Glucose transporter, lmgt3

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glucose transporter 3

Species:

Leishmania major

UniProt:

Q4Q0D2_LEIMA

TriTrypDb:

LmjF.36.6280 , LMJLV39_000012600 , LMJSD75_360076100

Length:

568

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 40
NetGPI	no	yes: 0, no: 40

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	4
GO:0016020	membrane	2	41
GO:0051286	cell tip	3	4
GO:0060187	cell pole	2	4
GO:0110165	cellular anatomical entity	1	41

Expansion

Sequence features

Q4Q0D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0D2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0008643	carbohydrate transport	5	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16
GO:0071702	organic substance transport	4	16
GO:0009987	cellular process	1	1
GO:0015749	monosaccharide transmembrane transport	4	1
GO:0034219	carbohydrate transmembrane transport	3	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	41
GO:0015144	carbohydrate transmembrane transporter activity	3	15
GO:0022857	transmembrane transporter activity	2	41
GO:0015145	monosaccharide transmembrane transporter activity	5	2
GO:0015149	hexose transmembrane transporter activity	6	2
GO:0051119	sugar transmembrane transporter activity	4	2
GO:0005353	fructose transmembrane transporter activity	7	1
GO:0005354	galactose transmembrane transporter activity	7	1
GO:0015578	mannose transmembrane transporter activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	540	544	PF00656	0.668
CLV_NRD_NRD_1	114	116	PF00675	0.560
CLV_PCSK_KEX2_1	114	116	PF00082	0.483
CLV_PCSK_KEX2_1	246	248	PF00082	0.334
CLV_PCSK_KEX2_1	541	543	PF00082	0.478
CLV_PCSK_KEX2_1	546	548	PF00082	0.520
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.346
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.478
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.520
CLV_PCSK_PC7_1	542	548	PF00082	0.408
CLV_PCSK_SKI1_1	403	407	PF00082	0.263
CLV_PCSK_SKI1_1	45	49	PF00082	0.337
DEG_ODPH_VHL_1	373	384	PF01847	0.346
DOC_CYCLIN_RxL_1	400	410	PF00134	0.534
DOC_MAPK_gen_1	244	253	PF00069	0.482
DOC_MAPK_HePTP_8	216	228	PF00069	0.434
DOC_MAPK_MEF2A_6	186	194	PF00069	0.480
DOC_MAPK_MEF2A_6	219	228	PF00069	0.318
DOC_MAPK_MEF2A_6	244	253	PF00069	0.492
DOC_MAPK_NFAT4_5	219	227	PF00069	0.387
DOC_PP1_RVXF_1	184	190	PF00149	0.474
DOC_PP4_FxxP_1	175	178	PF00568	0.454
DOC_PP4_FxxP_1	534	537	PF00568	0.347
DOC_SPAK_OSR1_1	219	223	PF12202	0.416
DOC_USP7_MATH_1	178	182	PF00917	0.472
DOC_USP7_MATH_1	427	431	PF00917	0.344
DOC_USP7_UBL2_3	432	436	PF12436	0.298
DOC_USP7_UBL2_3	541	545	PF12436	0.679
LIG_14-3-3_CanoR_1	11	16	PF00244	0.778
LIG_14-3-3_CanoR_1	114	120	PF00244	0.353
LIG_14-3-3_CanoR_1	137	143	PF00244	0.314
LIG_14-3-3_CanoR_1	186	190	PF00244	0.492
LIG_14-3-3_CanoR_1	474	479	PF00244	0.474
LIG_14-3-3_CanoR_1	84	90	PF00244	0.362
LIG_BIR_II_1	1	5	PF00653	0.767
LIG_BIR_III_2	34	38	PF00653	0.554
LIG_BRCT_BRCA1_1	157	161	PF00533	0.283
LIG_BRCT_BRCA1_1	273	277	PF00533	0.303
LIG_BRCT_BRCA1_1	295	299	PF00533	0.454
LIG_BRCT_BRCA1_1	396	400	PF00533	0.419
LIG_BRCT_BRCA1_1	558	562	PF00533	0.514
LIG_BRCT_BRCA1_1	59	63	PF00533	0.347
LIG_BRCT_BRCA1_1	67	71	PF00533	0.286
LIG_deltaCOP1_diTrp_1	211	220	PF00928	0.325
LIG_FHA_1	219	225	PF00498	0.334
LIG_FHA_1	246	252	PF00498	0.489
LIG_FHA_1	256	262	PF00498	0.248
LIG_FHA_1	301	307	PF00498	0.422
LIG_FHA_1	349	355	PF00498	0.349
LIG_FHA_1	440	446	PF00498	0.368
LIG_FHA_1	480	486	PF00498	0.375
LIG_FHA_1	496	502	PF00498	0.277
LIG_FHA_2	128	134	PF00498	0.343
LIG_GBD_Chelix_1	179	187	PF00786	0.445
LIG_GBD_Chelix_1	48	56	PF00786	0.431
LIG_LIR_Apic_2	173	178	PF02991	0.454
LIG_LIR_Gen_1	141	150	PF02991	0.320
LIG_LIR_Gen_1	188	197	PF02991	0.339
LIG_LIR_Gen_1	211	220	PF02991	0.312
LIG_LIR_Gen_1	296	306	PF02991	0.380
LIG_LIR_Gen_1	332	343	PF02991	0.485
LIG_LIR_Gen_1	477	486	PF02991	0.280
LIG_LIR_Nem_3	188	192	PF02991	0.341
LIG_LIR_Nem_3	209	215	PF02991	0.253
LIG_LIR_Nem_3	296	302	PF02991	0.361
LIG_LIR_Nem_3	332	336	PF02991	0.571
LIG_LIR_Nem_3	477	481	PF02991	0.403
LIG_LIR_Nem_3	60	66	PF02991	0.329
LIG_LYPXL_S_1	425	429	PF13949	0.329
LIG_LYPXL_yS_3	426	429	PF13949	0.267
LIG_NRBOX	186	192	PF00104	0.561
LIG_NRBOX	297	303	PF00104	0.423
LIG_Pex14_2	295	299	PF04695	0.444
LIG_Pex14_2	408	412	PF04695	0.434
LIG_Pex14_2	447	451	PF04695	0.282
LIG_Pex14_2	467	471	PF04695	0.479
LIG_Pex14_2	534	538	PF04695	0.369
LIG_PTB_Apo_2	488	495	PF02174	0.317
LIG_PTB_Phospho_1	488	494	PF10480	0.357
LIG_SH2_CRK	67	71	PF00017	0.288
LIG_SH2_GRB2like	119	122	PF00017	0.179
LIG_SH2_NCK_1	119	123	PF00017	0.276
LIG_SH2_STAP1	67	71	PF00017	0.311
LIG_SH2_STAT3	236	239	PF00017	0.495
LIG_SH2_STAT5	105	108	PF00017	0.323
LIG_SH2_STAT5	117	120	PF00017	0.325
LIG_SH2_STAT5	236	239	PF00017	0.446
LIG_SH2_STAT5	335	338	PF00017	0.602
LIG_SH2_STAT5	398	401	PF00017	0.530
LIG_SH2_STAT5	460	463	PF00017	0.371
LIG_SH3_3	228	234	PF00018	0.311
LIG_SH3_3	421	427	PF00018	0.307
LIG_SH3_3	489	495	PF00018	0.318
LIG_SUMO_SIM_anti_2	300	306	PF11976	0.311
LIG_SxIP_EBH_1	118	131	PF03271	0.138
LIG_TRFH_1	533	537	PF08558	0.347
MOD_CK1_1	120	126	PF00069	0.310
MOD_CK1_1	141	147	PF00069	0.282
MOD_CK1_1	151	157	PF00069	0.312
MOD_CK1_1	300	306	PF00069	0.396
MOD_CK1_1	410	416	PF00069	0.394
MOD_CK1_1	430	436	PF00069	0.334
MOD_CK1_1	98	104	PF00069	0.263
MOD_CK2_1	11	17	PF00069	0.756
MOD_CK2_1	127	133	PF00069	0.337
MOD_CK2_1	140	146	PF00069	0.322
MOD_CK2_1	151	157	PF00069	0.284
MOD_CK2_1	203	209	PF00069	0.435
MOD_Cter_Amidation	543	546	PF01082	0.490
MOD_GlcNHglycan	150	153	PF01048	0.459
MOD_GlcNHglycan	157	160	PF01048	0.429
MOD_GlcNHglycan	39	42	PF01048	0.429
MOD_GlcNHglycan	501	504	PF01048	0.447
MOD_GlcNHglycan	505	508	PF01048	0.445
MOD_GSK3_1	109	116	PF00069	0.293
MOD_GSK3_1	148	155	PF00069	0.277
MOD_GSK3_1	293	300	PF00069	0.347
MOD_GSK3_1	348	355	PF00069	0.324
MOD_GSK3_1	363	370	PF00069	0.270
MOD_GSK3_1	386	393	PF00069	0.340
MOD_GSK3_1	394	401	PF00069	0.314
MOD_GSK3_1	407	414	PF00069	0.245
MOD_GSK3_1	495	502	PF00069	0.318
MOD_GSK3_1	9	16	PF00069	0.736
MOD_N-GLC_1	120	125	PF02516	0.444
MOD_N-GLC_1	98	103	PF02516	0.512
MOD_N-GLC_2	491	493	PF02516	0.374
MOD_NEK2_1	161	166	PF00069	0.325
MOD_NEK2_1	170	175	PF00069	0.263
MOD_NEK2_1	179	184	PF00069	0.192
MOD_NEK2_1	271	276	PF00069	0.268
MOD_NEK2_1	310	315	PF00069	0.459
MOD_NEK2_1	348	353	PF00069	0.317
MOD_NEK2_1	387	392	PF00069	0.344
MOD_NEK2_1	407	412	PF00069	0.127
MOD_NEK2_1	71	76	PF00069	0.287
MOD_NEK2_2	109	114	PF00069	0.317
MOD_NEK2_2	294	299	PF00069	0.416
MOD_NEK2_2	398	403	PF00069	0.499
MOD_OFUCOSY	106	113	PF10250	0.485
MOD_PIKK_1	460	466	PF00454	0.351
MOD_PIKK_1	476	482	PF00454	0.316
MOD_PKA_2	113	119	PF00069	0.357
MOD_PKA_2	138	144	PF00069	0.339
MOD_PKA_2	185	191	PF00069	0.507
MOD_PKA_2	218	224	PF00069	0.190
MOD_PKA_2	499	505	PF00069	0.248
MOD_PKB_1	472	480	PF00069	0.474
MOD_Plk_4	161	167	PF00069	0.340
MOD_Plk_4	170	176	PF00069	0.288
MOD_Plk_4	185	191	PF00069	0.451
MOD_Plk_4	197	203	PF00069	0.282
MOD_Plk_4	271	277	PF00069	0.325
MOD_Plk_4	294	300	PF00069	0.319
MOD_Plk_4	363	369	PF00069	0.272
MOD_Plk_4	394	400	PF00069	0.331
MOD_Plk_4	407	413	PF00069	0.285
MOD_Plk_4	66	72	PF00069	0.334
MOD_SUMO_rev_2	553	558	PF00179	0.577
TRG_AP2beta_CARGO_1	209	219	PF09066	0.334
TRG_DiLeu_BaEn_1	211	216	PF01217	0.334
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.512
TRG_ENDOCYTIC_2	142	145	PF00928	0.254
TRG_ENDOCYTIC_2	333	336	PF00928	0.550
TRG_ENDOCYTIC_2	426	429	PF00928	0.267
TRG_ENDOCYTIC_2	459	462	PF00928	0.407
TRG_ENDOCYTIC_2	67	70	PF00928	0.264
TRG_ER_diArg_1	136	139	PF00400	0.296
TRG_ER_diArg_1	471	474	PF00400	0.481
TRG_ER_diLys_1	565	568	PF00400	0.523
TRG_NLS_MonoExtN_4	542	549	PF00514	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VG78	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	25%	100%
A0A0N0P2E1	Leptomonas seymouri	51%	100%
A0A0N0P3Z7	Leptomonas seymouri	45%	74%
A0A0N0P4D8	Leptomonas seymouri	48%	77%
A0A0N1IG16	Leptomonas seymouri	71%	100%
A0A0N1P9H5	Leptomonas seymouri	46%	100%
A0A0S4J363	Bodo saltans	28%	100%
A0A0S4JDF9	Bodo saltans	40%	100%
A0A0S4JEY7	Bodo saltans	40%	100%
A0A0S4JH90	Bodo saltans	35%	100%
A0A0S4JS00	Bodo saltans	33%	100%
A0A1X0NLE0	Trypanosomatidae	57%	100%
A0A1X0NM05	Trypanosomatidae	57%	100%
A0A1X0NN62	Trypanosomatidae	52%	100%
A0A1X0P9L7	Trypanosomatidae	37%	100%
A0A381N054	Leishmania infantum	93%	100%
A0A3Q8IDK1	Leishmania donovani	44%	96%
A0A3Q8IK60	Leishmania donovani	93%	100%
A0A3Q8IWJ4	Leishmania donovani	92%	87%
A0A3R7KPU3	Trypanosoma rangeli	35%	100%
A0A3S7WY58	Leishmania donovani	21%	100%
A0A3S7XC27	Leishmania donovani	94%	100%
A0A422MNQ4	Trypanosoma rangeli	55%	100%
A0A422MRN5	Trypanosoma rangeli	62%	100%
A4HL65	Leishmania braziliensis	43%	92%
A4HQD6	Leishmania braziliensis	85%	100%
A4HQD7	Leishmania braziliensis	86%	100%
A4HQE7	Leishmania braziliensis	88%	100%
A4I0Q6	Leishmania infantum	21%	100%
A4I8N6	Leishmania infantum	44%	96%
A4IC83	Leishmania infantum	91%	87%
C0SPB2	Bacillus subtilis (strain 168)	23%	100%
C7GWV6	Saccharomyces cerevisiae (strain JAY291)	20%	99%
C9ZMM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A3U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A3U2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A3U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AU62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AU63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AU64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	93%
E9AWQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9B3K8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	91%
K0E3U9	Aspergillus rugulosus	23%	100%
O04249	Arabidopsis thaliana	24%	100%
O34718	Bacillus subtilis (strain 168)	21%	100%
O52733	Levilactobacillus brevis	21%	100%
O59932	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
O74849	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
O74969	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P11166	Homo sapiens	23%	100%
P11167	Rattus norvegicus	23%	100%
P12336	Rattus norvegicus	22%	100%
P13355	Oryctolagus cuniculus	23%	100%
P13865	Leishmania enriettii	82%	100%
P15686	Parachlorella kessleri	24%	100%
P15729	Synechocystis sp. (strain PCC 6803 / Kazusa)	24%	100%
P17809	Mus musculus	23%	100%
P18631	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	20%	100%
P20303	Sus scrofa	23%	100%
P23585	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P27674	Bos taurus	23%	100%
P38142	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P38695	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	96%
P39003	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
P39004	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
P39924	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P43427	Rattus norvegicus	22%	100%
P43581	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
P46333	Bacillus subtilis (strain 168)	23%	100%
P46896	Gallus gallus	22%	100%
P47185	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P49374	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	100%
P53631	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P54854	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P58351	Bos taurus	23%	100%
P78831	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
P79365	Ovis aries	23%	100%
Q01440	Leishmania donovani	21%	100%
Q01441	Leishmania donovani	44%	100%
Q06221	Trypanosoma brucei brucei	44%	100%
Q06222	Trypanosoma brucei brucei	46%	100%
Q09037	Trypanosoma brucei brucei	44%	100%
Q10PW9	Oryza sativa subsp. japonica	24%	100%
Q27115	Trypanosoma vivax	47%	100%
Q39524	Parachlorella kessleri	22%	100%
Q39525	Parachlorella kessleri	24%	100%
Q41144	Ricinus communis	23%	100%
Q4Q0D0	Leishmania major	94%	100%
Q4Q0D1	Leishmania major	97%	100%
Q4Q4J1	Leishmania major	42%	96%
Q6PXP3	Homo sapiens	21%	100%
Q8L6Z8	Arabidopsis thaliana	23%	100%
Q8L7R8	Arabidopsis thaliana	22%	100%
Q8TFG1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q8WMN1	Ovis aries	23%	100%
Q92253	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	96%
Q92339	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q94AZ2	Arabidopsis thaliana	24%	100%
Q94EC3	Oryza sativa subsp. japonica	24%	100%
Q9P3U6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q9P3U7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q9WV38	Mus musculus	21%	100%