Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTPase activating protein, putative

Species:

Leishmania major

UniProt:

Q4Q0C1_LEIMA

TriTrypDb:

LmjF.36.6370 , LMJLV39_360077700 , LMJSD75_360077600

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q0C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0C1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051236	establishment of RNA localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	420	424	PF00656	0.350
CLV_NRD_NRD_1	274	276	PF00675	0.473
CLV_NRD_NRD_1	308	310	PF00675	0.352
CLV_NRD_NRD_1	68	70	PF00675	0.492
CLV_PCSK_KEX2_1	308	310	PF00082	0.398
CLV_PCSK_KEX2_1	505	507	PF00082	0.510
CLV_PCSK_KEX2_1	529	531	PF00082	0.461
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.510
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.461
CLV_PCSK_SKI1_1	153	157	PF00082	0.640
CLV_PCSK_SKI1_1	214	218	PF00082	0.457
CLV_PCSK_SKI1_1	270	274	PF00082	0.413
CLV_PCSK_SKI1_1	300	304	PF00082	0.274
CLV_PCSK_SKI1_1	403	407	PF00082	0.300
CLV_PCSK_SKI1_1	72	76	PF00082	0.441
CLV_Separin_Metazoa	462	466	PF03568	0.336
DEG_APCC_DBOX_1	241	249	PF00400	0.358
DEG_APCC_DBOX_1	434	442	PF00400	0.334
DEG_APCC_DBOX_1	444	452	PF00400	0.243
DEG_SPOP_SBC_1	125	129	PF00917	0.731
DEG_SPOP_SBC_1	161	165	PF00917	0.661
DOC_MAPK_gen_1	275	283	PF00069	0.493
DOC_MAPK_gen_1	308	314	PF00069	0.308
DOC_MAPK_MEF2A_6	403	412	PF00069	0.274
DOC_MAPK_MEF2A_6	546	554	PF00069	0.471
DOC_PP1_RVXF_1	308	315	PF00149	0.289
DOC_PP1_RVXF_1	390	396	PF00149	0.417
DOC_PP2B_LxvP_1	123	126	PF13499	0.489
DOC_PP4_FxxP_1	224	227	PF00568	0.377
DOC_PP4_FxxP_1	229	232	PF00568	0.379
DOC_PP4_FxxP_1	302	305	PF00568	0.308
DOC_SPAK_OSR1_1	431	435	PF12202	0.350
DOC_USP7_MATH_1	117	121	PF00917	0.610
DOC_USP7_MATH_1	124	128	PF00917	0.640
DOC_USP7_MATH_1	131	135	PF00917	0.594
DOC_USP7_MATH_1	140	144	PF00917	0.572
DOC_USP7_MATH_1	194	198	PF00917	0.619
DOC_USP7_MATH_1	24	28	PF00917	0.392
DOC_USP7_MATH_1	31	35	PF00917	0.282
DOC_USP7_MATH_1	450	454	PF00917	0.483
DOC_USP7_UBL2_3	111	115	PF12436	0.727
DOC_USP7_UBL2_3	213	217	PF12436	0.559
DOC_USP7_UBL2_3	266	270	PF12436	0.447
DOC_USP7_UBL2_3	388	392	PF12436	0.350
DOC_USP7_UBL2_3	528	532	PF12436	0.469
DOC_USP7_UBL2_3	55	59	PF12436	0.551
DOC_WW_Pin1_4	162	167	PF00397	0.773
LIG_14-3-3_CanoR_1	513	522	PF00244	0.465
LIG_AP2alpha_1	421	425	PF02296	0.288
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BIR_III_3	1	5	PF00653	0.418
LIG_BIR_III_4	23	27	PF00653	0.500
LIG_BRCT_BRCA1_1	176	180	PF00533	0.694
LIG_BRCT_BRCA1_2	176	182	PF00533	0.634
LIG_Clathr_ClatBox_1	463	467	PF01394	0.466
LIG_deltaCOP1_diTrp_1	265	273	PF00928	0.342
LIG_eIF4E_1	228	234	PF01652	0.404
LIG_FHA_1	205	211	PF00498	0.629
LIG_FHA_1	343	349	PF00498	0.274
LIG_FHA_1	352	358	PF00498	0.274
LIG_FHA_2	339	345	PF00498	0.417
LIG_LIR_Apic_2	222	227	PF02991	0.446
LIG_LIR_Apic_2	299	305	PF02991	0.308
LIG_LIR_Gen_1	20	30	PF02991	0.478
LIG_LIR_Gen_1	38	47	PF02991	0.324
LIG_LIR_Gen_1	417	426	PF02991	0.276
LIG_LIR_Gen_1	459	468	PF02991	0.334
LIG_LIR_Nem_3	20	25	PF02991	0.473
LIG_LIR_Nem_3	321	325	PF02991	0.284
LIG_LIR_Nem_3	38	42	PF02991	0.433
LIG_LIR_Nem_3	417	422	PF02991	0.284
LIG_LIR_Nem_3	553	557	PF02991	0.430
LIG_LIR_Nem_3	84	89	PF02991	0.479
LIG_LYPXL_SIV_4	324	332	PF13949	0.289
LIG_PCNA_PIPBox_1	383	392	PF02747	0.417
LIG_Pex14_1	373	377	PF04695	0.350
LIG_Pex14_1	396	400	PF04695	0.274
LIG_Pex14_2	35	39	PF04695	0.428
LIG_Pex14_2	415	419	PF04695	0.274
LIG_Pex14_2	421	425	PF04695	0.274
LIG_Pex14_2	432	436	PF04695	0.274
LIG_PTB_Apo_2	313	320	PF02174	0.368
LIG_PTB_Phospho_1	313	319	PF10480	0.417
LIG_SH2_CRK	218	222	PF00017	0.521
LIG_SH2_CRK	274	278	PF00017	0.435
LIG_SH2_PTP2	280	283	PF00017	0.371
LIG_SH2_STAP1	503	507	PF00017	0.430
LIG_SH2_STAT3	377	380	PF00017	0.350
LIG_SH2_STAT5	218	221	PF00017	0.425
LIG_SH2_STAT5	228	231	PF00017	0.460
LIG_SH2_STAT5	280	283	PF00017	0.342
LIG_SH2_STAT5	331	334	PF00017	0.283
LIG_SH2_STAT5	356	359	PF00017	0.285
LIG_SH2_STAT5	377	380	PF00017	0.350
LIG_SH2_STAT5	400	403	PF00017	0.274
LIG_SUMO_SIM_anti_2	474	481	PF11976	0.471
LIG_SUMO_SIM_anti_2	494	500	PF11976	0.225
LIG_SUMO_SIM_par_1	336	342	PF11976	0.274
LIG_SUMO_SIM_par_1	446	456	PF11976	0.495
LIG_TYR_ITIM	278	283	PF00017	0.355
LIG_UBA3_1	448	452	PF00899	0.404
LIG_ULM_U2AF65_1	528	534	PF00076	0.438
LIG_WRC_WIRS_1	196	201	PF05994	0.615
LIG_WRC_WIRS_1	32	37	PF05994	0.339
LIG_WRC_WIRS_1	418	423	PF05994	0.437
MOD_CDK_SPK_2	162	167	PF00069	0.603
MOD_CK1_1	127	133	PF00069	0.600
MOD_CK1_1	143	149	PF00069	0.640
MOD_CK1_1	195	201	PF00069	0.764
MOD_CK1_1	38	44	PF00069	0.370
MOD_CK1_1	78	84	PF00069	0.562
MOD_CK1_1	97	103	PF00069	0.670
MOD_CK2_1	338	344	PF00069	0.334
MOD_CK2_1	450	456	PF00069	0.434
MOD_CK2_1	78	84	PF00069	0.488
MOD_GlcNHglycan	119	122	PF01048	0.631
MOD_GlcNHglycan	129	132	PF01048	0.596
MOD_GlcNHglycan	133	136	PF01048	0.609
MOD_GlcNHglycan	370	373	PF01048	0.334
MOD_GlcNHglycan	77	80	PF01048	0.429
MOD_GlcNHglycan	89	92	PF01048	0.368
MOD_GlcNHglycan	96	99	PF01048	0.413
MOD_GSK3_1	125	132	PF00069	0.637
MOD_GSK3_1	140	147	PF00069	0.548
MOD_GSK3_1	180	187	PF00069	0.708
MOD_GSK3_1	31	38	PF00069	0.335
MOD_GSK3_1	338	345	PF00069	0.308
MOD_GSK3_1	97	104	PF00069	0.631
MOD_N-GLC_1	117	122	PF02516	0.597
MOD_NEK2_1	180	185	PF00069	0.683
MOD_NEK2_1	35	40	PF00069	0.397
MOD_NEK2_1	368	373	PF00069	0.274
MOD_NEK2_1	47	52	PF00069	0.441
MOD_NEK2_1	497	502	PF00069	0.424
MOD_NEK2_2	298	303	PF00069	0.274
MOD_PIKK_1	101	107	PF00454	0.725
MOD_PIKK_1	141	147	PF00454	0.761
MOD_PIKK_1	497	503	PF00454	0.493
MOD_PK_1	482	488	PF00069	0.458
MOD_Plk_1	298	304	PF00069	0.312
MOD_Plk_1	47	53	PF00069	0.522
MOD_Plk_2-3	417	423	PF00069	0.350
MOD_Plk_2-3	491	497	PF00069	0.424
MOD_Plk_4	327	333	PF00069	0.287
MOD_Plk_4	396	402	PF00069	0.274
MOD_ProDKin_1	162	168	PF00069	0.769
MOD_SUMO_for_1	515	518	PF00179	0.488
MOD_SUMO_rev_2	521	531	PF00179	0.461
TRG_DiLeu_BaEn_1	459	464	PF01217	0.466
TRG_DiLeu_BaEn_2	416	422	PF01217	0.334
TRG_DiLeu_LyEn_5	241	246	PF01217	0.431
TRG_ENDOCYTIC_2	228	231	PF00928	0.460
TRG_ENDOCYTIC_2	280	283	PF00928	0.349
TRG_ENDOCYTIC_2	319	322	PF00928	0.383
TRG_ENDOCYTIC_2	461	464	PF00928	0.320
TRG_ER_diArg_1	260	263	PF00400	0.361
TRG_NES_CRM1_1	230	241	PF08389	0.415
TRG_NLS_MonoCore_2	528	533	PF00514	0.472
TRG_NLS_MonoExtN_4	528	533	PF00514	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL31	Leptomonas seymouri	65%	90%
A0A0S4IUJ5	Bodo saltans	51%	98%
A0A1X0NLM8	Trypanosomatidae	54%	100%
A0A3Q8IRX0	Leishmania donovani	96%	100%
A0A3R7LIA2	Trypanosoma rangeli	53%	100%
A4HQF7	Leishmania braziliensis	78%	90%
A4IC93	Leishmania infantum	96%	100%
D0A3K6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AU73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5B8C0	Trypanosoma cruzi	56%	98%