Putative homocysteine S-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

homocysteine S-methyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q0C9_LEIMA

TriTrypDb:

LmjF.36.6310 , LMJLV39_360076200 , LMJSD75_360076300

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0C9

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	6
GO:0000097	sulfur amino acid biosynthetic process	5	6
GO:0006082	organic acid metabolic process	3	6
GO:0006520	amino acid metabolic process	3	6
GO:0006555	methionine metabolic process	5	6
GO:0006575	cellular modified amino acid metabolic process	3	2
GO:0006790	sulfur compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0008652	amino acid biosynthetic process	4	6
GO:0009058	biosynthetic process	2	6
GO:0009066	aspartate family amino acid metabolic process	5	6
GO:0009067	aspartate family amino acid biosynthetic process	6	6
GO:0009086	methionine biosynthetic process	6	6
GO:0009987	cellular process	1	6
GO:0016053	organic acid biosynthetic process	4	6
GO:0019752	carboxylic acid metabolic process	5	6
GO:0032259	methylation	2	6
GO:0033477	S-methylmethionine metabolic process	4	2
GO:0033528	S-methylmethionine cycle	5	2
GO:0043436	oxoacid metabolic process	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	6
GO:0044272	sulfur compound biosynthetic process	4	6
GO:0044281	small molecule metabolic process	2	6
GO:0044283	small molecule biosynthetic process	3	6
GO:0046394	carboxylic acid biosynthetic process	5	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901566	organonitrogen compound biosynthetic process	4	6
GO:1901576	organic substance biosynthetic process	3	6
GO:1901605	alpha-amino acid metabolic process	4	6
GO:1901607	alpha-amino acid biosynthetic process	5	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0008168	methyltransferase activity	4	6
GO:0008172	S-methyltransferase activity	5	2
GO:0008270	zinc ion binding	6	6
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	6	2
GO:0016740	transferase activity	2	6
GO:0016741	transferase activity, transferring one-carbon groups	3	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.426
CLV_NRD_NRD_1	96	98	PF00675	0.226
CLV_PCSK_KEX2_1	96	98	PF00082	0.226
CLV_PCSK_SKI1_1	56	60	PF00082	0.299
CLV_PCSK_SKI1_1	96	100	PF00082	0.388
DEG_Nend_UBRbox_1	1	4	PF02207	0.474
DOC_CKS1_1	86	91	PF01111	0.516
DOC_MAPK_MEF2A_6	237	246	PF00069	0.529
DOC_USP7_MATH_1	145	149	PF00917	0.559
DOC_USP7_MATH_1	207	211	PF00917	0.511
DOC_USP7_MATH_1	252	256	PF00917	0.508
DOC_USP7_MATH_1	331	335	PF00917	0.573
DOC_USP7_MATH_2	218	224	PF00917	0.529
DOC_WW_Pin1_4	214	219	PF00397	0.516
DOC_WW_Pin1_4	58	63	PF00397	0.588
DOC_WW_Pin1_4	85	90	PF00397	0.516
LIG_14-3-3_CanoR_1	112	122	PF00244	0.400
LIG_14-3-3_CanoR_1	206	212	PF00244	0.568
LIG_14-3-3_CanoR_1	78	87	PF00244	0.516
LIG_14-3-3_CanoR_1	96	104	PF00244	0.516
LIG_Actin_WH2_2	160	176	PF00022	0.529
LIG_Actin_WH2_2	61	76	PF00022	0.529
LIG_BRCT_BRCA1_1	333	337	PF00533	0.614
LIG_CSL_BTD_1	285	288	PF09270	0.588
LIG_CtBP_PxDLS_1	288	292	PF00389	0.426
LIG_FHA_1	211	217	PF00498	0.533
LIG_FHA_1	264	270	PF00498	0.588
LIG_FHA_1	294	300	PF00498	0.588
LIG_FHA_2	37	43	PF00498	0.516
LIG_Integrin_RGD_1	151	153	PF01839	0.316
LIG_LIR_Gen_1	163	172	PF02991	0.529
LIG_LIR_Gen_1	226	235	PF02991	0.515
LIG_LIR_Gen_1	26	37	PF02991	0.313
LIG_LIR_LC3C_4	266	271	PF02991	0.588
LIG_LIR_Nem_3	159	164	PF02991	0.516
LIG_LIR_Nem_3	226	231	PF02991	0.515
LIG_LIR_Nem_3	277	282	PF02991	0.531
LIG_LIR_Nem_3	283	289	PF02991	0.501
LIG_PDZ_Class_2	334	339	PF00595	0.555
LIG_SH2_CRK	279	283	PF00017	0.529
LIG_SH2_GRB2like	272	275	PF00017	0.516
LIG_SH2_NCK_1	279	283	PF00017	0.516
LIG_SH2_STAT5	143	146	PF00017	0.516
LIG_SH2_STAT5	154	157	PF00017	0.516
LIG_SH2_STAT5	23	26	PF00017	0.456
LIG_SH2_STAT5	272	275	PF00017	0.503
LIG_SH2_STAT5	29	32	PF00017	0.417
LIG_SH2_STAT5	5	8	PF00017	0.477
LIG_SH2_STAT5	72	75	PF00017	0.516
LIG_SUMO_SIM_par_1	178	184	PF11976	0.516
LIG_SUMO_SIM_par_1	265	273	PF11976	0.522
LIG_SUMO_SIM_par_1	29	34	PF11976	0.416
LIG_TRAF2_1	106	109	PF00917	0.499
LIG_TRAF2_1	157	160	PF00917	0.516
LIG_UBA3_1	231	237	PF00899	0.529
LIG_WRC_WIRS_1	231	236	PF05994	0.529
MOD_CK1_1	210	216	PF00069	0.474
MOD_CK1_1	223	229	PF00069	0.474
MOD_CK1_1	275	281	PF00069	0.516
MOD_CK1_1	292	298	PF00069	0.516
MOD_CK2_1	113	119	PF00069	0.537
MOD_CK2_1	154	160	PF00069	0.516
MOD_CK2_1	184	190	PF00069	0.588
MOD_CK2_1	214	220	PF00069	0.472
MOD_CK2_1	230	236	PF00069	0.541
MOD_CK2_1	36	42	PF00069	0.516
MOD_CK2_1	88	94	PF00069	0.588
MOD_GlcNHglycan	115	118	PF01048	0.267
MOD_GlcNHglycan	156	159	PF01048	0.388
MOD_GlcNHglycan	186	189	PF01048	0.388
MOD_GlcNHglycan	253	257	PF01048	0.316
MOD_GlcNHglycan	274	277	PF01048	0.311
MOD_GlcNHglycan	333	336	PF01048	0.618
MOD_GlcNHglycan	53	56	PF01048	0.316
MOD_GSK3_1	207	214	PF00069	0.516
MOD_GSK3_1	289	296	PF00069	0.473
MOD_GSK3_1	36	43	PF00069	0.572
MOD_GSK3_1	81	88	PF00069	0.516
MOD_NEK2_1	211	216	PF00069	0.503
MOD_PIKK_1	181	187	PF00454	0.516
MOD_PKA_1	96	102	PF00069	0.426
MOD_PKA_2	96	102	PF00069	0.426
MOD_Plk_1	107	113	PF00069	0.516
MOD_Plk_1	252	258	PF00069	0.516
MOD_Plk_2-3	230	236	PF00069	0.570
MOD_Plk_4	88	94	PF00069	0.588
MOD_ProDKin_1	214	220	PF00069	0.516
MOD_ProDKin_1	58	64	PF00069	0.588
MOD_ProDKin_1	85	91	PF00069	0.516
MOD_SUMO_rev_2	157	164	PF00179	0.522
TRG_AP2beta_CARGO_1	159	168	PF09066	0.516
TRG_ENDOCYTIC_2	279	282	PF00928	0.520
TRG_ENDOCYTIC_2	29	32	PF00928	0.291
TRG_ER_diArg_1	166	169	PF00400	0.516
TRG_ER_diArg_1	96	98	PF00400	0.426
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P604	Leptomonas seymouri	75%	100%
A0A1X0NWF3	Trypanosomatidae	24%	81%
A0A3S7XC66	Leishmania donovani	93%	100%
A0A422NJL4	Trypanosoma rangeli	25%	83%
A4HQE8	Leishmania braziliensis	83%	100%
A4ZGQ8	Brassica oleracea var. italica	38%	100%
C9ZI75	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	78%
E9AU65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O31463	Bacillus subtilis (strain 168)	47%	100%
P56707	Astragalus bisulcatus	38%	100%
Q08985	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q12525	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q47690	Escherichia coli (strain K12)	53%	100%
Q4VNK0	Brassica oleracea var. italica	38%	98%
Q5M8Z0	Xenopus tropicalis	27%	84%
Q8LAX0	Arabidopsis thaliana	39%	98%
Q9FUM7	Zea mays	39%	99%
Q9FUM8	Zea mays	43%	100%
Q9FUM9	Zea mays	43%	100%
Q9FUN0	Zea mays	37%	100%
Q9M1W4	Arabidopsis thaliana	39%	100%
Q9SDL7	Arabidopsis thaliana	38%	100%
V5C098	Trypanosoma cruzi	26%	83%