Poly(A)-specific ribonuclease PARN

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly(A)-specific ribonuclease PARN, putative

Species:

Leishmania major

UniProt:

Q4Q0C3_LEIMA

TriTrypDb:

LmjF.36.6350 , LMJLV39_360077100 , LMJSD75_360077000

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	3
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q0C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0C3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	4
GO:0003676	nucleic acid binding	3	19
GO:0003723	RNA binding	4	3
GO:0003824	catalytic activity	1	4
GO:0004518	nuclease activity	4	4
GO:0004527	exonuclease activity	5	4
GO:0004532	RNA exonuclease activity	5	4
GO:0004540	RNA nuclease activity	4	4
GO:0005488	binding	1	19
GO:0008408	3'-5' exonuclease activity	6	4
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	4
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	4
GO:0097159	organic cyclic compound binding	2	19
GO:0140098	catalytic activity, acting on RNA	3	4
GO:0140640	catalytic activity, acting on a nucleic acid	2	4
GO:1901363	heterocyclic compound binding	2	19
GO:0004535	poly(A)-specific ribonuclease activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.357
CLV_C14_Caspase3-7	302	306	PF00656	0.357
CLV_NRD_NRD_1	178	180	PF00675	0.273
CLV_NRD_NRD_1	249	251	PF00675	0.302
CLV_NRD_NRD_1	444	446	PF00675	0.377
CLV_NRD_NRD_1	481	483	PF00675	0.501
CLV_PCSK_KEX2_1	178	180	PF00082	0.301
CLV_PCSK_KEX2_1	225	227	PF00082	0.314
CLV_PCSK_KEX2_1	481	483	PF00082	0.434
CLV_PCSK_KEX2_1	54	56	PF00082	0.264
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.214
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.274
CLV_PCSK_SKI1_1	136	140	PF00082	0.235
CLV_PCSK_SKI1_1	244	248	PF00082	0.239
CLV_PCSK_SKI1_1	281	285	PF00082	0.341
DEG_APCC_DBOX_1	95	103	PF00400	0.515
DEG_MDM2_SWIB_1	239	247	PF02201	0.410
DEG_Nend_UBRbox_2	1	3	PF02207	0.306
DOC_CYCLIN_RxL_1	133	141	PF00134	0.357
DOC_CYCLIN_RxL_1	240	249	PF00134	0.377
DOC_MAPK_gen_1	231	239	PF00069	0.524
DOC_MAPK_gen_1	469	476	PF00069	0.416
DOC_MAPK_gen_1	54	60	PF00069	0.387
DOC_MIT_MIM_1	477	487	PF04212	0.356
DOC_PP1_RVXF_1	203	209	PF00149	0.568
DOC_PP4_FxxP_1	43	46	PF00568	0.417
DOC_USP7_MATH_1	160	164	PF00917	0.533
DOC_USP7_MATH_1	388	392	PF00917	0.440
DOC_USP7_MATH_1	416	420	PF00917	0.307
DOC_USP7_UBL2_3	349	353	PF12436	0.515
DOC_WW_Pin1_4	489	494	PF00397	0.538
DOC_WW_Pin1_4	495	500	PF00397	0.377
LIG_14-3-3_CanoR_1	178	184	PF00244	0.456
LIG_14-3-3_CanoR_1	191	195	PF00244	0.571
LIG_14-3-3_CanoR_1	322	330	PF00244	0.556
LIG_14-3-3_CanoR_1	445	450	PF00244	0.326
LIG_14-3-3_CanoR_1	481	487	PF00244	0.413
LIG_14-3-3_CanoR_1	96	102	PF00244	0.522
LIG_BIR_III_2	305	309	PF00653	0.397
LIG_BRCT_BRCA1_1	326	330	PF00533	0.441
LIG_BRCT_BRCA1_1	39	43	PF00533	0.397
LIG_BRCT_BRCA1_1	390	394	PF00533	0.497
LIG_FHA_1	115	121	PF00498	0.510
LIG_FHA_1	406	412	PF00498	0.342
LIG_FHA_1	427	433	PF00498	0.575
LIG_FHA_1	76	82	PF00498	0.501
LIG_FHA_2	209	215	PF00498	0.387
LIG_FHA_2	288	294	PF00498	0.465
LIG_FHA_2	30	36	PF00498	0.463
LIG_FHA_2	300	306	PF00498	0.464
LIG_FHA_2	308	314	PF00498	0.549
LIG_FHA_2	70	76	PF00498	0.459
LIG_GBD_Chelix_1	176	184	PF00786	0.217
LIG_GBD_Chelix_1	366	374	PF00786	0.272
LIG_HCF-1_HBM_1	185	188	PF13415	0.357
LIG_IRF3_LxIS_1	451	457	PF10401	0.321
LIG_LIR_Apic_2	331	337	PF02991	0.421
LIG_LIR_Apic_2	40	46	PF02991	0.416
LIG_LIR_Gen_1	23	31	PF02991	0.522
LIG_LIR_Gen_1	274	284	PF02991	0.497
LIG_LIR_Gen_1	4	13	PF02991	0.516
LIG_LIR_Gen_1	460	470	PF02991	0.393
LIG_LIR_Gen_1	59	69	PF02991	0.442
LIG_LIR_Nem_3	23	27	PF02991	0.455
LIG_LIR_Nem_3	274	280	PF02991	0.462
LIG_LIR_Nem_3	356	362	PF02991	0.441
LIG_LIR_Nem_3	391	397	PF02991	0.311
LIG_LIR_Nem_3	4	9	PF02991	0.470
LIG_LIR_Nem_3	460	466	PF02991	0.374
LIG_LIR_Nem_3	59	64	PF02991	0.437
LIG_MAD2	244	252	PF02301	0.515
LIG_MLH1_MIPbox_1	390	394	PF16413	0.262
LIG_PCNA_yPIPBox_3	96	105	PF02747	0.397
LIG_Pex14_2	239	243	PF04695	0.453
LIG_SH2_CRK	334	338	PF00017	0.500
LIG_SH2_STAP1	131	135	PF00017	0.540
LIG_SH2_STAP1	188	192	PF00017	0.417
LIG_SH2_STAP1	359	363	PF00017	0.453
LIG_SH2_STAT3	201	204	PF00017	0.501
LIG_SH2_STAT5	201	204	PF00017	0.479
LIG_SH2_STAT5	277	280	PF00017	0.538
LIG_SH2_STAT5	393	396	PF00017	0.456
LIG_SH2_STAT5	87	90	PF00017	0.433
LIG_SH3_3	36	42	PF00018	0.476
LIG_SUMO_SIM_par_1	498	503	PF11976	0.336
LIG_SUMO_SIM_par_1	8	14	PF11976	0.456
LIG_TRAF2_1	125	128	PF00917	0.449
LIG_TRAF2_1	130	133	PF00917	0.452
LIG_TRFH_1	334	338	PF08558	0.515
LIG_WRC_WIRS_1	101	106	PF05994	0.397
LIG_WRC_WIRS_1	180	185	PF05994	0.397
LIG_WRC_WIRS_1	463	468	PF05994	0.434
MOD_CK1_1	100	106	PF00069	0.505
MOD_CK1_1	111	117	PF00069	0.505
MOD_CK1_1	190	196	PF00069	0.561
MOD_CK1_1	457	463	PF00069	0.460
MOD_CK1_1	492	498	PF00069	0.529
MOD_CK2_1	217	223	PF00069	0.503
MOD_CK2_1	307	313	PF00069	0.515
MOD_CK2_1	69	75	PF00069	0.471
MOD_GlcNHglycan	117	120	PF01048	0.242
MOD_GlcNHglycan	162	165	PF01048	0.243
MOD_GlcNHglycan	345	348	PF01048	0.266
MOD_GlcNHglycan	386	389	PF01048	0.428
MOD_GlcNHglycan	39	42	PF01048	0.315
MOD_GlcNHglycan	390	393	PF01048	0.404
MOD_GlcNHglycan	91	94	PF01048	0.310
MOD_GSK3_1	111	118	PF00069	0.491
MOD_GSK3_1	287	294	PF00069	0.443
MOD_GSK3_1	324	331	PF00069	0.461
MOD_GSK3_1	384	391	PF00069	0.310
MOD_GSK3_1	426	433	PF00069	0.483
MOD_GSK3_1	457	464	PF00069	0.416
MOD_GSK3_1	71	78	PF00069	0.446
MOD_LATS_1	480	486	PF00433	0.317
MOD_N-GLC_1	343	348	PF02516	0.319
MOD_N-GLC_1	495	500	PF02516	0.408
MOD_N-GLC_1	75	80	PF02516	0.197
MOD_N-GLC_1	89	94	PF02516	0.315
MOD_N-GLC_1	97	102	PF02516	0.315
MOD_NEK2_1	1	6	PF00069	0.388
MOD_NEK2_1	208	213	PF00069	0.481
MOD_NEK2_1	246	251	PF00069	0.436
MOD_NEK2_1	284	289	PF00069	0.543
MOD_NEK2_1	97	102	PF00069	0.571
MOD_PIKK_1	328	334	PF00454	0.576
MOD_PKA_1	445	451	PF00069	0.357
MOD_PKA_1	461	467	PF00069	0.276
MOD_PKA_2	190	196	PF00069	0.367
MOD_Plk_1	1	7	PF00069	0.355
MOD_Plk_1	343	349	PF00069	0.463
MOD_Plk_1	75	81	PF00069	0.503
MOD_Plk_1	97	103	PF00069	0.397
MOD_Plk_2-3	217	223	PF00069	0.417
MOD_Plk_2-3	75	81	PF00069	0.501
MOD_Plk_4	111	117	PF00069	0.390
MOD_Plk_4	134	140	PF00069	0.560
MOD_Plk_4	179	185	PF00069	0.519
MOD_Plk_4	287	293	PF00069	0.474
MOD_Plk_4	405	411	PF00069	0.350
MOD_Plk_4	97	103	PF00069	0.518
MOD_ProDKin_1	489	495	PF00069	0.534
MOD_SUMO_for_1	125	128	PF00179	0.357
MOD_SUMO_rev_2	127	135	PF00179	0.481
MOD_SUMO_rev_2	195	200	PF00179	0.409
MOD_SUMO_rev_2	217	227	PF00179	0.486
MOD_SUMO_rev_2	274	283	PF00179	0.471
TRG_DiLeu_BaLyEn_6	496	501	PF01217	0.557
TRG_ENDOCYTIC_2	277	280	PF00928	0.456
TRG_ENDOCYTIC_2	463	466	PF00928	0.467
TRG_ENDOCYTIC_2	61	64	PF00928	0.441
TRG_ER_diArg_1	178	180	PF00400	0.397
TRG_ER_diArg_1	481	483	PF00400	0.501
TRG_NES_CRM1_1	2	14	PF08389	0.251
TRG_Pf-PMV_PEXEL_1	445	450	PF00026	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P603	Leptomonas seymouri	56%	99%
A0A0N1ILJ1	Leptomonas seymouri	26%	84%
A0A0S4IMW3	Bodo saltans	23%	100%
A0A0S4IR41	Bodo saltans	23%	80%
A0A0S4J225	Bodo saltans	34%	70%
A0A1X0NLC6	Trypanosomatidae	34%	99%
A0A3Q8ICI3	Leishmania donovani	26%	85%
A0A3R7K5K5	Trypanosoma rangeli	36%	98%
A0A3S7XC77	Leishmania donovani	91%	100%
A0A422N5N5	Trypanosoma rangeli	27%	86%
A4HCS6	Leishmania braziliensis	27%	86%
A4HQF5	Leishmania braziliensis	75%	100%
A4I0A0	Leishmania infantum	26%	85%
A4IC91	Leishmania infantum	91%	100%
B2RXZ1	Mus musculus	23%	96%
C9ZV58	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	87%
D0A3T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AU71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AW65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	86%
H9JAQ7	Bombyx mori	25%	96%
O95453	Homo sapiens	23%	80%
P69341	Bos taurus	24%	80%
Q21412	Caenorhabditis elegans	24%	90%
Q4QBB3	Leishmania major	26%	100%
Q5R6R6	Pongo abelii	24%	98%
Q5RC51	Pongo abelii	23%	80%
Q7ZU92	Danio rerio	26%	77%
Q8NA58	Homo sapiens	24%	98%
Q8VDG3	Mus musculus	23%	82%
Q90ZA1	Xenopus laevis	26%	81%
V5ASU9	Trypanosoma cruzi	36%	99%
V5BCG2	Trypanosoma cruzi	25%	100%