Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0C5_LEIMA

TriTrypDb:

LmjF.36.6345

Length:

241

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0C5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	50	54	PF00656	0.733
CLV_PCSK_KEX2_1	157	159	PF00082	0.515
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.553
CLV_PCSK_PC7_1	153	159	PF00082	0.553
CLV_PCSK_SKI1_1	158	162	PF00082	0.420
CLV_PCSK_SKI1_1	230	234	PF00082	0.600
DEG_APCC_DBOX_1	152	160	PF00400	0.498
DEG_Nend_Nbox_1	1	3	PF02207	0.449
DOC_CDC14_PxL_1	24	32	PF14671	0.452
DOC_CKS1_1	221	226	PF01111	0.569
DOC_CKS1_1	233	238	PF01111	0.448
DOC_CYCLIN_RxL_1	157	171	PF00134	0.535
DOC_CYCLIN_RxL_1	28	39	PF00134	0.450
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.515
DOC_MAPK_gen_1	85	92	PF00069	0.538
DOC_MAPK_MEF2A_6	85	92	PF00069	0.493
DOC_MAPK_RevD_3	143	158	PF00069	0.584
DOC_PP1_RVXF_1	29	36	PF00149	0.452
DOC_PP4_FxxP_1	140	143	PF00568	0.614
DOC_PP4_FxxP_1	221	224	PF00568	0.476
DOC_PP4_FxxP_1	233	236	PF00568	0.517
DOC_USP7_UBL2_3	87	91	PF12436	0.537
DOC_WW_Pin1_4	220	225	PF00397	0.530
DOC_WW_Pin1_4	232	237	PF00397	0.569
LIG_14-3-3_CanoR_1	110	118	PF00244	0.649
LIG_14-3-3_CanoR_1	207	211	PF00244	0.509
LIG_14-3-3_CanoR_1	230	236	PF00244	0.494
LIG_14-3-3_CanoR_1	31	36	PF00244	0.630
LIG_14-3-3_CanoR_1	59	63	PF00244	0.608
LIG_BRCT_BRCA1_1	15	19	PF00533	0.432
LIG_BRCT_BRCA1_1	60	64	PF00533	0.587
LIG_Clathr_ClatBox_1	7	11	PF01394	0.406
LIG_eIF4E_1	2	8	PF01652	0.423
LIG_FHA_1	126	132	PF00498	0.583
LIG_FHA_1	19	25	PF00498	0.525
LIG_FHA_1	221	227	PF00498	0.569
LIG_FHA_1	37	43	PF00498	0.691
LIG_FHA_2	214	220	PF00498	0.600
LIG_GBD_Chelix_1	176	184	PF00786	0.507
LIG_IRF3_LxIS_1	102	109	PF10401	0.559
LIG_LIR_Apic_2	139	143	PF02991	0.565
LIG_LIR_Apic_2	219	224	PF02991	0.490
LIG_LIR_Apic_2	23	29	PF02991	0.452
LIG_LIR_Gen_1	16	27	PF02991	0.445
LIG_LIR_Nem_3	16	22	PF02991	0.438
LIG_LIR_Nem_3	61	67	PF02991	0.567
LIG_LYPXL_yS_3	27	30	PF13949	0.520
LIG_NRBOX	2	8	PF00104	0.423
LIG_Rb_pABgroove_1	4	12	PF01858	0.409
LIG_SH2_STAP1	104	108	PF00017	0.563
LIG_SH2_STAP1	185	189	PF00017	0.509
LIG_SH2_STAT5	189	192	PF00017	0.579
LIG_SH2_STAT5	2	5	PF00017	0.437
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.451
LIG_SUMO_SIM_par_1	127	134	PF11976	0.573
LIG_SUMO_SIM_par_1	144	149	PF11976	0.477
LIG_TRFH_1	189	193	PF08558	0.575
LIG_TYR_ITIM	25	30	PF00017	0.520
LIG_UBA3_1	6	12	PF00899	0.402
LIG_WRC_WIRS_1	32	37	PF05994	0.451
MOD_CK1_1	109	115	PF00069	0.605
MOD_CK1_1	125	131	PF00069	0.427
MOD_CK1_1	20	26	PF00069	0.451
MOD_CK2_1	231	237	PF00069	0.554
MOD_CK2_1	52	58	PF00069	0.657
MOD_GlcNHglycan	111	114	PF01048	0.517
MOD_GlcNHglycan	213	216	PF01048	0.582
MOD_GlcNHglycan	98	101	PF01048	0.456
MOD_GSK3_1	13	20	PF00069	0.424
MOD_GSK3_1	96	103	PF00069	0.473
MOD_N-GLC_1	106	111	PF02516	0.543
MOD_N-GLC_1	125	130	PF02516	0.351
MOD_N-GLC_2	203	205	PF02516	0.506
MOD_NEK2_1	106	111	PF00069	0.478
MOD_NEK2_1	13	18	PF00069	0.419
MOD_NEK2_1	180	185	PF00069	0.450
MOD_NEK2_1	67	72	PF00069	0.587
MOD_NEK2_1	98	103	PF00069	0.525
MOD_NEK2_2	69	74	PF00069	0.618
MOD_PKA_2	109	115	PF00069	0.653
MOD_PKA_2	206	212	PF00069	0.506
MOD_PKA_2	58	64	PF00069	0.661
MOD_Plk_1	106	112	PF00069	0.545
MOD_Plk_1	52	58	PF00069	0.661
MOD_Plk_2-3	206	212	PF00069	0.552
MOD_Plk_2-3	213	219	PF00069	0.512
MOD_Plk_4	180	186	PF00069	0.581
MOD_Plk_4	20	26	PF00069	0.451
MOD_ProDKin_1	220	226	PF00069	0.521
MOD_ProDKin_1	232	238	PF00069	0.582
MOD_SUMO_rev_2	149	159	PF00179	0.547
TRG_DiLeu_BaEn_1	155	160	PF01217	0.552
TRG_ENDOCYTIC_2	189	192	PF00928	0.579
TRG_ENDOCYTIC_2	27	30	PF00928	0.516
TRG_ER_diArg_1	73	76	PF00400	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK6	Leptomonas seymouri	53%	100%
A0A1X0NLE1	Trypanosomatidae	29%	100%
A0A3S5IQS5	Trypanosoma rangeli	32%	100%
A0A3S7XC31	Leishmania donovani	99%	100%
A4HQF2	Leishmania braziliensis	85%	100%
A4IC89	Leishmania infantum	98%	100%
E9AU69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%