Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0B6_LEIMA

TriTrypDb:

LmjF.36.6420 , LMJLV39_360078300 , LMJSD75_360078200

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q0B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0B6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.534
CLV_PCSK_KEX2_1	162	164	PF00082	0.536
CLV_PCSK_SKI1_1	134	138	PF00082	0.351
CLV_PCSK_SKI1_1	71	75	PF00082	0.274
DEG_APCC_DBOX_1	6	14	PF00400	0.377
DEG_Nend_Nbox_1	1	3	PF02207	0.364
DOC_CKS1_1	56	61	PF01111	0.217
DOC_MAPK_MEF2A_6	7	15	PF00069	0.377
DOC_MAPK_MEF2A_6	71	78	PF00069	0.334
DOC_MAPK_NFAT4_5	71	79	PF00069	0.317
DOC_PP2B_LxvP_1	193	196	PF13499	0.728
DOC_PP4_FxxP_1	15	18	PF00568	0.317
DOC_PP4_FxxP_1	56	59	PF00568	0.430
DOC_USP7_MATH_1	187	191	PF00917	0.714
DOC_USP7_MATH_2	192	198	PF00917	0.630
DOC_WW_Pin1_4	147	152	PF00397	0.540
DOC_WW_Pin1_4	176	181	PF00397	0.734
DOC_WW_Pin1_4	25	30	PF00397	0.584
DOC_WW_Pin1_4	55	60	PF00397	0.260
LIG_14-3-3_CanoR_1	134	142	PF00244	0.514
LIG_14-3-3_CanoR_1	92	98	PF00244	0.562
LIG_FHA_1	150	156	PF00498	0.700
LIG_FHA_1	186	192	PF00498	0.671
LIG_FHA_1	38	44	PF00498	0.329
LIG_FHA_1	56	62	PF00498	0.366
LIG_FHA_2	143	149	PF00498	0.644
LIG_LIR_Apic_2	14	18	PF02991	0.377
LIG_LIR_Apic_2	53	59	PF02991	0.282
LIG_LIR_Gen_1	42	52	PF02991	0.377
LIG_LIR_Gen_1	58	68	PF02991	0.303
LIG_LIR_Gen_1	91	102	PF02991	0.541
LIG_LIR_Nem_3	42	48	PF02991	0.377
LIG_LIR_Nem_3	91	97	PF02991	0.532
LIG_LIR_Nem_3	99	105	PF02991	0.531
LIG_NRBOX	1	7	PF00104	0.315
LIG_Pex14_2	56	60	PF04695	0.356
LIG_SH2_SRC	200	203	PF00017	0.672
LIG_SH2_STAP1	90	94	PF00017	0.570
LIG_SH2_STAT3	124	127	PF00017	0.555
LIG_SH2_STAT3	21	24	PF00017	0.354
LIG_SH2_STAT5	101	104	PF00017	0.568
LIG_SH2_STAT5	67	70	PF00017	0.309
LIG_SH2_STAT5	77	80	PF00017	0.434
LIG_SH2_STAT5	9	12	PF00017	0.386
LIG_SH3_3	178	184	PF00018	0.770
LIG_SUMO_SIM_anti_2	40	45	PF11976	0.317
LIG_SUMO_SIM_par_1	190	197	PF11976	0.629
LIG_SUMO_SIM_par_1	47	53	PF11976	0.358
LIG_WRC_WIRS_1	12	17	PF05994	0.377
LIG_WW_3	180	184	PF00397	0.662
MOD_CDK_SPxxK_3	176	183	PF00069	0.704
MOD_CK1_1	150	156	PF00069	0.635
MOD_CK2_1	142	148	PF00069	0.639
MOD_GlcNHglycan	118	121	PF01048	0.353
MOD_GSK3_1	112	119	PF00069	0.527
MOD_GSK3_1	147	154	PF00069	0.611
MOD_GSK3_1	183	190	PF00069	0.707
MOD_GSK3_1	93	100	PF00069	0.616
MOD_N-GLC_1	37	42	PF02516	0.283
MOD_NEK2_1	34	39	PF00069	0.542
MOD_NEK2_1	76	81	PF00069	0.479
MOD_NEK2_1	93	98	PF00069	0.494
MOD_NEK2_2	151	156	PF00069	0.565
MOD_PIKK_1	162	168	PF00454	0.707
MOD_PKA_1	162	168	PF00069	0.690
MOD_PKA_2	162	168	PF00069	0.690
MOD_Plk_1	37	43	PF00069	0.286
MOD_Plk_4	104	110	PF00069	0.535
MOD_Plk_4	11	17	PF00069	0.412
MOD_Plk_4	142	148	PF00069	0.592
MOD_Plk_4	194	200	PF00069	0.697
MOD_Plk_4	39	45	PF00069	0.377
MOD_Plk_4	93	99	PF00069	0.624
MOD_ProDKin_1	147	153	PF00069	0.544
MOD_ProDKin_1	176	182	PF00069	0.734
MOD_ProDKin_1	25	31	PF00069	0.583
MOD_ProDKin_1	55	61	PF00069	0.260
TRG_ENDOCYTIC_2	101	104	PF00928	0.522
TRG_ENDOCYTIC_2	12	15	PF00928	0.377
TRG_ENDOCYTIC_2	90	93	PF00928	0.521
TRG_ER_diArg_1	161	163	PF00400	0.700
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P600	Leptomonas seymouri	65%	74%
A0A1X0NN71	Trypanosomatidae	37%	79%
A0A3Q8IK72	Leishmania donovani	94%	100%
A4HQG2	Leishmania braziliensis	75%	100%
A4IC98	Leishmania infantum	94%	100%
E9AU78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5B8C5	Trypanosoma cruzi	37%	100%