Tputative artrate-sensitive acid phosphatase acp-3.2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tartrate-sensitive acid phosphatase acp-3.2, putative

Species:

Leishmania major

UniProt:

Q4Q0B2_LEIMA

TriTrypDb:

LmjF.36.6460 , LMJLV39_360078700 , LMJSD75_360078600

Length:

224

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 1
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0B2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0B2

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.444
CLV_NRD_NRD_1	213	215	PF00675	0.465
CLV_PCSK_KEX2_1	212	214	PF00082	0.468
CLV_PCSK_SKI1_1	11	15	PF00082	0.628
CLV_PCSK_SKI1_1	146	150	PF00082	0.648
DEG_COP1_1	115	122	PF00400	0.436
DOC_MAPK_gen_1	187	195	PF00069	0.271
DOC_MAPK_MEF2A_6	187	195	PF00069	0.271
DOC_USP7_MATH_1	118	122	PF00917	0.441
DOC_WW_Pin1_4	180	185	PF00397	0.493
DOC_WW_Pin1_4	56	61	PF00397	0.407
LIG_14-3-3_CanoR_1	108	114	PF00244	0.484
LIG_14-3-3_CanoR_1	75	83	PF00244	0.463
LIG_BIR_III_2	117	121	PF00653	0.443
LIG_BRCT_BRCA1_1	203	207	PF00533	0.632
LIG_FHA_1	108	114	PF00498	0.412
LIG_FHA_1	152	158	PF00498	0.458
LIG_FHA_1	218	224	PF00498	0.654
LIG_FHA_1	85	91	PF00498	0.356
LIG_LIR_Apic_2	70	76	PF02991	0.367
LIG_LIR_Apic_2	96	101	PF02991	0.377
LIG_LIR_Gen_1	49	57	PF02991	0.392
LIG_LIR_Nem_3	49	54	PF02991	0.385
LIG_LIR_Nem_3	96	102	PF02991	0.377
LIG_LYPXL_S_1	133	137	PF13949	0.630
LIG_LYPXL_yS_3	134	137	PF13949	0.430
LIG_MYND_1	180	184	PF01753	0.456
LIG_Pex14_2	145	149	PF04695	0.443
LIG_SH2_CRK	73	77	PF00017	0.361
LIG_SH2_NCK_1	73	77	PF00017	0.361
LIG_SH2_STAT5	147	150	PF00017	0.448
LIG_SH2_STAT5	73	76	PF00017	0.387
LIG_SH2_STAT5	98	101	PF00017	0.377
LIG_SH3_3	54	60	PF00018	0.410
LIG_WW_3	178	182	PF00397	0.441
MOD_CDK_SPxxK_3	180	187	PF00069	0.297
MOD_CK1_1	56	62	PF00069	0.372
MOD_CK2_1	52	58	PF00069	0.404
MOD_GlcNHglycan	10	14	PF01048	0.635
MOD_GlcNHglycan	162	165	PF01048	0.725
MOD_GlcNHglycan	84	87	PF01048	0.574
MOD_GSK3_1	102	109	PF00069	0.413
MOD_GSK3_1	147	154	PF00069	0.468
MOD_GSK3_1	52	59	PF00069	0.416
MOD_GSK3_1	62	69	PF00069	0.400
MOD_N-GLC_1	106	111	PF02516	0.599
MOD_N-GLC_1	151	156	PF02516	0.653
MOD_N-GLC_1	17	22	PF02516	0.658
MOD_N-GLC_1	67	72	PF02516	0.596
MOD_NEK2_1	157	162	PF00069	0.476
MOD_NEK2_1	201	206	PF00069	0.641
MOD_NEK2_1	218	223	PF00069	0.626
MOD_NEK2_1	46	51	PF00069	0.371
MOD_NEK2_1	71	76	PF00069	0.449
MOD_NEK2_1	89	94	PF00069	0.341
MOD_PIKK_1	157	163	PF00454	0.522
MOD_PIKK_1	62	68	PF00454	0.437
MOD_PIKK_1	76	82	PF00454	0.340
MOD_PKA_2	107	113	PF00069	0.409
MOD_PKA_2	74	80	PF00069	0.463
MOD_Plk_1	52	58	PF00069	0.436
MOD_Plk_1	67	73	PF00069	0.398
MOD_Plk_1	9	15	PF00069	0.400
MOD_Plk_2-3	53	59	PF00069	0.363
MOD_Plk_4	118	124	PF00069	0.438
MOD_Plk_4	22	28	PF00069	0.432
MOD_Plk_4	67	73	PF00069	0.473
MOD_Plk_4	89	95	PF00069	0.300
MOD_ProDKin_1	180	186	PF00069	0.297
MOD_ProDKin_1	56	62	PF00069	0.399
MOD_SUMO_rev_2	12	20	PF00179	0.421
TRG_DiLeu_BaEn_1	10	15	PF01217	0.404
TRG_ENDOCYTIC_2	134	137	PF00928	0.430
TRG_ENDOCYTIC_2	51	54	PF00928	0.385
TRG_ER_diArg_1	211	214	PF00400	0.662
TRG_ER_diArg_1	48	51	PF00400	0.387
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ILZ1	Leishmania donovani	61%	71%
A4ICA2	Leishmania infantum	61%	71%