Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2962), putative

Species:

Leishmania major

UniProt:

Q4Q0C2_LEIMA

TriTrypDb:

LmjF.36.6360 , LMJLV39_360077600 , LMJSD75_360077500

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0C2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.551
CLV_NRD_NRD_1	2	4	PF00675	0.663
CLV_NRD_NRD_1	212	214	PF00675	0.664
CLV_NRD_NRD_1	255	257	PF00675	0.558
CLV_PCSK_FUR_1	10	14	PF00082	0.607
CLV_PCSK_KEX2_1	12	14	PF00082	0.410
CLV_PCSK_KEX2_1	194	196	PF00082	0.544
CLV_PCSK_KEX2_1	2	4	PF00082	0.663
CLV_PCSK_KEX2_1	242	244	PF00082	0.509
CLV_PCSK_KEX2_1	255	257	PF00082	0.544
CLV_PCSK_KEX2_1	31	33	PF00082	0.284
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.355
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.674
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.509
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.344
CLV_PCSK_SKI1_1	168	172	PF00082	0.570
CLV_PCSK_SKI1_1	195	199	PF00082	0.557
CLV_PCSK_SKI1_1	242	246	PF00082	0.424
CLV_PCSK_SKI1_1	3	7	PF00082	0.616
DEG_Nend_UBRbox_1	1	4	PF02207	0.670
DOC_MAPK_gen_1	185	192	PF00069	0.610
DOC_MAPK_gen_1	28	36	PF00069	0.357
DOC_MAPK_gen_1	42	51	PF00069	0.357
DOC_MAPK_gen_1	86	93	PF00069	0.282
DOC_PP1_RVXF_1	193	200	PF00149	0.571
DOC_PP2B_LxvP_1	125	128	PF13499	0.410
DOC_USP7_MATH_1	154	158	PF00917	0.359
DOC_USP7_MATH_1	201	205	PF00917	0.529
DOC_USP7_MATH_1	246	250	PF00917	0.630
DOC_USP7_MATH_1	251	255	PF00917	0.477
DOC_USP7_UBL2_3	194	198	PF12436	0.572
DOC_USP7_UBL2_3	215	219	PF12436	0.619
DOC_USP7_UBL2_3	40	44	PF12436	0.353
DOC_WW_Pin1_4	161	166	PF00397	0.572
LIG_14-3-3_CanoR_1	2	6	PF00244	0.462
LIG_14-3-3_CanoR_1	213	219	PF00244	0.577
LIG_APCC_ABBA_1	80	85	PF00400	0.306
LIG_FAT_LD_1	171	179	PF03623	0.495
LIG_FHA_1	147	153	PF00498	0.314
LIG_FHA_1	223	229	PF00498	0.496
LIG_FHA_1	46	52	PF00498	0.306
LIG_FHA_1	66	72	PF00498	0.339
LIG_FHA_2	129	135	PF00498	0.429
LIG_NRBOX	170	176	PF00104	0.494
LIG_PDZ_Class_3	259	264	PF00595	0.593
LIG_REV1ctd_RIR_1	52	62	PF16727	0.279
LIG_SH2_STAP1	66	70	PF00017	0.410
LIG_SH2_STAT5	66	69	PF00017	0.410
LIG_SH2_STAT5	83	86	PF00017	0.337
LIG_SH3_3	12	18	PF00018	0.357
LIG_SH3_3	187	193	PF00018	0.557
LIG_SUMO_SIM_anti_2	134	141	PF11976	0.274
LIG_SUMO_SIM_anti_2	148	154	PF11976	0.343
LIG_TRAF2_1	234	237	PF00917	0.563
MOD_CDK_SPxxK_3	161	168	PF00069	0.525
MOD_CK2_1	256	262	PF00069	0.559
MOD_CK2_1	5	11	PF00069	0.664
MOD_GlcNHglycan	120	123	PF01048	0.410
MOD_GlcNHglycan	248	251	PF01048	0.552
MOD_GlcNHglycan	258	261	PF01048	0.633
MOD_GlcNHglycan	7	10	PF01048	0.669
MOD_GSK3_1	1	8	PF00069	0.464
MOD_GSK3_1	201	208	PF00069	0.546
MOD_GSK3_1	214	221	PF00069	0.593
MOD_GSK3_1	242	249	PF00069	0.408
MOD_LATS_1	17	23	PF00433	0.410
MOD_NEK2_1	1	6	PF00069	0.672
MOD_NEK2_1	108	113	PF00069	0.389
MOD_NEK2_1	45	50	PF00069	0.350
MOD_NEK2_1	64	69	PF00069	0.271
MOD_PIKK_1	201	207	PF00454	0.613
MOD_PK_1	19	25	PF00069	0.410
MOD_PK_1	214	220	PF00069	0.579
MOD_PKA_1	214	220	PF00069	0.619
MOD_PKA_1	242	248	PF00069	0.529
MOD_PKA_2	1	7	PF00069	0.466
MOD_PKA_2	242	248	PF00069	0.529
MOD_Plk_1	108	114	PF00069	0.391
MOD_Plk_1	19	25	PF00069	0.428
MOD_Plk_1	45	51	PF00069	0.407
MOD_Plk_1	72	78	PF00069	0.414
MOD_Plk_1	89	95	PF00069	0.424
MOD_Plk_4	148	154	PF00069	0.381
MOD_Plk_4	72	78	PF00069	0.371
MOD_Plk_4	89	95	PF00069	0.210
MOD_ProDKin_1	161	167	PF00069	0.571
MOD_SUMO_for_1	43	46	PF00179	0.410
TRG_DiLeu_BaEn_4	89	95	PF01217	0.322
TRG_ER_diArg_1	1	3	PF00400	0.677
TRG_ER_diArg_1	177	180	PF00400	0.546
TRG_ER_diArg_1	228	231	PF00400	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I784	Leptomonas seymouri	67%	100%
A0A0S4IUC3	Bodo saltans	34%	98%
A0A1X0NLZ7	Trypanosomatidae	42%	100%
A0A3Q8IJD2	Leishmania donovani	93%	100%
A0A422MX73	Trypanosoma rangeli	40%	100%
A4HQF6	Leishmania braziliensis	80%	99%
A4IC92	Leishmania infantum	93%	100%
D0A3K4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AU72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%