LeishMANIAdb
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Putative histidine secretory acid phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative histidine secretory acid phosphatase
Gene product:
histidine secretory acid phosphatase, putative
Species:
Leishmania major
UniProt:
Q4Q0A9_LEIMA
TriTrypDb:
LmjF.36.6480 , LMJLV39_360078700 * , LMJLV39_360079100 * , LMJSD75_360078900 * , LMJSD75_360079000 *
Length:
420

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 65
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 22, no: 4
NetGPI no yes: 0, no: 26
Cellular components
Term Name Level Count
GO:0016020 membrane 2 18
GO:0110165 cellular anatomical entity 1 18

Expansion

Sequence features

Q4Q0A9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0A9

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 5
GO:0016311 dephosphorylation 5 5
GO:0044237 cellular metabolic process 2 5
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016787 hydrolase activity 2 6
GO:0016788 hydrolase activity, acting on ester bonds 3 6
GO:0016791 phosphatase activity 5 6
GO:0042578 phosphoric ester hydrolase activity 4 6
GO:0003993 acid phosphatase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 126 130 PF00656 0.378
CLV_C14_Caspase3-7 228 232 PF00656 0.359
CLV_C14_Caspase3-7 314 318 PF00656 0.335
CLV_NRD_NRD_1 284 286 PF00675 0.588
CLV_NRD_NRD_1 410 412 PF00675 0.668
CLV_NRD_NRD_1 417 419 PF00675 0.511
CLV_PCSK_KEX2_1 284 286 PF00082 0.557
CLV_PCSK_KEX2_1 417 419 PF00082 0.506
CLV_PCSK_SKI1_1 11 15 PF00082 0.541
CLV_PCSK_SKI1_1 146 150 PF00082 0.542
CLV_PCSK_SKI1_1 398 402 PF00082 0.235
DEG_COP1_1 115 122 PF00400 0.300
DEG_SPOP_SBC_1 357 361 PF00917 0.455
DOC_MAPK_gen_1 238 247 PF00069 0.325
DOC_MAPK_gen_1 48 56 PF00069 0.296
DOC_PP4_FxxP_1 373 376 PF00568 0.448
DOC_PP4_MxPP_1 213 216 PF00568 0.410
DOC_USP7_MATH_1 118 122 PF00917 0.399
DOC_USP7_MATH_1 218 222 PF00917 0.263
DOC_USP7_MATH_1 230 234 PF00917 0.461
DOC_USP7_MATH_1 331 335 PF00917 0.338
DOC_USP7_MATH_1 357 361 PF00917 0.539
DOC_USP7_MATH_1 381 385 PF00917 0.619
DOC_USP7_MATH_1 386 390 PF00917 0.595
DOC_WW_Pin1_4 180 185 PF00397 0.522
DOC_WW_Pin1_4 196 201 PF00397 0.353
DOC_WW_Pin1_4 308 313 PF00397 0.413
DOC_WW_Pin1_4 382 387 PF00397 0.481
DOC_WW_Pin1_4 56 61 PF00397 0.443
LIG_14-3-3_CanoR_1 108 114 PF00244 0.384
LIG_14-3-3_CanoR_1 270 280 PF00244 0.362
LIG_14-3-3_CanoR_1 382 386 PF00244 0.464
LIG_14-3-3_CanoR_1 75 83 PF00244 0.384
LIG_BIR_III_2 117 121 PF00653 0.292
LIG_BIR_III_4 231 235 PF00653 0.305
LIG_BIR_III_4 265 269 PF00653 0.381
LIG_eIF4E_1 51 57 PF01652 0.315
LIG_FHA_1 108 114 PF00498 0.369
LIG_FHA_1 152 158 PF00498 0.318
LIG_FHA_1 218 224 PF00498 0.411
LIG_FHA_1 399 405 PF00498 0.374
LIG_FHA_1 85 91 PF00498 0.490
LIG_FHA_2 202 208 PF00498 0.360
LIG_FHA_2 312 318 PF00498 0.348
LIG_LIR_Apic_2 371 376 PF02991 0.445
LIG_LIR_Apic_2 70 76 PF02991 0.393
LIG_LIR_Apic_2 96 101 PF02991 0.321
LIG_LIR_Gen_1 183 193 PF02991 0.326
LIG_LIR_Gen_1 220 230 PF02991 0.292
LIG_LIR_Gen_1 233 244 PF02991 0.304
LIG_LIR_Gen_1 49 57 PF02991 0.300
LIG_LIR_Nem_3 183 189 PF02991 0.419
LIG_LIR_Nem_3 220 225 PF02991 0.321
LIG_LIR_Nem_3 233 239 PF02991 0.313
LIG_LIR_Nem_3 49 54 PF02991 0.331
LIG_LIR_Nem_3 96 102 PF02991 0.384
LIG_LYPXL_S_1 133 137 PF13949 0.560
LIG_LYPXL_yS_3 134 137 PF13949 0.426
LIG_MYND_1 180 184 PF01753 0.370
LIG_Pex14_1 326 330 PF04695 0.258
LIG_Pex14_2 145 149 PF04695 0.336
LIG_Pex14_2 201 205 PF04695 0.355
LIG_SH2_CRK 330 334 PF00017 0.298
LIG_SH2_CRK 73 77 PF00017 0.270
LIG_SH2_GRB2like 306 309 PF00017 0.355
LIG_SH2_NCK_1 330 334 PF00017 0.301
LIG_SH2_NCK_1 73 77 PF00017 0.270
LIG_SH2_PTP2 236 239 PF00017 0.368
LIG_SH2_STAT5 147 150 PF00017 0.402
LIG_SH2_STAT5 236 239 PF00017 0.386
LIG_SH2_STAT5 252 255 PF00017 0.493
LIG_SH2_STAT5 341 344 PF00017 0.351
LIG_SH2_STAT5 73 76 PF00017 0.397
LIG_SH2_STAT5 98 101 PF00017 0.411
LIG_SH3_3 380 386 PF00018 0.516
LIG_SH3_3 54 60 PF00018 0.428
LIG_SUMO_SIM_anti_2 220 229 PF11976 0.264
LIG_SUMO_SIM_anti_2 53 59 PF11976 0.326
LIG_WRC_WIRS_1 219 224 PF05994 0.248
LIG_WRC_WIRS_1 370 375 PF05994 0.437
LIG_WW_3 178 182 PF00397 0.357
MOD_CDC14_SPxK_1 385 388 PF00782 0.426
MOD_CDK_SPK_2 308 313 PF00069 0.305
MOD_CDK_SPxK_1 382 388 PF00069 0.437
MOD_CK1_1 299 305 PF00069 0.379
MOD_CK1_1 311 317 PF00069 0.304
MOD_CK1_1 359 365 PF00069 0.568
MOD_CK1_1 368 374 PF00069 0.564
MOD_CK2_1 357 363 PF00069 0.475
MOD_CK2_1 381 387 PF00069 0.441
MOD_CK2_1 52 58 PF00069 0.508
MOD_DYRK1A_RPxSP_1 382 386 PF00069 0.436
MOD_GlcNHglycan 10 14 PF01048 0.619
MOD_GlcNHglycan 162 165 PF01048 0.520
MOD_GlcNHglycan 191 194 PF01048 0.588
MOD_GlcNHglycan 231 235 PF01048 0.528
MOD_GlcNHglycan 248 251 PF01048 0.579
MOD_GlcNHglycan 298 301 PF01048 0.681
MOD_GlcNHglycan 343 346 PF01048 0.592
MOD_GlcNHglycan 84 87 PF01048 0.573
MOD_GSK3_1 102 109 PF00069 0.375
MOD_GSK3_1 147 154 PF00069 0.338
MOD_GSK3_1 189 196 PF00069 0.349
MOD_GSK3_1 226 233 PF00069 0.508
MOD_GSK3_1 304 311 PF00069 0.497
MOD_GSK3_1 333 340 PF00069 0.477
MOD_GSK3_1 358 365 PF00069 0.558
MOD_GSK3_1 382 389 PF00069 0.571
MOD_GSK3_1 398 405 PF00069 0.448
MOD_GSK3_1 52 59 PF00069 0.440
MOD_GSK3_1 62 69 PF00069 0.358
MOD_N-GLC_1 106 111 PF02516 0.616
MOD_N-GLC_1 151 156 PF02516 0.576
MOD_N-GLC_1 17 22 PF02516 0.638
MOD_N-GLC_1 209 214 PF02516 0.520
MOD_N-GLC_1 357 362 PF02516 0.684
MOD_N-GLC_1 67 72 PF02516 0.678
MOD_NEK2_1 157 162 PF00069 0.320
MOD_NEK2_1 189 194 PF00069 0.372
MOD_NEK2_1 201 206 PF00069 0.353
MOD_NEK2_1 217 222 PF00069 0.376
MOD_NEK2_1 239 244 PF00069 0.445
MOD_NEK2_1 254 259 PF00069 0.354
MOD_NEK2_1 264 269 PF00069 0.335
MOD_NEK2_1 46 51 PF00069 0.399
MOD_NEK2_1 71 76 PF00069 0.405
MOD_NEK2_1 89 94 PF00069 0.256
MOD_NEK2_2 209 214 PF00069 0.317
MOD_OFUCOSY 332 337 PF10250 0.553
MOD_PIKK_1 157 163 PF00454 0.371
MOD_PIKK_1 62 68 PF00454 0.314
MOD_PIKK_1 76 82 PF00454 0.295
MOD_PKA_2 107 113 PF00069 0.395
MOD_PKA_2 254 260 PF00069 0.321
MOD_PKA_2 271 277 PF00069 0.362
MOD_PKA_2 381 387 PF00069 0.541
MOD_PKA_2 74 80 PF00069 0.396
MOD_PKB_1 270 278 PF00069 0.299
MOD_Plk_1 194 200 PF00069 0.351
MOD_Plk_1 209 215 PF00069 0.395
MOD_Plk_1 368 374 PF00069 0.662
MOD_Plk_1 52 58 PF00069 0.407
MOD_Plk_1 67 73 PF00069 0.400
MOD_Plk_1 9 15 PF00069 0.403
MOD_Plk_4 118 124 PF00069 0.338
MOD_Plk_4 218 224 PF00069 0.347
MOD_Plk_4 22 28 PF00069 0.445
MOD_Plk_4 248 254 PF00069 0.326
MOD_Plk_4 337 343 PF00069 0.288
MOD_Plk_4 52 58 PF00069 0.527
MOD_Plk_4 67 73 PF00069 0.436
MOD_Plk_4 89 95 PF00069 0.446
MOD_ProDKin_1 180 186 PF00069 0.510
MOD_ProDKin_1 196 202 PF00069 0.355
MOD_ProDKin_1 308 314 PF00069 0.409
MOD_ProDKin_1 382 388 PF00069 0.480
MOD_ProDKin_1 56 62 PF00069 0.436
MOD_SUMO_rev_2 12 20 PF00179 0.329
MOD_SUMO_rev_2 311 321 PF00179 0.298
TRG_DiLeu_BaEn_1 10 15 PF01217 0.311
TRG_DiLeu_BaLyEn_6 235 240 PF01217 0.326
TRG_ENDOCYTIC_2 134 137 PF00928 0.462
TRG_ENDOCYTIC_2 186 189 PF00928 0.380
TRG_ENDOCYTIC_2 236 239 PF00928 0.405
TRG_ENDOCYTIC_2 306 309 PF00928 0.370
TRG_ENDOCYTIC_2 51 54 PF00928 0.290
TRG_ER_diArg_1 283 285 PF00400 0.387
TRG_ER_diArg_1 416 418 PF00400 0.691
TRG_ER_diArg_1 48 51 PF00400 0.447
TRG_Pf-PMV_PEXEL_1 313 317 PF00026 0.620
TRG_Pf-PMV_PEXEL_1 41 45 PF00026 0.534

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Y5 Leptomonas seymouri 26% 73%
A0A3Q8ILZ1 Leishmania donovani 63% 100%
A0A3Q8IR23 Leishmania donovani 27% 74%
A0A3R7MEN7 Trypanosoma rangeli 30% 81%
A0A3S5H827 Leishmania donovani 29% 82%
A0A3S7WXU0 Leishmania donovani 30% 79%
A4HCZ0 Leishmania braziliensis 31% 68%
A4HGW8 Leishmania braziliensis 26% 77%
A4HPC1 Leishmania braziliensis 32% 81%
A4HPC5 Leishmania braziliensis 29% 73%
A4HQG6 Leishmania braziliensis 58% 95%
A4HQG9 Leishmania braziliensis 57% 81%
A4I0H5 Leishmania infantum 30% 79%
A4ICA2 Leishmania infantum 63% 100%
A4ICG3 Leishmania infantum 29% 82%
A4ICG5 Leishmania infantum 27% 74%
D0A3E0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 80%
D0A9J5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 80%
E9AT34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 81%
E9AT36 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 74%
E9AWD7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 79%
E9B088 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 76%
Q4Q1G2 Leishmania major 27% 74%
Q4Q1G4 Leishmania major 29% 82%
Q4QB35 Leishmania major 30% 77%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS