HU-CCDC81_euk_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4496), putative

Species:

Leishmania major

UniProt:

Q4Q0B7_LEIMA

TriTrypDb:

LmjF.36.6410 , LMJLV39_360078200 , LMJSD75_360078100

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0B7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.801
CLV_C14_Caspase3-7	319	323	PF00656	0.570
CLV_NRD_NRD_1	187	189	PF00675	0.529
CLV_NRD_NRD_1	271	273	PF00675	0.608
CLV_NRD_NRD_1	286	288	PF00675	0.591
CLV_NRD_NRD_1	294	296	PF00675	0.563
CLV_NRD_NRD_1	329	331	PF00675	0.779
CLV_NRD_NRD_1	416	418	PF00675	0.714
CLV_NRD_NRD_1	438	440	PF00675	0.689
CLV_NRD_NRD_1	46	48	PF00675	0.464
CLV_NRD_NRD_1	509	511	PF00675	0.752
CLV_NRD_NRD_1	81	83	PF00675	0.471
CLV_PCSK_KEX2_1	204	206	PF00082	0.574
CLV_PCSK_KEX2_1	271	273	PF00082	0.615
CLV_PCSK_KEX2_1	286	288	PF00082	0.597
CLV_PCSK_KEX2_1	294	296	PF00082	0.567
CLV_PCSK_KEX2_1	329	331	PF00082	0.779
CLV_PCSK_KEX2_1	438	440	PF00082	0.689
CLV_PCSK_KEX2_1	46	48	PF00082	0.464
CLV_PCSK_KEX2_1	511	513	PF00082	0.684
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.606
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.684
CLV_PCSK_PC7_1	434	440	PF00082	0.686
CLV_PCSK_PC7_1	507	513	PF00082	0.691
CLV_PCSK_SKI1_1	137	141	PF00082	0.411
CLV_PCSK_SKI1_1	169	173	PF00082	0.375
CLV_PCSK_SKI1_1	248	252	PF00082	0.691
CLV_PCSK_SKI1_1	26	30	PF00082	0.530
CLV_PCSK_SKI1_1	46	50	PF00082	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.542
DEG_SPOP_SBC_1	206	210	PF00917	0.630
DOC_ANK_TNKS_1	106	113	PF00023	0.676
DOC_CYCLIN_RxL_1	148	156	PF00134	0.403
DOC_CYCLIN_RxL_1	43	53	PF00134	0.461
DOC_MAPK_gen_1	149	157	PF00069	0.502
DOC_MAPK_gen_1	166	172	PF00069	0.221
DOC_MAPK_gen_1	329	335	PF00069	0.574
DOC_MAPK_gen_1	80	90	PF00069	0.565
DOC_MAPK_MEF2A_6	149	157	PF00069	0.408
DOC_MAPK_MEF2A_6	166	174	PF00069	0.247
DOC_MAPK_MEF2A_6	36	43	PF00069	0.446
DOC_MAPK_RevD_3	153	167	PF00069	0.513
DOC_PP1_RVXF_1	80	87	PF00149	0.464
DOC_PP2B_LxvP_1	155	158	PF13499	0.411
DOC_PP2B_LxvP_1	333	336	PF13499	0.658
DOC_PP4_FxxP_1	432	435	PF00568	0.703
DOC_USP7_MATH_1	213	217	PF00917	0.628
DOC_USP7_MATH_1	222	226	PF00917	0.574
DOC_USP7_MATH_1	254	258	PF00917	0.657
DOC_USP7_MATH_1	274	278	PF00917	0.374
DOC_USP7_MATH_1	334	338	PF00917	0.692
DOC_USP7_MATH_1	359	363	PF00917	0.728
DOC_USP7_MATH_1	495	499	PF00917	0.569
DOC_USP7_MATH_2	455	461	PF00917	0.802
DOC_WW_Pin1_4	252	257	PF00397	0.664
DOC_WW_Pin1_4	469	474	PF00397	0.800
LIG_14-3-3_CanoR_1	115	119	PF00244	0.411
LIG_14-3-3_CanoR_1	130	140	PF00244	0.411
LIG_14-3-3_CanoR_1	229	233	PF00244	0.726
LIG_14-3-3_CanoR_1	271	280	PF00244	0.587
LIG_14-3-3_CanoR_1	368	377	PF00244	0.784
LIG_14-3-3_CanoR_1	438	442	PF00244	0.686
LIG_14-3-3_CanoR_1	497	503	PF00244	0.678
LIG_14-3-3_CanoR_1	5	14	PF00244	0.502
LIG_BIR_III_2	305	309	PF00653	0.537
LIG_BRCT_BRCA1_1	210	214	PF00533	0.686
LIG_BRCT_BRCA1_1	514	518	PF00533	0.580
LIG_FHA_1	222	228	PF00498	0.776
LIG_FHA_1	353	359	PF00498	0.677
LIG_FHA_1	466	472	PF00498	0.607
LIG_FHA_1	478	484	PF00498	0.713
LIG_FHA_1	487	493	PF00498	0.598
LIG_FHA_1	7	13	PF00498	0.462
LIG_FHA_1	79	85	PF00498	0.472
LIG_FHA_1	98	104	PF00498	0.520
LIG_FHA_2	237	243	PF00498	0.800
LIG_FHA_2	317	323	PF00498	0.573
LIG_FHA_2	438	444	PF00498	0.703
LIG_FHA_2	499	505	PF00498	0.648
LIG_IBAR_NPY_1	77	79	PF08397	0.601
LIG_LIR_Apic_2	429	435	PF02991	0.692
LIG_LIR_Apic_2	449	455	PF02991	0.449
LIG_LIR_Gen_1	111	121	PF02991	0.513
LIG_LIR_Gen_1	138	147	PF02991	0.411
LIG_LIR_Gen_1	197	206	PF02991	0.655
LIG_LIR_Gen_1	341	352	PF02991	0.705
LIG_LIR_Gen_1	35	45	PF02991	0.445
LIG_LIR_Gen_1	501	508	PF02991	0.556
LIG_LIR_Gen_1	65	73	PF02991	0.489
LIG_LIR_Nem_3	111	116	PF02991	0.631
LIG_LIR_Nem_3	138	143	PF02991	0.355
LIG_LIR_Nem_3	197	202	PF02991	0.637
LIG_LIR_Nem_3	231	235	PF02991	0.559
LIG_LIR_Nem_3	341	347	PF02991	0.702
LIG_LIR_Nem_3	35	41	PF02991	0.390
LIG_LIR_Nem_3	501	505	PF02991	0.552
LIG_LIR_Nem_3	65	71	PF02991	0.483
LIG_Pex14_1	64	68	PF04695	0.474
LIG_Pex14_2	60	64	PF04695	0.432
LIG_SH2_CRK	344	348	PF00017	0.685
LIG_SH2_CRK	452	456	PF00017	0.688
LIG_SH2_GRB2like	92	95	PF00017	0.577
LIG_SH2_NCK_1	315	319	PF00017	0.772
LIG_SH2_NCK_1	344	348	PF00017	0.809
LIG_SH2_NCK_1	452	456	PF00017	0.688
LIG_SH2_PTP2	113	116	PF00017	0.411
LIG_SH2_PTP2	68	71	PF00017	0.481
LIG_SH2_SRC	344	347	PF00017	0.577
LIG_SH2_SRC	502	505	PF00017	0.553
LIG_SH2_STAP1	502	506	PF00017	0.555
LIG_SH2_STAP1	92	96	PF00017	0.470
LIG_SH2_STAT5	113	116	PF00017	0.411
LIG_SH2_STAT5	142	145	PF00017	0.353
LIG_SH2_STAT5	315	318	PF00017	0.698
LIG_SH2_STAT5	68	71	PF00017	0.478
LIG_SH3_3	328	334	PF00018	0.810
LIG_SH3_3	403	409	PF00018	0.773
LIG_SUMO_SIM_anti_2	390	395	PF11976	0.725
LIG_SUMO_SIM_par_1	392	401	PF11976	0.826
LIG_TRAF2_1	265	268	PF00917	0.587
LIG_UBA3_1	30	36	PF00899	0.478
MOD_CDK_SPxxK_3	252	259	PF00069	0.659
MOD_CK1_1	212	218	PF00069	0.627
MOD_CK1_1	220	226	PF00069	0.601
MOD_CK1_1	228	234	PF00069	0.611
MOD_CK1_1	24	30	PF00069	0.529
MOD_CK1_1	339	345	PF00069	0.692
MOD_CK1_1	372	378	PF00069	0.833
MOD_CK1_1	437	443	PF00069	0.682
MOD_CK1_1	465	471	PF00069	0.724
MOD_CK1_1	472	478	PF00069	0.662
MOD_CK1_1	482	488	PF00069	0.651
MOD_CK1_1	498	504	PF00069	0.595
MOD_CK2_1	29	35	PF00069	0.472
MOD_CK2_1	437	443	PF00069	0.704
MOD_Cter_Amidation	508	511	PF01082	0.693
MOD_GlcNHglycan	211	214	PF01048	0.614
MOD_GlcNHglycan	215	218	PF01048	0.622
MOD_GlcNHglycan	256	259	PF01048	0.739
MOD_GlcNHglycan	276	279	PF01048	0.364
MOD_GlcNHglycan	336	339	PF01048	0.691
MOD_GlcNHglycan	371	374	PF01048	0.769
MOD_GlcNHglycan	443	447	PF01048	0.761
MOD_GlcNHglycan	464	467	PF01048	0.739
MOD_GlcNHglycan	484	488	PF01048	0.690
MOD_GlcNHglycan	497	500	PF01048	0.583
MOD_GlcNHglycan	51	55	PF01048	0.476
MOD_GSK3_1	20	27	PF00069	0.434
MOD_GSK3_1	205	212	PF00069	0.579
MOD_GSK3_1	213	220	PF00069	0.602
MOD_GSK3_1	221	228	PF00069	0.582
MOD_GSK3_1	371	378	PF00069	0.800
MOD_GSK3_1	430	437	PF00069	0.691
MOD_GSK3_1	465	472	PF00069	0.740
MOD_GSK3_1	479	486	PF00069	0.811
MOD_N-GLC_1	21	26	PF02516	0.624
MOD_N-GLC_1	313	318	PF02516	0.614
MOD_N-GLC_1	359	364	PF02516	0.609
MOD_NEK2_1	1	6	PF00069	0.533
MOD_NEK2_1	153	158	PF00069	0.408
MOD_NEK2_1	450	455	PF00069	0.676
MOD_NEK2_1	50	55	PF00069	0.535
MOD_NEK2_2	161	166	PF00069	0.513
MOD_PIKK_1	359	365	PF00454	0.592
MOD_PIKK_1	450	456	PF00454	0.682
MOD_PKA_1	272	278	PF00069	0.581
MOD_PKA_2	114	120	PF00069	0.408
MOD_PKA_2	220	226	PF00069	0.670
MOD_PKA_2	228	234	PF00069	0.691
MOD_PKA_2	352	358	PF00069	0.830
MOD_PKA_2	437	443	PF00069	0.682
MOD_PKB_1	510	518	PF00069	0.705
MOD_Plk_1	24	30	PF00069	0.550
MOD_Plk_4	24	30	PF00069	0.529
MOD_Plk_4	339	345	PF00069	0.692
MOD_Plk_4	522	528	PF00069	0.677
MOD_ProDKin_1	252	258	PF00069	0.664
MOD_ProDKin_1	469	475	PF00069	0.798
MOD_SUMO_rev_2	242	249	PF00179	0.685
TRG_DiLeu_BaEn_1	66	71	PF01217	0.464
TRG_DiLeu_BaEn_4	66	72	PF01217	0.471
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.444
TRG_ENDOCYTIC_2	113	116	PF00928	0.369
TRG_ENDOCYTIC_2	199	202	PF00928	0.643
TRG_ENDOCYTIC_2	344	347	PF00928	0.708
TRG_ENDOCYTIC_2	502	505	PF00928	0.553
TRG_ENDOCYTIC_2	68	71	PF00928	0.481
TRG_ER_diArg_1	149	152	PF00400	0.389
TRG_ER_diArg_1	285	287	PF00400	0.526
TRG_ER_diArg_1	294	296	PF00400	0.567
TRG_ER_diArg_1	328	330	PF00400	0.781
TRG_ER_diArg_1	46	48	PF00400	0.464
TRG_ER_diArg_1	510	513	PF00400	0.689
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.715
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I476	Leptomonas seymouri	57%	94%
A0A3Q8IPX9	Leishmania donovani	92%	100%
A4HQG1	Leishmania braziliensis	76%	97%
A4IC97	Leishmania infantum	92%	100%
E9AU77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%