LeishMANIAdb
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Peroxin-12

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Peroxin-12
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q0C7_LEIMA
TriTrypDb:
LmjF.36.6330 , LMJLV39_360076500 * , LMJSD75_360076500
Length:
278

Annotations

LeishMANIAdb annotations

Appears to be a transporter for some unknown substrate

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005777 peroxisome 6 2
GO:0020015 glycosome 7 2
GO:0042579 microbody 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 1

Expansion

Sequence features

Q4Q0C7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0C7

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0016559 peroxisome fission 6 1
GO:0048285 organelle fission 5 1
GO:0071840 cellular component organization or biogenesis 2 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 263 267 PF00656 0.624
CLV_MEL_PAP_1 178 184 PF00089 0.528
CLV_NRD_NRD_1 156 158 PF00675 0.551
CLV_NRD_NRD_1 54 56 PF00675 0.304
CLV_PCSK_KEX2_1 156 158 PF00082 0.550
CLV_PCSK_KEX2_1 56 58 PF00082 0.305
CLV_PCSK_PC1ET2_1 56 58 PF00082 0.259
CLV_PCSK_SKI1_1 123 127 PF00082 0.589
CLV_PCSK_SKI1_1 131 135 PF00082 0.566
CLV_PCSK_SKI1_1 139 143 PF00082 0.557
CLV_PCSK_SKI1_1 231 235 PF00082 0.384
CLV_PCSK_SKI1_1 251 255 PF00082 0.471
CLV_PCSK_SKI1_1 36 40 PF00082 0.282
DOC_CKS1_1 242 247 PF01111 0.579
DOC_CYCLIN_RxL_1 139 147 PF00134 0.289
DOC_MAPK_HePTP_8 186 198 PF00069 0.364
DOC_MAPK_MEF2A_6 189 198 PF00069 0.407
DOC_MAPK_MEF2A_6 26 33 PF00069 0.502
DOC_PP1_RVXF_1 121 127 PF00149 0.382
DOC_PP1_RVXF_1 206 213 PF00149 0.271
DOC_PP2B_LxvP_1 108 111 PF13499 0.383
DOC_PP2B_LxvP_1 234 237 PF13499 0.538
DOC_PP4_FxxP_1 74 77 PF00568 0.552
DOC_USP7_MATH_1 260 264 PF00917 0.569
DOC_USP7_MATH_1 271 275 PF00917 0.658
DOC_USP7_MATH_1 7 11 PF00917 0.690
DOC_USP7_UBL2_3 251 255 PF12436 0.602
DOC_WW_Pin1_4 166 171 PF00397 0.419
DOC_WW_Pin1_4 232 237 PF00397 0.701
DOC_WW_Pin1_4 241 246 PF00397 0.666
LIG_14-3-3_CanoR_1 139 145 PF00244 0.318
LIG_14-3-3_CanoR_1 173 179 PF00244 0.378
LIG_14-3-3_CanoR_1 76 82 PF00244 0.512
LIG_BIR_II_1 1 5 PF00653 0.724
LIG_BRCT_BRCA1_1 136 140 PF00533 0.294
LIG_BRCT_BRCA1_2 136 142 PF00533 0.289
LIG_deltaCOP1_diTrp_1 95 101 PF00928 0.337
LIG_FHA_1 145 151 PF00498 0.322
LIG_FHA_1 228 234 PF00498 0.585
LIG_LIR_Gen_1 105 114 PF02991 0.337
LIG_LIR_Gen_1 193 202 PF02991 0.368
LIG_LIR_Gen_1 95 104 PF02991 0.396
LIG_LIR_Nem_3 105 110 PF02991 0.303
LIG_LIR_Nem_3 135 141 PF02991 0.303
LIG_LIR_Nem_3 193 198 PF02991 0.357
LIG_LIR_Nem_3 203 207 PF02991 0.335
LIG_LIR_Nem_3 95 100 PF02991 0.396
LIG_Pex14_1 200 204 PF04695 0.299
LIG_Pex14_1 97 101 PF04695 0.367
LIG_Pex14_2 136 140 PF04695 0.363
LIG_Pex14_2 212 216 PF04695 0.269
LIG_REV1ctd_RIR_1 104 110 PF16727 0.328
LIG_REV1ctd_RIR_1 138 146 PF16727 0.269
LIG_SH2_CRK 204 208 PF00017 0.308
LIG_SH2_STAP1 48 52 PF00017 0.627
LIG_SH2_STAT5 120 123 PF00017 0.380
LIG_SH2_STAT5 195 198 PF00017 0.297
LIG_SH2_STAT5 232 235 PF00017 0.641
LIG_SH2_STAT5 58 61 PF00017 0.586
LIG_SH3_3 230 236 PF00018 0.651
LIG_SH3_3 239 245 PF00018 0.730
LIG_SUMO_SIM_anti_2 9 16 PF11976 0.591
LIG_SUMO_SIM_par_1 17 23 PF11976 0.568
LIG_TRFH_1 232 236 PF08558 0.621
LIG_UBA3_1 87 93 PF00899 0.489
MOD_CDK_SPK_2 166 171 PF00069 0.418
MOD_CDK_SPxxK_3 166 173 PF00069 0.433
MOD_CK1_1 10 16 PF00069 0.627
MOD_CK1_1 2 8 PF00069 0.650
MOD_CK1_1 37 43 PF00069 0.510
MOD_CK2_1 61 67 PF00069 0.490
MOD_CMANNOS 224 227 PF00535 0.413
MOD_GlcNHglycan 114 117 PF01048 0.588
MOD_GlcNHglycan 157 160 PF01048 0.531
MOD_GlcNHglycan 217 220 PF01048 0.291
MOD_GlcNHglycan 271 274 PF01048 0.484
MOD_GSK3_1 140 147 PF00069 0.288
MOD_N-GLC_1 7 12 PF02516 0.408
MOD_NEK2_1 1 6 PF00069 0.642
MOD_NEK2_1 134 139 PF00069 0.307
MOD_NEK2_1 140 145 PF00069 0.272
MOD_NEK2_1 180 185 PF00069 0.334
MOD_NEK2_1 34 39 PF00069 0.495
MOD_NEK2_1 61 66 PF00069 0.566
MOD_NEK2_1 79 84 PF00069 0.442
MOD_PIKK_1 260 266 PF00454 0.613
MOD_PIKK_1 79 85 PF00454 0.509
MOD_PKA_2 155 161 PF00069 0.372
MOD_PKA_2 180 186 PF00069 0.350
MOD_PKA_2 227 233 PF00069 0.586
MOD_Plk_1 7 13 PF00069 0.691
MOD_Plk_4 10 16 PF00069 0.654
MOD_Plk_4 102 108 PF00069 0.285
MOD_Plk_4 34 40 PF00069 0.516
MOD_Plk_4 61 67 PF00069 0.625
MOD_ProDKin_1 166 172 PF00069 0.419
MOD_ProDKin_1 232 238 PF00069 0.708
MOD_ProDKin_1 241 247 PF00069 0.666
TRG_ENDOCYTIC_2 138 141 PF00928 0.355
TRG_ENDOCYTIC_2 195 198 PF00928 0.275
TRG_ENDOCYTIC_2 204 207 PF00928 0.263
TRG_ENDOCYTIC_2 58 61 PF00928 0.494
TRG_ER_diArg_1 55 58 PF00400 0.644
TRG_Pf-PMV_PEXEL_1 162 166 PF00026 0.532
TRG_Pf-PMV_PEXEL_1 189 193 PF00026 0.484

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDG3 Leptomonas seymouri 62% 100%
A0A0S4JRR1 Bodo saltans 32% 100%
A0A1X0NLN6 Trypanosomatidae 38% 100%
A0A3Q8ILX5 Leishmania donovani 92% 100%
A0A422N9F2 Trypanosoma rangeli 38% 100%
A4HQF0 Leishmania braziliensis 77% 100%
A4IC87 Leishmania infantum 92% 100%
D0A3T7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9AU67 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
V5D8S7 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS