	100%
A0A3R7LXW6	Trypanosoma rangeli	28%	100%
A0A3R7RHV7	Trypanosoma rangeli	31%	100%
A0A3S5H5Y5	Leishmania donovani	31%	100%
A0A3S5H6H3	Leishmania donovani	29%	100%
A0A3S7WRA9	Leishmania donovani	34%	100%
A0A3S7WUY8	Leishmania donovani	29%	100%
A0A3S7WV84	Leishmania donovani	29%	100%
A0A3S7X3D1	Leishmania donovani	32%	100%
A0A3S7X5J2	Leishmania donovani	31%	100%
A1KXP5	Leishmania donovani	29%	100%
A4H506	Leishmania braziliensis	29%	100%
A4H679	Leishmania braziliensis	31%	100%
A4H6A4	Leishmania braziliensis	30%	100%
A4H6A5	Leishmania braziliensis	28%	100%
A4H9M3	Leishmania braziliensis	29%	100%
A4HEE8	Leishmania braziliensis	30%	100%
A4HFK0	Leishmania braziliensis	32%	100%
A4HHR8	Leishmania braziliensis	29%	100%
A4HIB4	Leishmania braziliensis	28%	100%
A4HK33	Leishmania braziliensis	33%	100%
A4HKH2	Leishmania braziliensis	31%	100%
A4HKJ3	Leishmania braziliensis	33%	100%
A4HLP5	Leishmania braziliensis	33%	100%
A4HQE5	Leishmania braziliensis	66%	99%
A4HT72	Leishmania infantum	31%	100%
A4HUK3	Leishmania infantum	34%	100%
A4HUM8	Leishmania infantum	32%	100%
A4HUM9	Leishmania infantum	29%	100%
A4HVF7	Leishmania infantum	28%	100%
A4HXY7	Leishmania infantum	29%	100%
A4I1I6	Leishmania infantum	30%	100%
A4I5J8	Leishmania infantum	32%	100%
A4I7N3	Leishmania infantum	33%	100%
A4I7Z9	Leishmania infantum	31%	100%
A4I825	Leishmania infantum	33%	100%
A4I946	Leishmania infantum	34%	100%
A4IC86	Leishmania infantum	85%	100%
B1A5Z4	Leishmania donovani	30%	100%
B6DT76	Bodo saltans	31%	100%
C9ZVM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZVR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZVS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E2RQ15	Canis lupus familiaris	31%	100%
E9AD53	Leishmania major	33%	100%
E9AGQ4	Leishmania infantum	29%	100%
E9AHE8	Leishmania infantum	33%	100%
E9AL68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ANA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9ANC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9ANC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AP56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ARM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ARQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AU60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9AXM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AYX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B0U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B2H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B2W1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B2Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B420	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
O00194	Homo sapiens	33%	100%
O24466	Arabidopsis thaliana	31%	100%
O35509	Rattus norvegicus	31%	100%
O49513	Arabidopsis thaliana	31%	100%
O97572	Oryctolagus cuniculus	32%	100%
P09527	Rattus norvegicus	30%	100%
P17610	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P19892	Arabidopsis thaliana	29%	100%
P22129	Diplobatis ommata	32%	100%
P25228	Drosophila melanogaster	33%	100%
P35288	Mus musculus	39%	100%
P35293	Mus musculus	28%	100%
P35294	Mus musculus	33%	100%
P36017	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P36409	Dictyostelium discoideum	29%	100%
P41916	Arabidopsis thaliana	30%	100%
P46629	Oryctolagus cuniculus	32%	100%
P46638	Mus musculus	31%	100%
P51149	Homo sapiens	30%	100%
P51150	Mus musculus	30%	100%
P51151	Homo sapiens	33%	100%
P53994	Mus musculus	31%	100%
P59279	Mus musculus	30%	100%
P61028	Mus musculus	31%	100%
P61106	Homo sapiens	31%	100%
P61107	Rattus norvegicus	31%	100%
P70550	Rattus norvegicus	31%	100%
Q0WQN4	Arabidopsis thaliana	32%	100%
Q15907	Homo sapiens	31%	100%
Q1PEX3	Arabidopsis thaliana	32%	100%
Q38922	Arabidopsis thaliana	30%	100%
Q39570	Chlamydomonas reinhardtii	30%	100%
Q3MHP2	Bos taurus	31%	100%
Q3T0F5	Bos taurus	34%	100%
Q4Q404	Leishmania major	33%	100%
Q4Q573	Leishmania major	33%	100%
Q4Q595	Leishmania major	31%	100%
Q4Q5N4	Leishmania major	33%	100%
Q4Q7C3	Leishmania major	31%	100%
Q4Q9V1	Leishmania major	30%	100%
Q4QDS9	Leishmania major	29%	100%
Q4QGD2	Leishmania major	31%	100%
Q4QH97	Leishmania major	29%	100%
Q4QH98	Leishmania major	32%	100%
Q4QHC3	Leishmania major	33%	100%
Q4QIN6	Leishmania major	31%	100%
Q52NJ6	Sus scrofa	31%	100%
Q54QR3	Dictyostelium discoideum	32%	100%
Q550H6	Dictyostelium discoideum	31%	100%
Q58DW6	Bos taurus	31%	100%
Q5R4W9	Pongo abelii	34%	100%
Q5R8Z8	Pongo abelii	31%	100%
Q5R9Y4	Pongo abelii	30%	100%
Q5ZKU5	Gallus gallus	31%	100%
Q63481	Rattus norvegicus	30%	100%
Q6DHC1	Danio rerio	28%	100%
Q8T6H9	Leishmania braziliensis	30%	100%
Q8WUD1	Homo sapiens	30%	100%
Q91V41	Mus musculus	31%	100%
Q91YQ1	Mus musculus	30%	100%
Q99P58	Mus musculus	32%	100%
Q99P74	Rattus norvegicus	32%	100%
Q99P75	Rattus norvegicus	32%	100%
Q9FJH0	Arabidopsis thaliana	29%	100%
Q9LZD4	Arabidopsis thaliana	33%	100%
Q9N2P5	Leishmania major	30%	100%
Q9NP90	Homo sapiens	34%	100%
Q9R0M6	Mus musculus	31%	100%
Q9S810	Arabidopsis thaliana	32%	100%
Q9SID8	Arabidopsis thaliana	30%	100%
Q9SIP0	Arabidopsis thaliana	30%	100%
Q9ULC3	Homo sapiens	39%	100%
Q9WTL2	Mus musculus	32%	100%
V5BJM4	Trypanosoma cruzi	30%	100%
V5D1K6	Trypanosoma cruzi	62%	100%