Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0A7_LEIMA

TriTrypDb:

LmjF.36.6500 , LMJLV39_360079400 , LMJSD75_360079200

Length:

683

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q0A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0A7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	369	373	PF00656	0.604
CLV_NRD_NRD_1	121	123	PF00675	0.554
CLV_NRD_NRD_1	126	128	PF00675	0.513
CLV_NRD_NRD_1	203	205	PF00675	0.492
CLV_NRD_NRD_1	328	330	PF00675	0.462
CLV_NRD_NRD_1	479	481	PF00675	0.476
CLV_NRD_NRD_1	585	587	PF00675	0.597
CLV_NRD_NRD_1	613	615	PF00675	0.596
CLV_NRD_NRD_1	67	69	PF00675	0.431
CLV_NRD_NRD_1	671	673	PF00675	0.589
CLV_NRD_NRD_1	73	75	PF00675	0.402
CLV_PCSK_FUR_1	611	615	PF00082	0.595
CLV_PCSK_KEX2_1	121	123	PF00082	0.552
CLV_PCSK_KEX2_1	125	127	PF00082	0.527
CLV_PCSK_KEX2_1	203	205	PF00082	0.492
CLV_PCSK_KEX2_1	303	305	PF00082	0.417
CLV_PCSK_KEX2_1	479	481	PF00082	0.450
CLV_PCSK_KEX2_1	585	587	PF00082	0.597
CLV_PCSK_KEX2_1	613	615	PF00082	0.561
CLV_PCSK_KEX2_1	66	68	PF00082	0.433
CLV_PCSK_KEX2_1	671	673	PF00082	0.615
CLV_PCSK_KEX2_1	73	75	PF00082	0.402
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.417
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.450
CLV_PCSK_PC7_1	121	127	PF00082	0.468
CLV_PCSK_SKI1_1	101	105	PF00082	0.425
CLV_PCSK_SKI1_1	172	176	PF00082	0.491
CLV_PCSK_SKI1_1	330	334	PF00082	0.478
CLV_PCSK_SKI1_1	525	529	PF00082	0.644
CLV_PCSK_SKI1_1	69	73	PF00082	0.400
CLV_PCSK_SKI1_1	82	86	PF00082	0.385
CLV_Separin_Metazoa	268	272	PF03568	0.592
DEG_APCC_DBOX_1	100	108	PF00400	0.642
DEG_SCF_FBW7_1	129	135	PF00400	0.685
DEG_SCF_FBW7_1	444	451	PF00400	0.628
DEG_SCF_FBW7_2	116	123	PF00400	0.692
DEG_SPOP_SBC_1	109	113	PF00917	0.703
DEG_SPOP_SBC_1	180	184	PF00917	0.714
DEG_SPOP_SBC_1	506	510	PF00917	0.570
DOC_CKS1_1	129	134	PF01111	0.683
DOC_CKS1_1	423	428	PF01111	0.574
DOC_CKS1_1	445	450	PF01111	0.628
DOC_CKS1_1	606	611	PF01111	0.405
DOC_CYCLIN_yCln2_LP_2	515	521	PF00134	0.445
DOC_MAPK_gen_1	203	209	PF00069	0.625
DOC_MAPK_gen_1	479	486	PF00069	0.632
DOC_PP2B_LxvP_1	515	518	PF13499	0.466
DOC_PP2B_LxvP_1	548	551	PF13499	0.445
DOC_PP4_FxxP_1	11	14	PF00568	0.389
DOC_PP4_FxxP_1	606	609	PF00568	0.360
DOC_USP7_MATH_1	103	107	PF00917	0.618
DOC_USP7_MATH_1	109	113	PF00917	0.683
DOC_USP7_MATH_1	12	16	PF00917	0.390
DOC_USP7_MATH_1	199	203	PF00917	0.686
DOC_USP7_MATH_1	28	32	PF00917	0.406
DOC_USP7_MATH_1	289	293	PF00917	0.575
DOC_USP7_MATH_1	312	316	PF00917	0.552
DOC_USP7_MATH_1	384	388	PF00917	0.563
DOC_USP7_MATH_1	439	443	PF00917	0.667
DOC_USP7_MATH_1	448	452	PF00917	0.706
DOC_USP7_MATH_1	490	494	PF00917	0.481
DOC_USP7_MATH_1	562	566	PF00917	0.395
DOC_USP7_MATH_1	612	616	PF00917	0.427
DOC_USP7_UBL2_3	317	321	PF12436	0.608
DOC_WW_Pin1_4	116	121	PF00397	0.733
DOC_WW_Pin1_4	125	130	PF00397	0.807
DOC_WW_Pin1_4	213	218	PF00397	0.672
DOC_WW_Pin1_4	233	238	PF00397	0.675
DOC_WW_Pin1_4	344	349	PF00397	0.630
DOC_WW_Pin1_4	422	427	PF00397	0.563
DOC_WW_Pin1_4	444	449	PF00397	0.616
DOC_WW_Pin1_4	508	513	PF00397	0.524
DOC_WW_Pin1_4	58	63	PF00397	0.652
DOC_WW_Pin1_4	605	610	PF00397	0.397
DOC_WW_Pin1_4	629	634	PF00397	0.426
DOC_WW_Pin1_4	661	666	PF00397	0.352
DOC_WW_Pin1_4	77	82	PF00397	0.549
DOC_WW_Pin1_4	87	92	PF00397	0.592
LIG_14-3-3_CanoR_1	160	165	PF00244	0.797
LIG_14-3-3_CanoR_1	181	186	PF00244	0.697
LIG_14-3-3_CanoR_1	189	198	PF00244	0.714
LIG_14-3-3_CanoR_1	203	208	PF00244	0.648
LIG_14-3-3_CanoR_1	230	238	PF00244	0.724
LIG_14-3-3_CanoR_1	329	339	PF00244	0.660
LIG_14-3-3_CanoR_1	532	539	PF00244	0.379
LIG_14-3-3_CanoR_1	611	617	PF00244	0.397
LIG_14-3-3_CanoR_1	654	662	PF00244	0.330
LIG_Actin_WH2_2	276	293	PF00022	0.537
LIG_Actin_WH2_2	43	61	PF00022	0.264
LIG_Actin_WH2_2	92	107	PF00022	0.568
LIG_Clathr_ClatBox_1	579	583	PF01394	0.383
LIG_deltaCOP1_diTrp_1	39	42	PF00928	0.410
LIG_deltaCOP1_diTrp_1	647	655	PF00928	0.334
LIG_DLG_GKlike_1	160	168	PF00625	0.749
LIG_EH1_1	480	488	PF00400	0.560
LIG_eIF4E_1	136	142	PF01652	0.614
LIG_EVH1_2	550	554	PF00568	0.480
LIG_FHA_1	181	187	PF00498	0.749
LIG_FHA_1	238	244	PF00498	0.755
LIG_FHA_1	295	301	PF00498	0.626
LIG_FHA_1	362	368	PF00498	0.579
LIG_FHA_1	460	466	PF00498	0.586
LIG_FHA_1	543	549	PF00498	0.446
LIG_FHA_1	566	572	PF00498	0.425
LIG_FHA_1	602	608	PF00498	0.366
LIG_FHA_1	635	641	PF00498	0.382
LIG_FHA_2	332	338	PF00498	0.656
LIG_FHA_2	367	373	PF00498	0.643
LIG_FHA_2	423	429	PF00498	0.574
LIG_FHA_2	526	532	PF00498	0.457
LIG_FHA_2	573	579	PF00498	0.457
LIG_HCF-1_HBM_1	560	563	PF13415	0.475
LIG_LIR_Apic_2	260	266	PF02991	0.596
LIG_LIR_Apic_2	603	609	PF02991	0.354
LIG_LIR_Gen_1	337	346	PF02991	0.616
LIG_LIR_Gen_1	39	50	PF02991	0.278
LIG_LIR_Gen_1	552	562	PF02991	0.470
LIG_LIR_Gen_1	596	607	PF02991	0.375
LIG_LIR_Gen_1	647	656	PF02991	0.333
LIG_LIR_Nem_3	135	141	PF02991	0.651
LIG_LIR_Nem_3	318	322	PF02991	0.623
LIG_LIR_Nem_3	337	342	PF02991	0.559
LIG_LIR_Nem_3	39	45	PF02991	0.326
LIG_LIR_Nem_3	552	557	PF02991	0.472
LIG_LIR_Nem_3	596	602	PF02991	0.335
LIG_LIR_Nem_3	647	653	PF02991	0.324
LIG_MYND_1	513	517	PF01753	0.485
LIG_NRBOX	377	383	PF00104	0.593
LIG_SH2_CRK	343	347	PF00017	0.737
LIG_SH2_GRB2like	339	342	PF00017	0.601
LIG_SH2_PTP2	339	342	PF00017	0.601
LIG_SH2_SRC	339	342	PF00017	0.601
LIG_SH2_STAP1	191	195	PF00017	0.646
LIG_SH2_STAP1	363	367	PF00017	0.582
LIG_SH2_STAP1	374	378	PF00017	0.613
LIG_SH2_STAP1	563	567	PF00017	0.439
LIG_SH2_STAT3	363	366	PF00017	0.585
LIG_SH2_STAT3	383	386	PF00017	0.524
LIG_SH2_STAT3	641	644	PF00017	0.373
LIG_SH2_STAT5	301	304	PF00017	0.573
LIG_SH2_STAT5	319	322	PF00017	0.729
LIG_SH2_STAT5	339	342	PF00017	0.601
LIG_SH2_STAT5	355	358	PF00017	0.581
LIG_SH2_STAT5	363	366	PF00017	0.585
LIG_SH2_STAT5	421	424	PF00017	0.572
LIG_SH2_STAT5	499	502	PF00017	0.332
LIG_SH2_STAT5	54	57	PF00017	0.312
LIG_SH2_STAT5	601	604	PF00017	0.356
LIG_SH3_1	126	132	PF00018	0.651
LIG_SH3_2	609	614	PF14604	0.402
LIG_SH3_3	11	17	PF00018	0.401
LIG_SH3_3	126	132	PF00018	0.737
LIG_SH3_3	20	26	PF00018	0.439
LIG_SH3_3	420	426	PF00018	0.604
LIG_SH3_3	428	434	PF00018	0.587
LIG_SH3_3	510	516	PF00018	0.474
LIG_SH3_3	606	612	PF00018	0.399
LIG_SH3_3	659	665	PF00018	0.349
LIG_SUMO_SIM_anti_2	278	286	PF11976	0.571
LIG_SUMO_SIM_anti_2	424	431	PF11976	0.548
LIG_SUMO_SIM_anti_2	493	498	PF11976	0.243
LIG_SUMO_SIM_par_1	139	147	PF11976	0.629
LIG_TRAF2_1	373	376	PF00917	0.606
LIG_WW_2	513	516	PF00397	0.601
MOD_CDC14_SPxK_1	632	635	PF00782	0.499
MOD_CDK_SPK_2	116	121	PF00069	0.683
MOD_CDK_SPK_2	77	82	PF00069	0.409
MOD_CDK_SPxK_1	116	122	PF00069	0.686
MOD_CDK_SPxK_1	605	611	PF00069	0.488
MOD_CDK_SPxK_1	629	635	PF00069	0.480
MOD_CK1_1	128	134	PF00069	0.618
MOD_CK1_1	163	169	PF00069	0.755
MOD_CK1_1	187	193	PF00069	0.615
MOD_CK1_1	202	208	PF00069	0.674
MOD_CK1_1	231	237	PF00069	0.681
MOD_CK1_1	24	30	PF00069	0.528
MOD_CK1_1	257	263	PF00069	0.512
MOD_CK1_1	278	284	PF00069	0.453
MOD_CK1_1	315	321	PF00069	0.464
MOD_CK1_1	565	571	PF00069	0.504
MOD_CK1_1	573	579	PF00069	0.504
MOD_CK2_1	27	33	PF00069	0.526
MOD_CK2_1	331	337	PF00069	0.535
MOD_CK2_1	572	578	PF00069	0.568
MOD_CK2_1	597	603	PF00069	0.540
MOD_CK2_1	657	663	PF00069	0.537
MOD_CK2_1	87	93	PF00069	0.479
MOD_GlcNHglycan	231	234	PF01048	0.743
MOD_GlcNHglycan	248	251	PF01048	0.483
MOD_GlcNHglycan	256	259	PF01048	0.559
MOD_GlcNHglycan	26	29	PF01048	0.559
MOD_GlcNHglycan	285	290	PF01048	0.502
MOD_GlcNHglycan	291	294	PF01048	0.554
MOD_GlcNHglycan	314	317	PF01048	0.451
MOD_GlcNHglycan	386	389	PF01048	0.536
MOD_GlcNHglycan	450	453	PF01048	0.583
MOD_GlcNHglycan	475	478	PF01048	0.630
MOD_GlcNHglycan	502	505	PF01048	0.315
MOD_GlcNHglycan	540	543	PF01048	0.702
MOD_GlcNHglycan	575	578	PF01048	0.696
MOD_GlcNHglycan	659	662	PF01048	0.465
MOD_GSK3_1	110	117	PF00069	0.652
MOD_GSK3_1	128	135	PF00069	0.513
MOD_GSK3_1	158	165	PF00069	0.802
MOD_GSK3_1	180	187	PF00069	0.631
MOD_GSK3_1	198	205	PF00069	0.516
MOD_GSK3_1	224	231	PF00069	0.680
MOD_GSK3_1	233	240	PF00069	0.642
MOD_GSK3_1	24	31	PF00069	0.527
MOD_GSK3_1	246	253	PF00069	0.493
MOD_GSK3_1	285	292	PF00069	0.561
MOD_GSK3_1	331	338	PF00069	0.585
MOD_GSK3_1	444	451	PF00069	0.546
MOD_GSK3_1	534	541	PF00069	0.539
MOD_GSK3_1	54	61	PF00069	0.532
MOD_GSK3_1	565	572	PF00069	0.525
MOD_GSK3_1	597	604	PF00069	0.485
MOD_GSK3_1	629	636	PF00069	0.520
MOD_GSK3_1	657	664	PF00069	0.480
MOD_N-GLC_1	149	154	PF02516	0.510
MOD_NEK2_1	164	169	PF00069	0.702
MOD_NEK2_1	179	184	PF00069	0.531
MOD_NEK2_1	534	539	PF00069	0.574
MOD_NEK2_1	569	574	PF00069	0.539
MOD_NEK2_1	674	679	PF00069	0.471
MOD_NEK2_2	103	108	PF00069	0.553
MOD_NEK2_2	144	149	PF00069	0.553
MOD_NEK2_2	237	242	PF00069	0.587
MOD_NEK2_2	54	59	PF00069	0.336
MOD_NEK2_2	601	606	PF00069	0.385
MOD_PIKK_1	189	195	PF00454	0.597
MOD_PK_1	203	209	PF00069	0.518
MOD_PKA_1	203	209	PF00069	0.545
MOD_PKA_1	585	591	PF00069	0.479
MOD_PKA_2	180	186	PF00069	0.677
MOD_PKA_2	202	208	PF00069	0.567
MOD_PKA_2	229	235	PF00069	0.721
MOD_PKA_2	278	284	PF00069	0.444
MOD_PKA_2	585	591	PF00069	0.479
MOD_PKA_2	612	618	PF00069	0.538
MOD_PKB_1	125	133	PF00069	0.631
MOD_PKB_1	160	168	PF00069	0.619
MOD_Plk_1	285	291	PF00069	0.549
MOD_Plk_1	358	364	PF00069	0.415
MOD_Plk_1	542	548	PF00069	0.638
MOD_Plk_1	563	569	PF00069	0.557
MOD_Plk_1	591	597	PF00069	0.516
MOD_Plk_2-3	224	230	PF00069	0.639
MOD_Plk_4	110	116	PF00069	0.637
MOD_Plk_4	181	187	PF00069	0.647
MOD_Plk_4	278	284	PF00069	0.449
MOD_Plk_4	315	321	PF00069	0.695
MOD_Plk_4	331	337	PF00069	0.604
MOD_Plk_4	534	540	PF00069	0.525
MOD_Plk_4	553	559	PF00069	0.509
MOD_Plk_4	565	571	PF00069	0.461
MOD_Plk_4	601	607	PF00069	0.456
MOD_Plk_4	634	640	PF00069	0.422
MOD_Plk_4	674	680	PF00069	0.448
MOD_ProDKin_1	116	122	PF00069	0.676
MOD_ProDKin_1	125	131	PF00069	0.773
MOD_ProDKin_1	213	219	PF00069	0.587
MOD_ProDKin_1	233	239	PF00069	0.584
MOD_ProDKin_1	344	350	PF00069	0.519
MOD_ProDKin_1	422	428	PF00069	0.444
MOD_ProDKin_1	444	450	PF00069	0.519
MOD_ProDKin_1	508	514	PF00069	0.657
MOD_ProDKin_1	58	64	PF00069	0.560
MOD_ProDKin_1	605	611	PF00069	0.488
MOD_ProDKin_1	629	635	PF00069	0.528
MOD_ProDKin_1	661	667	PF00069	0.415
MOD_ProDKin_1	77	83	PF00069	0.418
MOD_ProDKin_1	87	93	PF00069	0.472
TRG_DiLeu_BaEn_1	39	44	PF01217	0.538
TRG_DiLeu_BaEn_1	647	652	PF01217	0.430
TRG_DiLeu_BaEn_2	267	273	PF01217	0.479
TRG_ENDOCYTIC_2	138	141	PF00928	0.514
TRG_ENDOCYTIC_2	319	322	PF00928	0.520
TRG_ENDOCYTIC_2	339	342	PF00928	0.521
TRG_ER_diArg_1	120	122	PF00400	0.687
TRG_ER_diArg_1	125	127	PF00400	0.657
TRG_ER_diArg_1	159	162	PF00400	0.615
TRG_ER_diArg_1	212	215	PF00400	0.546
TRG_ER_diArg_1	241	244	PF00400	0.639
TRG_ER_diArg_1	584	586	PF00400	0.478
TRG_ER_diArg_1	611	614	PF00400	0.482
TRG_ER_diArg_1	670	672	PF00400	0.459
TRG_ER_diArg_1	72	74	PF00400	0.518
TRG_ER_FFAT_1	216	227	PF00635	0.604
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHH7	Leptomonas seymouri	43%	100%
A0A3S7XCG4	Leishmania donovani	91%	100%
A4HQH1	Leishmania braziliensis	68%	96%
A4ICA7	Leishmania infantum	91%	100%
E9AU84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%