Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0C4_LEIMA

TriTrypDb:

LmjF.36.6347 , LMJLV39_360076900 , LMJSD75_360076800

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q0C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0C4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.547
CLV_NRD_NRD_1	2	4	PF00675	0.573
CLV_NRD_NRD_1	38	40	PF00675	0.486
CLV_PCSK_KEX2_1	143	145	PF00082	0.470
CLV_PCSK_KEX2_1	149	151	PF00082	0.413
CLV_PCSK_KEX2_1	15	17	PF00082	0.359
CLV_PCSK_KEX2_1	2	4	PF00082	0.587
CLV_PCSK_KEX2_1	38	40	PF00082	0.397
CLV_PCSK_KEX2_1	51	53	PF00082	0.409
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.506
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.538
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.463
CLV_PCSK_SKI1_1	144	148	PF00082	0.566
CLV_PCSK_SKI1_1	15	19	PF00082	0.668
CLV_PCSK_SKI1_1	175	179	PF00082	0.467
CLV_PCSK_SKI1_1	67	71	PF00082	0.484
DEG_Nend_UBRbox_1	1	4	PF02207	0.611
DOC_CDC14_PxL_1	121	129	PF14671	0.520
DOC_CYCLIN_RxL_1	141	152	PF00134	0.495
DOC_MAPK_gen_1	38	45	PF00069	0.458
LIG_14-3-3_CanoR_1	16	22	PF00244	0.465
LIG_14-3-3_CanoR_1	166	174	PF00244	0.407
LIG_14-3-3_CanoR_1	96	106	PF00244	0.364
LIG_BRCT_BRCA1_1	24	28	PF00533	0.512
LIG_FHA_1	68	74	PF00498	0.530
LIG_FHA_2	39	45	PF00498	0.465
LIG_GBD_Chelix_1	98	106	PF00786	0.511
LIG_LIR_Gen_1	157	162	PF02991	0.465
LIG_LIR_Nem_3	152	158	PF02991	0.427
LIG_MYND_3	124	128	PF01753	0.501
LIG_NRBOX	102	108	PF00104	0.564
LIG_Pex14_1	169	173	PF04695	0.376
LIG_Pex14_1	30	34	PF04695	0.519
LIG_RPA_C_Fungi	91	103	PF08784	0.464
LIG_SH2_CRK	158	162	PF00017	0.417
LIG_SH2_NCK_1	158	162	PF00017	0.442
LIG_SH2_STAT5	173	176	PF00017	0.373
LIG_SH2_STAT5	34	37	PF00017	0.456
LIG_TRAF2_1	137	140	PF00917	0.504
LIG_WRC_WIRS_1	18	23	PF05994	0.514
MOD_CK1_1	157	163	PF00069	0.455
MOD_CK1_1	167	173	PF00069	0.444
MOD_CK1_1	19	25	PF00069	0.522
MOD_CK1_1	9	15	PF00069	0.685
MOD_CK1_1	97	103	PF00069	0.449
MOD_CK2_1	157	163	PF00069	0.480
MOD_CK2_1	17	23	PF00069	0.447
MOD_CK2_1	38	44	PF00069	0.455
MOD_CMANNOS	169	172	PF00535	0.383
MOD_GlcNHglycan	169	172	PF01048	0.384
MOD_GlcNHglycan	67	70	PF01048	0.561
MOD_GSK3_1	2	9	PF00069	0.634
MOD_N-GLC_1	65	70	PF02516	0.517
MOD_NEK2_1	92	97	PF00069	0.515
MOD_NEK2_2	138	143	PF00069	0.469
MOD_PKA_1	149	155	PF00069	0.450
MOD_PKA_1	2	8	PF00069	0.659
MOD_PKA_1	38	44	PF00069	0.548
MOD_PKA_2	149	155	PF00069	0.450
MOD_PKA_2	165	171	PF00069	0.466
MOD_PKA_2	2	8	PF00069	0.605
MOD_PKA_2	38	44	PF00069	0.548
MOD_Plk_1	138	144	PF00069	0.495
MOD_Plk_1	164	170	PF00069	0.436
MOD_Plk_1	80	86	PF00069	0.561
MOD_Plk_2-3	81	87	PF00069	0.505
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.532
TRG_ENDOCYTIC_2	158	161	PF00928	0.420
TRG_ER_diArg_1	1	3	PF00400	0.576
TRG_ER_diArg_1	142	144	PF00400	0.532
TRG_ER_diArg_1	59	62	PF00400	0.521
TRG_ER_diLys_1	178	183	PF00400	0.525
TRG_NES_CRM1_1	44	57	PF08389	0.426
TRG_NLS_Bipartite_1	38	54	PF00514	0.508
TRG_NLS_MonoExtC_3	49	54	PF00514	0.527
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5I8	Leptomonas seymouri	60%	67%
A0A1X0NM61	Trypanosomatidae	42%	100%
A0A3Q8II22	Leishmania donovani	93%	96%
A0A3R7LRR3	Trypanosoma rangeli	40%	100%
A4HQF3	Leishmania braziliensis	84%	96%
A4IC90	Leishmania infantum	93%	96%
D0A3T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AU70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	96%