Putative carboxypeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carboxypeptidase, putative

Species:

Leishmania major

UniProt:

Q4Q0D4_LEIMA

TriTrypDb:

LmjF.36.6260 , LMJLV39_360075600 , LMJSD75_360075800

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 9

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q0D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0D4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	25
GO:0006807	nitrogen compound metabolic process	2	25
GO:0008152	metabolic process	1	25
GO:0019538	protein metabolic process	3	25
GO:0043170	macromolecule metabolic process	3	25
GO:0044238	primary metabolic process	2	25
GO:0071704	organic substance metabolic process	2	25
GO:1901564	organonitrogen compound metabolic process	3	25
GO:0006518	peptide metabolic process	4	1
GO:0043603	amide metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0004180	carboxypeptidase activity	5	25
GO:0004181	metallocarboxypeptidase activity	6	25
GO:0008233	peptidase activity	3	25
GO:0008235	metalloexopeptidase activity	5	25
GO:0008237	metallopeptidase activity	4	25
GO:0008238	exopeptidase activity	4	25
GO:0016787	hydrolase activity	2	25
GO:0140096	catalytic activity, acting on a protein	2	25
GO:0016853	isomerase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.361
CLV_NRD_NRD_1	252	254	PF00675	0.439
CLV_NRD_NRD_1	355	357	PF00675	0.520
CLV_PCSK_KEX2_1	17	19	PF00082	0.439
CLV_PCSK_KEX2_1	355	357	PF00082	0.491
CLV_PCSK_PC7_1	351	357	PF00082	0.433
CLV_PCSK_SKI1_1	101	105	PF00082	0.446
CLV_PCSK_SKI1_1	175	179	PF00082	0.398
CLV_PCSK_SKI1_1	196	200	PF00082	0.444
CLV_PCSK_SKI1_1	378	382	PF00082	0.485
CLV_PCSK_SKI1_1	394	398	PF00082	0.397
CLV_Separin_Metazoa	14	18	PF03568	0.236
DEG_APCC_DBOX_1	315	323	PF00400	0.290
DEG_SPOP_SBC_1	399	403	PF00917	0.420
DOC_CKS1_1	117	122	PF01111	0.290
DOC_CKS1_1	232	237	PF01111	0.386
DOC_CKS1_1	370	375	PF01111	0.427
DOC_CYCLIN_RxL_1	172	180	PF00134	0.391
DOC_CYCLIN_RxL_1	391	401	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	347	350	PF00134	0.387
DOC_MAPK_gen_1	304	311	PF00069	0.355
DOC_PP2B_LxvP_1	347	350	PF13499	0.387
DOC_PP2B_LxvP_1	388	391	PF13499	0.382
DOC_PP2B_LxvP_1	408	411	PF13499	0.333
DOC_USP7_MATH_1	399	403	PF00917	0.420
DOC_USP7_MATH_1	61	65	PF00917	0.325
DOC_WW_Pin1_4	116	121	PF00397	0.290
DOC_WW_Pin1_4	166	171	PF00397	0.474
DOC_WW_Pin1_4	231	236	PF00397	0.380
DOC_WW_Pin1_4	369	374	PF00397	0.427
DOC_WW_Pin1_4	64	69	PF00397	0.481
LIG_14-3-3_CanoR_1	131	140	PF00244	0.277
LIG_14-3-3_CanoR_1	163	167	PF00244	0.481
LIG_14-3-3_CanoR_1	21	26	PF00244	0.440
LIG_14-3-3_CanoR_1	364	373	PF00244	0.669
LIG_14-3-3_CanoR_1	398	408	PF00244	0.402
LIG_Actin_WH2_2	45	62	PF00022	0.322
LIG_BRCT_BRCA1_1	225	229	PF00533	0.315
LIG_BRCT_BRCA1_1	417	421	PF00533	0.420
LIG_CaM_NSCaTE_8	361	368	PF13499	0.403
LIG_Clathr_ClatBox_1	49	53	PF01394	0.290
LIG_CSL_BTD_1	41	44	PF09270	0.382
LIG_deltaCOP1_diTrp_1	136	142	PF00928	0.410
LIG_deltaCOP1_diTrp_1	324	332	PF00928	0.355
LIG_FHA_1	172	178	PF00498	0.469
LIG_FHA_1	212	218	PF00498	0.447
LIG_FHA_1	232	238	PF00498	0.364
LIG_FHA_1	342	348	PF00498	0.321
LIG_FHA_1	370	376	PF00498	0.596
LIG_FHA_1	399	405	PF00498	0.590
LIG_FHA_2	178	184	PF00498	0.427
LIG_FHA_2	264	270	PF00498	0.264
LIG_FHA_2	43	49	PF00498	0.391
LIG_GBD_Chelix_1	7	15	PF00786	0.200
LIG_LIR_Apic_2	165	170	PF02991	0.472
LIG_LIR_Apic_2	231	235	PF02991	0.355
LIG_LIR_Gen_1	67	75	PF02991	0.457
LIG_LIR_Gen_1	86	97	PF02991	0.244
LIG_LIR_Nem_3	226	232	PF02991	0.340
LIG_LIR_Nem_3	418	422	PF02991	0.429
LIG_LIR_Nem_3	67	72	PF02991	0.469
LIG_LIR_Nem_3	86	92	PF02991	0.201
LIG_NRBOX	11	17	PF00104	0.351
LIG_Pex14_1	327	331	PF04695	0.433
LIG_REV1ctd_RIR_1	419	427	PF16727	0.440
LIG_SH2_CRK	69	73	PF00017	0.508
LIG_SH2_NCK_1	147	151	PF00017	0.290
LIG_SH2_SRC	147	150	PF00017	0.290
LIG_SH2_SRC	89	92	PF00017	0.419
LIG_SH2_STAP1	173	177	PF00017	0.497
LIG_SH2_STAP1	273	277	PF00017	0.390
LIG_SH2_STAP1	69	73	PF00017	0.340
LIG_SH2_STAT5	173	176	PF00017	0.463
LIG_SH2_STAT5	232	235	PF00017	0.403
LIG_SH2_STAT5	263	266	PF00017	0.386
LIG_SH2_STAT5	338	341	PF00017	0.355
LIG_SH3_2	373	378	PF14604	0.426
LIG_SH3_3	292	298	PF00018	0.264
LIG_SH3_3	330	336	PF00018	0.454
LIG_SH3_3	346	352	PF00018	0.492
LIG_SH3_3	370	376	PF00018	0.426
LIG_SUMO_SIM_par_1	48	53	PF11976	0.290
LIG_TRAF2_1	45	48	PF00917	0.351
LIG_TYR_ITSM	85	92	PF00017	0.200
LIG_UBA3_1	11	19	PF00899	0.200
LIG_WRC_WIRS_1	416	421	PF05994	0.416
LIG_WW_3	348	352	PF00397	0.413
MOD_CDK_SPxxK_3	116	123	PF00069	0.290
MOD_CDK_SPxxK_3	231	238	PF00069	0.264
MOD_CK1_1	363	369	PF00069	0.435
MOD_CK1_1	415	421	PF00069	0.412
MOD_CK1_1	64	70	PF00069	0.376
MOD_CK2_1	110	116	PF00069	0.364
MOD_CK2_1	177	183	PF00069	0.486
MOD_CK2_1	42	48	PF00069	0.384
MOD_GlcNHglycan	207	210	PF01048	0.420
MOD_GlcNHglycan	225	228	PF01048	0.276
MOD_GlcNHglycan	366	369	PF01048	0.545
MOD_GlcNHglycan	63	66	PF01048	0.318
MOD_GSK3_1	112	119	PF00069	0.290
MOD_GSK3_1	162	169	PF00069	0.458
MOD_GSK3_1	177	184	PF00069	0.473
MOD_GSK3_1	259	266	PF00069	0.441
MOD_GSK3_1	360	367	PF00069	0.429
MOD_GSK3_1	400	407	PF00069	0.395
MOD_GSK3_1	411	418	PF00069	0.368
MOD_GSK3_1	60	67	PF00069	0.447
MOD_N-GLC_1	171	176	PF02516	0.470
MOD_NEK2_1	177	182	PF00069	0.365
MOD_NEK2_1	404	409	PF00069	0.371
MOD_NEK2_1	412	417	PF00069	0.368
MOD_PIKK_1	211	217	PF00454	0.431
MOD_PIKK_1	341	347	PF00454	0.200
MOD_PIKK_1	6	12	PF00454	0.509
MOD_PKA_2	162	168	PF00069	0.346
MOD_PKA_2	20	26	PF00069	0.439
MOD_PKA_2	363	369	PF00069	0.429
MOD_PKB_1	58	66	PF00069	0.417
MOD_Plk_1	110	116	PF00069	0.285
MOD_Plk_4	162	168	PF00069	0.447
MOD_Plk_4	213	219	PF00069	0.326
MOD_Plk_4	259	265	PF00069	0.417
MOD_Plk_4	84	90	PF00069	0.362
MOD_ProDKin_1	116	122	PF00069	0.290
MOD_ProDKin_1	166	172	PF00069	0.474
MOD_ProDKin_1	231	237	PF00069	0.380
MOD_ProDKin_1	369	375	PF00069	0.426
MOD_ProDKin_1	64	70	PF00069	0.481
MOD_SUMO_for_1	187	190	PF00179	0.276
MOD_SUMO_rev_2	86	94	PF00179	0.398
TRG_DiLeu_BaEn_1	213	218	PF01217	0.290
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.391
TRG_ENDOCYTIC_2	100	103	PF00928	0.436
TRG_ENDOCYTIC_2	69	72	PF00928	0.347
TRG_ENDOCYTIC_2	89	92	PF00928	0.483
TRG_ER_diArg_1	16	18	PF00400	0.438
TRG_NES_CRM1_1	231	244	PF08389	0.290
TRG_NLS_MonoExtN_4	17	22	PF00514	0.245
TRG_Pf-PMV_PEXEL_1	131	136	PF00026	0.340
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.340
TRG_PTS2	1	29	PF00400	0.213

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ28	Bodo saltans	45%	95%
A0A1X0NY67	Trypanosomatidae	51%	84%
A0A1X0P441	Trypanosomatidae	52%	85%
A0A1X0P598	Trypanosomatidae	55%	85%
A0A3Q8IBW2	Leishmania donovani	93%	85%
A0A3Q8IJY8	Leishmania donovani	89%	94%
A0A3Q8IU74	Leishmania donovani	51%	86%
A0A3S7WSA3	Leishmania donovani	51%	85%
A0A422P042	Trypanosoma rangeli	49%	85%
A0A422P4R1	Trypanosoma rangeli	52%	85%
A4H716	Leishmania braziliensis	49%	85%
A4HLW4	Leishmania braziliensis	48%	86%
A4HVE5	Leishmania infantum	51%	85%
A4HVW0	Leishmania infantum	93%	85%
A4I993	Leishmania infantum	51%	86%
A4IC85	Leishmania infantum	88%	100%
D0A656	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	85%
E9AP43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	85%
E9B493	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	86%
P42663	Thermus aquaticus	33%	84%
P50848	Bacillus subtilis (strain 168)	34%	85%
Q4Q3T3	Leishmania major	50%	86%
Q4QFW7	Leishmania major	96%	85%
Q4QGE5	Leishmania major	51%	85%
Q5SLM3	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	33%	84%
Q8U3L0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	31%	86%
V5DQA0	Trypanosoma cruzi	52%	85%