LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Glucose transporter, lmgt1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glucose transporter, lmgt1
Gene product:
glucose transporter 1
Species:
Leishmania major
UniProt:
Q4Q0D0_LEIMA
TriTrypDb:
LmjF.36.6300 , LMJLV39_000012600 * , LMJSD75_360076100 *
Length:
653

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 39
NetGPI no yes: 0, no: 39
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 4
GO:0016020 membrane 2 40
GO:0051286 cell tip 3 4
GO:0060187 cell pole 2 4
GO:0110165 cellular anatomical entity 1 40

Expansion

Sequence features

Q4Q0D0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0D0

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 16
GO:0008643 carbohydrate transport 5 16
GO:0051179 localization 1 16
GO:0051234 establishment of localization 2 16
GO:0071702 organic substance transport 4 16
GO:0009987 cellular process 1 1
GO:0015749 monosaccharide transmembrane transport 4 1
GO:0034219 carbohydrate transmembrane transport 3 1
GO:0055085 transmembrane transport 2 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 40
GO:0005353 fructose transmembrane transporter activity 7 2
GO:0005354 galactose transmembrane transporter activity 7 2
GO:0015144 carbohydrate transmembrane transporter activity 3 15
GO:0015145 monosaccharide transmembrane transporter activity 5 3
GO:0015149 hexose transmembrane transporter activity 6 3
GO:0015578 mannose transmembrane transporter activity 7 2
GO:0022857 transmembrane transporter activity 2 40
GO:0051119 sugar transmembrane transporter activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 103 107 PF00656 0.550
CLV_C14_Caspase3-7 625 629 PF00656 0.660
CLV_NRD_NRD_1 199 201 PF00675 0.557
CLV_PCSK_KEX2_1 199 201 PF00082 0.462
CLV_PCSK_KEX2_1 331 333 PF00082 0.327
CLV_PCSK_KEX2_1 626 628 PF00082 0.472
CLV_PCSK_KEX2_1 631 633 PF00082 0.553
CLV_PCSK_PC1ET2_1 331 333 PF00082 0.341
CLV_PCSK_PC1ET2_1 626 628 PF00082 0.470
CLV_PCSK_PC1ET2_1 631 633 PF00082 0.550
CLV_PCSK_PC7_1 627 633 PF00082 0.389
CLV_PCSK_SKI1_1 488 492 PF00082 0.261
DEG_ODPH_VHL_1 458 469 PF01847 0.341
DOC_CYCLIN_RxL_1 485 495 PF00134 0.527
DOC_CYCLIN_yCln2_LP_2 44 47 PF00134 0.572
DOC_CYCLIN_yCln2_LP_2 93 99 PF00134 0.551
DOC_MAPK_gen_1 329 338 PF00069 0.470
DOC_MAPK_HePTP_8 301 313 PF00069 0.427
DOC_MAPK_MEF2A_6 271 279 PF00069 0.474
DOC_MAPK_MEF2A_6 304 313 PF00069 0.301
DOC_MAPK_MEF2A_6 329 338 PF00069 0.480
DOC_MAPK_NFAT4_5 304 312 PF00069 0.373
DOC_PP1_RVXF_1 269 275 PF00149 0.469
DOC_PP2B_LxvP_1 44 47 PF13499 0.583
DOC_PP4_FxxP_1 260 263 PF00568 0.450
DOC_PP4_FxxP_1 619 622 PF00568 0.340
DOC_SPAK_OSR1_1 304 308 PF12202 0.406
DOC_USP7_MATH_1 109 113 PF00917 0.679
DOC_USP7_MATH_1 263 267 PF00917 0.471
DOC_USP7_MATH_1 512 516 PF00917 0.353
DOC_USP7_MATH_1 67 71 PF00917 0.722
DOC_USP7_UBL2_3 517 521 PF12436 0.297
DOC_USP7_UBL2_3 626 630 PF12436 0.658
DOC_WW_Pin1_4 117 122 PF00397 0.621
LIG_14-3-3_CanoR_1 169 175 PF00244 0.359
LIG_14-3-3_CanoR_1 199 205 PF00244 0.348
LIG_14-3-3_CanoR_1 222 228 PF00244 0.304
LIG_14-3-3_CanoR_1 271 275 PF00244 0.481
LIG_14-3-3_CanoR_1 559 564 PF00244 0.463
LIG_BIR_II_1 1 5 PF00653 0.604
LIG_BRCT_BRCA1_1 119 123 PF00533 0.566
LIG_BRCT_BRCA1_1 144 148 PF00533 0.331
LIG_BRCT_BRCA1_1 152 156 PF00533 0.274
LIG_BRCT_BRCA1_1 242 246 PF00533 0.271
LIG_BRCT_BRCA1_1 358 362 PF00533 0.303
LIG_BRCT_BRCA1_1 380 384 PF00533 0.450
LIG_BRCT_BRCA1_1 481 485 PF00533 0.409
LIG_deltaCOP1_diTrp_1 296 305 PF00928 0.316
LIG_FHA_1 304 310 PF00498 0.356
LIG_FHA_1 331 337 PF00498 0.482
LIG_FHA_1 341 347 PF00498 0.239
LIG_FHA_1 386 392 PF00498 0.451
LIG_FHA_1 434 440 PF00498 0.343
LIG_FHA_1 525 531 PF00498 0.353
LIG_FHA_1 565 571 PF00498 0.378
LIG_FHA_1 581 587 PF00498 0.379
LIG_FHA_2 213 219 PF00498 0.337
LIG_GBD_Chelix_1 264 272 PF00786 0.440
LIG_Integrin_RGD_1 39 41 PF01839 0.384
LIG_LIR_Apic_2 258 263 PF02991 0.450
LIG_LIR_Gen_1 120 131 PF02991 0.551
LIG_LIR_Gen_1 226 235 PF02991 0.311
LIG_LIR_Gen_1 273 282 PF02991 0.330
LIG_LIR_Gen_1 296 305 PF02991 0.302
LIG_LIR_Gen_1 381 391 PF02991 0.377
LIG_LIR_Gen_1 417 428 PF02991 0.480
LIG_LIR_Gen_1 562 571 PF02991 0.265
LIG_LIR_Nem_3 145 151 PF02991 0.312
LIG_LIR_Nem_3 273 277 PF02991 0.332
LIG_LIR_Nem_3 294 300 PF02991 0.246
LIG_LIR_Nem_3 381 387 PF02991 0.358
LIG_LIR_Nem_3 417 421 PF02991 0.568
LIG_LIR_Nem_3 562 566 PF02991 0.400
LIG_LYPXL_S_1 510 514 PF13949 0.319
LIG_LYPXL_yS_3 511 514 PF13949 0.259
LIG_MYND_1 43 47 PF01753 0.575
LIG_NRBOX 271 277 PF00104 0.558
LIG_NRBOX 382 388 PF00104 0.431
LIG_Pex14_2 380 384 PF04695 0.438
LIG_Pex14_2 493 497 PF04695 0.427
LIG_Pex14_2 532 536 PF04695 0.271
LIG_Pex14_2 552 556 PF04695 0.470
LIG_Pex14_2 619 623 PF04695 0.357
LIG_PTB_Apo_2 573 580 PF02174 0.306
LIG_PTB_Phospho_1 573 579 PF10480 0.349
LIG_SH2_CRK 152 156 PF00017 0.277
LIG_SH2_GRB2like 204 207 PF00017 0.172
LIG_SH2_NCK_1 204 208 PF00017 0.255
LIG_SH2_STAP1 152 156 PF00017 0.301
LIG_SH2_STAT3 321 324 PF00017 0.493
LIG_SH2_STAT5 190 193 PF00017 0.314
LIG_SH2_STAT5 202 205 PF00017 0.317
LIG_SH2_STAT5 321 324 PF00017 0.437
LIG_SH2_STAT5 420 423 PF00017 0.609
LIG_SH2_STAT5 483 486 PF00017 0.553
LIG_SH2_STAT5 545 548 PF00017 0.356
LIG_SH2_STAT5 88 91 PF00017 0.589
LIG_SH3_1 66 72 PF00018 0.575
LIG_SH3_3 313 319 PF00018 0.301
LIG_SH3_3 40 46 PF00018 0.754
LIG_SH3_3 50 56 PF00018 0.746
LIG_SH3_3 506 512 PF00018 0.295
LIG_SH3_3 574 580 PF00018 0.308
LIG_SH3_3 66 72 PF00018 0.573
LIG_SH3_3 93 99 PF00018 0.760
LIG_SUMO_SIM_anti_2 385 391 PF11976 0.301
LIG_TRAF2_1 82 85 PF00917 0.566
LIG_TRFH_1 618 622 PF08558 0.340
MOD_CK1_1 122 128 PF00069 0.541
MOD_CK1_1 183 189 PF00069 0.251
MOD_CK1_1 2 8 PF00069 0.708
MOD_CK1_1 205 211 PF00069 0.301
MOD_CK1_1 226 232 PF00069 0.271
MOD_CK1_1 236 242 PF00069 0.302
MOD_CK1_1 385 391 PF00069 0.410
MOD_CK1_1 495 501 PF00069 0.446
MOD_CK1_1 515 521 PF00069 0.328
MOD_CK1_1 645 651 PF00069 0.769
MOD_CK2_1 111 117 PF00069 0.650
MOD_CK2_1 212 218 PF00069 0.330
MOD_CK2_1 225 231 PF00069 0.313
MOD_CK2_1 236 242 PF00069 0.272
MOD_CK2_1 288 294 PF00069 0.428
MOD_Cter_Amidation 628 631 PF01082 0.474
MOD_Cter_Amidation 638 641 PF01082 0.552
MOD_GlcNHglycan 10 13 PF01048 0.569
MOD_GlcNHglycan 235 238 PF01048 0.447
MOD_GlcNHglycan 242 245 PF01048 0.417
MOD_GlcNHglycan 586 589 PF01048 0.438
MOD_GlcNHglycan 590 593 PF01048 0.437
MOD_GlcNHglycan 647 650 PF01048 0.551
MOD_GSK3_1 194 201 PF00069 0.282
MOD_GSK3_1 233 240 PF00069 0.266
MOD_GSK3_1 378 385 PF00069 0.358
MOD_GSK3_1 433 440 PF00069 0.315
MOD_GSK3_1 448 455 PF00069 0.264
MOD_GSK3_1 471 478 PF00069 0.323
MOD_GSK3_1 479 486 PF00069 0.325
MOD_GSK3_1 492 499 PF00069 0.298
MOD_GSK3_1 58 65 PF00069 0.784
MOD_GSK3_1 580 587 PF00069 0.303
MOD_GSK3_1 641 648 PF00069 0.625
MOD_GSK3_1 67 74 PF00069 0.783
MOD_N-GLC_1 183 188 PF02516 0.502
MOD_N-GLC_1 205 210 PF02516 0.432
MOD_N-GLC_2 576 578 PF02516 0.369
MOD_NEK2_1 1 6 PF00069 0.584
MOD_NEK2_1 156 161 PF00069 0.276
MOD_NEK2_1 246 251 PF00069 0.312
MOD_NEK2_1 255 260 PF00069 0.252
MOD_NEK2_1 264 269 PF00069 0.186
MOD_NEK2_1 356 361 PF00069 0.263
MOD_NEK2_1 395 400 PF00069 0.470
MOD_NEK2_1 433 438 PF00069 0.319
MOD_NEK2_1 472 477 PF00069 0.336
MOD_NEK2_1 492 497 PF00069 0.307
MOD_NEK2_1 643 648 PF00069 0.624
MOD_NEK2_2 194 199 PF00069 0.308
MOD_NEK2_2 379 384 PF00069 0.406
MOD_NEK2_2 483 488 PF00069 0.497
MOD_OFUCOSY 191 198 PF10250 0.474
MOD_PIKK_1 111 117 PF00454 0.543
MOD_PIKK_1 18 24 PF00454 0.762
MOD_PIKK_1 545 551 PF00454 0.346
MOD_PIKK_1 561 567 PF00454 0.306
MOD_PKA_2 198 204 PF00069 0.353
MOD_PKA_2 223 229 PF00069 0.333
MOD_PKA_2 270 276 PF00069 0.496
MOD_PKA_2 303 309 PF00069 0.181
MOD_PKA_2 584 590 PF00069 0.236
MOD_PKB_1 557 565 PF00069 0.463
MOD_Plk_4 151 157 PF00069 0.318
MOD_Plk_4 246 252 PF00069 0.329
MOD_Plk_4 255 261 PF00069 0.278
MOD_Plk_4 270 276 PF00069 0.440
MOD_Plk_4 282 288 PF00069 0.269
MOD_Plk_4 356 362 PF00069 0.318
MOD_Plk_4 379 385 PF00069 0.313
MOD_Plk_4 448 454 PF00069 0.267
MOD_Plk_4 479 485 PF00069 0.334
MOD_Plk_4 492 498 PF00069 0.316
MOD_ProDKin_1 117 123 PF00069 0.612
TRG_AP2beta_CARGO_1 294 304 PF09066 0.341
TRG_DiLeu_BaEn_1 296 301 PF01217 0.327
TRG_DiLeu_BaEn_1 85 90 PF01217 0.559
TRG_DiLeu_BaLyEn_6 40 45 PF01217 0.578
TRG_DiLeu_BaLyEn_6 423 428 PF01217 0.503
TRG_DiLeu_BaLyEn_6 457 462 PF01217 0.150
TRG_ENDOCYTIC_2 152 155 PF00928 0.252
TRG_ENDOCYTIC_2 227 230 PF00928 0.242
TRG_ENDOCYTIC_2 418 421 PF00928 0.545
TRG_ENDOCYTIC_2 511 514 PF00928 0.259
TRG_ENDOCYTIC_2 544 547 PF00928 0.396
TRG_ER_diArg_1 221 224 PF00400 0.273
TRG_ER_diArg_1 556 559 PF00400 0.469
TRG_NLS_MonoExtN_4 627 634 PF00514 0.616
TRG_Pf-PMV_PEXEL_1 52 57 PF00026 0.373

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2E1 Leptomonas seymouri 51% 100%
A0A0N0P3Z7 Leptomonas seymouri 43% 85%
A0A0N0P4D8 Leptomonas seymouri 49% 88%
A0A0N1IG16 Leptomonas seymouri 71% 100%
A0A0N1P9H5 Leptomonas seymouri 45% 100%
A0A0S4J363 Bodo saltans 28% 100%
A0A0S4JDF9 Bodo saltans 40% 100%
A0A0S4JEY7 Bodo saltans 40% 100%
A0A0S4JH90 Bodo saltans 34% 100%
A0A0S4JS00 Bodo saltans 33% 100%
A0A1X0NLE0 Trypanosomatidae 58% 100%
A0A1X0NM05 Trypanosomatidae 57% 100%
A0A1X0NN62 Trypanosomatidae 52% 100%
A0A1X0P9L7 Trypanosomatidae 35% 100%
A0A381N054 Leishmania infantum 91% 100%
A0A3Q8IDK1 Leishmania donovani 42% 100%
A0A3Q8IK60 Leishmania donovani 90% 100%
A0A3Q8IWJ4 Leishmania donovani 89% 100%
A0A3R7KPU3 Trypanosoma rangeli 35% 100%
A0A3S7WY58 Leishmania donovani 21% 100%
A0A3S7XC27 Leishmania donovani 90% 100%
A0A422MNQ4 Trypanosoma rangeli 54% 100%
A4HL65 Leishmania braziliensis 41% 100%
A4HQD6 Leishmania braziliensis 85% 100%
A4HQD7 Leishmania braziliensis 86% 100%
A4HQE7 Leishmania braziliensis 90% 100%
A4I0Q6 Leishmania infantum 21% 100%
A4I8N6 Leishmania infantum 42% 100%
A4IC83 Leishmania infantum 89% 100%
C9ZMM0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
D0A3U1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
D0A3U2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
D0A3U3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9AU62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AU63 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9AU64 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9AWQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9B3K8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
K0E3U9 Aspergillus rugulosus 22% 100%
O52733 Levilactobacillus brevis 22% 100%
O74849 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 100%
P12336 Rattus norvegicus 22% 100%
P13865 Leishmania enriettii 83% 100%
P43427 Rattus norvegicus 21% 100%
Q01441 Leishmania donovani 43% 100%
Q06221 Trypanosoma brucei brucei 46% 100%
Q06222 Trypanosoma brucei brucei 47% 100%
Q09037 Trypanosoma brucei brucei 45% 100%
Q27115 Trypanosoma vivax 47% 100%
Q4Q0D1 Leishmania major 96% 100%
Q4Q0D2 Leishmania major 94% 100%
Q4Q4J1 Leishmania major 43% 100%
Q4QAR5 Leishmania major 21% 100%
Q6AWX0 Arabidopsis thaliana 22% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS